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Rifaximin on epigenetics and autophagy in animal model of hepatocellular carcinoma secondary to metabolic-dysfunction associated steatotic liver disease

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World Journal of Hepatology 2024年第1期16卷 75-90页

作者： Matheus Truccolo Michalczuk Larisse Longo Melina Belén Keingeski Bruno de Souza Basso Gabriel Tayguara Silveira Guerreiro Jessica T Ferrari JoséEduardo Vargas Cláudia P Oliveira Carolina Uribe-Cruz Carlos Thadeu Schmidt Cerski Eduardo Filippi-Chiela Mário ReisÁlvares-da-silva Division of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Graduate Program in Gastroenterology and Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Experimental Laboratory of Hepatology and Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Laboratory of Inflammatory and Neoplastic Cells Universidade Federal do ParanáParaná81530900Brazil Department of Gastroenterology(LIM07) Faculdade de Medicina da Universidade de São PauloSão Paulo 01246903Brazil Facultad de Ciencias de la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Unit of Surgical Pathology Hospital de Clinicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Center of Biotechnology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Department of Morphological Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90.050-170Rio Grande do SulBrazil Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)ResearcherBrasília 71.605-001Brazil

BACKGROUND Prevalence of hepatocellular carcinoma(HCC)is increasing,especially in patients with metabolic dysfunctionassociated steatotic liver disease(MASLD).AIM To investigate rifaximin(RIF)effects on epigenetic/autophagy markers in *** Adult Sprague-dawley rats were randomly assigned(n=8,each)and treated from 5-16 wk:Control[standard diet,water plus gavage with vehicle(Veh)],HCC[high-fat choline deficient diet(HFCD),diethylnitrosamine(DEN)in drinking water and Veh gavage],and RIF[HFCD,DEN and RIF(50 mg/kg/d)gavage].Gene expression of epigenetic/autophagy markers and circulating miRNAs were *** All HCC and RIF animals developed metabolic-dysfunction associated steatohepatitis fibrosis,and cirrhosis,but three RIF-group did not develop *** animals who developed HCC with those who did not,miR-122,miR-34a,tubulin alpha-1c(Tuba-1c),metalloproteinases-2(Mmp2),and metalloproteinases-9(Mmp9)were significantly higher in the *** opposite occurred with Becn1,coactivator associated arginine methyltransferase-1(Carm1),enhancer of zeste homolog-2(Ezh2),autophagy-related factor LC3A/B(Map1 Lc3b),and p62/sequestosome-1(p62/SQSTM1)-*** with controls,Map1 Lc3b,Becn1 and Ezh2 were lower in HCC and RIF-groups(P0.05).miR-122 was higher in HCC,and miR-34a in RIF compared to controls(P0.05).CONCLUSION RIF might have a possible beneficial effect on preventing/delaying liver carcinogenesis throu

关键词： Animal model Autophagy Epigenetic Hepatocellular carcinoma Metabolic dysfunction-associated steatotic liver disease Rifaximin

Integrating geochemical(surface waters, stream sediments)and biological(diatoms) approaches to assess AMD environmental impact in a pyritic mining area： Aljustrel(Alentejo, Portugal)

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Journal of Environmental Sciences 2016年第4期28卷 215-226页

作者： Ana Teresa Luís Nuno Duraes SaloméFernandes Pinheiro de almeida Eduardo Ferreira da silva University of Aveiro Department of GeosciencesGeoBioTec--GeobiosciencesGeotechnologies and Geoengineering Research CenterCampus de Santiago3810-193 AveiroPortugal University of Aveiro Department of BiologyGeoBioTec--GeobiosciencesGeotechnologies and Geoengineering Research CenterCampus de Santiago3810-193 AveiroPortugal Centro de Ciencias do Mar CCMARUniversidade do AlgarveCampus de Gambelas8005-139 FaroPortugal

Aljustrel mines were classified as having high environmental hazard due to their large tailings volume and high metal concentrations in waters and *** assess acid mine drainage impacted systems whose environmental conditions change quickly,the use of biological indicators with short generation time such as diatoms is *** study combined geochemical and diatom data,whose results were highlighted in 3 groups：Group 1,with low p H（1.9–5.1）and high metal/metalloid（Al,As,Cd,Co,Cu,Fe,Mn,Ni,Pb,Zn;0.65–1032 mg/L）and SO4（405–39124 mg/L）*** acidophilic species,Pinnularia aljustrelica,was perfectly adapted to the adverse conditions;in contrast,teratological forms of Eunotia exigua were found,showing that metal toxicity affected this *** low availability of metals/metalloids in sediments of this group indicates that metals/metalloids of the exchangeable fractions had been solubilized,which in fact enables metal/metalloid diatom uptake and consequently the occurrence of teratologies;Group 2,with sites of near neutral p H（5.0–6.8）and intermediate metal/metalloid（0.002–6 mg/L）and SO4（302–2179 mg/L）concentrations;this enabled the existence of typical species of uncontaminated streams（Brachysira neglectissima,Achnanthidium minutissimum）;Group 3,with samples from unimpacted sites,showing low metal/metalloid（0–0.8 mg/L）and SO4（10–315 mg/L）concentrations,high pH（7.0–8.4）and Cl contents（10–2119 mg/L）and the presence of brackish to marine species（Entomoneis paludosa）.For similar conditions of acidity,differences in diversity,abundance and teratologies of diatoms can be explained by the levels of metals/metalloids.

关键词： Surface waters Stream sediments Diatoms Metals/metalloids AMD Teratologies

Toxicological effects of mining hazard elements

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Energy Geoscience 2022年第3期3卷 255-262页

作者： Leonardo Lucas da silva-Rego Leonardo Augusto de almeida Juciano Gasparotto Instituto de Ciencias Biomedicas-Universidade Federal de Alfenas AlfenasMinas GeraisRua Gabriel Monteiro da Silva700CEP:37130-001Centro-Alfenas/MGBrazil

Mining plays a prominent role in the economy worldwide since human efforts have been more concentrated in extraction than recycling of natural *** composed of various minerals vary according to the geological *** are raw materials for the conventional industries or fossil fuels for power *** can also be used in new *** mining industry triggers intense environmental *** exposure to multiple small particles from mining effluent,such as dust,uranium,iron,lead,zinc,silicon,titanium,sulfur,nitrogen,platinum,chromium,vanadium,manganese,and mercury,is a health *** elements can have several pathological effects,such as respiratory and cardiovascular,multiple chronic inflammation,and neurodegenerative ***,mining results in severe soil,water(surface and aquifer),and air contamination,reaching large areas far away from the *** of mining companies,with the recovery of ancient mined areas during the early development of environmental laws and regulations,compromises environmental integrity for more extended periods,increasing coverage of the affected *** review evaluates the toxicological effects on humans exposed to the mining wastes and the impact of these compounds on the *** results of our evaluation can be used by the government,manufacturers,scientists,private environmental organizations,decision-makers,and readers from different areas of knowledge to explore the potential risk of mining to the ecosystem and human health.

关键词： Mining operation Toxicology Environmental impact Ecosystem Human health

Correlation between Intestinal Health and Coccidiosis Prevalence in Broilers during Different Seasons of the Year in Brazil from 2012 to 2018

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Food and Nutrition Sciences 2024年第3期15卷 179-198页

作者： Fabio Luis Gazoni Gabriela Miotto Galli Marcel Manente Boiago Lenita Moura Stefani Aline Zampar Marco A. Juárez-Estrada Guillermo Tellez-Isaias Aleksandro S. da silva Animal Health and Reproduction Veterinary Medicine Graduate Program Federal University of Santa Maria (UFSM) Santa Maria Brazil Animal Science Graduate Program Federal University of Rio Grande do Sul (UFRGS) Porto Alegre Brazil Animal Science Graduate Program Santa Catarina State University (UDESC) Chapecó Brazil Departamento de Medicina y Zootecnia de Aves Facultad de Medicina Veterinaria y Zootecnia Universidad Nacional Autonoma de Mexico Ciudad Universitaria Ciudad de Mexico Mexico Department of Poultry Science Division of Agriculture University of Arkansas Fayetteville AR USA

Coccidiosis is a disease caused by intracellular protozoan parasites, specifically belonging to the genus Eimeria. These parasites target the gastrointestinal tract in different types of hosts, causing sores in the intestinal lining. The presence of these lesions reduces the animal’s ability to digest and absorb nutrients, significantly impacting their overall performance. The current study aimed to explore the potential correlation between seasonal variations and the incidence of Eimeria spp-induced lesions in broiler chickens’ gastrointestinal tracts in Brazil from 2012 to 2018. A total of 8,607 broiler chickens, aged 14 to 42 days, were sampled from 103 poultry integrated companies in Brazil to conduct intestinal health examinations. The sampling process involved selecting 3 to 6 chickens from each poultry house for examination. The assessment included various abnormalities such as shedding of intestinal cells and excessive fluid and mucus presence, thickening and tension of the intestines, food movement, roughened mucosal surface resembling a Turkish towel in the small intestine, tissue death, duodenal inflammation, intestinal inflammation, gizzard erosion, presence of worms and bedding material, and ingestion of mealworms. During the seasons, winter exhibited the highest average occurrence of Eimeria maxima microorganisms at 52.83%, with E. acervulina following closely at 26.42% in second place. In spring, E. maxima had an occurrence of 11.31%, while in fall, E. tenella had the lowest occurrence at 6.74%. When analyzing the seasonal occurrence of Eimeria, it was observed that E. maxima micro was more common during winter compared to summer (P = 0.0491). However, no discernible variation was observed in the occurrence of the remaining species across different seasons. Research findings suggest that subclinical coccidiosis is most prevalent during the winter season in Brazil. Likewise, clinical disease caused by E. acervulina is also prevalent during this time. I

关键词： Eimeria Epidemiology Intestinal Pathology Broiler Chickens Brazil

Induced pluripotent stem cells, a giant leap for mankind therapeutic applications

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World Journal of Stem Cells 2019年第7期11卷 421-430页

作者： JoséBraganca Joao andréLopes Leonardo Mendes-silva Joao Miguel almeida Santos Department of Biomedical Sciences and Medicine University of AlgarveFaro 8005-139Portugal Centre for Biomedical Research(CBMR) University of AlgarveFaro 8005-139Portugal

Induced pluripotent stem cells(iPSC)technology has propelled the field of stem cells biology,providing new cells to explore the molecular mechanisms of pluripotency,cancer biology and aging.A major advantage of human iPSC,compared to the pluripotent embryonic stem cells,is that they can be generated from virtually any embryonic or adult somatic cell type without destruction of human *** addition,iPSC can be generated from somatic cells harvested from normal individuals or patients,and used as a cellular tool to unravel mechanisms of human development and to model diseases in a manner not possible *** these fundamental aspects of human biology and physiology that are revealed using iPSC or iPSC-derived cells,these cells hold an immense potential for cell-based therapies,and for the discovery of new or personalized pharmacological treatments for many ***,we review some of the current challenges and concerns about iPSC *** introduce the potential held by iPSC for research and development of novel health-related *** briefly present the efforts made by the scientific and clinical communities to create the necessary guidelines and regulations to achieve the highest quality standards in the procedures for iPSC generation,characterization and long-term ***,we present some of the audacious and pioneer clinical trials in progress with iPSC-derived cells.

关键词： Induced pluripotent stem cells Reprogramming Cell-based therapy Stem cell banking Disease modelling

Prognosis of forest production using machine learning techniques

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Information Processing in Agriculture 2023年第1期10卷 71-84页

作者： Jeferson Pereira Martins silva Mayra Luiza Marques da silva Adriano Ribeiro de Mendonca Gilson Fernandes da silva Antoˆnio almeida de Barros Junior Evandro Ferreira da silva Marcelo Otone Aguiar Jeangelis silva Santos Nı´vea Maria Mafra Rodrigues Federal University of Espirito Santo UFESDepartment of Forestry and Wood ScienceAvenue Governor Lindemberg31629550-000 Jeroˆnimo MonteiroESBrasil b Departamento de Cieˆncias Agra´riasUniversidade Federal de Sa o Joa del-Rei Sete Lagoas CampusHighway MG 424-Km 47Sete LagoasMinas Gerais 35701-970Brazil Federal University of Para(UFPA) University Campus of AltamiraStreet Cel.Jose Porfırio2515Sa o Sebastiao68372-040 AltamiraPABrazil

Forest production and growth are obtained from statistical models that allow the generation of information at the tree or forest stand *** the use of regression models is common in forest measurement,there is a constant search for estimation procedures that provide greater ***,machine learning techniques have been used with satisfactory performance in measuring ***,methods such as Adaptive NeuroFuzzy Inference System(ANFIS)and Random Forest are relatively poorly studied for predicting the volume of wood in eucalyptus plantations in ***,it is essential to check whether these techniques can provide gains in terms of ***,this study aimed to evaluate the use of Random Forest and ANFIS techniques in the prognosis of forest *** data used come from continuous forest inventories carried out in stands of eucalyptus *** data were divided into 70%for training and 30%for *** algorithms used to generate rules in ANFIS were Subtractive Clustering and ***,training was done with the hybrid algorithm(descending gradient and least squares)with the number of seasons ranging from 1 to *** RFs were trained,varying the number of trees from 50 to 850 and the number of observations by five leaves to *** neural networks and decision trees were also trained to compare the feasibility of the *** evaluation of the estimates generated by the techniques for training and validation was calculated based on the following statistics:correlation coefficient(r),relative Bias(RB),and the relative root mean square error(RRMSE)in *** general,the techniques studied in this work showed excellent performance for the training and validation data set with RRMSE values*** RF presented inferior statistics about the ANFIS for the prognosis of forest *** Subtractive Clustering(SC)and Fuzzy-C-Means(FCM)algorithms provide accurate baseline

关键词： Artificial Intelligence Ensemble Learning Forest Measurement Forest inventory Artificial Neural Networks Regression

In Silico and in Vitro Analysis of Pyrazolone Derivatives against Zika Virus and Identification of Potential NS5 Methyltransferase Inhibitors by Molecular Docking

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Journal of Biosciences and Medicines 2024年第7期12卷 214-229页

作者： Luciene Soares silva Tiago Soares Barbosa Maria Leonisa Sanchez-Nuñez Aldenise Mont Serrat Rosa da silva Vitor Won-Held Rabelo Leonardo dos Santos Corrêa Amorim Leonardo Alves Miceli Percilene Fazolin Vegi Alice Bernardino Helena Carla Castro Izabel Christina Nunes de Palmer Paixão Science and Biotechnology Graduate Program Department of Cellular and Molecular Biology Institute of Biology Fluminense Federal University Niteri Brazil Science and Biotechnology Graduate Program Department of Cellular and Molecular Biology Institute of Biology Fluminense Federal University Niterói Brazil Laboratory of Antibiotics Biochemistry Teaching and Molecular Modeling Institute of Biology Fluminense Federal University Niterói Brazil Laboratory of Organic Chemistry at the Institute of Chemistry Institute of Biology Fluminense Federal University Niterói Brazil

Zika virus (ZIKV), a mosquito-borne flavivirus, has been associated with benign infections for decades. However, it has become a public health concern due to its association with severe fetal and neurological complications. Although many efforts have been made to control ZIKV infection, approved vaccines or antiviral drugs are still lacking. Consequently, the development of new effective anti-ZIKV agents is urgently needed. In this context, we investigated the antiviral potential of pyrazolone derivatives against ZIKV replication using in silico and in vitro methods. The four pyrazolone derivatives evaluated (1a, 1b, 1c, and 1d) inhibited over 50% of ZIKV replication with low cytotoxicity. Among them, compound 1b exhibited the most potent activity (EC50 = 4.3 μM) and the highest selectivity (SI = 342). Mechanism of action studies indicated that these compounds act at early stages of virus replication, and compound 1b can also directly inactivate ZIKV particles. Molecular docking studies suggested that these compounds can bind to and block the activity of ZIKV NS5 methyltransferase. Finally, pharmacokinetic and toxicological predictions have reinforced the safety and drug-like profiles of these derivatives. In conclusion, the pyrazolone scaffold proved to be valuable for anti-ZIKV drug development, and the derivatives studied deserve further investigation.

关键词： Zika Pyrazolone NS5 Methyltransferase Antivirals

Antifungal activity of natural compounds against Candida species isolated from HIV-positive patients

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Asian Pacific Journal of Tropical Biomedicine 2015年第9期5卷 750-752页

作者： Débora Oro andréia Heissler Eliandra Mirlei Rossi Diane Scapin Patrícia da silva Malheiros Everton Boff Microbiological Research and Diagnostic Laboratory Department of Biological and Health Sciences University of Western Santa Catarina Sao Miguel Oeste Hygiene and Food Microbiology Laboratory Department of Food Sciences Food Science and Technology Institute Federal University of Rio Grande do Sul

Objective: To evaluate the antifungal effect of Cinnamomum zeylanicum(C. zeylanicum) and Melaleuca alternifolia essential oils and honey against strains of Candida sp. from HIV-positive patients in order to subsidize new therapeutic strategies for ***: The study evaluated the antifungal effect of natural antimicrobials against 30 strains of Candida sp. isolated from oral cavities in HIV-infected patients. Then, they were compared to the action of fl uconazole and amphotericin B. Antifungal susceptibility was evaluated by the broth macrodilution technique and the minimum inhibitory concentration and the minimum fungicidal concentration were ***: Among all antifungals evaluated in this study, amphotericin B was the one showing the best results; however, all compounds studied here showed inhibitory activities against isolates of Candida sp. Honey(0.031 3 to 64 μg/m L) demonstrated fungistatic activity inhibiting 70% of the isolates. C. zeylanicum essential oil(0.031 3 to 64 μg/m L) inhibited 93.3% of the Candida strains and Melaleuca alternifolia essential oil(0.031 3 to 64 μg/m L) was able to inhibit 73.3% of ***: Therefore, all natural compounds evaluated in this study, especially C. zeylanicum essential oil, may become promising agents for oral candidiasis therapy including in HIV-positive patients.

关键词： Candida sp. Essential oils Honey HIV Susceptibility

Ferroelectricity Induced by Oxygen Vacancies in Rhombohedral ZrO_(2) Thin Films

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Energy & Environmental Materials 2024年第1期7卷 229-237页

作者： Veniero Lenzi José P.B.silva Břetislav Šmíd Vladimir Matoín Cosmin M.Istrate Corneliu Ghica Judith L.MacManus-Driscoll Luís Marques Physics Center of Minho and Porto Universities(CF-UM-UP) University of MinhoCampus de Gualtar 4710-057Braga Portugal Laboratory of Physics for Materials and Emergent Technologies LapMETUniversity of Minho4710-057Braga Portugal Department of Surface and Plasma Science Faculty of Mathematics and PhysicsCharles UniversityV Holešovičkách 218000Prague 8 Czech Republic National Institute of Materials Physics 105 bis Atomistilor 077125Magurele Romania Department of Materials Science and Metallurgy 27 Charles Babbage Rd.Cambridge CB3 OFSUK

Rhombohedral phase Hf_(x)Zr_(1.x)O_(2)(HZO,x from 0 to 1)films are promising for achieving robust ferroelectric polarization without the need for an initial wake-up pre-cycling,as is normally the case for the more commonly studied orthorhombic ***,a large spontaneous polarization observed in rhombohedral films is not fully understood,and there are also large discrepancies between experimental and theoretical *** this work,in rhombohedral ZrO_(2)thin films,we show that oxygen vacancies are not only a key factor for stabilizing the phase,but they are also a source of ferroelectric polarization in the *** is shown experimentally through the investigation of the structural properties,chemical composition and the ferroelectric properties of the films before and after an annealing at moderate temperature(400℃)in an oxygen environment to reduce the V_(o)concentration *** experimental work is supported by density functional theory(DFT)calculations which show that the rhombohedral phase is the most stable one in highly oxygen defective ZrO_(2)*** DFT calculations also show that V_(o)contribute to the ferroelectric *** findings reveal the importance of V_(o)for stabilizing rhombohedral ZrO_(2)thin films with superior ferroelectric properties.

关键词： charged defects ferroelectric polarization rhombohedral phase stability zirconia