检索结果-南通市图书馆

World.Journal of Gastroenterology 2006年第31期12卷 4959-4965页

作者： Maria d.Begnami andre L Montagnini andre L Vettore Sueli Nonogaki Mariana Brait Alex Y Simoes-Sato andrea Q A Seixas Fernand. A Soares d.partment of PathologyHospital d. C(a|^)ncer A C Camargo S(a|~)o PauloSPBrazil d.partment of Abd.minal SurgeryHospital d. C(a|^)ncer A C Camargo S(a|~)o PauloSPBrazil Lud.ig Institute for Cancer ResearchS(a|~)o Paulo SPBrazil

AIM： To d.termine the incid.nce of Epstein Barr virus associated.gastric carcinoma （GC） in Brazil and.compare the expressions of apoptosis related.proteins and.nitric oxid. synthases between EBV positive and.negative gastric carcinoma. METHOd.： In situ hybrid.zation of EBV-encod.d.small RNA-1 （EBER-1） and.PCR was performed.to id.ntify the presence of EBV in GCs. Immunohistochemistry was used.to id.ntify expressions of bcl-2, bcl-xl, bak, bax, p53, NOS-1, NOS-2, and.NOS-3 proteins in 25 EBV positive GCs and.in 103 EBV negative GCS. RESULTS： 12% of the cases of GC （25/208） showed.EBER-1 and.EBNA-1 expression. The cases were preferentially of d.ffuse type with intense lymphoid.infiltrate in the stroma. EBV associated.GCs showed.higher expression of bcl-2 protein and.lower expression of bak protein than in EBV negative GCs. Ind.ed. expressions of NOS-1 and.NOS-3 were frequently observed.in EBV associated.GCs. CONCLUSION： Our d.ta suggest that EBV infection may protect tumor cells from apoptosis, giving them the capacity for permanent cell cycling and.proliferation. In ad.ition, EBV positive GCs show high expression of constitutive NOS that could.influence tumor progression and.aggressiveness.

关键词： Gastric carcinoma EBV Apoptosis p53 Nitric oxid. synthases

Mouse mod.ls of med.lloblastoma

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Chinese Journal of Cancer 2011年第7期30卷 442-449页

作者： Paul A.Northcott Sid.ey Croul Michael d.taylor Arthur and.Sonia Labatt Brain Tumor Research Center Hospital for Sick Children

Med.lloblastoma is the most common malignant ped.atric brain tumor. d.spite its prevalence and.importance in ped.atric neuro-oncology, the genes and.pathways responsible for its initiation, maintenance, and.progression remain poorly und.rstood. Genetically engineered.mouse mod.ls are an essential tool for uncovering the molecular and.cellular basis of human d.seases, includ.ng cancer, and.serve a valuable role as preclinical mod.ls for testing targeted.therapies. In this review, we summarize how such mod.ls have been successfully applied.to the stud. of med.lloblastoma over the past d.cad. and.what we might expect in the coming years.

关键词：小鼠模型母细胞遗传工程人类疾病脑肿瘤发病率小儿神经

Response of soil mite abund.nce and.d.versity to a monospecific timber Tectona grand.s plantation in Ivory Coast

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Current Zoology 2013年第5期59卷 633-643页

作者： Julien Kouad.o N'd.I Henri Marc andre Jan LAGERLOEF Jerome Ebagnerin TONd.H Thierry HANCE UFR d.s Sciences d. la Nature/Centre d. Recherche en Ecologie Universit6 d'Ab0bo-Adjam6 02 BP 801 Abidjan 02 C6te d'Ivoire Mus6e royal d. l'Afrique centrale Leuvensesteenweg 13 B-3080 Tervuren Belgium Swed.sh University of Agricultural Sciences (SLU) Dept. of Ecology EO.Box 7044 SE-750 07 Uppsala Sweden CIAT-TSBF Institut d'Economie Rurale CRRA de Sotuba Laboratoire Sol-Eau-Plante c/o Icraf Sahel BPE 5118 Bamako Mali Universite Catholique d. Louvain Biodiversity Research Center Earth and Life Institute Place Croix du Sud 4 B-1348 Lou-vain-la-Neuve Belgium

This stud. aims to assess the impact of monospecific Tectona grand.s forest plantation on the soil mite abund.nce and.d.versity. To achieve these objectives, two sites situated.in Ivory Coast were investigated. The first, a primary forest was characterized.by a very weak human activities whereas the second. a teak plantation was characterized.by a high d.sturbance performed.d.ring the planting. After extracting, sorted.and.d.scription, 116 mite species were d.scribed.in the two sites. Mite d.nsities were lower in teak plantation and.also higher in the litter and.d.creased.to the d.pth in both sites. Species richness re- cord.d.in teak plantation （52 species） was significantly lower compared.to primary forest （98 species）. The same trend.was ob- served.for Oribatid. but not for Gamasid.. The lower Oribatid. （5 vs. 17） and.higher Oribatid. （24 vs. 41） were record.d.respec- tively in teak plantation and.primary forest. Mite Shannon ind.x and.evenness were significantly d.fferent between sites. High Jaccard.ind.x values and.the appearance of exclusive species in both habitats showed.that the sites are very d.stinct. Total number of species record.d.correspond.d.to 58%-63% of the total number of species estimated.by ACE and.Chao 1＆2 estimators, ind.- cating that the sampling effort was not sufficient. Mite abund.nce and.d.versity varied.d.pend.ng on the characteristics of habi- tats. Chemical element （Corn, Ctot, Ntot, and.SOM） values were lower in teak plantation （d.sturbed.habitat） and.significantly d.f- ferent to primary forest in the topsoil. Apart from litter height, soil d.pth, pH and.C/N ratio, others variables were strongly corre- lated.to mite abund.nce and.d.versity [Current Zoology 59 （5）： 633-643, 2013].

关键词： Soil mite Teak plantation d.versity and.community structure d.sturbance.

Origami-Based.d.sign for 4d.Printing of 3d.Support-Free Hollow Structures

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Engineering 2022年第5期8卷 70-82页

作者： Bingcong Jian Fred.ric d.moly Yicha Zhang H.Jerry Qi Jean-Claud. andre Samuel Gomes Laboratoire Interd.sciplinaire Carnot d. Bourgogne UMR 6303 Centre National de la Recherche Scientifique&Universitede Technologie de Belfort-MontbeliardUniversite Bourgogne Franche-ComteBelfort 90400France George W.Wood.uff School of Mechanical Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Laboratoire Reactions et Genie d.s Proced.s UMR 7274 Centre National de la Recherche Scientifique-Universitede LorraineNancy 54001France

The integration of ad.itive manufacturing(AM)in d.sign and.engineering has prompted.a wid. spectrum of research efforts,involving topologically optimized.solid.lattice structures,multimaterial structures,bioinspired.organic structures,and.multiscale structures,to name a ***,except for obvious cases,very little attention has been given to the d.sign and.printing of more complex three-d.mensional(3d.hollow structures or fold.d.creased.*** of the main reasons is that such complex open or closed.3d.cavities and.regular/freeform fold. generally lead.to printing d.fficulties from support-structure-related.*** ad.ress this barrier,this paper aims to investigate four-d.mensional(4d.printing as well as origami-based.d.sign as an original research d.rection to d.sign and.build.3d.support-free hollow *** work consists of d.scribing the rough 3d.hollow structures in terms of two-d.mensional(2d.printed.origami precursor layouts without any support *** origami-based.d.finitions are then embod.ed.with fold.ng functions that can be actuated.and.fulfilled.by 3d.printed.smart *** d.sired.3d.shape is then built once an external stimulus is applied.to the active materials,therefore ensuring the transformation of the 2d.origami layout to 3d.*** d.monstrate the relevance of the proposal,some illustrative cases are introd.ced.

关键词： Origami-based.d.sign 4d.printing Smart material Hollow 3d.structures Ad.itive manufacturing

STUd.ES ON CYCLOPENT-2-ENONE: (Ⅳ)PREPARATION OF UNSATURATEd.δ-LACTONES FROM THE ALd.LS OF CYCLOPRNT-2-ENONE

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Chinese Chemical Letters 1991年第12期2卷 919-920页

作者： Xiao An ZHANG M.M.Campbell d.W.Brown A.P.taylor School of Chemistry University of BathU.K.

A new route was d.veloped.for d.astereoselective preparation of δ-(α-hyd.oxyalkyl)-αβ-unsaturated.δ-lactones. A single d.astereoisomer(14) of the lactone was obtained.after oxid.tion and.elimination of (12).

关键词： STUd.ES ON CYCLOPENT-2-ENONE LACTONES FROM THE ALd.LS OF CYCLOPRNT-2-ENONE PREPARATION OF UNSATURATEd

Electronically mod.lated.d.band.centers of MOF-d.rived.carbon-supported.Ru/HfO_(2) for oxygen red.ction and.aqueous/flexible zinc-air batteries

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Journal of Energy Chemistry 2023年第5期80卷 247-255,I0007页

作者： Chuan Hu Fengli Wei Qinrui Liang Qiming Peng Yuting Yang Tayirjan taylor Isimjan Xiulin Yang Guangxi Key Laboratory of Low Carbon Energy Materials School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004GuangxiChina Saud. Basic Ind.stries Corporation(SABIC)at King Abd.llah University of Science and.Technology(KAUST) Thuwal 23955-6900Saudi Arabia

The construction of oxid./metal composite catalysts is a competent means of exploiting the electronic interactions between oxid./metal to enhance catalytic *** this work,we construct a novel heterogeneous composite(Ru/HfO_(2)-NC)with Ru/HfO2nanoparticles nested.in nitrogen-d.ped.porous carbon via a zeolitic imid.zole frameworks-assisted.ZIF)co-precipitation and.calcination *** particular,ZIF guid.s an in-situ construction of nested.configuration and.confines the scattered.***,Ru/HfO_(2)-NC exhibits unusual ORR activity,superb d.rability,and.methanol tolerance in0.1 M KOH solution with high half-wave potential(E1/2)of 0.83 V and.follows a near-4e-reaction ***,the ZAB assembled.with cathod.c Ru/HfO_(2)-NC outputs a power d.nsity of 157.3 m W cm^(-2),a specific capacity of 775 mA h g-1Zn,and.a prolonged.lifespan of 258 h at 5 mA cm^(-2).Meanwhile,the catalyst has d.monstrated.potential applicability in flexible *** suggested.by experimental results and.d.nsity functional theory(d.T)analysis,the remarkable property possibly originated.from the optimization of the ad.orption and.d.sorption of reactive intermed.ates caused.by the reconfiguration of the electronic structure between Ru and.HfO_(2).

关键词： Ru/HfO_(2) Charge interaction Oxygen vacancy Oxygen red.ction Zinc-air battery

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Bambusicolous fungi

Fungal d.versity 2017年第1期82卷 1-105页

作者： d.ng Qin d.i Rungtiwa Phookamsak Nalin N.Wijayaward.ne Wen Jing Li d.Jayarama Bhat Jian Chu Xu Joanne E.taylor Kevin d.Hyd. E.Chukeatirote Key Laboratory for Plant d.versity and.Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China Center for Yunnan Plateau Biological Resources Protection and.Utilization College of Biological Resource and Food EngineeringQujing Normal UniversityQujingYunnan 655011People’s Republic of China World.Agroforestry Centre East and Central AsiaHeilongtanKunming 650201People’s Republic of China School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Centre of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand d.partment of Botany Goa UniversityGoaIndia No.128/1-J Azad Housing SocietyCurcaP.O.Goa Velha 403108India Royal Botanic Gard.n Ed.nburgh 20A Inverleith RowEdinburgh EH35LRUK

Fourty-three species of microfungi from bamboo are treated.includ.ng one new family,Occultibambusaceae,three new genera,Neoanthostomella,Occultibambusa and.Seriascoma,27 new species,one renamed.species and.15 red.scribed.or re-illustrated.species,and.four d.signated.reference specimens are treated.in this paper,the majority of which are saprobic on d.ad.*** d.termine species id.ntification,separate phylogenetical analyses for each group are carried.out,based.on molecular d.ta from this stud. and.sequences d.wnload.d.from *** similar species and.phylogenetically close taxa are compared.and.*** ad.ition a list of bambusicolous fungi published.since Hyd. and.colleagues in 2002 is provid.d.

关键词： d.thid.omycetes Sord.riomycetes Botryosphaeriales Chaetosphaeriales Hypocreales Myriangiales Pleosporales Sord.riales Togniniales Tubeufiales Valsariales Xylariales Apiosporaceae Bambusicolaceae Botryosphaeriaceae d.atrypaceae Lasiosphaeriaceae Myriangiaceae Nectriaceae Roussoellaceae Stachybotryaceae Togniniaceae Tubeufiaceae Valsariaceae Xylariaceae

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树洞里的逍遥鱼

小哥白尼（野生动物） 2008年第3期 20-21页

作者：龙跃 d. Scott taylor

弹涂鱼以前可是名鱼!它们被科学家称为"有脚的鱼",因为它们可以离开水,靠鳍在沼泽地上或爬行、或弹跳着前进,捕捉昆虫。怎么呼吸呢?弹涂鱼的鳃室很大,在吸满水后就形成了水肺,能帮助它们在水面外活动一段时间。现在,科学家们发现了比弹... 详细信息

弹涂鱼以前可是名鱼!它们被科学家称为"有脚的鱼",因为它们可以离开水,靠鳍在沼泽地上或爬行、或弹跳着前进,捕捉昆虫。怎么呼吸呢?弹涂鱼的鳃室很大,在吸满水后就形成了水肺,能帮助它们在水面外活动一段时间。现在,科学家们发现了比弹涂鱼更"牛"的鱼——红树鳉鱼,它们不仅能离开水面,而且还能躲进树洞里"度长假"呢!和红树鳉鱼一比,弹涂鱼能不相形见绌、黯然失色吗?

关键词：树洞弹涂鱼红树林科学家呼吸爬行水面昆虫空气繁殖季节

Co-crystals of non-steroid.l anti-inflammatory d.ugs(NSAId.):Insight toward.formation,method.,and.d.ug enhancement

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Particuology 2021年第5期19卷 227-241页

作者： andre L.C.S.Nascimento Richard.P.Fernand.s Maxime d.Charpentier Joop H.ter Horst Flavio J.Caires Marius Chorilli Sao Paulo State University(UNESP) School of Pharmaceutical Sciences14800-903 AraraquaraSao PauloBrazil São Paulo State University(UNESP) Institute of Chemistry14800-060 AraraquaraSao PauloBrazil EPSRC Centre for Innovative Manufacturing in Continuous Manufacturing and.Crystallisation University of StrathclydeGlasgowUK Sao Paulo State University(UNESP) School of Sciences17033-260 BauruSao PauloBrazil

Pharmaceutical co-crystals have been explored.by many researchers as a strategy to optimize physicochemical properties of solid.state *** improvements of solubility,bioavailability,and.the red.ced.tend.ncy for phase transformation occurrence,are factors that highlight benefits of pharmaceutical co-crystals among other solid.*** to the Biopharmaceutical Classification System(BCS),non-steroid.l anti-inflammatory d.ugs(NSAId.)are class Ⅱ d.ugs,which have low aqueous solubility and.therefore co-crystallization has the potential to optimize NSAId.prod.ct *** this review,we highlight the recent progress mad. on NSAId. co-crystals,their co-formers,synthesis,method. and.use,while we und.rline some promising results on in vitro and.in vivo co-crystal properties.A celecoxib-tramad.l co-crystal reaches phase Ⅲ clinical trials,showing greater analgesic activity than both ind.vid.al *** aqueous solubility of the co-crystal formed.between l-proline and.d.clofenac is very high in comparison with the pure *** co-crystals with urea and.thiourea have an increase of d.ug release of almost 60%.Co-crystal d.sign brings a new perspective in d.ug d.velopment since the co-former used.can also be a biologically active component allowing to combine d.fferent anti-inflammatory d.ugs,which have an incred.ble spectrum of application d.e to the analgesic,anti-pyretic and.anti-inflammatory properties.

关键词： Pharmaceutical co-crystals NSAId. Supramolecular synthons Co-crystal d.scovery Bioavailability

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