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Fractions of a chloroform extract of ajenjo leaves (Artemisiamendozana DC. var. mendozana) inhibit the proliferation,viability and clonogenicity of B16-F0 melanoma cells

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BIOCELL 2020年第3期44卷 293-299页

作者： MARÍA ELISA MILLÁn MARÍA FERnAnDA MARRA LEOnARDO andrÉS SALVARREDI EMILIO FERnAnDO LIZARRAGA LUIS ALBERTO LOPEZ Universidad nacional de Cuyo MendozaArgentina Comisión nacional de Energía Atómica Buenos AiresArgentina Fundación Escuela de Medicina nuclear MendozaArgentina Fundación Miguel Lillo y Universidad nacional de Tucumán San Miguel de TucumánArgentina

The ajenjo,Artemisia mendozana ***(Asteraceae),grows in the Andean foothills of Mendoza and San Juan,Argentina,and is used as a medicinal plant for its antispasmodic and antifungal *** aim of this work was to obtain fractions of a chloroform extract of ajenjo leaves and to evaluate the in vitro effects on proliferation,viability and clonogenicity of B16-F0 melanoma *** a silica gel chromatography column,120 fractions were collected and grouped according to the chromatographic profile in 9 main fractions(F1–F9).Their major compounds identified were:terpenes(F1),terpenes and sesquiterpene lactones(F2–F3),sesquiterpenes(F4–F6)and phenols and sesquiterpenes(F7-9).B16-F0 cells were incubated for 72 h with DMSO(vehicle)or 0.1 mg/ml F1–*** 72 h of culture,F1 decreased both the growing index(GI)and cell viability.F2 and F3 both decreased GI and only F3 decreased clonogenic activity.F4 and F5 both decreased *** F5 decreased cell viability and F4 decreased ***,fractions F6–F8 did not affect any of the cell parameters assayed,while F9 decreased cell viability and inhibited clonogenicity.

关键词： Terpenes Sesquiterpene lactones Sesquiterpenes Phenols

Spontaneous Infection of Ascites Fluid at the national and University Hospital Hubert Koutoukou Maga in Cotonou: Prevalence and Associated Factors

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Object removal from complex videos using a few annotations

Open Journal of Gastroenterology（肠胃病学期刊） 2024年第1期

作者： Aboudou Raïmi Kpossou Comlan n’dehougbèa Martin Sokpon Chloé andr.a Obekandon Opè Mahouton Jacques Tovizounkou Kadiatou Diallo Rodolph Koffi Vignon Jean Séhonou

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Computational Visual Media 2019年第3期5卷 267-291页

作者： Thuc Trinh Le andrés Almansa Yann Gousseau Simon Masnou LTCI T′el′ecom ParisTechUniversit′e Paris-Saclay75013 ParisFrance MAP5 CNRS&Universit′e Paris Descartes75006 ParisFrance Univ Lyon Universit′e Claude Bernard Lyon 1CNRS UMR 5208Institut Camille Jordan69622 VilleurbanneFrance

We present a system for the removal of objects from videos. As input, the system only needs a user to draw a few strokes on the first frame, roughly delimiting the objects to be removed. To the best of our knowledge, this is the first system allowing the semi-automatic removal of objects from videos with complex backgrounds. The key steps of our system are the following: after initialization, segmentation masks are first refined and then automatically propagated through the video. Missing regions are then synthesized using video inpainting techniques. Our system can deal with multiple, possibly crossing objects, with complex motions, and with dynamic textures. This results in a computational tool that can alleviate tedious manual operations for editing high-quality videos.

关键词： object removal object segmentation object tracking video inpainting video completion

Vortex　Simulation　of　Axisymmetrical　Flows　in　Cylindrical　***：Application　to　Pipes　Incorporating　an　Orifice　Plate

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Journal of Thermal Science 1995年第4期4卷 221-228页

作者： andré Giovannini Yves Gagnon Université Paul Sabatier and Centre d’études et de recherches de Toulouse Toulouse France Université de Moncton Campus d’Edmundston Edmundston Canada

The Random Vortex Method extended to an azisymmetrical flow is used in the study of the flow field inside pipes incorporating an orifice plate with different contraction ratios and different inlet velocity profiles. Three test-cases, each having experimental measurements available in the literature, are studied. In particular, instantaneous and average velocity fields along with the turbulent statistics for high Reynolds number flows are computed and compared to the corresponding experimental *** comparisons show the ability and the citations of the method. The results of the numerical simulations are used in the physical analysis of the flow fields and thus allow for a better understanding of the dynamics of the flow in pipes incorporating an orifice plate.

关键词： orifice plate axisymmetrical flows vorticity.

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Helminth parasites of freshwater fishes from Cuatro Ciénegas,Coahuila,in the Chihuahuan Desert of Mexico:inventory and biogeographical implications

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Integrative Zoology 2014年第3期9卷 328-339页

作者： Rogelio AGUILAR-AGUILAR andrés MARTÍnEZ-AQUInO Héctor ESPInOSA-PÉREZ Gerardo PÉREZ-POnCE DE LEÓn Comparative Biology Department National Autonomous University of MexicoMexico CityMexico Laboratory of Helminthology National Autonomous University of MexicoMexico CityMexico Graduate Program in Biological Sciences National Autonomous University of MexicoMexico CityMexico national Collection of Fish National Autonomous University of MexicoMexico CityMexico

As part of an ongoing inventory of the helminth parasites of freshwater fishes in Mexico, 570 individual fish were collected between Apr 2008 and Oct 2011 in 26 localities along the Cuatro Ciénegas region in Coahuila State, northern Mexico. Seventeen species of hosts, mostly corresponding to nearctic freshwater elements, were studied. A total of 8324 individual worms were collected during this survey, representing 25 species of helminths, of which 9 were digeneans, 3 monogeneans, 3 acanthocephalans, 9 nematodes and 1 cestode. Most of the records in this checklist represent new host or locality records. The information provided in this checklist may be helpful for our understanding of the biodiversity and historical biogeography of this host-parasite system, because in the Cuatro Ciénegas region occur a nearctic freshwater fish fauna, along with neotropical and endemic elements, and from a biogeographical point of view, this may represent a transitional area.

关键词： Acanthocephala Cestoda Cuatro Ciénegas Digenea freshwater fish Mexico Monogenea nematoda

Predictive value of bleeding risk scores in elderly patients with atrial fibrillation and oral anticoagulation

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老年心脏病学杂志:英文版 2023年第9期20卷 684-692页

作者： Pablo Domínguez-Erquicia Sergio Raposeiras-Roubín Emad Abu-Assi andr.a Lizancos-Castro Jose A Parada-Barcia andréGonzález-García Ana Ledo-Piñeiro Vanesa noriega-Caro Carla Iglesias-Otero andrésÍñiguez-Romo Department of Cardiology University HospitalÁlvaro CunqueiroVigoSpain Health Research Institute Galicia Sur VigoSpain

BACKGROUnD The predictive value of bleeding risk scores for atrial fibrillation in older patients is not as well *** goal of this study was to evaluate the predictive value of HASBLED,ORBIT and ATRIA for major bleeding(MB)and intracranial hemorrhage(ICH)in patients≥75 years with atrial fibrillation and oral anticoagulation(OAC).METHODS A retrospective unicenter study including patients≥75 years with atrial fibrillation(AF)and OAC.A total of 7613 patients≥75 years with AF and OAC included between 2014 and 2018(registry:nCT04364516).We analyzed the discriminative value of HASBLED,ATRIA and ORBIT scores for bleeding endpoints(major bleeding as primary endpoint and intracerebral hemorrhage as secondary).Cox regression was used to predict major bleeding with each scale and also for searching other variables potentially predictor of major *** discrimination was assessed using Harrell’s *** was assessed with goodness-of-fit test proposed by Gronnesby and *** During a mean follow up of 4.0 years(IQR:2.4–5.7 years),729 patients developed MB(2.61 per 100 patients/year)and 243 patients developed ICH(0.85 per 100 patients/year).Three scores showed a low discrimination for major bleeding,being ORBIT the best(HASBLED C statistic=0.557;ATRIA C statistic=0.568;ORBIT C statistic=0.595)and also a low discrimination for ICH(HASBLED C statistic=0.509;ATRIA C statistic=0.522;ORBIT C statistic=0.526).Among the variables that are part of the scores and other baseline characteristics,after multivariable adjustment only sex(male),dementia,prior admission for bleeding,anemia and liver disease were found as a predictors of *** In older patients under oral anticoagulation with atrial fibrillation,the risk scores HASBLED,ATRIA and ORBIT showed a weak discrimination for major bleeding and intracranial ***,other better alternatives should be evaluated for this purpose.

关键词： patients bleeding fibrillation

Behaviour of layered sandstone under Brazilian test conditions:Layer orientation and shape effects

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Journal of Rock Mechanics and Geotechnical Engineering 2013年第5期5卷 366-377页

作者： Abbass Tavallali andré Vervoort Department of Civil Engineering University of Leuven

The experimental study in this paper focuses on the effects of the layer orientation and sample shape on failure strength and fracture pattern of samples tested under Brazilian test conditions(*** loading of cylindrical discs)for one particular layered sandstone which is from Modave in the south of *** variations of the strength in combination with the failure patterns are examined as a function of the inclination angle between the layer plane and the loading *** experimental,results clearly show that the induced fracture patterns are a combination of tensile and/or shear *** shape effect experiments the layer thickness and the number of layer boundaries are *** blocks of Modave sandstone are used to prepare *** layer thickness is different among the various blocks,but the layer thickness in each studied rock block can be considered to be constant;hence,the number of layer boundaries changes according to the sample diameter for samples of the same *** experimental study shows that the layer thickness plays a more important role than the number of layer boundaries per sample.

关键词： Layered sandstone Brazilian test Fracture pattern Layer activation Shape effect

Initial medication adherence in newly diagnosed glaucoma patients:three adherence measures

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International Journal of Ophthalmology(English edition) 2023年第4期16卷 630-637页

作者： Joana Menino Pedro Camacho andréCoelho Escola Superior de Tecnologia da Saúde Instituto Politécnico de LisboaLisbon 1990-096Portugal H&TRC-Health&Technology Research Center ESTeSLEscola Superior de Tecnologia da SaúdeInstituto Politécnico de LisboaLisbon 1990-096Portugal inOVA4Health NOVA Medical SchoolFaculdade de Ciências MédicasNMSFCMUniversidade NOVA de LisboaLisbon 1150-82Portugal Instituto de Oftalmologia Dr.Gama Pinto Lisbon 1150-255Portugal

AIM:To determine initial medication adherence in newly diagnosed glaucoma patients treated with anti-glaucoma ***:This retrospective and observational study included all patients diagnosed with glaucoma in the Primary Health Care units in Portugal during the years 2012 and 2013,which in consequence received a first prescription for anti-glaucoma *** was collected from electronic prescribing records of the primary care units and from pharmacy claims *** of glaucoma treatment and early discontinuation were measured,and the combination of(non)-initiation and early discontinuation accounted for initial medication(non)-***:A total of 3548 new glaucoma patients(40.1%male;59.9%female)were *** 1133(31.9%)patients were initially classified as non-users,since there was no pharmacy claim found for their first prescription for glaucoma ***,277(11.5%)patients early discontinued their treatment,acquiring only their first ***,the initial medication non-adherence rate was 39.7%since 1410 patients either didn’t initiate treatment or discontinued it ***:This study,reveals a major opportunity to improve glaucoma treatment and its control,since a large proportion of patients fail to engage with their prescribed therapy,which implies that implementation of individual or group strategies that enable patients with glaucoma to correctly perform their treatment is still needed.

关键词： glaucoma glaucoma treatment initiation early discontinuation initial medication adherence

Arrested development? Investigating the role of bamboo in Araucaria Forest succession in Southern Brazil

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Journal of Plant Ecology 2019年第6期12卷 1034-1046页

作者： Betina Kellermann andréEduardo Biscaia Lacerda EMBRAPA Forestry Brazilian Agriculture Research CorporationEstrada da Ribeirakm 111Caixa Postal 319Colombo 83411-000PRBrazil

Aims Assessing the role of a dominant native bamboo species on tree species diversity and structure in the medium *** Over a 7-year period,we studied the natural regeneration of two dominant forest types in Southern Brazil(Araucaria Forest or AF;Bamboo Forest or BF)after a bamboo(Merostachys skvortzovii Send.)die-off between 2004 and *** study was carried out in the Embrapa Research Station in Cacador,Santa Catarina State,*** Findings The die-off provided ideal conditions for the establishment of several species and it kickstarted forest succession dynamics,which in turn affected regeneration *** species richness was relatively stable with a transitory increase between 2007 and 2014 in both AF and ***,species richness rose in BF because of a relative increase in abundance of some species(especially late and secondary species)while a plunge in some pioneer species drove an increase in ***,we found that BF has a lower diversity of recruits and that density declined over time,while AF is more diverse,with a more stable *** BF,the bamboo die-off created optimal conditions for initial regeneration development(mainly fast-growing pioneer trees),which quickly transited to higher size ***,after this initial stage of pioneer recruitment,the number of recruits dropped followed by a virtual absence of growth regardless of the species group as a result of a quick bamboo *** bamboo recreated a dense understory it reduced species diversity to original levels,suggesting a self-maintaining cycle that halts forest *** the other hand,the bamboo die-off had little impact on AF where a slow recruitment process typical of old-growth forests was *** results indicate that the die-off event had a temporary effect on species diversity *** to forests where bamboos are dominant in a similar process described in other southern South American *** the first study to obser

关键词： dominant species Merostachys skvortzovii Send. forest succession biodiversity forest regeneration