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Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

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Neural Regeneration Research 2025年第11期20卷 3209-3210页

作者： Marta García-Juan Mario villa Irene Benito-Cuesta Lara Ordónez-Gutiérrez francisco Wandosell Centro de Biología Molecular“severo Ochoa”(CsIC-UAM) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain fisiología Animal Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset SolnaStockholmSweden Departamento de Bioquímica y Biología Molecular Universidad Complutense de MadridMadridSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) MadridSpain

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called"autophagy"),microa utophagy,and chape rone-media ted autophagy(fleming et al.,2022).

关键词： homeostasis system hereafter

Touristic urbanization and greening of coastal dune fields:A long-term assessment of a temperate sandy barrier of Argentina

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Journal of Geographical sciences 2025年第1期 206-230页

作者： GARZO Pedro andrés DADON José Roberto IsLA federico Ignacio Instituto de Investigaciones Marinas y Costeras (IIMyC-CONICET/UNMDP) Instituto de Geología de Costas y del Cuaternario Dr.Enrique J.schnack (IGCC-CIC/UNMDP) Universidad de Buenos Aires Facultad de Arquitectura Dise?o y Urbanismo Centro de Investigaciones Gestión de Espacios Costeros (GEC-FADU/UBA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)

Dune barrier systems represent highly sought-after coastal landscapes for tourism and urban development around the world. However, a century ago, they were considered hazardous environments due to their great dynamic nature. As a result, stabilization practices were considered necessary. The systematic introduction of fast-growing exotic trees helped stabilize the sand, making it easier for tourism urbanization to take place, but also leading to erosion processes. This paper aims to assess long-term changes in vegetation cover over a large temperate barrier in Argentina. This complex region includes urban resorts, afforestation zones, and protected areas. A GIs-based geospatial analysis was conducted using a large satellite database(> 350 images), and the future evolution of the vegetation was modeled. The results revealed two primary spatiotemporal patterns associated with a gradual expansion of vegetation cover, accompanied by a concurrent reduction in sandy areas. In 1986, the dune area comprised 75% more surface than vegetation, whereas in 2021, it represented 60% less than vegetation. furthermore, the 2050 scenario suggests a potential 40% reduction of dunes in certain areas. It is necessary to enhance management actions aimed at maintaining dune mobility and ensuring local and regional sediment balance. Long-term management strategies must focus on restoring native plant communities and controlling invasive species, and avoiding new dune fixation initiatives based on the introduction of exotic species.

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setpoint feasibility and stability of Wind Park Control Interactions at Weak Grids

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Journal of Modern Power systems and Clean Energy 2022年第6期10卷 1790-1796页

作者： Argüello andrés IEEE the school of Electrical Engi‐neering and Computation University of CampinasCampinasBrazil

The controllers of wind parks that are connected to weak grids can induce unstable oscillations near the fundamental *** phenomenon can be studied with equivalent impedances of the wind generators,which depend on their operational setpoints at the fundamental *** feasibility of such setpoint,i.e.,solution to the power flow,does not depend on the control ***,oscillations from unfeasible setpoints and control instabilities both occur at weak grids and near the fundamental *** letter presents an exploratory study to map the conditions where both phenomena occur,using sensitivity studies comprising multiple setpoints and control parameter *** results are visually presented as the regions which inform the configurations leading to unfeasible setpoints,and unstable control interaction *** the results,it can be observed that the trajectory of the eigenvalues in the Nyquist plots towards an unfeasible setpoint approaches a fundamental frequency instability.

关键词： Control interaction impedance power quality resonance stability wind generator

Affinity-Based Network Interfaces for Efficient Communication on Multicore Architectures

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Journal of Computer science & Technology 2013年第3期28卷 508-524页

作者： andrés Ortiz Julio Ortega Antonio f.Díaz Alberto Prieto Department of Communications Engineering University of Málaga Department of Computer Architecture and Technology/CITIC University of Granada

Improving the network interface performance is needed by the demand of applications with high communication requirements （for example, some multimedia, real-time, and high-performance computing applications）, and the availability of network links providing multiple gigabits per second bandwidths that could require many processor cycles for communication tasks. Multicore architectures, the current trend in the microprocessor development to cope with the difficulties to further increase clock frequencies and microarchitecture efficiencies, provide new opportunities to exploit the parallelism available in the nodes for designing efficient communication architectures. Nevertheless, although present Os network stacks include multiple threads that make it possible to execute network tasks concurrently in the kernel, the implementations of packet-based or connection-based parallelism are not trivial as they have to take into account issues related with the cost of synchronization in the access to shared resources and the efficient use of caches. Therefore, a common trend in many recent researches on this topic is to assign network interrupts and the corresponding protocol and network application processing to the same core, as with this affinity scheduling it would be possible to reduce the contention for shared resources and the cache misses. In this paper we propose and analyze several configurations to distribute the network interface among the different cores available in the server. These alternatives have been devised according to the affinity of the corresponding communication tasks with the location （proximity to the memories where the different data structures are stored） and characteristics of the processing core. As this approach uses several cores to accelerate the communication path of a given connection, it can be seen as complementary to those that consider several cores to simultaneously process packets belonging to either the same or different connections.

关键词： interrupt affinity processor affinity network interface offioading, sIMICs

Litterfall production modeling based on climatic variables and nutrient return from stands of Eucalyptus grandis Hill ex Maiden and Pinus taeda L.

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Journal of forestry Research 2024年第5期35卷 26-36页

作者： andrés Baietto andrés Hirigoyen Jorge Hernández Amabelia del Pino forest Department Faculty of AgronomyUniversity of the Republic12900 MontevideoUruguay National Research Program of forest Production National Agriculture Research InstituteINIA97000 TacuarembóUruguay soil and Water Department Faculty of AgronomyUniversity of the Republic12900 MontevideoUruguay

Native grasslands in the Pampas of south America are increasingly being replaced by Eucalyptus and Pinus *** short rotation regimes used for the stands require high nutrient levels,with litterfall being a major source of nutrient *** model the litterfall production using climatic variables and assess the nutrient return in 14-year-old Eucalyptus grandis and Pinus taeda stands,we measured litter production over 2 years,using conical litter traps,and monitored climatic *** temperature,accumulated precipitation,and mean maximum vapor pres-sure deficit at the seasonal level influenced litterfall produc-tion by ***;seasonal accumulated precipitation and mean maximum temperature affected litterfall by *** regression tree modeling based on these climatic vari-ables had great accuracy and predictive power for ***(N=33;MAE(mean absolute error)=0.65;RMsE(root mean square error)=0.91;R^(2)=0.71)and ***(N=108;MAE=1.50;RMsE=1.59;R^(2)=0.72).The nutrient return followed a similar pattern to litterfall deposition,as well as the order of importance of macronutrients(***:Ca>N>K>Mg>P;***:N>Ca>K>Mg>P)and micronutrients(*** and ***:Mn>fe>Zn>Cu)in both *** study constitutes a first approximation of factors that affect litterfall and nutrient return in these systems.

关键词： Afforestation Litterfall Nutrient recycling Climate modeling Myrtaceae Pinaceae

Merging bound states in the continuum in an open acoustic resonator

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science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun Huang Bin Jia Artem s.Pilipchuk sibo Huang Chen shen Almas f.sadreev Yong Li andrey E.Miroshnichenko school of Physics and Electronic sciences East China Normal University Institute of Acoustics Tongji University L.V.Kirensky Institute of Physics Department of Mechanical Engineering Rowan University school of Engineering and Technology University of New South Wales at Canberra

Bound states in the continuum （BICs） are perfectly localized resonances despite embedding in the continuum ***,an isolated BIC is very sensitive to the structure ***,we report merging acoustic BICs in a single open resonator,robust against the structure *** find that both symmetry-protected BIC and friedrich-Wintgen BIC are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BICs move toward each other and merge into a single one at a critical *** to an individual BIC,the merged BIC is robust against fabrication error because its Q-factor is proportional to ΔL-4,whereΔL embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective nonHermitian ***,we present direct experimental demonstrations of the moving and merging of BICs in a coupled 3D waveguide-resonator,which are evidenced by the vanishing of the linewidth of fano resonance in the transmission *** results may find exciting applications in designing high-quality acoustic sources,sensors and filters.

关键词： acoustic resonances bound state in the continuum high-Q resonances

Electrocardiographic and echocardiographic dyssynchrony parameters that might better predict the response to cardiac resynchronization therapy than QRs morphology and duration

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Journal of Geriatric Cardiology 2022年第2期19卷 98-100页

作者： andrás Vereckei Department of Medicine and Hematology Semmelweis UniversityBudapestHungary

Cardiac resynchronization therapy(CRT)is an evidence-based effective therapy of symptomatic heart failure with reduced ejection fraction refractory to optimal medical ther-apy and associated with intraventricular conduction disturbance,that results in a significant electrical ventricular ***,the non-response rate to CRT is still 20%−40%.[1]The potential underlying causes of CRT nonresponse are:(1)suboptimal localization of the left ventricular(LV)electrode,far away from the latest activated LV region.

关键词： ventricular synchronization echocardiographic

Cobalamin deficiency as an extra intestinal manifestation of Helicobacter pylori infection

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World Journal of Gastroenterology 2015年第11期21卷 3447-3448页

作者： Emmanuel andrès Department of Internal Medicine University Hospital of Strasbourg

We read with great interest the excellent review by Wong et al on extra intestinal manifestations of Helicobacter pylori(***) infection published in the *** is a well-documented and structured ***,I believe that Wong ... 详细信息

关键词： Cobalamin deficiency Helicobacter pylori food-coba

Gastric endoscopic submucosal dissection:from animal model to patient

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World Journal of Gastroenterology 2013年第45期19卷 8326-8334页

作者： Nicolás González Adolfo Parra-Blanco Miguel villa-Gómez Alejandra Gamba andrés Taullard Anaulina silveira Alberto sanguinetti Carolina Olano Henry Cohen Department of Gastroenterology Faculty of MedicineHospital de Clínicas Montevideo 11600 Uruguay Department of Gastroenterology Escuela de Medicina Pontificia Universidad Católica de Chile Santiago 6510260 Chile Department of Quantitative Methods Hospital de Clínicas Montevideo 11600 Uruguay

AIM:To assess whether the use of porcine models is useful for learning endoscopic submucosal dissection(EsD),thus contributing to its subsequent application in human ***:This study/learning process was carried out in 3 phases:PhaseⅠ:Ex vivo animal;PhaseⅡ:In vivo animal;PhaseⅢ:*** endoscopist performed 30 gastric EsDs in porcine models,and later 5gastric EsDs in 5 *** EsD was done following the method practiced at the National Cancer Center in Tokyo,*** aspects,size,time and speed of EsD,as well as complications were *** patients,their clinical,endoscopic and histologic evolution was additionally ***:Thirty en bloc EsDs were carried out in animal *** mean±sD size of the pieces was of28.4±1.2 mm,and the time of EsD was 41.7±*** time of EsD in the first 15 procedures was 43.0±3.0 min whereas in the next 15 procedures,the time was 40.3±3.9 min,P=*** speed in the first 15EsDs was 1.25±0.11 cm2/min vs 2.12±0.36 cm2/min in the remaining 15,P=*** were no *** patients,5 lesions were resected en *** size of the pieces was 25.2±5.1 mm and the time was85.0±25.6 *** and histological controls did not show evidence of residual neoplastic ***:A sequential EsD training program of a unique endoscopist,based on the practice in porcine models,contributed to learning EsD for its subsequent application in humans,yielding good results in efficacy and safety.

关键词： Endoscopic submucosal dissection Porcine models Animal models Training