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Immersion Tools as a Strategy for Adolescents Mental Health: A Qualitative Study

Health 2020年第7期12卷 866-875页

作者： Diana Cecilia Tapia-Pancardo Juan Carlos Gutiérrez-Martínez Rodolfo Martínez-Mondragón Claudia Gabriela Rivera-Ramírez Cristina Piñón-Atilano Wendy de Jesús Hernández-Bravo andrea navarrete-mejorada Viviana Sánchez-Gómez Rafael Villalobos-Molina División de Investigación y Posgrado Unidad de Biomedicina Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México Carrera de Enfermería. Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de México Tlalnepantla México

Background: Information and communication technologies have revolutionized education, due to development of didactic strategies to take advantage of them for maximizing learning. The aim was to analyze the influence of immersion tools as a strategy to improve adolescents’ mental health. Methods: Qualitative research was employed, and participants’ experiences, opinions, values, behaviors, emotions, feelings were recorded. Twenty six students of both sexes, aged 13 to 15 years, from the three grades of secondary school were selected by convenience, and supported by the school’s psychologist. A workshop on emotional intelligence (EI) based on educational technology was implemented using a video;students practiced a reflexive process to understand themselves and their surroundings, creating a video + audio as a product of the workshop. In it, students analyzed several problems they face and their relationship with their contextual situation. Data collection was through semi-structured interviews before and after the workshop on EI. Data analysis was according to Souza Minayo, and the theoretical framework according to Goleman, Tapia et al., Gorostieta et al., and Vigotsky. Results: Two categories emerged: Category I, EI as a risk factors transformer from living with addictions to protection factors in adolescents. Category II, EI development through immersion tools to improve mental health in adolescents. Conclusions: Immersion tools favor user to be closer, with a humanist focus where real necessities are studied after the vivid experience of the problem to solve or get a better situation. The goal is that students experience real situations inside controlled surroundings, in such a way that they learn from their experiences and acquire knowledge through self-learning. EI program through immersion tools favored to modulate feelings, and to get a bett

关键词： Mental Health Adolescence Immersion Tools

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Oral administration of the cannabigerol derivative VCE-003.2 promotes subventricular zone neurogenesis and protects against mutant huntingtin-induced neurodegeneration

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Translational Neurodegeneration 2019年第1期8卷 111-125页

作者： José Aguareles Juan Paraíso-Luna Belén Palomares Raquel Bajo-Grañeras Carmen navarrete andrea Ruiz-Calvo Daniel García-Rincón Elena García-Taboada Manuel Guzmán Eduardo Muñoz Ismael Galve-Roperh Instituto Ramón y Cajal de Investigación Sanitaria(IRYCIS) Ctra.Colmenar Viejokm9100 MadridSpain Departamento de Bioquímica y Biología Molecular and Instituto Universitario de Investigación Neuroquímica Universidad ComplutenseMadridSpain Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas(CIBERNED) MadridSpain Instituto Maimónides de Investigación Biomédica de Córdoba(IMIBIC) CórdobaSpain Departamento de Biología Celular Fisiología e InmunologíaUniversidad de CórdobaCórdobaSpain Hospital Universitario Reina Sofía CórdobaSpain Emerald Health Pharmaceuticals San DiegoUSA

Background:The administration of certain cannabinoids provides neuroprotection in models of neurodegenerative diseases by acting through various cellular and molecular *** cannabinoid actions in the nervous system are mediated by CB1 receptors,which can elicit psychotropic effects,but other targets devoid of psychotropic activity,including CB2 and nuclear PPARγreceptors,can also be the target of specific ***:We investigated the pro-neurogenic potential of the synthetic cannabigerol derivative,VCE-003.2,in striatal neurodegeneration by using adeno-associated viral expression of mutant huntingtin in vivo and mouse embryonic stem cell differentiation in ***:Oral administration of VCE-003.2 protected striatal medium spiny neurons from mutant huntingtin-induced damage,attenuated neuroinflammation and improved motor ***-003.2 bioavailability was characterized and the potential undesired side effects were evaluated by analyzing hepatotoxicity after chronic ***-003.2 promoted subventricular zone progenitor mobilization,increased doublecortin-positive migrating neuroblasts towards the injured area,and enhanced effective ***,we demonstrated the proneurogenic activity of VCE-003.2 in embryonic stem ***-003.2 was able to increase neuroblast formation and striatal-like CTIP2-mediated ***:The cannabigerol derivative VCE-003.2 improves subventricular zone-derived neurogenesis in response to mutant huntingtin-induced neurodegeneration,and is neuroprotective by oral administration.

关键词： Cannabinoid Huntingtin Neurodegeneration Neurogenesis PPAR

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