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Glial response in the m.d.ingulate cortex in Huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani H.Palpagama andrea Kwakowsky Center for Brain Research and department of Anatomy and m.d.cal Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

Huntington’s disease(Hd)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying Hd results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： Huntington degeneration cortex

Neuroinflammation as a therapeutic target in Huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： andrea Kwakowsky Thulani H.Palpagama Center for Brain Research and department of Anatomy and m.d.cal Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George Huntington presented his essay “On Chorea” to the meigs and mason Academy of m.d.cine and, in doing so, detailed a disease that would later bear his name. Huntington's disease(Hd) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： Huntington inflammation m.d.cine

Beyond neurodegeneration:engineering amyloids for biocatalysis

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Neural Regeneration Research 2025年第10期20卷 2915-2916页

作者： andrea Bartolomé-Nafría Javier García-Pardo Salvador Ventura Institut de Biotecnologia i de Biom.d.cina(IBB)and departament de Bioquímica i Biologia molecular Universitat Autònoma de BarcelonaBellaterraBarcelonaSpain Hospital Universitari Parc Taulí Institut d’Investigaciói InnovacióParc Taulí(I3PT-CERCA)Universitat Autònoma de BarcelonaSabadellSpain

Amyloid fibrils are highly organized protein or peptide aggregates,often characterized by a distinctive supramolecular cross-β-sheet *** formation and accumulation of these structures have been traditionally associated with neural or systemic human diseases,such as Alzheimer’s disease,Parkinson’s disease,type-2 diabetes,or amyotrophic lateral sclerosis(Wei et al.,2017;Wittung-Stafshede,2023).

关键词： structure amyloid

multifaceted superoxide dismutase 1 expression in amyotrophic lateral sclerosis patients:a rare occurrence?

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Neural Regeneration Research 2025年第1期20卷 130-138页

作者： Ilaria martinelli Jessica mandrioli andrea Ghezzi Elisabetta Zucchi Giulia Gianferrari Cecilia Simonini Francesco Cavallieri Franco Valzania department of Neurosciences Azienda Ospedaliero Universitaria di ModenaModenaItaly Clinical and Experimental m.d.cine Ph.d.Program University of Modena and Reggio EmiliaModenaItaly department of Biom.d.cal Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly Neurology Unit Neuromotor&Rehabilitation DepartmentAzienda USL-IRCCS di Reggio EmiliaReggio EmiliaItaly

Amyotrophic lateral sclerosis(ALS)is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex,brainstem,and spinal *** the typical clinical phenotype of ALS involves both upper and lower motor neurons,human and animal studies over the years have highlighted the potential spread to other motor and non-motor regions,expanding the phenotype of *** superoxide dismutase 1(SOd1)mutations represent a minority of ALS cases,the SOd1 gene remains a milestone in ALS research as it represents the first genetic target for personalized *** numerous single case reports or case series exhibiting extramotor symptoms in patients with ALS mutations in SOd1(SOd1-ALS),no studies have comprehensively explored the full spectrum of extramotor neurological manifestations in this *** this narrative review,we analyze and discuss the available literature on extrapyram.d.l and non-motor features during *** multifaceted expression of SOd1 could deepen our understanding of the pathogenic mechanisms,pointing towards a multidisciplinary approach for affected patients in light of new therapeutic strategies for SOd1-ALS.

关键词： amyotrophic lateral sclerosis(ALS) autonomic extramotor genotype-phenotype multisystem involvement Parkinson’s disease sensory SOd1 superoxide dismutase 1 urinary vocal cord palsy

HAGEN POISEUILLE FLOW OF A GRANULAR mATERIAL IN A CYLINdER

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Journal of Hydrodynamics 2001年第2期13卷 91-95页

作者： Liu, m.J. Tao, m.d. dept. of mech. and Eng. Sci. Fudan Univ. Shanghai 200433 China

The equations of motion for rapid flow of a granular material were derived and their solutions representing flow driven by a body force along an infinitely-long cylinder were obtained by the numerical method.

关键词： Boundary conditions Cylinders (shapes) Equations of motion Flow of solids Numerical methods

Lighting the shades of hidden pain:a role for spinal cord neurons and microglia in vestibulodynia

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Neural Regeneration Research 2025年第10期20卷 2898-2900页

作者： Rosmara Infantino Francesca Gargano Serena Boccella Carmela Belardo andrea maria morace Francesca Guida Sabatino maione Livio Luongo department of Experimental m.d.cine Division of PharmacologyUniversitàdegli Studi della Campania“L.Vanvitelli”Italy UniversitàCampus Bio-m.d.co di Roma RomeItaly

Vulvodynia,a chronic pain disorder affecting the vulvar region,represents a significant challenge in both diagnosis and treatment within the field of women’s *** condition is characterized by chronic pain that significantly affects the quality of life of afflicted *** present perspective paper examines the role of spinal sensitization and microglial activation in vulvodynia.

关键词： pain diagnosis activation

GRId GENERATION ANd NUmERICAL SImULATION OF 2-d RIVER FLOW

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Journal of Hydrodynamics 2001年第2期13卷 50-54页

作者： Zhao, m.d. Li, Y.T. dept. of River Eng. Wuhan Univ. Wuhan 430072 China

This paper presents new weighting functions in grid generation and new discretizing scheme of momentum equations in numerical simulation of river flow. By using the new weighting functions, the curvilinear grid could be concentrated as desired near the assigned points or lines in physical plane. By using the new discretizing scheme, the difficulties caused by movable boundary and dry riverbed can be overcome. As an application, the flow in the Wuhan Section of Yangtze River is simulated. The computational results are in good agreement with the measured results. The new method is applicable to the numerical simulation of 2-d river flow with irregular region and moveable boundary.

关键词： Computer simulation Flow of fluids mathematical m.d.ls Poisson equation Two dimensional

Hydrogen Storage Capacity of C120 Nanocapsules： density Functional Theory Based Treatments

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Communications in Theoretical Physics 2011年第3期55卷 519-526页

作者： m.d. Ganji Gh. Valizadeh m. Jahan-tigh department of Chemistry Islamic Azad University Ghaemshahr Branch Mazandaran Iran

The adsorption of hydrogen molecule on the external surface of pure 0120 nanocapsule and endohedrallyH2 @C120 complex has been examined using the density functional theory calculations. Several different bonding configu- rations are considered for the hydrogen molecule approaching the outer surface of the considered nanocages. It has been found that the adsorbed H2 molecule bound weakly to the outer surface of the pure C1~0 nanocapsules in agreement with the recent experimental and theoretical results while, it prefers to be adsorbed rather strongly on the side wall of the endohedrally /-/2@C120 complex. The adsorption of a single layer and bi-layer of two tt2 molecules on the most stable states of the considered H2@C120 complex appears to be feasible, although the molecules of the second layer are weakly bound. Furthermore, it is found that the formation of 100% coverage is favorable therm.d.namically, which corresponds to about 20% by weight storage of 1-12 molecules. Thus, surprisingly, we arrive at the prediction that the C120 nanocapsules can be implemented as a novel material for energy storage.

关键词： adsorption encapsulation hydrogen storages carbon nanocapsule ab initio calculations

Notes on the Landmark development of CBR in China

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中国康复医学杂志 2009年第1期24卷 3-4页

作者： dahong Zhuo, m.d. Faculty of Rehabilitation m.d.cine Sun Yat-Sen University WHO Collaborating Centre for Rehabilitation

Community-based rehabilitation has a history of 22 years in *** spite of the preliminary achievement and experiences obtained by the pioneering and trial projects,it was not until the beginning of the new century that CBR in China experienced a landmark *** is characterized by a number of favorable policy by the government for CBR;the mechanism facilitating primary health care with CBR,a new work-force system of CBR reorganized with better motivation and efficiency,99 demonstration projects of CBR bringing about benchmark promotion effect and the active involvement in CBR by social resources agents.

关键词： CBR 中国医疗卫生行业发展历史