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Computer Modeling in Engineering & Sciences 2019年第9期120卷 583-627页

作者： Mohammed A.Mohammed andre.R.Barbosa School of Civil and Construction Engineering Oregon State UniversityCorvallisORUSA

A three-dimensional nonlinear modeling strategy for simulating the seismic response of slender reinforced concrete structural walls with different cross-sectional shapes is presented in this paper.A combination of nonlinear multi-layer shell elements and displacement-based beam-column elements are used to model the unconfined and confined parts of the walls,respectively.A uniaxial material model for reinforcing steel bars that includes buckling and low-cyclic fatigue effects is used to model the longitudinal steel bars within the structural *** material model parameters related to the buckling length are defined based on an analytical expression for reinforcing steel bars embedded in reinforced concrete elements,which are developed based on beam-on-springs model,and validated with experimental tests of boundary elements of structural walls available in the *** experimental case studies of reinforced concrete walls with rectangularshape,T-shape,and U-shape cross-section are used to validate the structural wall numerical modeling strategy.

关键词： Bar buckling finite element modeling low-cycle fatigue reinforced concrete structural walls

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寡转移性前列腺癌:现状和挑战

中华核医学与分子影像杂志 2024年第9期44卷 572-576页

作者：陈翘楚邵泓达(译) 刘建军(审校) 上海交通大学医学院附属仁济医院核医学科上海200127

肿瘤寡转移主要指成像上只有很少数量(通常1~3个)可识别的转移性病变,是肿瘤自然演变过程中的中间状态,肿瘤寡转移状态可能是适合接受以转移灶为靶向的治疗时机。如果可以有效治疗寡转移性疾病,有可能以最低或可接受的毒性成本延缓疾病... 详细信息

肿瘤寡转移主要指成像上只有很少数量(通常1~3个)可识别的转移性病变,是肿瘤自然演变过程中的中间状态,肿瘤寡转移状态可能是适合接受以转移灶为靶向的治疗时机。如果可以有效治疗寡转移性疾病,有可能以最低或可接受的毒性成本延缓疾病进展和改善患者预后,影响肿瘤进一步发展。随着多种新一代显像剂的问世,对寡转移性前列腺癌的理解得到了进一步深化,其中最近批准的基于靶向前列腺特异膜抗原(PSMA)的PET显像剂最令人关注。目前,早期临床试验结果发现寡转移灶靶向治疗可以推迟应用全身系统治疗的时间,并改善特定患者的疗效。尽管结果令人鼓舞,但在前列腺癌的自然演变过程中,还需要对寡转移状态的潜在生物学特性进行充分研究和学习,确定相关的成像和非成像预测及预后生物标志物,并制定治疗策略以优化患者的短期和长期疗效。该文系统性回顾了前列腺癌寡转移这一临床领域的现状和挑战。

关键词：寡转移前列腺癌症 PET

Spectroscopic investigations on the effect of humic acid on the formation and solubility of secondary solid phases of Ln_2(CO_3)_3

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Journal of Rare Earths 2011年第6期29卷 516-521页

作者： Stella Antoniou Ioannis Pashalidis andre.Gessner Michael U Kumke Department of Chemistry University of Cyprus P.O. Box 20537 1678 Nicosia Cyprus Chemistry Department/Physical Chemistry University of Potsdam Karl- Liebknecht-Str. 24-25 14476 Potsdam-Golm Germany

The formation of secondary Ln（III） solid phases （e.g., Nd2（CO3）3 and Sm2（CO3）3） was studied as a function of the humic acid concentration in 0.1 mol/L NaClO4 aqueous solution in the neutral pH range （5–6.5）. The solid phases under investigation were prepared by alkaline precipitation under 100% CO2 atmosphere and characterized by attenuated total reflectance Fourier transform infrared spectroscopy （ATR-FTIR）, X-ray diffraction （XRD）, time-resolved laser fluorescence spectroscopy （TRLFS）, diffuse reflectance ultraviolet-visible （DR-UV-Vis）, Raman spectroscopy, and solubility measurements. The spectroscopic data obtained indicated that Nd2（CO3）3 and Sm2（CO3）3 were stable and remained the solubility limiting solid phases even in the presence of increased humic acid concentration （0.5 g/L） in solution. Upon base addition in the Ln（III）-HA system, decomplexation of the previously formed Ln（III）-humate complexes and precipitation of two distinct phases occurred, the inorganic （Ln2（CO3）3） and the organic phase （HA）, which was adsorbed on the particle surface of the former. Nevertheless, humic acid affected the particle size of the solid phases. Increasing humic acid concentration resulted in decreasing crystallite size of the Nd2（CO3）3 and increasing crystallite size of the Sm2（CO3）3 solid phase, and affected inversely the solubility of the solid phases. However, this impact on the solid phase properties was expected to be of minor relevance regarding the chemical behavior and migration of trivalent lanthanides and actinides in the geosphere.

关键词： lanthanide ions humic acid solid phase solubility Raman TRLFS DR-UV-Vis rare earths

Digital re-analysis of lost architecture and the particular case of Lutyens＇ Liverpool Metropolitan Cathedral

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Frontiers of Architectural Research 2016年第2期5卷 265-275页

作者： Nicholas Webb andre.Brown School of Architecture University of Liverpool Liverpool L69 7ZN United Kingdom

Research and critique of unbuilt or destroyed works of architecture is traditionally carried out through the examination of surviving information such as drawings, models, photographs, biographies and monographs. The case study presented here demonstrates that this approach cannot always give a fuU-picture of the architect or designer＇s intentions, and may miss inconsistencies in the design and links to other precedents or antecedents in such schemes. Here, we employ strategic contemporary digital representation techniques to re-present and re-analyse the evidence available for a particular architectural project. We describe a systematic methodology, which shows that these techniques can challenge or enhance current understanding. The focus therefore is on the digital re-analysis process that has been devised. Sir Edwin Lutyens＇ unbuilt Liverpool Metropolitan Cathedral design, that would have delivered one of the largest cathedrals in the world, is used as a case study. The findings reveal new information about the cathedral by following structured lines of enquiry generated from the study of primary and secondary source data, as well as serendipitous results that occur as a potential by-product of the methodological process.

关键词： Unbuitt architecture Digitalcritique Forensic anatysis Digitat modetting

Standing in the present, looking into the future—the 6th Joint Conference on Surgery and Academic Skills—precise treatment for tumors: medication and surgery

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Hepatobiliary Surgery and Nutrition 2018年第6期7卷 508-514页

作者： andre.Miao Santeria Qiu Editorial Office AME Publishing Company

Throughout the ages,the autumn in Beijing has been praised for its beauty by poets and *** seems to have a unique,magic power that can attract every *** was in such a wonderful setting that the 6th Joint Conference on Surgery and Academic Skills was successfully convened at the University of Chicago Center in *** conference was held from September 14–15,and jointly sponsored by the Peking Union Medical College Hospital,AME Publishing Company,Hepatobiliary Surgery and Nutrition(HBSN),the University of Chicago Global Surgery,the University of Chicago Department of Surgery,and the University of Chicago Center in *** year's conference mainly included five sessions:precision medicine,genomic therapy,modifying hosts and diseases,new insights into targeting malignancies,and finally,academic and publishing *** whole conference was aimed at examining both the science and art of providing precision medicine and surgery to patients with solid *** of experts and scholars from home and abroad attended this fabulous meeting and shared their research progress,along with their unique experience(Figure 1).

关键词： Surgery Chicago precise

A New Family of Moths from the Middle Jurassic(Insecta:Lepidoptera)

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Acta Geologica Sinica(English Edition) 2010年第4期84卷 874-885页

作者： HUANG Diying andre.NEL Joeel MINET Nanjing Institute of Geology and Palaeontology State Key Laboratory of Palaeobiology and Stratigraphy Chinese Academy of Sciences Nanjing 210008 China UMR CNRS 7205 Museum National d＇Histoire Naturelle Departement Systematique et Evolution C.P. 50 Entomologie F-75231 Paris Cedex 05 France

Three lepidopteran species, from the Middle Jurassic Daohugou beds （inner Mongolia, China）, are described in a new family, Mesokristenseniidae, and new genus, Mesokristensenia, which could represent the sister group of the Micropterigidae. Mesokristensenia differs from all extant Lepidoptera, but one genus （Agathiphaga, Agathiphagidae）, in retaining four median veins in the forewing, a plesiomorphy also present in many Trichoptera. Evidence for placing Mesokristensenia in the Lepidoptera includes four traits, notably a previously unrecorded autapomorphy of this insect order： beyond stem Ml＋2, vein M1 is bent and connected to cross-vein r-m （in both wing pairs）. Among 24 characters taken into account to assess the systematic position of Mesokristensenia, 12 are considered informative for a cladistic analysis involving this fossil taxon and the four suborders recognized in present-day Lepidoptera （Zeugloptera, Aglossata, Heterobathmiina, and Glossata）.

关键词： Trichoptera Lepidoptera Mesokristenseniidae wing venation phylogeny China Middle Jurassic

Levothyroxine therapy and impaired clearance are the strongest contributors to small intestinal bacterial overgrowth: Results of a retrospective cohort study

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World Journal of Gastroenterology 2017年第5期23卷 842-852页

作者： Thorsten Brechmann andre.Sperlbaum Wolff Schmiegel Department of Gastroenterology and Hepatology Berufsge--nossenschaftliches Universit?tsklinikum Bergmannsheil GmbHRuhr--University Bochum44789 BochumGermany

AIM To identify a set of contributors, and weight and rank them on a pathophysiological *** Patients who have undergone a lactulose or glucose hydrogen breath test to rule out small intestinal bacterial overgrowth(SIBO) for various clinical symptoms, including diarrhoea, weight loss, abdominal pain, cramping or bloating, were seen as eligible for inclusion in a retrospective single-centre study. Clinical data such as co-morbidities, medication, laboratory parameters and other possible risk factors have been identified from the electronic data system. Cases lacking or with substantially incomplete clinical data were excluded from the analysis. Suspected contributors were summarised under four different pathophysiological pathways(impaired gastric acid barrier, impaired intestinal clearance, immunosuppression and miscellaneous factors including thyroid gland variables) and investigated using the χ2 test, Student's t-test and logistic regression *** A total of 1809 patients who had undergone hydrogen breath testing were analysed. Impairment of the gastric acid barrier(gastrectomy, odds ratio: OR = 3.5, PPI therapy OR = 1.4), impairment of intestinal clearance(any resecting gastric surgery OR = 2.6, any colonicresection OR = 1.9, stenosis OR = 3.4, gastroparesis OR = 3.4, neuropathy 2.2), immunological factors(any drug-induced immunosuppression OR = 1.8), altered thyroid gland metabolism(hypothyroidism OR = 2.6, levothyroxine therapy OR = 3.0) and diabetes mellitus(OR = 1.9) were associated significantly to SIBO. Any abdominal surgery, ileocecal resection, vagotomy or Ig A-deficiency did not have any influence, and a history of appendectomy decreased the risk of SIBO. Multivariate analysis revealed gastric surgery, stenoses, medical immunosuppression and levothyroxine to be the strongest predictors. Levothyroxine therapy was the strongest contributor in a simplified model(OR = 3.0).CONCLUSION The most important contributors for the development of SI

关键词： Bacterial overgrowth syndrome Hydrogen breath tests Immunosuppression Intestinal motility Hypothyroidism

On the local convergence of a stochastic semismooth Newton method for nonsmooth nonconvex optimization

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Science China Mathematics 2022年第10期65卷 2151-2170页

作者： andre.Milzarek Xiantao Xiao Zaiwen Wen Michael Ulbrich School of Data Science The Chinese University of Hong KongShenzhenShenzhen 518172China Shenzhen Research Institute of Big Data Shenzhen 518172China Shenzhen Institute of Arti cial Intelligence and Robotics for Society Shenzhen 518172China School of Mathematical Sciences Dalian University of TechnologyDalian 116024China Beijing International Center for Mathematical Research Peking UniversityBeijing 100871China Department of Mathematics Technical University of MunichGarching bei Munchen 85748Germany

In this work,we present probabilistic local convergence results for a stochastic semismooth Newton method for a class of stochastic composite optimization problems involving the sum of smooth nonconvex and nonsmooth convex terms in the objective *** assume that the gradient and Hessian information of the smooth part of the objective function can only be approximated and accessed via calling stochastic firstand second-order *** approach combines stochastic semismooth Newton steps,stochastic proximal gradient steps and a globalization strategy based on growth *** present tail bounds and matrix concentration inequalities for the stochastic oracles that can be utilized to control the approximation errors via appropriately adjusting or increasing the sampling *** standard local assumptions,we prove that the proposed algorithm locally turns into a pure stochastic semismooth Newton method and converges r-linearly or r-superlinearly with high probability.

关键词： nonsmooth stochastic optimization stochastic approximation semismooth Newton method stochastic second-order information local convergence

Fragility Assessment of Pre-Northridge Steel Moment Frames Using Finite-Length Plastic Hinge Elements and Concentrated Plasticity Fracture Elements

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Computer Modeling in Engineering & Sciences 2019年第9期120卷 657-676页

作者： Filipe L.A.Ribeiro andre.RBarbosa Luis CNeves National Laboratory of Civil Engineering(LNEC)&CERIS-Civil Engineering Research and Innovation for Sustainability DECivilUniversity of LisbonLisbonPortugal School of Civil and Construction Engineering Oregon State UniversityOregonUSA and University of BristolBristolUK Resilience Engineering Research Group University of NottinghamNottinghamUK.

Although pre-Northridge earthquake steel moment resisting frame buildings have been shown to be susceptible to brittle connection failures,they still represent a large fraction of the existing steel buildings in the United States of *** this study,the performance of the 3-and 9-story Los Angeles pre-Northridge SAC buildings are analyzed considering ductile and brittle beam-column connection failures,and their *** paper contributes to understanding the influence of uncertainty associated with connections brittle fracture on building interstory deformation capacity and its impact on bias and variability of fragility functions and loss *** results show that considering brittle connections leads to significantly l arger d rift demands a nd t o h igher r epair costs,particularly under intense ground *** fragility curve parameters are derived that account for the effect of the uncertainty of the strength and deformation capacity of brittle connections.

关键词： Brittle fracture finite-length p lastic h inge f ragility c urves r epair c ost ratio welded-flange connections

Monitoring the effects of land transformation on African clawless otters(Aonyx capensis)using fecal glucocorticoid metabolite concentrations as a measure of stress

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Integrative Zoology 2020年第4期15卷 293-306页

作者： Tshepiso L.MAJELANTLE Trevor MCINTYRE andre.GANSWINDT Mammal Research Institute Department of Zoology and EntomologyUniversity of PretoriaPretoriaSouth Africa Department of Life and Consumer Sciences University of South AfricaPretoriaSouth Africa Endocrine Research Laboratory Department of Anatomy and PhysiologyUniversity of PretoriaOnderstepoortSouth Africa Centre for Veterinary Wildlife Studies Faculty of Veterinary ScienceUniversity of PretoriaOnderstepoortSouth Africa

In a time of increasing environmental change caused by anthropogenic disturbance,there is a greater need to understand animal adaptations to manmade *** this regard,the measurement of stress-related endocrine markers provides a useful tool to examine the impact of environmental challenges and the physiological consequences for wildlife occupying such *** aims of the present study were to validate fecal glucocorticoid metabolite(fGCM)concentrations as a measure of stress using samples from a male African clawless otter(Aonyx capensis;n=1)and to compare fGCM concentrations of otters occurring in a transformed and in 2 natural areas in South *** the 5 different enzyme-immunoassays(EIA)tested,a cortisol and oxoetiocholanolone(measuring 11,17 dioxoandrostanes)EIA revealed the highest response(74%and 48%increase,respectively)30 and 24 hours after a stress event(translocation of a captive individual as part of its rehabilitation prior to release),respec*** both EIAs,fGCM concentrations were comparable for samples collected up to 3 h *** the cortisol EIA for subsequent analyses,fGCM concentrations of animals from the transformed area(n=20;mean[±SD]:0.468[±0.539]µg/g dry weight[DW])were significantly higher(P=0.013)than those from otters in the natural areas(n=17;0.242[±0.226]µg/g DW).These preliminary results suggest that African clawless otters may have increased adrenocortical activity that could be due to conditions linked to living in a transformed environment.

关键词： African clawless otter fecal glucocorticoid metabolites non-invasive hormone measurement stress urbanization