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Gut-liver axis in sepsis-associated liver injury:Epidemiology,challenges and clinical practice

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World Journal of Gastroenterology 2025年第1期31卷 163-166页

作者： Fabiana andréa Moura Aryana Isabelle de Almeida Neves siqueira College of Nutrition Federal University of AlagoasMaceio 57072-970AlagoasBrazil College of Medicine Federal University of AlagoasMaceio 57072-970AlagoasBrazil

Although the liver has a remarkable regenerative capacity,sepsis-associated liver injury(sLI)is a complication often seen in intensive care *** to its role in immune and inflammatory regulation,the liver is particularly vulnerable during severe *** the global prevalence,causes,and management of sLI is essential to improve outcomes and reduce healthcare *** paper aims to explore these factors,with an emphasis on identifying effective strategies for clinical *** et al’s bibliometric analysis of 787 publications(745 original articles and 42 reviews,mostly in animal models)from 2000 to 2023 highlights the growing interest in sLI,focusing on oxidative stress,gut microbiota,and inflammatory *** components such as nuclear factor-kappa B and the NOD-like receptor thermal protein domain associated protein 3 inflammasome pathway,along with their links to gut microbiota imbalance and oxidative stress,are crucial for understanding sLI *** gut-liver axis,particularly the role of intestinal permeability and bacterial translocation in liver inflammation,is *** this context,bacterial translocation is especially relevant for critically ill patients,as it can exacerbate liver *** findings underscore the need for integrated care in intensive care units,prioritizing gut health and careful antibiotic use to prevent *** extensive research,there remains a lack of clinical trials to validate therapeutic *** abundance of experimental studies highlights potential therapeutic targets,stressing the need for high-quality randomized clinical trials to translate these findings into clinical practice.

关键词： Dysbiosis Oxidative stress Inflammation Microbiota sepsis-associated liver injury

Link between caries,periodontitis,and pregnancy:The role of personalized oral hygiene

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World Journal of Clinical Cases 2025年第6期13卷 51-57页

作者： Melissa Martínez Nieto Martha Leticia De León rodríguez Francisco Javier Alcaraz Baturoni Alma Alicia soto Chávez sarah Monserrat LomelíMartínez Periodontics Program Department of Integrated Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Department of Medical and Life sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810JaliscoMexico Master of Public Health Department of Well-being and SustainableCentro Universitario del NorteUniversidad de GuadalajaraColotlán 46200Mexico

Optimal health during pregnancy is crucial for ensuring the well-being of the mother and the developing *** article is focused on the impact of oral health and the role of personalized oral hygiene management in addressing prevalent dental issues among pregnant women,with particular emphasis on periodontal disease and dental *** the high prevalence of these dental problems and their association with obstetric complications such as pre-term birth and low birth weight,many pregnant women do not receive adequate dental *** gap in care is often due to misconceptions about the safety of dental treat-ments during pregnancy and lack of awareness on the part of healthcare *** of the impacts of oral health and personalization of oral hygiene strategies such as tailored education and support,have proven effective in improving oral health in this *** reductions in the incidence of caries and periodontal disease may be achieved by adapting care to the specific needs of each patient,thereby enhancing maternal and fetal health *** of personalized oral hygiene management into maternal health pro-grams and enhancement of ongoing education for pregnant women and healthcare professionals are essential steps in the reduction of pregnancy-related risks and improvement of maternal and neonatal *** Tip:In this article,we reviewed a recent study on the effects of personalized oral hygiene management on the oral health of pregnant women,as discussed in the article by Men et *** study demonstrated that personalized oral hygiene interventions significantly improved oral health outcomes during pregnancy by reducing the prevalence of dental caries and periodontal *** emphasized the importance of individualized oral care programs that integrate education and tailored support,and we highlighted their significance in enhancing maternal and fetal *** approach underscores the need for

关键词： Pregnancy Periodontal disease Periodontitis Dental caries Oral hygiene

Fungal contamination of stored automobile-fuels in a tropical environment

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Journal of Environmental sciences 2010年第10期22卷 1595-1601页

作者： Carlos E.rodríguez-rodríguez Evelyn rodríguez Rigoberto Blanco Ivannia Cordero Daniel segura Research Center in Tropical Diseases and Laboratory of Research in Anaerobic Bacteriology Faculty of MicrobiologyUniversity of Costa Rica Department of Chemical Engineering School of EngineeringAutonomous University of Barcelona Research Center in Electrochemistry and Chemical Energy University of Costa Rica

Because of the lack of reports, the base levels of microbial contamination on stored fuels are unknown in tropical regions and it is unclear whether these levels have some influence on fuel quality parameters. Therefore, fungal quality in automobile fuels stored across Costa Rican territory was evaluated during two years according to the standard AsTM D6974-04. For a total of 96 samples, counts and identification of molds and yeasts were performed on regular gas, premium gas and diesel taken from the bottom and superior part of the container tanks. The highest contamination was found on the bottom of the tanks, where an aqueous phase was usually identified, showing populations over the ones present in the hydrocarbon itself （up to 108 CFU/L）. Diesel was the most contaminated fuel （up to 107 CFO/L）; however, an alteration on the physicochemical parameters was not observed in any kind of fuel. seventy-five mold strains were isolated, Penicillium sp. being the most common genus （45.8% of the samples）, and ten yeast strains, from the genera Candida sp. and Rhodotorula sp. Four of the yeasts were able to grow on diesel as the sole carbon source, at concentrations ranging from 0.5% to 25%. Increasing the frequency of tank cleaning, adding antimicrobial agents and monitoring microbial populations are recommended strategies to improve microbial quality of stored fuels.

关键词： fuel microbial contamination biodegradation molds yeasts

Preparation and Characterization of Flexible, Transparent and Thermally stable Aromatic Co-polyamides

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Chinese Journal of Polymer science 2019年第2期37卷 136-141页

作者： José Antonio Tec-sánchez andrés Iván Oliva Arias Manuel Aguilar-Vega Juan Valerio Cauich-rodríguez José Luis santiago-García Unidad de Materiales Centro de Investigación Científica de Yucatán A. C. Centro de Investigación y de Estudios Avanzados del IPN Unidad Mérida Departamento de Física Aplicada

Two aromatic co-polyamides were synthesized combining two diacid monomers containing bulky pendant groups, 5-(9,10-dihydro-9,10-ethanoanthracene-11,12-dicarboximido)isophthalic acid(DEAIA) and 5-tert-butylisophthalic acid(TERT), with 4,4′-(hexafluoroisopropylidene)dianiline(HFA) or 2,3,5,6-tetramethyl-1,4-phenylenediamine(Durene) by direct polycondensation. The structures of the obtained aromatic co-polyamides were confirmed by FTIR, Raman and 1 H-NMR. The co-copolyamide films, DHTH and DDTD, exhibited rms-roughness values between 0.94 and 1.60 nm, respectively. Moreover, they presented good thermal stability up to300 °C. Young's moduli of the co-polyamide films were between 4.1 and 4.3 GPa. X-ray diffraction results showed that the co-polyamide films were amorphous due to the incorporation of both bulky pendant groups, tert-butyl and dibenzobarrelene. The combination of bulky pendant groups provided intrinsically transparent co-polyamide films with a transmittance higher than 88% in the range of 400-780 *** to these outstanding film and optical properties, they are suggested to be flexible substrates in applications for solar cell and other portable electronic devices.

关键词： Co-polyamides Flexible films Transmittance Thermal stability Polycondensation

Le Corbusier’s urbanism:An urban characterisation of his proposals for inner cities

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Frontiers of Architectural Research 2021年第4期10卷 701-714页

作者： Juan-andrés rodrı´guez-Lora Daniel Navas-Carrillo Marı´a Teresa Pérez-Cano Heritage and Territorial Urban Development in Andalusia School of ArchitectureUniversity of SevilleSevilleSpain

Le Corbusier’s urbanism is routinely met with a backlash of criticism,which often overlooks the complexity of his *** is a tendency to focus on the characteristics of his proposal for Paris in 1925 or on the ideas of CIAM’s Athens ***,such affirmations ignore the conceptual and qualitative evolution of his urban *** this sense,the research hypothesis is that Corbusian urban models go beyond the Plan Voisin,diffused by urban planning theories as the unique paradigm of his urban *** analysis and characterisation of the inner-city urban plans of Le Corbusier,this report seeks to demonstrate the existence of other models and compares them to those often showcased in the partial examination of Le Corbusier’s *** following parameters will be analysed:(1)population densities and areas for(2)buildings,(3)vehicles,and(4)*** results of this research indicate the need to parameterise and analyse Le Corbusier’s cities beyond a single case to demonstrate the diversity and evolution of his urbanistic *** process seeks to dissipate the common view that falsely extrapolates ideas of his urban planning,largely that of his first proposal,for Paris.

关键词： Cities Modern city Twentieth century Urbanism Plan voisin

Changes in microhabitat, but not allelopathy, affect plant establishment after Acacia dealbata invasion

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Journal of Plant Ecology 2017年第4期10卷 610-617页

作者： Paula Lorenzo Jonatan rodríguez Luís González susana rodríguez-Echeverría Centre for Functional Ecology(CFE) Department of Life SciencesUniversity of CoimbraCalçada Martim de Freitas3000-456 CoimbraPortugal Facultade de Bioloxía Departamento de Bioloxía Vexetal e Ciencia do SoloUniversidade de VigoAs Lagoas-Marcosende s/n36310PontevedraSpain

Aims The tree legume Acacia dealbata Link is an aggressive Australian invader that severely affects abiotic and biotic compartments of eco-systems *** invasive species outcompetes native plant communities through direct competition,changes in microhabitat and soil properties under the canopy and the release of allelopathic ***,these effects are usually studied separately and under controlled *** objective of this study was to evaluate the combined effect of these modifications exerted by *** on the establishment of native and invasive species in the *** A full factorial experiment was performed in order to test the com-bined effect of microhabitat,soil type and allelopathy on the establish-ment of the invasive *** and three native species in the field(North-West spain).We sowed seeds of native or invasive species in pots with different soil type(soil collected under *** or Pinus pinaster),allelopathy status(soil treated or untreated with activated car-bon)and microhabitat(under the canopy of *** or ***).The number and total biomass of established plants were evaluated after 8 *** abiotic properties were determined in all *** Findings The establishment of native and invasive species was signifi-cantly affected by the microhabitat,with a higher number of seedlings under the native forest(***).The establishment of *** seedlings was also significantly promoted by its own soil.A negligible effect of allelopathy was detected on the establishment and growth of both invasive and native *** conclude that(i)the main factor affecting seedling establish-ment was microhabitat rather than changes in soil properties or allelopathy,(ii)soil modifications by *** promote the establishment of its own seedlings,contributing to the progress of invasion and(iii)allelochemicals released by *** do not seem to play a key role for the establishment of native

关键词： plant invasion microhabitat soil changes allelopathy plant establishment

Origin and evolution of the genera Lonsdaleia and Actinocyathus:Insights for the Mississippian palaeogeography from the western Palaeotethys

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Journal of Palaeogeography 2023年第2期12卷 296-310页

作者： Isabel rodríguez-Castro Ian D.somerville sergio rodríguez Departamento de Geodinamica Estratigrafía y PaleontologíaUniversidad Complutense de Madrid28040MadridSpain UCD school of Earth sciences University College DublinBelfieldDublin 4Ireland Instituto de Geociencias(CsIC UCM)Ciudad Universitaria28040MadridSpain

Representatives of the subfamily Lonsdaleiinae Chapman,1893 are common in the Mississippian of the western Palaeotethys.A general analysis of the origin,distribution and evolution of that subfamily has been *** most probable hypothesis for the origin of the genus Lonsdaleia McCoy,1849 is to acquire colonialism via the genus Axophyllum Milne Edwards and Haime,*** d'Orbigny,1849 would be a descendant of Lonsdaleia by increasing integration in the *** first occurrences of Lonsdaleia have been recorded in the lower Visean from northern Britain and northern Tianshan Mountains of northwestern China,but the diversification and migration to the whole Palaeotethys only happened in the late *** hypotheses are proposed on that *** serpukhovian was also a period of migrations and diversification for these *** Lonsdaleia and Actinocyathus have been recorded in Bashkirian refuges,the sverdrup Basin in northern Laurasia and the Tindouf Basin in northern Africa,*** division of the western Palaeotethys into six subprovinces based on the distribution of corals is proposed.

关键词： Carboniferous Palaeotethys Biogeography Evolution Rugosa

Removal of carbofuran is not affected by co-application of chlorpyrifos in a coconut fiber/compost based biomixture after aging or pre-exposure

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Journal of Environmental sciences 2016年第8期28卷 182-189页

作者： Juan salvador Chin-Pampillo Mario Masís-Mora Karla Ruiz-Hidalgo Elizabeth Carazo-Rojas Carlos E.rodríguez-rodríguez Research Center of Environmental Contamination (CICA) University of Costa Rica

Biomixtures constitute the biologically active part of biopurification systems（BPs）, which are used to treat pesticide-containing wastewater. The aim of this work was to determine whether co-application of chlorpyrifos（CLP） affects the removal of carbofuran（CFN）（both insecticide/nematicides） in a coconut fiber–compost–soil biomixture（FCs biomixture）, after aging or previous exposure to CFN. Removal of CFN and two of its transformation products（3-hydroxycarbofuran and 3-ketocarbofuran） was enhanced in pre-exposed biomixtures in comparison to aged biomixtures. The co-application of CLP did not affect CFN removal, which suggests that CLP does not inhibit microbial populations in charge of CFN *** to the removal behavior, mineralization of radiolabeled14C-pesticides showed higher mineralization rates of CFN in aged biomixtures（with respect to freshly prepared or pre-exposed biomixtures）. In the case of CLP, mineralization was favored in freshly prepared biomixtures, which could be ascribed to high sorption during aging and microbial inhibition by CFN in pre-exposure. Regardless of removal and mineralization results, toxicological assays revealed a steep decrease in the acute toxicity of the matrix on the microcrustacean Daphnia magna（over 97%） after 8 days of treatment of individual pesticides or the mixture CFN/*** suggest that FCs biomixtures are suitable to be used in BPs for the treatment of wastewater in fields where both pesticides are employed.

关键词： Biomixture Pesticide Mineralization Toxicity Biopurification system

Complexity of adaptive testing in scenarios defined extensionally

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Frontiers of Computer science 2023年第3期17卷 11-28页

作者： Ismael rodrÍguez David RUBIO Fernando RUBIO Dpto.sistemas Informáticos y Computación Facultad de InformáticaUniversidad Complutense de MadridMadrid 28040Spain Instituto de Tecnologías del Conocimiento Universidad Complutense de MadridMadrid 28040Spain Instituto de Biomecánica de Valencia.Universitat Politècnica de València València 46022Spain

In this paper,we consider a testing setting where the set of possible definitions of the Implementation Under Test(IUT),as well as the behavior of each of these definitions in all possible interactions,are extensionally defined,i.e.,on an element-by-element and case-by-case *** this setting,the problem of finding the minimum testing strategy such that collected observations will necessarily let us decide whether the IUT is correct or not(i.e.,whether it necessarily belongs to the set of possible correct definitions or not)is studied in four possible problem variants:with or without non-determinism;and with or without more than one possible definition in the sets of possible correct and incorrect *** computational complexity of these variants is studied,and properties such as PsPACE-completeness and Log-APX-hardness are identified.

关键词： formal testing adaptive testing computational complexity PsPACE-completeness approximation hardness