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The risk of bleeding of triple therapy with vitamin K-antagonists,aspirin and clopidogrel after coronary stent implantation:Facts and questions

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Journal of Geriatric Cardiology 2011年第4期8卷 207-214页

作者： andrea Rubboli Division of Cardiology and Cardiac Catheterization Laboratory Ospedale Maggiore40133 BolognaItaly

Background Triple therapy(TT)with vitamin K-antagonists(VKA),aspirin and clopidogrel is the recommended antithrombotic treatment following percutaneous coronary intervention with stent implantation(PCI-S)in patients with an indication for oral *** is associated with an increased risk of bleeding,but available evidence is flawed by important limitations,including the limited size and the retrospective design of most of the studies,as well as the rare reporting of the incidence of in-hospital bleeding and the treatment which was actually ongoing at the time of *** the perceived high bleeding risk of TT may deny patients effective strategies,the determination of the true safety profile of TT is of paramount *** All the 27 published studies where the incidence of bleeding at various time points during follow-up has been reported separately for patients on TT were reviewed,and the weakness of the data was *** The absolute incidence of major bleeding upon discharge at in-hospital,≤1 month,6 months,12 months and≥12 months was:3.3%±1.9%,5.1%±6.7%,8.0%±5.2%,9.0%±8.0,and 6.2%±7.8%,respectively,and not substantially different from that observed in previous studies with prolonged dual antiplatelet treatment with aspirin and *** While waiting for the ongoing,large-scale,registries and clinical trials to clarify the few facts and to answer the many questions regarding the risk of bleeding of TT,this treatment should not be denied to patients with an indication for VKA undergoing PCI-S provided that the proper measures and cautions are implemented.

关键词： percutaneous coronary intervention stent bleeding oral anticoagulation vitamin K antagonists aspirin clopidogrel

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Variational Analysis of Toda Systems(To Ham with admiration and gratitude)

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Chinese Annals of Mathematics,Series B 2017年第2期38卷 539-562页

作者： andrea malchiodi Scuola Normale Superiore Piazza dei Cavalieri 750126 PisaItaly

The author surveys some recent progress on the Toda system on a twodimensional surface Σ, arising in models from self-dual non-abelian Chern-Simons vortices,as well as in differential geometry. In particular, its var... 详细信息

关键词： Geometric PDEs, Variational methods, Min-max schemes

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Theory of light sail acceleration by intense lasers:an overview

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High Power Laser Science and Engineering 2014年第2期2卷 1-6页

作者： andrea Macchi National Institute of Optics National Research Council (CNR/INO) Research Unit ‘Adriano Gozzini’Department of Physics ‘Enrico Fermi’ University of Pisa largo Bruno Pontecorvo 3 I-56127 Pisa Italy

A short overview of the theory of acceleration of thin foils driven by the radiation pressure of superintense lasers is presented. A simple criterion for radiation pressure dominance at intensities around 5×1020W cm-... 详细信息

关键词： light sail radiation pressure laser–plasma acceleration of electrons and ions laser-driven acceleration

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Editorial

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Science China(Physics,Mechanics & Astronomy) 2019年第5期62卷 1-2页

作者： andrea Santangelo Institute of Astronomy and Astrophysics University of Tübingen Institute of High Energy Physics Chinese Academy of Sciences

There can be no doubt that huge advances in our knowledge of the Universe have been attained thanks to spectral-timing studies of extreme celestial objects emitting in the *** the same time X-ray all sky monitors have made tremendous contributions to our understanding of the physics and astrophysics of the hot and violent Universe,by observing the variability of the sky and detecting new,transient,and often completely unexpected *** advances have always been prompted by groundbreaking instrumentation,based on innovative,challenging,technology.

关键词： Universe technology variability

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Metamaterials and plasmonics: From nanoparticles to nanoantenna arrays, metasurfaces, and metamaterials

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Chinese Physics B 2014年第4期23卷 64-75页

作者： Francesco Monticone andrea Alù Department of Electrical and Computer Engineering The University of Texas at Austin 1 University Station C0803Austin Texas 78712 USA

The rise of plasmonic metamaterials in recent years has unveiled the possibility of revolutionizing the entire field of optics and photonics, challenging well-established technological limitations and paving the way to innovations at an unprecedented level To capitalize the disruptive potential of this rising field of science and technology, it is important to be able to combine the richness of optical phenomena enabled by nanoplasmonics in order to realize metamaterial components, devices, and systems of increasing complexity. Here, we review a few recent research directions in the field of plasmonic metamaterials, which may foster further advancements in this research area. We will discuss the anomalous scattering features enabled by plasmonic nanoparticles and nanoclusters, and show how they may represent the fundamental building blocks of complex nanophotonic architectures. Building on these concepts, advanced components can be designed and operated, such as optical nanoantennas and nanoantenna arrays, which, in turn, may be at the basis of metasurface devices and complex systems. Following this path, from basic phenomena to advanced functionalities, the field of plasmonic metamaterials offers the promise of an important scientific and technological impact, with applications spanning from medical diagnostics to clean energy and information processing.

关键词： plasmonics metamaterials nanoparticles scattering

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Rhythm and synchrony in animal movement and communication

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Current Zoology 2019年第1期65卷 77-81页

作者： andrea RAViGNANi Artificial Intelligence Lab Vrije Universiteit Brussel Brussels Belgium Research Department Sealcentre Pieterburen Pieterburen The Netherlands

Introduction Animal communication and motoric behavior develop over time. Often, this temporal dimension has communicative relevance and is organized according to structural patterns. In other words, time is a crucial dimension for rhythm and synchrony in animal movement and communication. Rhythm is defined as temporal structure at a second-millisecond time scale (Kotz et al. 2018). Synchrony is defined as precise co-occurrence of 2 behaviors in time (Ravignani .2017).

关键词： Introduction Animal motoric behavior communicative relevance

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Avian genetic ecotoxicology： DNA of the canary in a coalmine

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Current Zoology 2014年第2期60卷 285-298页

作者： andrea BONISOLI-ALQUATI Department of Biological Sciences University of South Carolina Columbia SC 29208 USA

Genotoxic chemicals, through damage and alteration of the genetic material of wild organisms, pose significant threats to the persistence of wild animal populations. Their damaging effects can ultimately impair the health of the ecosystem and its provision of services to human society. Bird species are good candidates for the role of sentinels of the effects of genotoxins, thanks to （i） the diversity of their ecological niches, （ii） their ubiquity across environments, （iii） their conspicuousness, abundance and approachability, together with （iv） their well-known life histories and the availability of historical data series. Avian diversity increases the likelihood that adequate model species be available for monitoring genotoxicants and assessing their impact. This paper reviews the methods utilized by genetic ecotoxicological studies of wild birds, highlighting their benefits and shortcomings. It also summarizes the genetic ecotoxicological studies so far conducted. In spite of a paucity of studies, several classes of genotoxicants have already been investigated across a variety of species and environments, thus supporting the versatility of birds as monitors of genotoxic contamination. Future technical advancements and applications are suggested, with par- ticular reference to the analysis of mutational events, gene expression and methylation patterns. Finally, I argue that the development of avian genetic ecotoxicology will contribute to the understanding of natural variation in the underlying machinery for coping with DNA damage and oxidative stress, both of which are increasingly recognized as proximate factors in the evolution of life history adaptations [Current Zoology 60 （2）： 285-298, 2014].

关键词： Biomarker DNA damage Ecogenotoxicology Ecological indicator Ecological Risk assessment Environmental monitoring

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Poverty reduction through the development of inclusive food value chains

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Journal of Integrative Agriculture 2021年第4期20卷 964-978页

作者： Rob VOS andrea CATTANEO International Food Policy Research Institute(IFPRI) WashingtonD.C.20007USA Food and Agriculture Organization of the United Nations(FAO) Rome 00153Italy

Propelled by urbanization,rising incomes,and changing diets,food markets have been expanding in Africa and South Asia,creating the vast potential for job and income opportunities along food supply chains and,hence,for poverty *** novel coronavirus(COVID-19)that spread to a pandemic in early 2020 provokes enormous setbacks to this ***,however,should provide lessons regarding the importance of resilient and inclusive food *** responses to COVID-19 should consider interventions towards that end and leverage the opportunities provided by food markets growth as economies recover from the present economic *** paper assesses options of how this could be done by facilitating the better functioning and interconnectedness of the many small and medium-sized enterprises that are proliferating along the"hidden middle"of food value chains in storage,logistics,transportation,and wholesale and retail *** also explores how policies can help smallholder farmers connect to this"hidden middle"in more gainful ways and help them climb out of poverty as well.

关键词： poverty food security and hunger food supply chains South Asia sub-Saharan Africa

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State of the art and computational aspects of time-dependent waiting models for non-signalised intersections

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第6期7卷 808-831页

作者： Raffaele Mauro andrea Pompigna Department of Civil Environmental and Mechanical EngineeringUniversity of TrentoTrento 38123Italy

Time-dependent models are of great importance in highway engineering as they are appropriate for evaluating waiting times and queue lengths at intersections,which are integral parts of various activities in planning,verification and decision support for *** reviewing the literature of the main time-dependent models based on the coordinate transformation method and a discussion about some computational issues in time-evolution profiles for non-signalised intersections,the paper identifies the requirements these models have to satisfy in order to be used as"basic"cases for analysing complex evolutionary ***"basic"cases are presented with their timedependent equations for vehicle waiting times and vehicle number;they have been completed and dimensionally homogenised in this *** they are recursive,these formulas can be applied for sequential intervals in the time domain in both vehicles and passenger car *** closed-form expressions for state variables show to be mutually equivalent in comparison with discrete event simulation models and imbedded Markov chain *** all the three models the paper presents a common deterministic simplification for average waiting time,with good approximation results in the tested *** proposed time-dependent formulas will contribute to a better adherence to the real phenomena,compared to the extremely simplified and unrealistic methods suggested by the international manuals for level of service *** proposed formulas will be useful for current applications and possible future development in order to meet the emerging needs of road and transport engineering.

关键词： Traffic engineering Priority system Non-signalised intersections Time-dependent queue model Shared queue delay Coordinate transformation method

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Quantum ekpyrotic mechanism in Fermi-bounce curvaton cosmology

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Chinese Physics C 2020年第10期44卷 142-151页

作者： andrea Addazi Antonino Marciano Center for Field Theory and Particle Physics&Department of Physics Fudan UniversityShanghai 200433China

Within the context of the Fermi-bounce curvaton mechanism,we analyze the one-loop radiative corrections to the four-fermion interaction,generated by the non-dynamical torsion field in the Einstein-Cartan-Holst-Sciama-Kibble *** show that contributions that arise from the one-loop radiative corrections modify the energy-momentum tensor,mimicking an effective Ekpyrotic fluid ***,we call this effect quantum Ekpyrotic *** leads to the dynamical washing out of anisotropic contributions to the energy-momentum tensor,without introducing any new extra Ekpyrotic *** discuss the stability of the bouncing mechanism and derive the renormalization group flow of the dimensional coupling constantξ,checking whether any change of its sign takes place towards the *** enforces the theoretical motivations in favor of the torsion curvaton bounce cosmology as an alternative candidate to the inflation paradigm.

关键词： bounce cosmology fermion bounce ekpyrotic bounce non-dynamical torsion

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