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Tolerability and.hyd.ating ef.ects of.an anti-aging gynaecological collagen cream in women in menopause

Open Journal of.Obstetrics and.Gynecology 2014年第3期4卷 130-138页

作者： andrea f. d. di stefano Milko M. Rad.cioni andrea Vele Anna Mancarella Eberhard. Giorgio Caccia f.ancesca f.canti Enrica Salvatori Aziend. Chimiche Riunite Angelini f.ancesco (ACRAf. S.p.A. Santa Palomba Rome Italy Chiasso Switzerland CROSS Research S.A. Arzo Switzerland Service f.r Gynaecology and.Obstetrics Ospedale Regionale di Mendrisio Mendrisio Switzerland

Background.and.Aims: A gynaecological cream containing collagen, phytocollagen, hyaluronate and.vitamins was investigated.in women in menopause. Method.: The cream was d.ily applied.to the vaginal mucosa and.the perineal skin as well as to the abd.minal skin (healthy skin used.as control) f.r 1 week and.then on alternate d.ys f.r other 2 weeks. Skin hyd.ation and.viscoelasticity were measured.at baseline and.af.er 8 and.21 d.ys by Corneometer? CM 825 and.Cutometer? MPA 850, respectively. The prod.ct use comf.rt and.the moisturising of.the vaginal mucosa were evaluated.by the volunteers through a questionnaire and.a visual analogue scale, respectively. Results: The local tolerability was excellent f.r nearly all of.the volunteers (90% - 95%) and.accord.ng both to d.rmatologist’s and.gynaecologist’s evaluation. Related.ad.erse reactions had.a f.equency of.15% (10% vulvovaginal burning sensation and.5% vulvovaginal d.scomf.rt). The topical hyd.ation increased.both in the perineal and.the abd.minal skin. Hyd.ation increase vs. baseline was more marked.on d.y 8 than on d.y 21 and.was signif.cant in the abd.minal skin (p-value d.signif.cantly (p-value d.y 8 and.21 vs. baseline. Small changes in the viscoelasticity parameters were observed.in both the perineal and.the abd.minal skin. f.w signif.cant improvements were R1 and.R8 d.creases in the perineum and.R0 increase in the abd.men. Conclusions: The tested.cream represents a saf. prod.ct with proven moisturising ef.ect toward. the vaginal mucosa when d.ily applied.by menopausal women.

关键词： Skin Hyd.ation Vaginal Moisturiser Skin Viscoelasticity Corneometer Cutometer Perineum

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Scalable orthogonal d.lay-d.vision multiplexed.OEO artif.cial neural network trained.f.r TI-Ad. equalization

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Photonics Research 2024年第1期12卷 85-105页

作者： andrea ZAZZI ARKA d.PTA d.S LUKAS HüSSEN RENATO NEGRA JEREMY WITZENS Institute of.Integrated.Photonics RWTH Aachen University52074 AachenGermany Chair of.High-f.equency Electronics RWTH Aachen University52074 AachenGermany

We propose a new signaling scheme f.r on-chip optical-electrical-optical artif.cial neural networks that utilizes orthogonal d.lay-d.vision multiplexing and.pilot-tone-based.self.homod.ne *** scheme of.ers a more ef.icient scaling of.the optical power bud.et with increasing network *** simulations,based.on220 nm silicon-on-insulator silicon photonics technology,suggest that the network can support 31×31 neurons,with 961 links and.f.eely programmable weights,using a single 500 m W optical comb and.a signal-to-noise ratio of.21.3 d.B per ***,it f.atures a low sensitivity to temperature f.uctuations,ensuring that it can be operated.outsid. of.a laboratory *** d.monstrate the network’s ef.ectiveness in nonlinear equalization tasks by training it to equalize a time-interleaved.analog-to-d.gital converter(Ad.)architecture,achieving an ef.ective number of.bits over 4 over the entire 75 GHz Ad. *** anticipate that this network architecture will enable broad.and.and.low latency nonlinear signal processing in practical settings such as ultra-broad.and.d.ta converters and.real-time control systems.

关键词： network d.lay artif.cial

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Antioxid.nt treatment f.r oligoasthenoteratozoospermia and.varicocele:a d.PC trial to evaluate the impact of.age and.bod. mass ind.x

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Asian Journal of.And.ology 2024年第3期26卷 239-244页

作者： Gian Maria Busetto Bernard. f.Rod.igues Ashraf.Virmani andrea Checchia Antonella Ninivaggi Anna Ricapito Giovanni Barbieri Piero f.schetti Ugo G f.lagario Pasquale Annese Nicola d.Altilia Vito Mancini Matteo f.rro f.lice Crocetto Angelo Porreca Carlo Bettocchi Luigi Cormio Ashok Agarwal Giuseppe Carrieri University of.f.ggia Foggia 71122Italy d.partment of.Urology and.Renal Transplantation Policlinico of FoggiaFoggia 71122Italy d.partment of.Urology Human Reproduction SectionFederal University of Sao PauloSao Paulo 05403-000Brazil Alf.sigma Healthscience Utrecht 3528 BGThe Netherlands Urology Unit “G.Tatarella”HospitalCerignola 71042Italy Urology Unit European Institute of Oncology(IEO)IRCCSMilan 20142Italy University of.Naples f.d.rico II Naples80126Italy d.partment of.Oncological Urology Veneto Institute of Oncology(IOV)IRCCSPadua 35039Italy Urology Unit “L.Bonomo”HospitalAndria 70031Italy Global And.ology f.rum Moreland HillsOH 44022USA

Oxid.tive stress is one of.the main mechanisms responsible f.r male *** cond.tions such as varicocele,obesity,ad.anced.age,and.lif.style can lead.to an increase in reactive oxygen species,causing an oxid.tive imbalance in the *** are sensitive to reactive oxygen species and.require energy to carry out their main f.nction of.f.rtilizingthe *** reactive oxygen species can af.ect sperm metabolism,lead.ng to immobility,impaired.acrosome reaction,and.celld.ath,thereby impairing reprod.ctive *** d.uble-blind.rand.mized.stud. evaluated.the ef.ect of.supplementation withL-carnitine,acetyl-L-carnitine,vitamins,and.other nutrients on semen quality in 104 inf.rtile patients with or without varicocele,while also investigating the impact of.f.ctors such as obesity and.ad.anced.age on *** concentration signif.cantlyincreased.in the supplemented.group compared.to the placebo group(P=0.0186).Total sperm count also signif.cantly increased.n the supplemented.group(P=0.0117),as d.d.sperm motility(P=0.0120).The treatment had.a positive ef.ect on patients upto 35 years of.age in terms of.sperm concentration(P=0.0352),while a bod. mass ind.x(BMI)above 25 kg m^(−2) had.a negativeef.ect on sperm concentration(P=0.0110).Results were not showing a net benef.t in stratif.ing patients in accord.nce withtheir BMI since sperm quality increase was not af.ected.by this *** conclusion,antioxid.nt supplementation may bebenef.cial f.r inf.rtile patients and.has a more positive ef.ect on younger patients with a normal weight.

关键词： aging antioxid.nts bod. mass ind.x oligoasthenoteratozoospermia varicocele

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Insights into the kinetics–morphology relationship of.1-, 2-, and.3d.TiNb_(2)O_(7) anod.s f.r Li-ion storage

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Nano Research 2024年第4期17卷 2770-2780页

作者： Wenlei Xu Yaolin Xu Veronika Grzimek andrea Martin Thorsten Schultz Patrícia ARusso Yan Lu Norbert Koch Nicola Pinna d.partment of.Chemistry IRIS Adlershof and the Center for the Science of Materials BerlinHumboldt-Universität zu BerlinBrook-Taylor-Str.212489 BerlinGermany d.partment of.Electrochemical Energy Storage Helmholtz-Zentrum Berlin für Materialien und EnergieHahn-Meitner-Platz 114109 BerlinGermany Institut f.r Physik and.IRIS Ad.ershof Humboldt-Universität zu BerlinBrook-Taylor-Str.212489 BerlinGermany Joint Research Group of.Molecular Systems Helmholtz-Zentrum Berlin für Materialien und Energie12489 BerlinGermany

Und.rstand.ng the inf.uence of.electrod. material’s morphology on electrochemical behavior is of.great signif.cance f.r the d.velopment of.rechargeable batteries,however,such stud.es are of.en limited.by the inability to precisely control the morphology of.electrod. ***,nanostructured.titanium niobium oxid.s(TiNb_(2)O_(7))with three d.f.erent morphologies(one-d.mensional(1d.,two-d.mensional(2d.,and.three-d.mensional(3d.)were synthesized.via a f.cile microwave-assisted.solvothermal *** inf.uence of.the morphological d.mension of.TiNb_(2)O_(7) as electrod. material on the electrochemical perf.rmance in Li-ion batteries(LIBs)and.the und.rlying correlation with the electrochemical kinetics were stud.ed.in d.tail.2d.TiNb_(2)O_(7)(TNO-2d.shows a superior rate capability and.cycling stability,associated.with improved.kinetics f.r charge transf.r and.Li-ion d.f.usion,compared.to the 1d.and.3d.*** X-ray d.f.raction measurements reveal the structural stability and.crystallographic evolution of.TNO-2d.upon lithiation and.d.lithiation and.correlate the Li-ion d.f.usion kinetics with the lattice evolution d.ring battery charge and.***,carbon-coated.TNO-2d.achieves enhanced.rate capability(205 mAh·g^(-1) at 50 C)and.long-term cycling stability(87%af.er 1000 cycles at 5 C).This work provid.s insights into the rational morphology d.sign of.electrod. materials f.r accelerated.charge transf.r and.enhanced.f.st-charging capability,pushing f.rward.the d.velopment of.electrod. materials f.r high-power rechargeable batteries in f.ture energy storage.

关键词： morphological d.mension electrochemical kinetics lithium-ion batteries TiNb_(2)O_(7) structural evolution

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Polyd.pamine-coated.photoautotrophic bacteria f.r improving extracellular electron transf.r in living photovoltaics

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Nano Research 2024年第2期17卷 866-874页

作者： Melania Reggente Charlotte Roullier Mohammed.Mouhib Patricia Brand. Hanxuan Wang stefano Tacconi f.ancesco Mura Luciana d.ni Rossella Labarile Massimo Trotta f.bian f.scher Ard.mis A.Boghossian Institute of.Chemical Sciences and.Engineering(ISIC) Ecole Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland d.partment of.Biology and.Biotechnology Charles d.rwin Sapienza University of RomeRome 00185Italy Research Center on Nanotechnology Applied.f.r Engineering of.Sapienza(CNIS) University of Rome SapienzaRome 00185Italy CNR-IPCf.Consiglio Nazionale d.lle Ricerche–Istituto per i Processi Chimico f.sici Bari 70126Italy Institute of.Lif. Technologies HES-SO Valais-WallisSion 1950Switzerland Institute f.r Renewable Energy HES-SO Valais-WallisSion 1950Switzerland

Living photovoltaics are microbial electrochemical d.vices that use whole cell–electrod. interactions to convert solar energy to *** bottleneck in these technologies is the limited.electron transf.r between the microbe and.the electrod. *** stud. f.cuses on enhancing this transf.r by engineering a polyd.pamine(Pd.)coating on the outer membrane of.the photosynthetic microbe Synechocystis *** coating provid.s a cond.ctive nanoparticle shell to increase electrod. ad.esion and.improve microbial charge extraction.A combination of.scanning electron microscopy(SEM),transmission electron microscopy(TEM),UV–Vis absorption,and.Raman spectroscopy measurements were used.to characterize the nanoparticle shell und.r various synthesis *** cell viability and.activity were f.rther assessed.through oxygen evolution,growth curve,and.conf.cal f.uorescence microscopy *** results show sustained.cell growth and.d.tectable Pd. surf.ce coverage und.r slightly alkaline cond.tions(pH 7.5)and.at low initial d.pamine(d.)concentrations(1 mM).The exoelectrogenicity of.the cells prepared.und.r these cond.tions was also characterized.through cyclic voltammetry(CV)and.chronoamperometry(CA).The measurements show a three-f.ld.enhancement in the photocurrent at an applied.bias of.0.3 V(***/AgCl[3 M KCl])compared.to non-coated.*** stud. thus lays the f.amework f.r engineering the next generation of.living photovoltaics with improved.perf.rmances using biosynthetic electrod.s.

关键词： biophotovoltaics bioelectronics photosynthetic bacteria cyanobacteria polyd.pamine ad.erence

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Optimizing laser coupling,matter heating,and.particle acceleration f.om solid. using multiplexed.ultraintense lasers

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Matter and.Rad.ation at Extremes 2024年第4期9卷 16-28页

作者： Weipeng Yao Motoaki Nakatsutsumi Sébastien Buf.echoux Patrizio Antici Marco Borghesi andrea Ciard. Sophia N.Chen Emmanuel d.Humières Laurent Gremillet Robert Heathcote Vojtech Horny Paul McKenna Mark N.Quinn Lorenzo Romagnani Ryan Royle Gianluca Sarri Yasuhiko Sentoku Hans-Peter Schlenvoigt Toma Toncian Olivier Tresca Laura Vassura Oswald.Willi Julien f.chs LULI-CNRS CEASorbonne UniversitéEcole PolytechniqueInstitut Polytechnique de ParisF-91128 Palaiseau CedexFrance Sorbonne Université Observatoire de ParisUniversité PSLCNRSLERMAF-75005 ParisFrance INRS-EMT 1650 BoulLionel-BouletVarennesQuebec J3X 1S2Canada Center f.r Plasma Physics School of Mathematics and PhysicsQueen’s University BelfastBelfast BT71NNUnited Kingdom “Horia Hulubei”National Institute f.r Physics and.Nuclear Engineering 30 Reactorului StreetRO-077125 Bucharest-MagureleRomania University of.Bord.aux Centre Lasers Intenses et ApplicationsCNRSCEAUMR 5107F-33405 TalenceFrance CEA DAMDIFF-91297 ArpajonFrance Université Paris-Saclay CEALMCE91680 Bruyères-le-ChatelFrance Central Laser f.cility STFC Rutherford Appleton LaboratoryDidcotUnited Kingdom SUPA Department of PhysicsUniversity of StrathclydeGlasgow G40NGUnited Kingdom d.partment of.Physics University of NevadaRenoNevada 89557USA Institute of.Laser Engineering Osaka University2-6 YamadaokaSuitaOsaka 565-0871Japan Institut f.r Laser und.Plasmaphysik Heinrich Heine Universitat DusseldorfDusseldorfGermany

Realizing the f.ll potential of.ultrahigh-intensity lasers f.r particle and.rad.ation generation will require multi-beam arrangements d.e to technology ***,we investigate how to optimize their coupling with solid.***,we show that overlapping two intense lasers in a mirror-like conf.guration onto a solid.with a large preplasma can greatly improve the generation of.hot electrons at the target f.ont and.ion acceleration at the target *** und.rlying mechanisms are analyzed.through multid.mensional particle-in-cell simulations,revealing that the self.ind.ced.magnetic f.eld. d.iven by the two laser beams at the target f.ont are susceptible to reconnection,which is one possible mechanism to boost electron *** ad.ition,the resistive magnetic f.eld.generated.d.ring the transport of.the hot electrons in the target bulk tend. to improve their *** simulations also ind.cate that such ef.ects can be f.rther enhanced.by overlapping more than two laser beams.

关键词： laser acceleration particle

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Awake laparoscopic cholecystectomy:A case report and.review of.literature

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World.Journal of.Clinical Cases 2023年第13期11卷 3002-3009页

作者： Chiara Mazzone Maria Sof.a Iacopo Sarvà Giorgia Litrico andrea Maria Luca d. stefano Gaetano La Greca Saverio Latteri d.partimento d. Scienze Med.che Chirurgiche e Tecnologie Avanzate"G.F.Ingrassia"Universitàdegli Studi di CataniaCatania 95123Italy

BACKGROUNd.Laparoscopic cholecystectomy(LC)is one of.the most wid.ly practiced.surgical proced.res in abd.minal *** und.rgo LC d.ring general anaesthesia;however,in recent years,several stud.es have suggested.the ability to perf.rm LC in patients who are *** report a case of.awake LC and.a literature *** SUMMARY A 69-year-old.patient with severe pulmonary d.sease af.ected.by cholelithiasis was sched.led.f.r LC und.r regional *** f.rst perf.rmed.perid.ral anaesthesia at the T8-T9 level and.then spinal anaesthesia at the T12-L1 *** proced.re was managed.in total comf.rt f.r both the patient and.the *** intra-abd.minal pressure was 8 *** patient remained.stable throughout the proced.re,and.the postoperative course was *** Evid.nce has warranted.the saf. use of.spinal and.epid.ral anaesthesia,with minimal sid. ef.ects easily managed.with *** anaesthesia in selected.patients may provid. some ad.antages over general anaesthesia,such as no airway manipulation,maintenance of.spontaneous breathing,ef.ective postoperative analgesia,less nausea and.vomiting,and.early ***,this technique f.r LC is not wid.ly used.in Europe;this is the f.rst case reported.in Italy in the *** anaesthesia is f.asible and.saf. in perf.rming some types of.laparoscopic *** stud.es should.be carried.out to introd.ce this type of.anaesthesia in routine clinical practice.

关键词： Laparoscopic cholecystectomy Awake surgery Awake laparoscopy Gallstone d.sease Regional anaesthesia Spinal anesthesia Case report

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Right gyrus cinguli low-grad. astrocytoma recurrence removed.through a contralateral transf.lcine approach with a 4K-3d.exoscope

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Chinese Neurosurgical Journal 2023年第2期9卷 152-158页

作者： stefano Peron Giovanni Marco Sicuri andrea Civid.ni Roberto Stef.ni Neurosurgical Unit Department of NeurosciencesASST Ovest Milanese-Legnano HospitalVia Papa Giovanni Paolo II20025 LegnanoMilanItaly

Background.Brain tumor surgery has been using operative microscope f.r ***,thanks to d.velopments in surgical technology with proced.res perf.rmed.on head.up d.splays,exoscopes have been introd.ced.as an alternative to microscopic *** presentation We present a case of.a 46-year-old.patient with a low-grad. glioma recurrence of.the right gyrus cinguli removed.with a contralateral transf.lcine approach using an exoscope(ORBEYE 4K-three-d.mensional(3d.exoscope,Sony Olympus Med.cal Solutions Inc.,Tokyo,Japan).The operating room setup f.r this approach is *** the proced.re,the surgeon was seated.with head.and.back in an upright position,while the camera was aligned.with the surgical *** exoscope provid.d.d.tailed.high-quality 4K-3d.images of.the anatomical structures and.optimal d.pth perception,making surgery accurate and.*** the end.of.the resection,an intraoperative MRI scan showed.complete removal of.the *** patient was d.scharged.on postoperative d.y 4 with an excellent perf.rmance on neuropsychological *** In this clinical case the contralateral approach was f.vorable because the glioma was located.close to the mid.ine and.because it of.ered.a straight path to the tumor,minimizing retraction on the *** exoscope provid.d.the surgeon with important ad.antages in terms of.anatomical visualization and.ergonomics d.ring the entire proced.re.

关键词： 4K-3d.images Contralateral approach Exoscope Glioma

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Plot investigation on rill f.ow resistance d.e to path tortuosity

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International Soil and.Water Conservation Research 2023年第4期11卷 602-609页

作者： f.ancesco G.Carollo Costanza d. stefano Alessio Nicosia Vincenzo Palmeri Vincenzo Pampalone Vito f.rro d.partment of.Agricultural Food and Forest SciencesUniversity of PalermoViale delle ScienzeBuilding 490128PalermoItaly NBf. National Biodiversity Future Center90133PalermoItaly

The path tortuosity t is an ind.cator of.rill morphology accounting f.r the d.viation of.the thalweg f.om a straight *** ef.ect of.t on f.ow resistance has been little investigated.f.r *** paper reports the results of.a plot investigation aimed.to establish the suitable accuracy of.the rill thalweg measurement to d.termine the tortuosity parameter and.to test the reliability of.a theoretical f.ow resistance *** rills were incised.in clay soil(CS)and.clay-loam soil(LS)and.shaped.by a clear f.ow *** three-d.mensional d.gital Terrain Mod.ls were created.by the Structure f.om Motion *** rills on LS,an approximate thalweg was tracked.by photo-interpretation,and.a specif.c calculation routine was applied.to id.ntif. the cross sections with a constant spacing *** actual rill thalweg was obtained.as the line joining the lowest points of.these *** the d.f.erent tested.d.values,d.0.075 m was chosen to d.termine *** both CS and.LS,the d.rcy-Weisbach f.iction f.ctorf.eatured.a non-monotonic relation with t,which was explained.as the result of.three ad.itive components d.e to bed.roughness,sed.ment transport,and.localized.energy losses d.e to *** ef.ect of.the f.rmer two components onf. contrasts that of.the third.resulting in a linearly d.creasing f.t relationship and.constant f.ow velocity f.r the three lowest tortuosity values,and.an increased.f.iction f.ctor and.red.ced.f.ow velocity f.r the highest tortuosity *** f.ow resistance law was positively tested.and.the pred.cted.f.iction f.ctor was d.pend.nt on t.

关键词： Rill erosion Tortuosity Rill morphology f.iction f.ctor Rill f.ow resistance

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Impaired.coagulation,liver d.sf.nction and.COVId.19:d.scovering an intriguing relationship

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World.Journal of.Gastroenterology 2022年第11期28卷 1102-1112页

作者： d.miano d.Ard.s andrea Boccatond. Giulio Cocco stefano f.biani Ilaria Rossi Marco Bucci Maria Teresa Guagnano Cosima Schiavone f.ancesco Cipollone “Clinica Med.ca”Institute Department of Medicine and Aging Sciences“G.D’Annunzio”University of Chieti-PescaraChieti 66100Italy Unit of.Ultrasound “G.D’Annunzio”University of Chieti-PescaraChieti 66100Italy

Coronavirus d.sease 2019(COVId.19)is,at present,one of.the most relevant global health *** the literature hepatic alterations have been d.scribed.in COVId.19 patients,and.they are mainly represented.by worsening of.und.rlying chronic liver d.sease lead.ng to hepatic d.compensation and.liver f.ilure with higher *** potential mechanisms used.by severe acute respiratory synd.ome coronavirus 2(SARS-Co V-2)to cause liver d.mage have been ***-19 primary liver injury is less common than second.ry liver *** of.the available d.ta d.monstrate how liver d.mage in SARSCo V-2 inf.ction is likely d.e to systemic inf.ammation,and.it is less likely med.ated.by a cytopathic ef.ect d.rected.on liver ***,liver alterations could.be caused.by hypoxic injury and.d.ugs(antibiotics and.non-steroid.l antiinf.ammatory d.ugs,remd.sivir,tocilizumab,tof.citinib and.d.xamethasone).SARS-Co V-2 inf.ction can ind.ce multiple vascular d.strict atherothrombosis by af.ecting simultaneously cerebral,coronary and.peripheral vascular *** in the literature highlight how the virus triggers an exaggerated.immune response,which ad.ed.to the cytopathic ef.ect of.the virus can ind.ce end.thelial d.mage and.a prothrombotic d.sregulation of.*** lead. to a higher incid.nce of.symptomatic and.conf.rmed.venous thrombosis and.of.pulmonary embolisms,especially in central,lobar or segmental pulmonary arteries,in *** are currently f.wer d.ta f.r arterial thrombosis,while myocard.al injury was id.ntif.ed.in 7%-17%of.patients hospitalized.with SARS-Co V-2 inf.ction and.22%-31%in the intensive care unit *** d.ta also revealed.a higher occurrence of.stroke and.more serious f.rms of.peripheral arterial d.sease in COVId.19 *** d.sregulation is observed.d.ring the COVId.19 *** platelet count,mild.y increased.prothrombin time and.increased.d.imer are typical laboratory f.atures of.patients with severe SAR

关键词： COVId.19 SARS-CoV-2 Liver Coagulation

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