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Implications of receptor for advanced glycation end products for progression from obesity to diabetes and from diabetes to cancer

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World Journal of Diabetes 2023年第7期14卷 977-994页

作者： andrea Garza-campos José Roberto Prieto-Correa José Alfredo Domínguez-Rosales Zamira Helena Hernández-Nazará Programa de Doctorado en Ciencias en Biología Molecular en Medicina Universidad de GuadalajaraGuadalajara 44340JaliscoMexico Departamento de Biología Molecular y Genómica Instituto de Investigación en Enfermedades Crónico-DegenerativasUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico

Obesity and type 2 diabetes mellitus(T2DM)are chronic pathologies with a high incidence *** share some pathological mechanisms,including hyperinsulinemia,the production and release of hormones,and *** above,over time,affects other systems of the human body by causing tissue hypoxia,low-grade inflammation,and oxidative stress,which lay the pathophysiological groundwork for *** leading causes of death globally are T2DM and *** main alterations of this pathological triad include the accumulation of advanced glycation end products and the release of endogenous alarmins due to cell death(i.e.,damage-associated molecular patterns)such as the intracellular proteins high-mobility group box protein 1 and protein S100 that bind to the receptor for advanced glycation products(RAGE)-a multiligand receptor involved in inflammatory and metabolic and neoplastic *** review analyzes the latest advanced reports on the role of RAGE in the development of obesity,T2DM,and cancer,with an aim to understand the intracellular signaling mechanisms linked with cancer *** review also explores inflammation,oxidative stress,hypoxia,cellular senescence,RAGE ligands,tumor microenvironment changes,and the“cancer hallmarks”of the leading tumors associated with *** assimilation of this information could aid in the development of diagnostic and therapeutic approaches to lower the morbidity and mortality associated with these diseases.

关键词： Type 2 diabetes Cancer Obesity Advanced glycation end product receptor Receptor for advanced glycation end products Glycation end products,advanced

Irbesartan desmotropes:Solid-state characterization,thermodynamic study and dissolution properties

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Journal of Pharmaceutical Analysis 2019年第5期9卷 339-346页

作者： andrea Mariela Araya-Sibaja Carlos Eduardo Maduro de campos Cinira Fandaruff Jose Roberto Vega-Baudrit Teodolito Guillen-Giron Mirtha Navarro-Hoyos Silvia Lucía Cuffini Laboratorio Nacional de Nanotecnología LANOTEC-CeNAT-CONARE 1174-1200 Pavas San Jose Costa Rica Escuela de Ciencia e Ingeniería de los Materiales Tecnologico de Costa Rica Cartago 159-7050 Costa Rica Escuela de Química Universidad de Costa Rica San Pedro de Montes de Oca 2060 San Jose Costa Rica Programa de Pos-Graduacao em Física Universidade Federal de Santa Catarina Florianopolis Brazil Independent Researcher 06472-005 Barueri Sao Paulo Brazil Laboratorio de Investigacion y Tecnología de Polímeros POLIUNA Escuela de Química Universidad Nacional de Costa Rica Heredia 86-3000 Costa Rica Instituto de Ciencia e Tecnica Universidade Federal de Sao Paulo Sao Jose dos Campos Sao Paulo Brazil

Irbesartan (IBS) is a tetrazole derivative and antihypertensive drug that has two interconvertible structures, 1H- and 2H-tautomers. The difference between them lies in the protonation of the tetrazole ring. In the solid-state, both tautomers can be isolated as crystal forms A (1H-tautomer) and B (2H-tautomer). Studies have reported that IBS is a polymorphic system and its forms A and B are related monotropically. These reports indicate form B as the most stable and less soluble form. Therefore, the goal of this contribution is to demonstrate through a complete solid-state characterization, thermodynamic study and dissolution properties that the IBS forms are desmotropes that are not related monotropically. However, the intention is also to call attention to the importance of conducting strict chemical and in solid-state quality controls on the IBS raw materials. Hence, powder X-ray diffraction (PXRD) and Raman spectroscopy (RS) at ambient and non-ambient conditions, differential scanning calorimetry (DSC), hot stage microscopy (HSM), Fourier transform infrared (FT-IR) and scanning electron microscopy (SEM) techniques were applied. Furthermore, intrinsic dissolution rate (IDR) and structural stability studies at 98% relative humidity (RH), 25℃ and 40 ℃ were conducted as well. The results show that in fact, form A is approximately four-fold more soluble than form B. In addition, both IBS forms are stable at ambient conditions. Nevertheless, structural and/or chemical instability was observed in form B at 40℃ and 98% RH. IBS has been confirmed as a desmotropic system rather than a polymorphic one. Consequently, forms A and B are not related monotropically.

关键词： Irbesartan Solid-state characterization Intrinsic dissolution rate Tautomerism Desmotropic forms

Trends in Corporate Social Responsibility Among Public Service Media in Europe

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Economics World 2017年第6期5卷 560-565页

作者： Tania Femandez-Lombao andrea Valencia-Bermudez Francisco campos-Freire University of Santiago de Compostela Santiago Spain

Corporate Social Responsibility （CSR） is the voluntary commitment taken over by companies in social, economic, and environmental terms. The aim is to counteract impacts generated by their activity. While the concept is genuinely linked to the private sector, this self-regulated system has been steadily introduced in some European public service media. Indeed, CSR is one of the mechanisms to face the challenges of the sector, both the financial crisis and the lack of trust. Seven public service media from the European Union are reporting--via their websites--on their CSR strategies. Annual reports on their performance are issued by the German ZDF, the Spanish RTVE, the Portuguese RTP, the British BBC, the Irish RTI~, the Finnish YLE, and the Italian RAI. Also, four other corporations--VRT and RTBF from Belgium, FT from France, and DR from Denmark include a section on corporate social responsibility on their annual reports. The aim of this paper is to know which of the trends in CSR are dominant among public service media in Europe, namely economy, environment, and society. The content analysis of corporate reports is the method used for the research.

关键词： corporate social responsibility public service media accountability European Union

4^(th) generation synchrotron source boosts crystalline imaging at the nanoscale

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Light(Science & Applications) 2022年第4期11卷 662-673页

作者： Peng Li Marc Allain Tilman A.Grunewald Marcus Rommel andrea campos Dina Carbone Virginie Chamard Aix-Marseille Univ CNRSCentrale MarseilleInstitut FresnelMarseilleFrance Nanofabrication Laboratory Department of Microtechnology and NanoscienceMC2Chalmers University of TechnologySE-41296 GothenburgSweden Aix Marseille Univ CNRSCentrale MarseilleFSCM(FR1739)CP2M13397 MarseilleFrance. MAX IV Laboratory Fotongatan 222594 LundSweden Present address:Diamond Light Source Harwell Science and Innovation CampusFermi AveDidcot OX110DEUK

New 4^(th)-generation synchrotron sources,with their increased bilince,promise to greatly improve the performances of coherent X-ray *** perspective is of major interest for crystal microscopy,which aims at revealing the 3D crystalline structure of matter at the nanoscale,an approach strongly limited by the available coherent *** results,based on Bragg ptychography experiments performed at the frst 4-generation synchrotron source,demonstrate the possibility of retrieving a high-quality image of the crystalline sample,with unprecedented ***,the larger available coherent flux produces datasets with enough information to overcome experimental limitations,such as strongly deteriorated scanning *** show this achievement would not be posible with 30-generation sources,a limit that has inhibited the development of this otherwise powerful microscopy method,so ***,the advent of next-generation synchrotron sources not only makes Bragg ptychography suitable for high throughput studies but also strongly relaxes the associated experimental constraints,making it compatible with a wider range of experimental set-ups at the new synchrotrons.

关键词： crystalline coherent source

Fine needle aspiration cytology in the diagnosis of multiple myeloma

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Health 2012年第8期4卷 470-473页

作者： Luiz Antonio Guimaraes Cabral andrea Silveira Penteado Adriana Aigotti Haberbeck Brandão Janete Dias almeida Department of Biosciences and Oral Diagnosis Sao Josedos Campos Dental SchoolUNESP—Univ Estadual PaulistaSao Josedos CamposSao PauloBrazil Private Practice Cancao NovaCachoeira PaulistaSPBrazil

Multiple Myeloma (MM) is a disseminated plasma cell tumor caused by the proliferation of a single plasma cell clone which results from the production of monoclonal immunoglobulin, most commonly class G (IgG). MM is a cancer of the elderly, with a mean age at diagnosis of 68 years. A 79-year-old white patient sought the outpatient clinic of the Discipline of Stomatology, S?o José dos campos Dental School, UNESP, because of a fracture associated with an osteolytic lesion in the right ascending ramus of the mandible. In view of the clinical-radiographic findings, exploratory fine needle aspiration (FNA) of the lesion was performed and the sanguinolent material obtained was submitted to the preparations of smears for cytology analysis. The diagnosis of MM was based on laboratory and radiographic findings. FNA cytology analysis of the lesion permitted a diagnostic hypothesis of MM.

关键词： Multiple Myeloma Diagnostic Imaging Cytology

Financial Losses Associated with Bovine Brucellosis (Brucella abortus) in Carchi-Ecuador

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Open Journal of Animal Sciences 2023年第2期13卷 205-216页

作者： Marcelo Ibarra Martin campos Christian Ibarra Urgilés Gladys Danny Huera Milena Gutiérrez andrea Chamorro Luis Núñez Facultad de Industrias Agropecuarias y Ciencias Ambientales. Carrera Agropecuaria. Universidad Politécnica Estatal del Carchi (UPEC). Antisana S/N y Av Universitaria Tulcán Ecuador. Doctorando de la Facultad de Ciencias Veterinarias Universidad Nacional de Rosario Rosario Argentina Universidad Politécnica Estatal del Carchi (UPEC). Antisana S/N y Av Universitaria Tulcán Ecuador Facultad de Industrias Agropecuarias y Ciencias Ambientales Carrera Agropecuaria Tulcán Ecuador Universidad Politécnica Estatal del Carchi Maestrante Centro de Postgrado Tulcán Ecuador Facultad de Comercio Internacional Administración y Economía Empresarial Carrera de Comercio Exterior Universidad Politécnica Estatal del Carchi Tulcán Ecuador Facultad de Industrias Agropecuarias y Ciencias Ambientales Carrera de Enfermería Universidad Politécnica Estatal del Carchi Carchi Ecuador Facultad de Ciencias de la Salud Carrera de Medicina Veterinaria One Health Research Group Universidad de Las Américas (UDLA) Quito Ecuador

Brucellosis is an infectious disease of worldwide distribution, which has a great economic impact due to the productive and reproductive losses that it causes, in addition to the serious public health problem. The aim of this study is to estimate the economic losses, through financial analysis, caused by bovine brucellosis in the province of Carchi, over a one-year period. A random sampling was used to determine the prevalence in the study area, where 2976 animals were considered, and the Rose Bengal (RB) test was used as a screening test and the Fluorescence Polarized Assay (FPA) as a confirmatory test, obtaining a prevalence of 8.2% (244/2976). In addition, parameters associated to the losses caused by brucellosis in cattle were determined by literature review. To estimate costs, field information was collected through a survey of a total of 100 randomly selected farmers. The loss estimated due to calves lost as a result of abortions and neonatal death was USD. 79170.00. The loss due to death of 4 cows as a result of metritis was estimated at USD. 5000.00. The cost of examination and treatment of aborted cows was USD. 20100.00. The losses due to reduction in milk production from aborted and non-aborted seropositive cows were estimated at USD. 158114.21. The financial losses due to brucellosis in province of Carchi were estimated at USD. 262384.21.

关键词： Bovine Brucellosis Economic Losses Carchi-Ecuador

Comparison of the systemic action of electroacupuncture and laserpuncture in experimental injuries on the back skin of Wistar rats(Rattus novergicus)

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Journal of Traditional Chinese Medicine 2021年第5期41卷 779-788页

作者： Ivens Takechi Nakagawa Hamilton Ricardo Alonso Fabrício campos Kuroda JoséRoberto Passarini Junior Juan Guzman Quispe Cabanillas Fernanda Aparecida Sampaio Mendonça Gláucia Maria Tech dos Santos andrea Aparecida de Aro Edson Rosa Pimentel Maria Esméria Corezola do Amaral Marcelo Augusto Marretto Esquisatto Graduate Program in Biomedical Sciences University Center of Herminio Ometto Foundation-FHOAvenida Dr.Maximiliano Baruto500-Jardim UniversitarioArarasSao Paulo 13607-339Brazil Department of Structural and Functional Biology Institute of BiologyState University of Campinas-UNICAMPAvenida Bertrand Russels/n.Caixa Postal 6109CampinasSao Paulo 13083-865Brazil

OBJECTIVE:To evaluate the systemic action of electroacupuncture and laserpuncture in the repair of excisional cutaneous injuries on the back of adult female Wistar ***:Ninety animals were divided into three experimental groups:C-control;E-treated with electroacupuncture[acupoints:Feishu(BL13),Geshu(BL17),Zusanli(ST36)];L-treated with laserpuncture(same acupoints)and euthanized on the 7 th,14 th and 21 st days for tissue removal and preparation for histomorphometric and biochemical(dosages,zymography and Western blotting)***:The number of fibroblasts in the E and L groups presented higher values than the C on the14 th and 21 st *** number of granulocytes was lower than C on the 21 st day in groups E and *** total number of newly formed vessels increased on the 21 st day and was higher in both treatments when compared to *** birefringent collagen fibers detected on the 21 st day was lower in groups E and L than group *** glycosaminoglycans and hydroxyproline amount was similar among groups throughout the experimental *** active isoform of matrixmetallo proteinase(MMP)-2 and the latent isoform of MMP-9 did not show any differences among all groups and experimental *** amount of collagenⅠpresented higher values in the L group on the 14 th day and in the E and L groups on the 21 st *** typeⅢcollagen,groups E and L presented values lower than C in all experimental *** amount of transforming growth factor-β1 in the E and L groups showed higher amounts than C on the 7 th day and lower on the 14 th and 21 st *** vascular endothelial growth factor,E and L groups presented similar and lower values than C on the 7 th and 14 th days,respectively,and similar on the 21 st ***:The therapies evaluated in this article stimulated fibroblast proliferation,neoangiogenesis and altered the reorganization of collagen fibers in the repair of excisional injuries in female adult rats.

关键词： wound healing electroacupuncture inflammation morphological and morphometric findings

Traps and trumps from adjacent-to-tumor samples in gastric cancer research

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Chinese Journal of Cancer Research 2018年第5期30卷 564-567页

作者： Paulo Pimentel de Assumpcao Andre Salim Khayat Taissa Maira Thomaz Araujo Williams Fernandes Barra Geraldo Ishak Mine Maria Pereira Cruz Ramos Sidney Emanuel Batista dos Santos andrea Kely campos Ribeiro dos Santos Samia Demachki Paula Barauna de Assumpcao Danielle Queiroz Calcagno Ney Pereira Carneiro dos Santos Monica Barauna de Assumpcao Fabiano Cordeiro Moreira Andre Mauricio Ribeiro dos Santos Carolina Barauna de Assumpcao Gregory Joseph Riggins Rommel Mario Rodriguez Burbano Oncology Research Center Federal University of Para Belem 66075-110 Brazil PhD Program in Genetics and Molecular Biology Federal University of Para Belem 66075-110 Brazil Gastrointestinal Endoscopy Service Joao de Barros Barreto University Hospital Belem 66073-000 Brazil Department of Surgical Oncology Oswaldo Cruz Germany Hospital Sao Paulo 01327-001 Brazil Department of Neurosurgery Johns Hopkins University Baltimore 21287 USA Laboratory of Molecular Biology Ophir Loyola Hospital Belem 66060-281 Brazil

The search for cancer biomarkers is frequently based on comparisons between tumors and adjacent-to-tumor samples. However, even after histological confirmation of been free of cancer cells, these adjacent-to-tumor samples might harbor molecular alterations which are not sufficient to cause them to look like cancer, but can differentiate these cells from normal cells. When comparing them, potential biomarkers are missed, and mainly the opportunity of finding initial aberrations presents in both tumors and adjacent samples, but not in true normal samples from non-cancer patients, resulting in misinterpretations about the carcinogenic process. Nevertheless, collecting adjacent-to-tumor samples brings trumps to be explored. The addition of samples from non-cancer patients opens an opportunity to increase the finds of the molecular cascade of events in the carcinogenic process. Differences between normal samples and adjacent samples might represent the first steps of the carcinogenic process. Adding samples of non-cancer patients to the analysis of molecular alterations relevant to the carcinogenic process opens a new window of opporttmides to the discovery of cancer biomarkers and molecular targets.

关键词： Adjacent-to-tumor trumps traps

Development and internal validation of the Comprehensive ALPPS Preoperative Risk Assessment(CAPRA)score:is the patient suitable for Associating Liver Partition and Portal vein ligation for Staged hepatectomy(ALPPS)?

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 52-66,I0007,I0008页

作者： Ivan Capobianco Karl J.Oldhafer Mohammed-Hossein Fard-Aghaie Ricardo Robles-campos Roberto Brusadin Henrik Petrowsky Michael Linecker Arianeb Mehrabi Katrin Hoffmann Jun Li Asmus Heumann Roberto Hernandez-Alejandro Mauro Enrique Tun-Abraham Elio Jovine Matteo Serenari Bergthor Bjornsson Per Sandström Ruslan Alikhanov Mikhail Efanov Paolo Muiesan andrea Schlegel Thomas M.van Gulik Pim B.Olthof Gregor Alexander Stavrou Lina Maria Serna-Higuita Alfred Königsrainer Silvio Nadalin Department of General Visceral and Transplant SurgeryUniversity Hospital TübingenTübingenGermany Department of General and Abdominal Surgery Asklepios Hospital BarmbekHamburgGermany Department of Surgery Virgen de la Arrixaca Clinic and University HospitalMurciaSpain Swiss HPB and Transplantation Center Department of SurgeryZurich University HospitalZurichSwitzerland Department of General Visceraland Transplantation SurgeryUniversity of HeidelbergHeidelbergGermany General Visceral and Thoracic Surgery Department and ClinicHamburg-Eppendorf University Medical CenterHamburgGermany Division of Transplantation and Hepatobiliary Surgery University of RochesterRochesterNYUSA Division of HPB Surgery and Liver Transplantation Department of SurgeryLondon Health Sciences CentreLondonCanada General and Emergency Surgery Unit Azienda Ospedaliero-Universitaria di BolognaMaggiore HospitalBolognaItaly General Surgery and Transplantation Unit Azienda Ospedaliero-Universitaria di BolognaSant’Orsola-Malpighi HospitalBolognaItaly Department of Surgery in Linköping and Department of Biomedical and Clinical SciencesLinköping UniversityLinköpingSweden Department of Hepatopancreatobiliary Surgery Moscow Clinical Scientific CenterMoscowRussia Liver Unit Queen Elizabeth Hospital BirminghamUniversity Hospitals Birmingham NHS Foundation TrustBirminghamUK Department of Surgery Amsterdam UMC(Location AMC)University of AmsterdamAmsterdamThe Netherlands Department of General Abdominal and Thoracic SurgerySurgical OncologySaarbruecken General HospitalSaarbrueckenGermany Department of Clinical Epidemiology and Applied Biometry University of TübingenTübingenGermany

Background:Preoperative patient selection in Associating Liver Partition and Portal vein ligation for Staged hepatectomy(ALPPS)is not always reliable with currently available scores,particularly in patients with primary liver *** study aims to(I)to determine whether comorbidities and patients characteristics are a risk factor in ALPPS and(II)to create a score predicting 90-day mortality ***:Thirteen high-volume centers participated in this retrospective multicentric study.A risk analysis based on patient characteristics,underlying disease and procedure type was performed to identify risk factors and model the Comprehensive ALPPS Preoperative Risk Assessment(CAPRA)score.A nonparametric receiver operating characteristic analysis was performed to estimate the predictive ability of our score against the Charlson Comorbidity Index(CCI),the age-adjusted CCI(aCCI),the ALPPS risk score before Stage 1(ALPPS-RS1)and Stage 2(ALPPS-RS2).The model was internally validated applying ***:A total of 451 patients were *** was 14.4%.The CAPRA score is calculated based on the following formula:(0.1×age)−(2×BSA)+1(in the presence of primary liver tumor)+1(in the presence of severe cardiovascular disease)+2(in the presence of moderate or severe diabetes)+2(in the presence of renal disease)+2(if classic ALPPS is planned).The predictive ability was 0.837 for the CAPRA score,0.443 for CCI,0.519 for aCCI,0.693 for ALPPS-RS1 and 0.807 for *** 1,000 cycles of bootstrapping the C statistic was *** accuracy plot revealed a cut-off for optimal prediction of postoperative mortality of ***:Comorbidities play an important role in ALPPS and should be carefully considered when planning the *** assessing the patient’s preoperative condition in relation to ALPPS,the CAPRA score has a very good ability to predict postoperative mortality.

关键词： Associating Liver Partition and Portal vein ligation for Staged hepatectomy(ALPPS) comorbidity mortality prediction model patient selection