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Resolving the age-related decline in central nervous system myelin turnover and drug discovery for oligodendroglial rejuvenation

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Neural Regeneration Research 2022年第12期17卷 2677-2678页

作者： andrea Domenico Rivera Arthur Morgan Butt Kasum Azim Institute of Biomedical and Biomolecular Sciences School of Pharmacy and Biomedical ScienceUniversity of PortsmouthPortsmouthUK Section of Human Anatomy Department of NeuroscienceUniversity of PaduaPaduaItaly Department of Neurology Medical FacultyHeinrich-Heine-UniversityDüsseldorfGermany

Myel i n genes are amongst the most dysregulated genes in the aged brain:Just over half of the weight of an entire adult human brain is attributed to myelin,which wraps around neuronal axons and is essential for superfast axonal conduction and neuronal *** the central nervous system,it is the function of specialized cells called oligodendrocytes(OLs)to make myelin,which is made up of lipids and *** are generated throughout life by a significant population of oligodendrocyte progenitor cells(OPCs)that are responsible for the lifelong generation of OLs and myelin,essential for learning,as well as repair following pathological insults(*** demyelinating diseases that include multiple sclerosis)(Simons and Nave,2015;Philips and Rothstein,2017).Changes in myelin content in the human brain over the lifespan of individuals have been well documented,as well as evidence of myelin loss in rodent models using classical histological approaches(Bartzokis et al.,2012;Soreq et al.,2017).

关键词： myelin system specialized

Nihilism and Desire in"The Posthumous Memoirs of Bras Cubas":Literature and Psychoanalysis

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外国语言与文化(英文) 2023年第1期7卷 77-88页

作者： andrea Almeida Campos Catholic University of Pernambuco

Literature and psychoanalysis are put into dialogue in order to perform an innovative reading of Machado de Assis's The Posthumous Memoirs of Bras Cubas,which is considered one of his masterpieces,alongside Quincas Bo... 详细信息

关键词： Machado de Assis Literature and Psychoanalysis memory desire experimentalism

A WKNN-based approach for NB-IoT sensors localization

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Digital Communications and Networks 2023年第1期9卷 175-182页

作者： Ennio Gambi Linda Senigagliesi andrea Barbaresi Matteo Mellini Adelmo De Santis Department of Information Engineering Universita Politecnica delle Marche60131AnconaItaly TIM S.p.A.-Business-Pre Sales Engineer 60100AnconaItaly

With the recent introduction of NarrowBand Internet of Things(NB-IoT)technology in the 4th and 5th generations of mobile radio networks,the mobile communications context opens up significantly to the world of *** means of NB-IoT,the mobile systems within 3GPP standardization introduce the peculiar functions of sensor networks,thus making it possible to satisfy very specific requirements with respect to those which characterize traditional mobile *** the functions of interest for sensor networks,the possibility of locating the positions of the sensors without an increase in costs and energy consumption of the sensor nodes is of utmost *** present work describes a procedure for locating the NB-IoT nodes based on the quality of radio signals received by the mobile terminals,which therefore does not require further hardware implementations on board the *** procedure,based on the RF fingerprinting technique and on machine learning processing,has been tested experimentally and has achieved interesting performances.

关键词： Narrowband Internet of Things(NB-IoT) Sensor localization Sensor networks RF fingerprint Positioning LTE

Degradation of 3D-printed magnesium phosphate ceramics in vitro and a prognosis on their bone regeneration potential

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Bioactive Materials 2023年第1期19卷 376-391页

作者： Gefel Eugen Moseke Claus Schmitt Anna-Maria Dümmler Niklas Stahlhut Philipp Ewald andrea Meyer-Lindenberg andrea Vorndran Elke Institute and Department for Functional Materials in Medicine and Dentistry University Clinic WuerzburgWuerzburgGermany Institute for Biomedical Engineering(IBMT) University of Applied Sciences Mittelhessen(THM)Wiesenstraße 14GießenGermany Clinic for Small Animal Surgery and Reproduction Ludwig-Maximilians-UniversitätMunichGermany

Regenerative bone implants promote new bone formation and ideally degrade simultaneously to *** clinically established calcium phosphate bone grafts provide excellent osseointegration and osteoconductive efficacy,they are limited in terms of *** phosphate(MP)based ceramics are a promising alternative,because they are biocompatible,mechanically extremely stable,and degrade much faster than calcium phosphates under physiological *** of an implant material can include both chemical dissolution as well as cellular *** investigated the bioresorption of 3D powder printed struvite and newberyite based MP ceramics in vitro by a direct human osteoclast culture *** osteoclast response and cellular resorption was evaluated by means of fluorescence and TRAP staining,determination of osteoclast activities(CA II and TRAP),SEM imaging as well as by quantification of the ion release during cell ***,the bioactivity of the materials was investigated via SBF immersion,whereas hydroxyapatite precipitates were analyzed by SEM and EDX *** bioactive coating was resorbed by *** contrast,only chemical dissolution contributed to bioresorption of MP,while no cellular resorption of the materials was *** on our results,we expect an increased bone regeneration effect of MP compared to calcium phosphate based bone grafts and complete chemical degradation within a maximum of 1.5-3.1 years.

关键词： Newberyite Struvite Bioresorption Ceramic bone implants Human osteoclasts Bioactivity

Current practices regarding middle turbinate resection among otolaryngologists

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2023年第2期9卷 183-188页

作者： andrea Ziegler Monica Patadia Chirag Patel Department of Otolaryngology Loyola UniversityMedical CenterMaywoodIlinoisUSA

Objectives:Resection of the middle turbinate(MT)during endoscopic sinus surgery(ESS)has been a controversial topic among otolaryngologists for many *** studies advocate resection and have shown improved outcomes postoperatively,while studies favoring preservation show a decreased incidence of postoperative *** current practice pattern regarding this subject is *** goal of this study was to learn the current practice of MT resection during ESS among ***:We performed an electronic anonymous survey of practicing ***:We found that the majority of the 252 responders stated that they will perform an MT resection in certain clinical situations,while there is a small subset that advocates never resecting the MT for inflammatory sinus disease(n=6,2.4%).Participants were significantly more likely to perform MT resection in patients undergoing revision compared to primary ESS for all conditions *** complication of greatest concern among participants was iatrogenic frontal sinus obstruction,while empty nose was of the least *** majority of participants responded that MT resection was of extreme or moderate benefit for improved visualization and drug delivery *** compared to general otolaryngologists,fellowship-trained rhinologists were less concerned about potential complications following MT resection and were more likely to perceive an extreme or moderate benefit from turbinate resection ***:There remains debate over MT resection among otolaryngologists,but the results of this study show that the majority of participating otolaryngologists will perform a resection in certain clinical situations.

关键词： current practice trends endoscopic sinus surgery middle turbinate resection survey

Model Checking for Probabilistic Multiagent Systems

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Journal of Computer Science & Technology 2023年第5期38卷 1162-1186页

作者：付辰 andrea Turrini 黄小炜宋磊冯元张立军 State Key Laboratory of Computer Science Institute of SoftwareChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Institute of Intelligent Software Guangzhou 511455China Department of Computer Science University of LiverpoolLiverpool L693BXU.K Microsoft Research Beijing 100190China Centre for Quantum Software and Information University of Technology SydneySydney 2007Australia

In multiagent systems,agents usually do not have complete information of the whole system,which makes the analysis of such systems *** incompleteness of information is normally modelled by means of accessibility relations,and the schedulers consistent with such relations are called *** this paper,we consider probabilistic multiagent systems with accessibility relations and focus on the model checking problem with respect to the probabilistic epistemic temporal logic,which can specify both temporal and epistemic ***,the problem is undecidable in *** show that it becomes decidable when restricted to memoryless uniform ***,we present two algorithms for this case:one reduces the model checking problem into a mixed integer non-linear programming(MINLP)problem,which can then be solved by Satisfiability Modulo Theories(SMT)solvers,and the other is an approximate algorithm based on the upper confidence bounds applied to trees(UCT)algorithm,which can return a result whenever *** algorithms have been implemented in an existing model checker and then validated on *** experimental results show the efficiency and extendability of these algorithms,and the algorithm based on UCT outperforms the one based on MINLP in most cases.

关键词： probabilistic multiagent system model checking uniform scheduler probabilistic epistemic temporal logic

An Axiom System of Probabilistic Mu-Calculus

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Tsinghua Science and Technology 2022年第2期27卷 372-385页

作者： Wanwei Liu Junnan Xu David N.Jansen andrea Turrini Lijun Zhang College of Computer Science National University of Defense TechnologyChangsha 410073China State Key Laboratory of Computer Science Institute of SoftwareChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100039China Institute of Intelligent Software Guangzhou 511458China

Mu-calculus(a.k.a.μTL)is built up from modal/dynamic logic via adding the least fixpoint operatorμ.This type of logic has attracted increasing attention since Kozen’s seminal work.PμTL is a succinct probabilistic extension of the standardμTL obtained by making the modal operators *** of this logic,such as expressiveness and satisfiability decision,have been studied *** consider another important problem:the axiomatization of that *** extending the approaches of Kozen and Walukiewicz,we present an axiom system for Pμ*** addition,we show that the axiom system is complete for aconjunctive formulas.

关键词： PμTL axiom system aconjunctive formula tableau approach

Beyond Mendelian Inheritance:Genetic Buffering and Phenotype Variability

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Phenomics 2022年第2期2卷 79-87页

作者： andrea Rossi Zacharias Kontarakis Genome Engineering and Model Development Lab(GEMD) IUF-Leibniz Research Institute for Environmental Medicine40225 DüsseldorfGermany Genome Engineering and Measurement Laboratory(GEML) Eidgenössische Technische Hochschule(ETH)ZurichZurichSwitzerland Functional Genomics Center Zurich of ETH Zurich University of Zurich8093 ZurichSwitzerland

Understanding the way genes work amongst individuals and across generations to shape form and function is a common theme for many genetic *** recent advances in genetics,genome engineering and DNA sequencing reinforced the notion that genes are not the only players that determine a *** to physiological or pathological fluctuations in gene expression,even genetically identical cells can behave and manifest different phenotypes under the same ***,we discuss mechanisms that can influence or even disrupt the axis between genotype and phenotype;the role of modifier genes,the general concept of genetic redundancy,genetic compensation,the recently described transcriptional adaptation,environmental stressors,and phenotypic *** furthermore highlight the usage of induced pluripotent stem cells(iPSCs),the generation of isogenic lines through genome engineering,and sequencing technologies can help extract new genetic and epigenetic mechanisms from what is hitherto considered‘noise’.

关键词： Genetic compensation Transcriptional adaptation Modifiers Phenotypes Phenotypic plasticity

Bitcoin:a new proof‑of‑work system with reduced variance

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Financial Innovation 2023年第1期9卷 2325-2338页

作者： Danilo Bazzanella andrea Gangemi Dipartimento di Scienze Matematiche Politecnico di TorinoCorso Duca degli Abruzzi 2410129 TurinItaly

Since its inception,bitcoin has used the popular consensus protocol proof-of-work(PoW).PoW has a well-known flaw:it distributes all rewards to a single miner(or pool)who inserts a new ***,the variance of rewards and the mining enter-prise risk are extremely *** 2016,Shi proposed addressing this problem with a theoretical *** introduce an easily-implemented PoW variant that improves Shi’s *** network must not find a single nonce but a few to insert a *** simple change allows for a fairer distribution of rewards and also has the effect of regularizing the insertion time of *** method would facilitate the emergence of small pools or autonomous miners.

关键词： Proof-of-work Bitcoin Consensus protocol