检索结果-南通市图书馆

Late-onset hypogonadism： beyond testosterone

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2015年第2期17卷 236-238,I0008页

作者： Carlo Foresta Aldo E Calogero Francesco Lombardo andrea lenzi Alberto Ferlin Department of Medicine and Centre for Human Reproduction Pathology University of Padova Padova 35128 Italy Department of Medical and Pediatric Sciences Section of Endocrinology Andrology and Internal Medicine University of Catania Catania 95123 Italy Department of Experimental Medicine Section of Medical Pathophysiology and Endocrinology Sapienza University of Rome Rome 00185 Italy

Late-onset hypogonadism is defined as a combination of low testosterone （T） levels and typical symptoms and signs. A major area of uncertainty is whether T concentrations are always really sufficient to fully reflect Leydig cell （dys）function. Mild testicular alteration could be diagnosed only by additional biochemical markers, such as luteinizing hormone （LH） and 25-hydroxyvitamin D levels. These markers help in identifying the so-called ＂subclinical＂ hypogonadism （normal T, high LH levels）. Patients with hypogonadism have frequently low levels of 25-hydroxyvitamin D due to impairment of the hydroxylating enzyme CYP2R1 in the testis. However, no data have been published dealing with the best treatment option （cholecalciferol - the Vitamin D precursor, or calcidiol - 25-hydroxylated form of Vitamin D） in these patients. We studied 66 patients with classic hypogonadism （total T [TT] 〈12 nmol I-~, LH 〉 8 IU 1-1）（n = 26） and subclinical hypogonadism （TT 〉 12 nmol I-＊, LH 〉 8 IU I-~）（n = 40） and low 25-hydroxyvitamin D （〈50 nmol I-1）. Subjects received cholecalciferol （5000 IU per week）（n = 20） or calcidiol （4000 IU per week）（n -- 46）, and 25-hydroxyvitamin D and parathyroid hormone （PTH） were evaluated after 3 months of therapy. Supplementation with calcidiol significantly increased 25-hydroxyvitamin D and significantly decreased PI＂H levels in both groups of men with hypogonadism （primary, n = 16 and subclinical, n = 30）, whereas supplementation with cholecalciferol did not modify their levels. This study shows for the first time that the administration of the 25-hydroxylated form of Vitamin D （calcidiol）, and not the administration of the precursor cholecalciferol, restores 25-hydroxyvitamin D levels in subjects with hypogonadism.

关键词： insulin-like factor 3 late-onset hypogonadism male hypogonadism testosterone Vitamin D

Non-alcoholic fatty liver disease connections with fat-free tissues: A focus on bone and skeletal muscle

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第10期23卷 1747-1757页

作者： Eleonora Poggiogalle Lorenzo Maria Donini andrea lenzi Claudio Chiesa Lucia Pacifico Department of Experimental Medicine-Medical Pathophysiology Food Science and Endocrinology SectionSapienza University of Rome Institute of Translational Pharmacology National Research Council Policlinico Umberto I Hospital Sapienza University of Rome

The estimates of global incidence and prevalence of non-alcoholic fatty liver disease(NAFLD) are worrisome, due to the parallel burden of obesity and its metabolic complications. Indeed, excess adiposity and insulin resistance represent two of the major risk factors for NAFLD; interestingly, in the last years a growing body of evidence tended to support a novel mechanistic perspective, in which the liver is at the center of a complex interplay involving organs and systems, other than adipose tissue and glucose homeostasis. Bone and the skeletal muscle are fat- free tissues which appeared to be independently associated with NAFLD in several cross-sectional studies. The deterioration of bone mineral density and lean body mass, leading to osteoporosis and sarcopenia, respectively, are age-related processes. The prevalence of NAFLD also increases with age. Beyond physiological aging, the three conditions share some common underlying mechanisms, and their elucidations could be of paramount importance to design more effective treatment strategies for the management of NAFLD. In this review, we provide an overview on epidemiological data as well as on potential contributors to the connections of NAFLD with bone and skeletal muscle.

关键词： Non-alcoholic fatty liver disease Bone Skeletal muscle Osteoporosis Sarcopenia

Sperm glyceraldehyde 3-phosphate dehydrogenase gene expression in asthenozoospermic spermatozoa

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2017年第4期19卷 409-413页

作者： Donatella Paoli Marianna Pelloni Mariagrazia Gallo Giulia Coltrinari Francesco Lombardo andrea lenzi Loredana Gandini Laboratory of Seminology - Sperm Bank Department of Experimental Medicine University of Rome 'La Sapienza' 00161 Rome Italy

It has been suggested that the energy required for sperm motility is produced by oxidative phosphorylation while glycolysis seems to be an important source for ATP transmission along the flagellum. Some studies have investigated the chemical and kinetic properties of the enzyme glyceraldehyde 3-phosphate dehydrogenase to identify any changes in the regulation of glycolysis and sperm motility. In contrast, there are few studies analyzing the genetic basis of hypokinesis. For this reason, we investigated the glyceraldehyde 3-phosphate dehydrogenase gene in human sperm to evaluate whether asthenozoospermia was correlated with any changes in its expression. Semen examination and glyceraldehyde 3-phosphate dehydrogenase gene expression studies were carried out on 116 semen samples divided into two groups - Group A consisted of 58 normokinetic samples and Group B of 58 hypokinetic samples. Total RNA was extracted from spermatozoa, and real-time PCR quantification of mRNA was carried out using specific primers and probes. The expression profiles for the Groups A and B were very similar. The mean delta Ct was as follows - Group A, 5.79 ＋ 1.04; Group B, 5.47 ＋ 1.27. Our study shows that in human sperm, there is no difference in glyceraldehyde 3-phosphate dehydrogenase gene expression between samples with impaired motility and samples with normal kinetics. We believe that this study could help in the understanding of the molecular mechanisms of sperm kinetics, suggesting that hypomotility may be due to a possible posttranscriptional impairment of the control mechanism, such as mRNA splicing, or to posttranslational changes.

关键词： adenosine-5'-triphosphate gene expression sperm glyceraldehyde 3-phosphate dehydrogenase sperm motility

Inhibin B:are modified ranges needed for orchiectomised testicular cancer patients?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2019年第4期21卷 332-336页

作者： Alessandra Petrozzi Francesco Pallotti Marianna Pelloni Antonella Anzuini Antonio Francesco Radicioni andrea lenzi Donatella Paoli Francesco Lombardo Laboratory of Seminology Sperm Bank "Loredana Gandini" Department of Experimental Medicine Medical Pathophysiology Section"Sapienza" University of Rome Rome 00161 Italy Hormone Laboratory Department of Experimental Medicine Medical Pathophysiology Section"Sapienza" University of Rome Rome 00161 Italy

Inhibin B is a gon adal horm one that down regulates the pituitary production of follicle-stimulati ng horm one (FSH). In recent years, inhibin B has proved to be an excellent marker of spermatogenesis and even a predictive factor for the recovery of fertility in patients undergoing orchiectomy and antineoplastic treatments. We propose to study inhibin B levels in orchiectomised testicular cancer patients, in order to identify a minimum value representative of normal semen quality. This retrospective study evaluates horm onal and semen parameters of 290 no rmozoospermic patie nts atte nding the Laboratory of Semi no logy - Sperm Bank "Loredana Gandini"(Rome, Italy) for cryopreservation of seminal fluid following a diagnosis of testicular cancer (TC group) and 117 healthy, normozoospermic men as a control group (CTR group). The percentile distribution of gonadotropin and inhibin B values in the TC and CTR groups was analyzed. There was a statistically significant differenee between the two groups in the levels of all hormones (P ≤ 0.001) and in all semen parameters (P 95^th percentile of CTR group. Orchiectomised patients for testicular cancer presented inhibin B levels lower than healthy patients, despite normozoospermia. Our study revealed the poor sensitivity of the current inhibin B reference range when applied to monorchidic patients, suggesting the need to establish more representative ranges to enable more appropriate counseling in relation to the patienfs new endocrine condition.

关键词： inhibin B orchiectomy referenee range testicular cancer

A decade of WH02010:total sperm number temporal trend and role of lifestyle factors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2023年第5期25卷 572-577页

作者： Francesco Cargnelutti Francesco Pallotti Tania Carlini Fabiana Faja Anna Rita Vestri Danilo Alunni Fegatelli andrea lenzi Francesco Lombardo Donatella Paoli Laboratory of Seminology-Sperm Bank"Loredana Gandini" Department of Experimental MedicineSapienza University of RomeViale del Pliclinico 155Roma 00161Italy Department of Public Health and Infectious Disease Sapienza University of RomeViale del Polclinico 155Roma 00161Italy

After a huge decline in sperm concentration between 1938 and 1991 was reported,many researchers investigated the possibility of a worsening of human sperm *** massive efforts,published evidence is still ***,the role of lifestyle factors on semen parameters is *** conducted a monocentric Italian study to evaluate the total sperm number trend over the last 10 years(from 2010 to 2019).Additionally,we evaluated the association between lifestyle factors and total sperm number in order to identify possible damaging *** performed a retrospective study analyzing subjects aged 18-55 years who had their semen analyzed between 2010 and 2019.A total of 3329 subjects were included:1655 subjects referred to our department(Department of Experimental Medicine,Sapienza University of Rome,Roma,Italy)for idiopathic infertility and 1674 subjects referred for preconceptional or andrological screening with no confirmed andrological *** samples were examined according to World Health Organization(WHO)2010 criteria by two seminologists with the same training and the same *** statistical evaluations,only total sperm number(×10^(6)per ejaculate)was taken into *** detected no significant changes in mean total sperm number during the last decade,in either the entire population or the two subgroups(infertile group and control group).In a multivariate analysis total sperm number was significantly associated with the history of infertility,body mass index(BMI)and cigarette *** results suggest that infertile men are"vulnerable"subjects,particularly susceptible to several negative factors,many of which still remain *** study highlights the need for studies addressing men's lifestyle in order to find and reduce deleterious agents.

关键词： aging male infertility obesity smoking sperm decline

Effects of percutaneous varicocele repair on testicular volume:results from a 12-month follow-up

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2019年第4期21卷 408-412页

作者： andrea Sansone Danilo Alunni Fegatelli Carlotta Pozza Giorgio Fattorini Rosa Lauretta Marianna Minnetti Francesco Romanelli Pierleone Lucatelli Mario Corona Mario Bezzi Francesco Lombardo andrea lenzi Daniele Gianfrilli Departme nt of Experime ntal Medici ne Sa pie nza Un iversity of Rome Rome 00161 Italy Department of Public Health and In fectious Diseases Sapienza University of Rome Rome 00161 Italy Unit of Endocrinology Regina Elena National Cancer Institute Rome 00144 Italy Vascular and Interventional Radiology Unit Department of Radiological Oncological and Anatomo-Pathological Sciences Sapienza-University of Rome Rome 00161 Italy

Varicocele is a comm on fin ding in men. Varicocele correcti on has bee n advocated for young patients with testicular hypotrophy, but there is a lack of morphofunctional follow-up data. We assessed whether percutaneous treatment of left varicocele is associated with testicular "catch-up growth" in the following 12 months by retrospectively reviewing data from an electronic database of 10 656 patients followed up in our clinic between 2006 and 2016. We selected all young adults (20% difference between left and right testicular volume at baseline, was observed in 26 (22.8%) men. Participants with LTH (mean±s.d.: 14.5 ± 2.7 ml) had lower baseline testicular volume compared to those without LTH (mean±s.d.: 15.7 ± 3.8 ml;P= 0.032). Repeated measures mixed models showed a sign ifica nt in teraction betwee n LTH and time posttreatme nt when correcting for baseli ne left testicular volume (β= 0.114, 95% confidence interval [Cl]: 0.018-0.210, P=0.020), resulting in a catch-up growth of up to 1.37 ml per year (95% Cl: 0.221- 2.516). Age at intervention was also associated with reduced testicular volume (-0.072 ml per year, 95% Cl:-0.135--0.009;P = 0.024). Percutaneous treatment of left varicocele in young adults with LTH can result in catch-up growth over 1 year of follow-up. The reproductive and psychological implicati ons of these findings n eed to be confirmed in Ion ger and larger prospective studies.

关键词： catch-up growth percutaneous treatment testicular hypotrophy testicular ultrasound testicular volume varicocele young adults

Severe male factor in in vitro fertilization:definition,prevalence,and *** update

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2022年第2期24卷 125-134页

作者： Rossella Mazzilli Alberto Vaiarelli Lisa Dovere Danilo Cimadomo NicolòUbaldi Susanna Ferrero Laura Rienzi Francesco Lombardo andrea lenzi Herman Tournaye Filippo Maria Ubaldi Clinica Valle Giulia GeneraLife IVF CentersVia G.De NotarisRome 2B 00197Italy Department of Clinical and Molecular Medicine University of Rome“Sapienza”Via di Grottarossa 1035Rome 00189Italy Catholic University of the Sacred Heart Via della Pineta Sacchetti 217Rome 00168Italy Department of Experimental Medicine “Sapienza”University of RomeViale del Policlinico 155Rome 00161Italy Centre for Reproductive Medicine Free University Brussels(UZ Brussel)Brussels 1090Belgium

Infertility affects 10%–15%of couples *** all infertility cases,20%–70%are due to male *** the past,men with severe male factor(SMF)were considered ***,the development of intracytoplasmic sperm injection(ICSI)drastically modified this *** advances in assisted reproductive technology(ART),specifically regarding surgical sperm retrieval procedures,allowed the efficacious treatment of these ***,before undergoing ICSI,male factor infertility requires careful evaluation of clinical and lifestyle behavior together with medical *** speaking,women whose male partner is azoospermic tend to be younger and with a better ovarian *** couples,in fact,are proposed ART earlier in their life,and for this reason,their ovarian response after stimulation is generally ***,in younger couples,azoospermia can be partially compensated by the efficient ovarian response,resulting in an acceptable fertility rate following in vitro fertilization(IVF)***,when azoospermia is associated with a reduced ovarian reserve and/or advanced maternal age,the treatment becomes more challenging,with a consequent reduction in IVF ***,azoospermia seems to impair neither the euploidy rate at the blastocyst stage nor the implantation of euploid *** on the current knowledge,the assessment of male infertility factors should involve:(1)evaluation–to diagnose and quantify seminologic alterations;(2)potentiality–to determine the real possibilities to improve sperm parameters and/or retrieve spermatozoa;(3)time–to consider the available“treatment window”,based on maternal age and ovarian *** review represents an update of the definition,prevalence,causes,and treatment of SMF in a modern ART clinic.

关键词： azoospermia in vitro fertilization infertility intracytoplasmic sperm injection severe male factor sperm

Sarcopenic Obesity: Correlation with Clinical, Functional, and Psychological Status in a Rehabilitation Setting

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food and Nutrition Sciences 2014年第20期5卷 2020-2031页

作者： Lorenzo M. Donini Eleonora Poggiogalle Silvia Migliaccio Alessandro Pinto Carla Lubrano andrea lenzi Food Science and Human Nutrition Research Unit Medical Physiopatology Food Science and Endocrinology Section Department of Experimental Medicine Sapienza University of Rome Rome Italy Unit of Endocrinology Department of Movement Human and Health Sciences ForoItalico University of Rome Rome Italy

Obesity and sarcopenia combination, appropriately defined as sarcopenic obesity (SO), due to disproportionally reduced/low lean body mass compared to excess fat mass, may lead to disability. Aims: The aim of our study was to investigate the relationship among sarcopenic obesity, physical performance, disability, and quality of life in a rehabilitation setting. Methods: Participants were recruited among obese patients (BMI > 30 kg/m2) admitted to the rehabilitation facility at the Department of Experimental Medicine, Medical Physiopatology, Food Science and Endocrinology Section during a 1-year period. A multidimensional evaluation was performed through bioelectrical impedance analysis and anthropometry, handgrip strength test, Short Physical Performance Battery (SPPB), 6-minute walk test (6MWT) and blood chemistry parameters. Psychological status (SCL-90 questionnaire), quality of life, and comorbidity (Charlson comorbidity index score) were also evaluated. Obesity was diagnosed as increased fat mass by 35% in women and by 25% in men. Sarcopenia was defined if lean body mass (LBM) was <90% of the subject’s ideal LBM. Results: 79 patients (48 women and 31 men;mean age: 60.1 ± 11.5 years, and 58.6 ± 10.8 years, respectively) were enrolled. Results showed a high prevalence of SO (54.4%) in our samples of obese subjects. Sarcopenia was present not only among older obese adults but also among younger obese subjects, and was related to reduced functional performance, to inflammatory status and to worse psychological status and quality of life.

关键词： Sarcopenic Obesity Disability

Physical exercise intensity prescription to improve health and fitness in overweight and obese subjects: A review of the literature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Health 2013年第6期5卷 113-121页

作者： Gian Pietro Emerenziani Silvia Migliaccio Maria Chiara Gallotta andrea lenzi Carlo Baldari Laura Guidetti Department of Experimental Medicine University of Rome “La Sapienza” Rome Italy Department of Movement Human and Health Sciences University of Rome “Foro Italico” Rome Italy

Obesity is one of the greatest public health challenges of the 21st century. Overweight and obesity drastically increase a person’s risk of developing chronic non-communicable diseases (NCDs), including cardiovascular disease, cancer and diabetes. Furthermore, obesity is already responsible for 2% -8% of health costs and 10% -13% of deaths in several industrialized countries. Lifestyle modifications involving changes in exercise, diet and psychological support are effective in reducing the incidence of overweight. Moreover, positive effects of physical activity (PA) for weight loss and prevention of weight regain are well documented. It was recognized that health benefits regarding both psychological and physiological aspects, such as improving cardiorespiratory and muscular fitness and/or decreasing depression symptoms, can be obtained from numerous activities. Public health institutions (American College of Sports Medicine, World Health Organization) provide recommendations for PA (volume, frequency, intensity and type of exercise) to achieve positive effects, at all ages and for many diseases and disorders situations. Although exercise under guidelines can be safely performed by obese subjects, several questions still need to be fully answered. In facts, the exercise program should be tailored according to an individual’s habitual physical activity, physical function, health status, exercise responses, and stated goals. Thus, this review analyzes the intensity of PA parameters. In the last years, research has been focused on the individualization of the right intensity in which different types of subjects’ condition must undergo to achieve the health goals. Aerobic exercise has been commonly used to reach weight loss goal. Prescription of aerobic exercise in clinical practice is frequently based on the percentage of maximum heart rate (%HRmax), heart rate reserve (%HRreserve), rating of perceived exertion (RPE), maximal oxygen consumption (%VO2max) and for unheal

关键词： Obesity Overweight Exercise Intensity Prescription Gas Exchange Thresholds Health