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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1506-1517页

作者： Nicola Pescosolido andrea barbato Rossella Giannotti Chiara Komaiha Fiammetta Lenarduzzi Department of Cardiovascular RespiratoryNephrologicAnesthesiologic and Geriatric SciencesSapienza University of Rome Department of Sense Organs Sapienza University of Rome

The crystalline lens is a transparent,biconvex structure in the eye that,along with the cornea,helps to refract light to be focused on the retina and,by changing shape,it adjusts focal distance（accommodation）.The three classes of structural proteins found in the lens areα,β,and γ *** proteins make up more than 90% of the total dry mass of the eye *** components which can be found are sugars,lipids,water,several antioxidants and low weight *** ageing changes occur in the lens,it causes a gradual reduction in transparency,presbyopia and an increase in the scattering and aberration of light waves as well as a degradation of the optical quality of the *** main changes that occur with aging are： 1） reduced diffusion of water from the outside to the inside of the lens and from its cortical to its nuclear zone; 2）crystalline change due to the accumulation of high molecular weight aggregates and insoluble proteins; 3）production of advanced glycation end products（AGEs）,lipid accumulation,reduction of reduced glutathione content and destruction of ascorbic *** if effective strategies in preventing cataract onset are not already known,good results have been reached in some cases with oral administration of antioxidant substances such as caffeine,pyruvic acid,epigallocatechin gallate（EGCG）,α-lipoic acid and ascorbic ***,methionine sulfoxide reductase A（MSRA） over expression could protect lens cells both in presence and in absence of oxidative stress-induced ***,promising results have been obtained by reducing ultraviolet-induced oxidative damage.

关键词： antioxidants cataract crystalline eye lens kynurenines ultraviolet radiations

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Nd: Yag laser iridotomy in Shaffer-Etienne grade 1 and 2: angle widening in our case studies

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International Journal of Ophthalmology(English edition) 2015年第4期8卷 709-713页

作者： Sandra Cinzia Carlesimo Luigi Di Santo Pietro Bruni Aloisa Librando Antonietta Pompea Falace andrea barbato Department of Sense Organs Sapienza University of Rome Freelance Scientific Designer

·AIM: To obtain widening of a potentially occludable angle, in according to Kanski’s indications, through preventive Nd:Yag laser iridotomy. The observational study was performed by using gonioscopy for the selection and follow-up of 1165 treated eyes and exploiting Shaffer-Etienne gonioscopic classification as a quality/quantity test of the angle recession.·METHODS: Between September 2000 and July 2012,586 patients were selected at the Outpatients’ Ophthalmological Clinic of the Policlinico Umberto I of Rome in order to undergo Nd: Yag laser iridotomy. A Goldmann type contact lens, Q-switched mode, 2-3defocus, and 7-9 m J intensity with 2-3 impulse discharges were used for surgery.·RESULTS: From as early as the first week, a whole360° angle widening were evident in the patients, thus showing the success of Nd:Yag laser iridotomy in solving relative pupil block. The angle remained narrow by 270° in 14 eyes only, despite repetitions of further treatment with laser iridotomy in a different part of the iris, twice in 10 eyes and three times in 4 eyes.·CONCLUSION: Nd:Yag laser iridotomy revealed itself as being a safe and effective treatment in widening those critical Shaffer-Etienne grade 1 and 2 potentially occludable angles.

关键词： glaucoma gonioscopy intraocular pressure iridotomy narrow angle Nd:Yag laser

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Testicular parenchymal abnormalities in Klinefelter syndrome： a question of cancer？ Examination of 40 consecutive patients

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Asian Journal of Andrology 2015年第1期17卷 154-158,I0012页

作者： Giacomo Accardo Gianfranco Vallone Daniela Esposito Filomena barbato andrea Renzullo Giovanni Conzo Giovanni Docimo Katherine Esposito Daniela Pasquali Department of Cardiothoracic and Respiratory Sciences Endocrine Unit Department of Biomorphological and Functional Sciences Second University of Naples Naples Italy Department of Clinical and Experimental Medicine Second University of Naples Naples Italy.

Klinefelter syndrome （KS） is a hypergonadotropic hypogonadism characterized by a 47, XXY karyotype. The risk of testicular cancer in KS is of interest in relation to theories about testicular cancer etiology generally; nevertheless it seems to be low. We evaluated the need for imaging and serum tumor markers for testicular cancer screening in KS. Participants were 40 consecutive KSpatients, enrolled from December 2009 to January 2013. Lactate dehydrogenase （LDH）, alpha-fetoprotein （AFP）, and beta-human chorionic gonadotrophin subunit （^-HCG） serum levels assays and testicular ultrasound （US） with color Doppler, were carried out at study entry, after 6 months and every year for 3 years. Abdominal magnetic resonance （MR） was performed in KS when testicular US showed micro-calcifications, testicular nodules and cysts. Nearly 62% of the KS had regular testicular echotexture, 37.5% showed an irregular echotexture and 17.5% had micro-calcifications and cysts. Eighty seven percent of KS had a regular vascular pattern, 12.5% varicocele, 12.5% nodules 〈1 cm, but none had nodules 〉1 cm. MR ruled out the diagnosis of cancer in all KS with testicular micro calcifications, nodules and cysts. No significant variations in LDH, AFP, and ^-HCG levels and in US pattern have been detected during follow-up. We compared serum tumor markers and US pattern between KS with and without cryptorchidism and no statistical differences were found. We did not find testicular cancer in KS, and testicular US, tumor markers and MR were, in selected cases, useful tools for correctly discriminating benign from malignant lesions.

关键词： abdomen magnetic resonance alpha-fetoprotein beta-human chorionic gonadotrohin subunit klinefelter syndrome lactate dehydrogenase testicular ultrasound

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连续钢-混凝土组合梁的设计评估的概率分析

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钢结构(中英文) 2010年第6期 81-82页

作者： Alessandro Zona Michele barbato andrea Dall' Asta Luigino Dezi

在连续钢-混凝土组合梁的设计中,在下垂段可利用横截面的塑性抵抗,该区段内钢梁的受压法兰与钢筋混凝土板相连。然而,在弯曲段正常采用横截面的弹性验证,该区段内钢梁的受压部分不受混凝土板的约束,更易于屈曲。在下垂段采用利用塑性抵... 详细信息

在连续钢-混凝土组合梁的设计中,在下垂段可利用横截面的塑性抵抗,该区段内钢梁的受压法兰与钢筋混凝土板相连。然而,在弯曲段正常采用横截面的弹性验证,该区段内钢梁的受压部分不受混凝土板的约束,更易于屈曲。在下垂段采用利用塑性抵抗而在弯曲段采用弹性抵抗的综合设计方法,能满足弯曲段弯矩低于弹性极限时,下垂段的塑性弯矩仍能上升的要求。研究的目标是:提出钢-混组合桥梁简化的概率非线性分析的框架及通过此框架获得实际的三跨连续钢-混组合公路桥梁的弹塑性设计。基于一次二阶矩近似,采用所提方法计算结构响应量的一阶和二阶统计矩(方差、协方差)。说明和讨论了基准问题的确定及概率数值结果。

关键词：钢-混组合桥梁概率响应分析响应灵敏度分析非线性有限元分析部分交互塑性设计安全形式

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