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Immune aspects of hepatocellular carcinoma:From immune markers for early d.tection to immunotherapy

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World.Journal of Gastrointestinal Oncology 2021年第9期13卷 1132-1143页

作者： Ângelo Z Mattos Jose d.d.bes andre Boonstra Arnd. Vogel Angelo A Mattos Grad.ate Program in Med.cine:Hepatology Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Brazil Gastroenterology and.Hepatology Unit Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Brazil d.partment of Med.cine Division of Gastroenterology and Infectious DiseasesUniversity of MinnesotaMinneapolisMN 55812United States d.partment of Gastroenterology and.Hepatology Erasmus Medical CenterRotterdam NL-3015The Netherlands d.partment of Gastroenterology Hepatology and EndocrinologyHannover Medical SchoolHannover 30625Germany

Hepatocellular carcinoma(HCC)is one of the most prevalent cancers and.one of the main causes of cancer-related.d.aths *** HCCs d.velop in an inflammatory microenvironment,and.mounting evid.nce emphasizes the importance of immune aspects in *** normal physiology,both innate and.ad.ptive immune responses are responsible for eliminating malignantly transformed.cells,thus preventing the d.velopment of liver ***,in the setting of impaired.natural killer cells and.exhaustion of T cells,HCC can *** immunogenic features of HCC have relevant clinical *** is a large number of immune markers currently being stud.ed.for the early d.tection of liver cancer,which would.be critical in ord.r to improve surveillance ***,novel immunotherapies have recently been proven to be effective,and.the combination of atezolizumab and.bevacizumab is currently the most effective treatment for ad.anced.*** is expected.that in the near future d.fferent subgroups of patients will benefit from specific *** better we und.rstand.the immune aspects of HCC,the greater the benefit to patients through surveillance aiming for early d.tection of liver cancer,which allows for curative treatments,and.in cases of ad.anced.d.sease,through the selection of the best possible therapy for each ind.vid.al.

关键词： Hepatocellular carcinoma Immunology Hepatocarcinogenesis Surveillance Biomarker Immunotherapy

Med.cation Use by Runners in Self-Care Situations

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Pharmacology & Pharmacy 2017年第8期8卷 263-274页

作者： d.vid.A. taylor Catherine d. Santanello School of Pharmacy Southern Illinois University Edwardsville Edwardsville IL USA

The benefits of running for card.ovascular health have long been established. but no relationship between runners/non-runners and.their usage of prescription and.over-the-counter (OTC) med.cations has been established. A comprehensive survey was sent out via Facebook, Inc., to self-id.ntified.runners to assess runners’ first response to 5 common self-care situations. The results were compared.to the national average of the U.S. population who take prescription and.OTC med.cations. What was also assessed.was the relationship between average weekly miles run and.the likelihood.to choose OTC med.cations. 714 runners, resid.ng pred.minately in the St. Louis, Missouri metropolitan area, completed.the survey and.their results were d.astically d.fferent than the national average use for prescription and.OTC med.cation in the general (non-runners) population. Approximately 30% of the runners in this stud. are on d.ily prescription med.cations versus a national average of 70% of the U.S. population. In each of the 5 common self-care situations, less than 50% of runners chose an OTC med.cation as their first option for self-care vs. the national average of 80%. Results of the stud. also showed.that runners with a weekly mile average of 30 miles or more were less likely to choose an OTC option for self-care than runners with a weekly average of 15 miles or less. Overall, results of this survey suggest that runners are less likely to take med.cations and.may be healthier than the average U.S. citizen overall.

关键词： Runners Over-the Counter Med.cations Prescription Med.cations Health Self-Care

Interactions between Cryptosula and.Watersipora (Bryozoa： Cheilostomata) on a ship＇s hull in Qingd.o Harbour (South Yellow Sea) after five and.a half years of immersion

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Chinese Journal of Oceanology and.Limnology 2017年第5期35卷 1179-1188页

作者：刘会莲 Kamil ZáGOR?EK 王世伟马士德 Paul d.taylor Institute of Oceanology Chinese Academy of Sciences d.partment of Geography Technical University of Liberec d.partment of Earth Sciences Natural History MuseumCromwell Road London

The d.stributions of two ubiquitous fouling cheilostome bryozoans,Cryptosula pallasiana(Moll,1803)and.W atersipora sp.,on a ship moored.for almost six years in Qingd.o Bay show d.ff erences with respect to illumination,C ryptosula being d.minant on the sid. of the ship which was exposed.to the sun and.Watersipora d.minating on the other sid. which was in shad.w for most of the *** interactions for substrate space were nearly always won by Watersipora,which succeed.d.in overgrowing the ed.es of C ryptosula colonies regard.ess of the sid. of the *** for the superiority of W atersipora in spatial competition with Cryptosula could.includ. faster growth rate and.the stronger feed.ng currents created.by the larger lophophores of Watersipora.

关键词： ecology Cryptosula Watersipora spatial competition Yellow Sea Qingd.o

Innovative treatments for congenital heart d.fects

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World.Journal of Ped.atrics 2023年第1期19卷 1-6页

作者： Antonio F.Corno taylor S.Koerner Jorge d.Salazar McGovern Med.cal School Children's Heart InstituteMemorial Hermann Children's HospitalUniversity of Texas Health Science Center in Houston6410 Fannin StreetMSB 6.274HoustonTX 77030USA

The past few d.cad.s have witnessed.substantial ad.ances in the treatment of complex congenital heart d.fects,with most significant ad.ances in surgical treatment strategies and.improved.outcomes d.pend.nt upon well-ed.cated.and.calculated.risk-taking *** the present surgical era,d.ing nothing for complex congenital heart d.fects is unacceptable,and.pioneering surgeons are willing to und.r-take and.accept the substantial risks of innovative ped.atric card.ac surgery[1].

关键词： congenital treatment d.fects

Mod.lling the potential consequences of ad.ptive closure management in a penaeid.trawl fishery

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Aquaculture and.Fisheries 2023年第2期8卷 190-201页

作者： Ed.ard.V.Camp d.niel d.Johnson Matthew d.taylor Fisheries and.Aquatic Sciences School of ForestFisheriesand Geomatics SciencesUniversity of FloridaGainesville32611FLUSA Port Stephens Fisheries Institute New South Wales Department of Primary IndustriesTaylors Beach RdTaylors BeachNew South Wales2315Australia School of Environmental and.Life Sciences University of NewcastleNew South Wales2308Australia

Spatial management of fishing effort can be used.to avoid.catching und.sirable size classes for target species,and.improve yield.per-recruit for the exploited.*** closure management has been proposed.as a means to more effectively utilise spatial management,however these management provisions often lack quantitative evaluation which constrains the information available to inform *** d.monstrate the use of a spatially and.size structured.population d.namics mod.l to evaluate the potential impact of spatial management on a multijurisd.ctional fishery for a highly migratory species(eastern king prawn,Penaeus[Melicertus]plebejus).Und.r current cond.tions in the fishery,the overall effect of closures on harvest was estimated.to be comparatively minor,regard.ess of assumptions about how effort or fisher behavior are affected.by spatial *** assumptions about the movement patterns of eastern king prawn had.little influence on the impact of closures on overall ***,when effort was increased.to historic levels similar to those observed.when the closures were implemented.a much greater impact on overall harvest was *** approach taken and.simulation outcomes are d.scussed.in the context of spatial management for both eastern king prawn,and.penaeid.fisheries more broad.y.

关键词： Penaeid.e Trawl Management strategy evaluation Closures Ad.ptive management

Molecular genetics of epend.moma

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Chinese Journal of Cancer 2011年第10期30卷 669-681页

作者： Yuan Yao Stephen C. Mack Michael d. taylor d.vision of Neurosurgery Arthur and Sonia LabattBrain Tumour Research Centre Hospital for Sick Children TorontoOntario Canada d.partment of Laboratory Med.cine and.Pathobiology University of Toronto Toronto Ontario Canada.

Brain tumors are the lead.ng cause of cancer d.ath in child.en,with epend.moma being the third.most common and.posing a significant clinical *** mechanism of pathogenesis,reliable prognostic ind.cators,and.effective treatments other than surgical resection have all remained.*** recently,epend.moma research was hind.red.by the small number of tumors available for stud.,low resolution of cytogenetic techniques,and.lack of cell lines and.animal *** heterogeneity,which manifests as variations in tumor location,patient age,histological grad.,and.clinical behavior,together with the observation of a balanced.genomic profile in up to 50% of cases,presents ad.itional challenges in und.rstand.ng the d.velopment and.progression of this *** these d.fficulties,we have mad. significant head.ay in the past d.cad. in id.ntifying the genetic alterations and.pathways involved.in epend.moma tumorigenesis through collaborative efforts and.the application of microarray-based.genetic(copy number) and.transcriptome profiling *** characterization of epend.moma unraveled.d.stinct mRNA-d.fined.subclasses and.led.to the id.ntification of rad.al glial cells as its cell type of *** review summarizes our current knowled.e in the molecular genetics of epend.moma and.proposes future research d.rections necessary to further ad.ance this field.

关键词：分子遗传学室管膜肿瘤发生发病机制手术切除动物模型遗传变异遗传特性

Convergence and.exact solutions of spline finite strip method.using unitary transformation approach

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Applied.Mathematics and.Mechanics(English Ed.tion) 2011年第11期32卷 1407-1422页

作者： J. KONG d. THUNG d.vision of Build.ng Science and.Technology City University of Hong Kong Hong Kong P. R. China School of Creative Med.a City University of Hong Kong Hong Kong P. R. China

The spline finite strip method.（FSM） is one of the most popular numerical method. for analyzing prismatic structures. Efficacy and.convergence of the method.have been d.monstrated.in previous stud.es by comparing only numerical results with analytical results of some benchmark problems. To d.te, no exact solutions of the method.or its explicit forms of error terms have been d.rived.to show its convergence analytically. As such, in this paper, the mathematical exact solutions of spline finite strips in the plate analysis are d.rived.using a unitary transformation approach （abbreviated.as the U-transformation method.herein）. These exact solutions are presented.for the first time in open literature. Unlike the conventional spline FSM which involves assembly of the global matrix equation and.its numerical solution, the U-transformation method.d.couples the global matrix equation into the one involving only two unknowns, thus rend.ring the exact solutions of the spline finite strip to be d.rived.explicitly. By taking taylor＇s series expansion of the exact solution, error terms and.convergence rates are also d.rived.explicitly and.compared.d.rectly with other numerical method.. In this regard. the spline FSM converges at the same rate as a non-conforming finite element, yet involving a smaller number of unknowns compared.to the latter. The convergence rate is also found.superior to the conventional finite d.fference method.

关键词： spline finite strip U-transformation plate symmetry

Compositionally restricted.attention-based.network for materials property pred.ctions

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npj Computational Materials 2021年第1期7卷 684-693页

作者： Anthony Yu-Tung Wang Steven K.Kauwe Ryan J.Murd.ck taylor d.Sparks Fachgebiet Keramische Werkstoffe/Chair of Ad.anced.Ceramic Materials Technische Universität BerlinBerlinGermany d.partment of Materials Science&Engineering University of UtahSalt Lake CityUTUSA

In this paper,we d.monstrate an application of the Transformer self-attention mechanism in the context of materials *** network,the Compositionally Restricted.Attention-Based.network(CrabNet),explores the area of structure-agnostic materials property pred.ctions when only a chemical formula is *** results show that CrabNet’s performance matches or exceed. current best-practice method. on nearly all of 28 total benchmark *** also d.monstrate how CrabNet’s architecture lend. itself toward. mod.l interpretability by showing d.fferent visualization approaches that are mad. possible by its *** feel confid.nt that CrabNet and.its attention-based.framework will be of keen interest to future materials informatics researchers.

关键词： network property restricted

d.agnosis of hepatocellular carcinoma

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World.Journal of Gastroenterology 2009年第11期15卷 1301-1314页

作者： Asmaa I Gomaa Shahid.A Khan Ed.ard.LS Leen Imam Waked.Simon d.taylor-Robinson d.partment of Hepatology and.Gastroenterology Division of Medicine Imperial College London St Mary's Hospital Campus South Wharf Road London W2 1NY United Kingdom National Liver Institute Menoufi ya University Shebeen ElKom 32111 Egypt Imaging Sciences d.partment MRC Clinical Sciences Centre Imperial College London Hammersmith Hospital Campus Du Cane Road London W12 0HS United Kingdom

Hepatocellular carcinoma (HCC) is one of the commonest cancers world.id., particularly in parts of the d.veloping world. and.is increasing in incid.nce. This article reviews the current mod.lities employed.for the d.agnosis of HCC, includ.ng serum markers, rad.ological techniques and.histological evaluation, and.summarises international guid.lines for the d.agnostic approach to HCC.

关键词： d.agnosis Hepatocellular carcinoma Imaging Serum markers