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Insights into gastric neuroendocrine tumors burden

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Chinese Journal of Cancer Research 2017年第2期29卷 137-143页

作者： Taíssa Maíra Thomaz Araújo Williams Fernandes Barra andré Salim Khayat Paulo pimentel de Assumpcao Oncology Research Center Federal University of paráPara 66073-005Brazil

Type 1 gastric neuroendocrine tumors （gNETs） are usually small lesions, restricted to mucosal and sub-mucosal layers of corpus and fundus, with low aggressive behavior, for the majority of cases. Nevertheless, some cases present aggressive behavior. The increasing incidence of gNETs brings together a new relevant problem： how to identify potentially aggressive type I gNETs. The challenging problem seems to be finding out signs or features able to predict potentially aggressive cases, allowing a tailored approach, since the involved societies dedicated to provide guidelines for management of these neoplasms apparently failed in producing staging systems able to accurately predict prognosis of these tumors. Additionally, it is also important to try to find out explanations for increasing incidence, as well as to identify potential targets aiming to reach better control of this neoplasia. Here, we discuss potential pathways implicated in aggressive behavior, as well as new strategies to improve clinical management of these tumors.

关键词： gNETs gastrin receptor epidemiology

Impact of rainfed and irrigated agriculture systems on soil carbon stock under different climate scenarios in the semi-arid region of Brazil

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Journal of Arid Land 2022年第4期14卷 359-373页

作者： andré L CARVALHO Renato A ARAúJO-NETO Guilherme B LYRA Carlos E P CERRI Stoécio M F maia Center for Agrarian Sciences Federal University of AlagoasRio Largo 57072-900Brazil Luiz de Queiroz College of Agriculture The University of Sao PauloPiracicaba 13418-900Brazil Federal Institute of Alagoas Marechal Deodoro 57160-000Brazil

Understanding the dynamics of soil organic carbon(SOC) is of fundamental importance in land use and management, whether in the current researches or in future scenarios of agriculture systems considering climate change. In order to evaluate SOC stock of the three districts(Delmiro Gouveia, Pariconha, and Inhapi districts) in the semi-arid region of Brazil in rainfed and irrigated agriculture systems under different climate scenarios using the Century model, we obtained RCP4.5 and RCP8.5 climate scenarios derived from the Eta Regional Climate Model(Eta-Had GEM2-ES and Eta-MIROC5) from the National Institute for Space Research, and then input the data of bulk density, p H, soil texture, maximum temperature, minimum temperature, and rainfall into the soil and climate files of the Century model. The results of this study showed that the Eta-Had GEM2-ES model was effective in estimating air temperature in the future period. In rainfed agriculture system, SOC stock under the baseline scenario was lower than that under RCP4.5 and RCP8.5 climate scenarios, while in irrigated agriculture system, SOC stock in the almost all climate scenarios(RCP4.5 and RCP8.5) and models(Eta-Had GEM2-ES and Eta-MIROC5) will increase by 2100. The results of this study will help producers in the semi-arid region of Brazil adopt specific agriculture systems aimed at mitigating greenhouse gas emissions.

关键词： soil carbon stock agriculture systems climate scenarios Century model semi-arid region

Analgesic-like activity of perillyl acetate:In vivo and in silico studies

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Asian Pacific Journal of Tropical Biomedicine 2022年第4期12卷 156-163页

作者： Renan Braga Humberto andrade Ryldene Cruz Mayara maia Carolina Lima Anderson Santos andréMiranda Allana Duarte Marcus Scotti Reinaldo Almeida Damião Sousa Postgraduate Program in Natural and Synthetic Bioactive Products Federal University of Paraíba58051-970João PessoaPBBrazil Research Institute for Drugs and Medicines Federal University of ParaíbaCP 5009João Pessoa58051-900PBBrazil Department of Pharmaceutical Sciences Federal University of Paraíba58051-970João PessoaPBBrazil

Objective:To evaluate the antinociceptive activity of perillyl acetate in mice and in silico ***:The vehicle,perillyl acetate(100,150 and/or 200 mg/kg,i.p.),diazepam(2 mg/kg,i.p.)or morphine(6 mg/kg,i.p.)was administered to mice,*** test,acetic acidinduced abdominal writhing,formalin-induced nociception,hot plate test,and tail-flick test were *** receptorsinvolvement in perillyl acetate antinociceptive effect was also ***:Perillyl acetate did not affect the motor coordination of ***,it reduced the number of acetic acid-induced abdominal twitches and licking times in the formalin *** was an increase of latency time in the tail-flick test of 30 and *** with naloxone reversed the antinociceptive effect of perillyl acetate(200 mg/kg).In silico analysis demonstrated that perillyl acetate could bind toμ-opioid ***:Perillyl acetate has antinociceptive effect at the spinal level in animal nociception models,without affecting the locomotor integrity and possibly throughμ-opioid *** silico studies have suggested that perillyl acetate can act as aμ-opioid receptor agonist.

关键词： Analgesic Biological products Opioid Essential oil Pain Monoterpene Perillyl acetate

Efficacy of oral consumption of curcumin/Curcuma longa for symptom improvement in inflammatory bowel disease:A systematic review of animal models and a meta-analysis of randomized clinical trials

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BIOCELL 2022年第9期46卷 2015-2047页

作者： MARLA DE CERQUEIRA ALVES MONISE OLIVEIRA SANTOS NASSIB BEZERRA BUENO ORLANDO ROBERTO pimentel DE ARAúJO MARíLIA OLIVEIRA FONSECA GOULART FABIANA andréA MOURA Programa de Pós-Graduacao em Nutricao(PPGNUT) Universidade Federal de Alagoas(UFAL)MaceióAL 57072-970Brazil Instituto de Química e Biotecnologia(IQB) Universidade Federal de Alagoas(UFAL)MaceióAL 57072-970Brazil Programa de Pós-Gradua玢o em Ciências da Saúde(PPGCS) Universidade Federal de Alagoas(UFAL)MaceióAL 57072-970Brazil Programa de Pós-Gradua玢o da Rede Nordeste de Biotecnologia(RENORBIO) Universidade Federal de Alagoas(UFAL)MaceióAL 57072-970Brazil Programa de Pós-Gradua玢o em Ciências Médicas(PPGCM) Universidade Federal de Alagoas(UFAL)MaceióAL 57072-970Brazil

The roots of the vegetal Curcuma due to its high content of polyphenols,has been used successfully in several clinical *** review assessed the effect of curcumin/Curcuma longa on symptoms and metabolic changes in inflammatory bowel disease(IBD).A systematic review of animal models and randomized clinical trials(RCTs)was conducted by searching the following electronic databases:PubMed,CENTRAL,LILACS,Science Direct,and *** 997 found records,62 were *** than 90%of the animal studies reported an improvement in macroscopic,histologic and/or functional activity;80%identified decreased oxidative and/or inflammatory biomarkers in animals treated with *** the RCTs,intention-to-treat analysis showed that oral curcumin was effective in inducing clinical remission(n=281,RR:3.15 CI 95%[1.22–8.10]p=0.0017;i2=72.2%,p=0.006)and clinical response(n=259,RR:1.60 CI 95%[1.09–2.35]p=0.0017;i2=59.7%,p=0.042)but not endoscopic remission(n=161,RR:2.91 CI 95%[0.58–14.58]p=0.195;i2=72.7%,p=0.026).These results confirm that oral supplementation with curcumin/Curcuma longa has beneficial actions in animal colitis and,when associated with drug therapy,is effective in the treatment of patients with IBD.

关键词： Ulcerative colitis Crohn’s disease Oxidative stress Curcuma Turmeric

Curcumin in inflammatory bowel diseases:Cellular targets and molecular mechanisms

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BIOCELL 2023年第11期47卷 2547-2566页

作者： AMYLLY SANUELLY DA PAZ MARTINS MARLA DE CERQUEIRA ALVES ORLANDO ROBERTO pimentel DE ARAÚJO FABIANA OLIVEIRA DOS SANTOS CAMATARI MARÍLIA OLIVEIRA FONSECA GOULART FABIANA andrÉA MOURA Rede Nordeste de Biotecnologia(RENORBIO) Instituto de química e BiotecnologiaUniversidade Federal de Alagoas(UFAL)Maceió57072-900Brasil Programa de Pós-graduação em Nutrição(PPGNUT) Faculdade de Nutrição(FANUT)Universidade Federal de Alagoas(UFAL)Maceió57072-900Brasil Programa de Pós-Graduação em Química e Biotecnologia(PPGQB) Instituto de química e BiotecnologiaUniversidade Federal de Alagoas(UFAL)Maceió57072-900Brasil Colegiado de Nutrição Universidade de Pernambuco(UPE)Campus PetrolinaPernambuco56328-900Brasil Programa de Pós-Graduação em Ciências da Saúde(PPGCS) Instituto de Ciências da SaúdeUniversidade Federal de Alagoas(UFAL)Maceió57072-900Brasil Programa de Pós-graduação em Ciências Médicas(PPGCM) Faculdade de MedicinaUniversidade Federal de Alagoas(UFAL)Maceió57072-900Brasil

Curcumin,a natural product,has exhibited promising effects in both animal models and clinical trials,interacting with a multitude of factors linked to Inflammatory Bowel Disease(IBD).These factors encompass cytokines,oxidative stress-associated enzymes,and modulation of the intestinal ***,curcumin has demonstrated therapeutic potential in animal models of colitis,wherein it exerts a negative regulatory influence on pivotal signaling pathways such as PI3/Akt,JAK/STAT,andβ-***,it inhibits the expression of proinflammatory enzymes and co-stimulatory molecules(including RANKL,ICAM-1,CD205,CD256,TLR4,among others),while curbing immune cell chemotaxis,thereby attenuating the characteristic neutrophil infiltration observed in *** facet of curcumin’s action involves its modulation of the intestinal ***,the microbiota itself contributes to beneficial biotrans formations of curcumin,thereby enhancing its effectiveness in IBD *** a clinical front,curcumin has demonstrated the ability to induce clinical and/or endoscopic remission without any reported toxic ***,curcumin warrants consideration as an adjunctive therapy in IBD *** clinical investigations should concentrate on meticulously evaluating curcumin’s impact on these precise therapeutic targets.

关键词： Curcuminoids Polyphenols CDAI scores Ulcerative colitis Antioxidant

Antioxidant,hypolipidemic and hypoglycemic effect of red wine in wistar rats fed with obesogenic diet

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Food Bioscience 2022年第3期47卷 756-764页

作者： Cornélio Mucaca José Henrique Tavares Filho Luciana Lima Arruda andré Martins Galvão Maria Bernadete de Sousa maia Eryka Maria dos Santos Alves Eryvelton de Souza Franco Elizabeth do Nascimento Department of Nutrition Center of Health SciencesFederal University of Pernambuco (UFPE)Cidade Universitaria50670-901RecifePEBrazil Rural Technology Department Federal Rural University of Pernambuco (UFRPE)AD.Manoel de Medeiros Ave.s/nDois Irmãos52171-900RecifePEBrazil Department of Physiology and Pharmacology Center of Biological SciencesFederal University of Pernambuco (UFPE)Cidade Universitaria50670-901RecifePEBrazil

The health benefits resulting from the usual ingestion of red wines have been studied in humans and ***,the evaluation of benefits in antioxidant,hypoglycemic and hypolipemic activity concomitant with the use of an obesogenic diet in adult Wistar rats has been little *** present study investigated the use of red wine derived from Northeast Brazil in adult rats fed with an obesogenic diet on antioxidant activity,glucose tolerance,adipose,glycemic and lipemic *** 45-day old male Wistar rats formed two groups:standard diet and westernized *** changes in body mass and glycemic levels,the animals were subdivided into six subgroups (n = 10 per group) and received water,red wine or hydroalcoholic solution by *** data reveal that the moderate and chronic use of red wine improves the glycemic,lipid and oxidative stress profile,being favorable in preventing the risk of cardiovascular diseases in rats fed with an obesogenic diet.

关键词： Dyslipidemia Obesity Rats Westernized diet Red wine

Innate immunity and hepatocarcinoma:Can toll-likereceptors open the door to oncogenesis?

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World Journal of Hepatology 2016年第3期8卷 162-182页

作者： Jorge andréGomes Lopes Marta Borges-Canha Pedro pimentel-Nunes Department of Physiology and Cardiothoracic Surgery Cardiovascular Research and Development UnitFaculty of MedicineUniversity of Porto4200-319 PortoPortugal Gastroenterology Department Portuguese Oncology Institute4200-072 PortoPortugal CINTESIS/Department of Biostatistics and Medical Informatics Faculty of MedicineUniversity of Porto4200-319 PortoPortugal

Hepatocarcinoma(HCC) is a highly prevalent cancer worldwide and its inflammatory background was established long *** studies have shown that innate immunity is closely related to the HCC *** effective innate immunity response relies on the tolllike receptors(TLR) found in several different liver cells which,through different ligands and many signaling pathways can elicit,not only a pro-inflammatory but also an oncogenic or anti-oncogenic *** aim was to study the role of TLRs in the liver oncogenesis and as a consequence their value as potential therapeutic *** performed a systematic review of PubMed searching for original articles studying the relationship between HCC and TLRs until March ***2 appears to be a fundamental stress-sensor as its absence reveals an augmented tendency to accumulate DNAdamages and to cell ***,pathways are still not fully understood as TLR2 up-regulation was also associated to enhanced ***3 has a wellknown protective role influencing crucial processes like angiogenesis,cell growth or ***4 works as an interesting epithelial-mesenchymal transition's inducer and a promoter of cell survival probably inducing HCC carcinogenesis even though an anti-cancer role has already been ***9's influence on carcinogenesis is also controversial and despite a potential anticancer capacity,a pro-tumorigenic role is more *** polymorphisms in some TLRs have been found and its influence on the risk of HCC has been *** therapeutic targets,TLRs are already in use and have a great *** conclusion,TLRs have been shown to be an interesting influence on the HCCs microenvironment,with TLR3 clearly determining an antitumour ***4 and TLR9 are considered to have a positive relationship with tumour development even though,in each of them anti-tumorigenic signals have been ***2 presents a more ambiguous role,possibly depending on the stag

关键词： Hepatocarcinoma Carcinogenesis Toll-likereceptor Innate immunity Chronic inflammation

Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease

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World Journal of Gastroenterology 2007年第7期13卷 1067-1073页

作者： andre Castro lyra Milena Botelho Pereira Soares luiz Flavio maia da Silva Marcos Fraga Fortes andré Goyanna Pinheiro Silva Augusto César de andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson andrade de Carvalho Bernd Genser Ricardo Ribeiro dos Santos luiz Guilherme Costa lyra Hos-pital Sao Rafael Salvador Bahia Brazil Centro de Pesquisas Goncalo Moniz Fundacao Oswaldo Cruz Salvador Bahia Brazil BGStats Consulting Graz Austria

AIM： To evaluate the safety and feasibility of bone marrow cell （BMC） transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS： Ten patients （eight males） with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 mL of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS： The median age of the patients was 52 years （range 24-70 years）. All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 （2.19 ± 0.9） and 4 mo （2.10 ± 1.0） after cell transplantation that baseline levels （238 ± 1.2）. Albumin levels 4 mo after BMC infusion （3.73 ± 0.5） were higher than baseline levels （3.47 ± 0.5）. International normalized ratio （INR） decreased from 1.48 （SD = 0.23） to 1.43 （SD = 0.23） one month after cell transplantation. CONCLUSION： BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease.

关键词： Bone marrow Cell transplantation Liverfailure Stem cell Cirrhosis

Belowground Carbon and Nitrogen on a Thinned and Un-Thinned Seasonally Dry Tropical Forest

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American Journal of Plant Sciences 2017年第9期8卷 2083-2100页

作者： Deodato do Nascimento Aquino Eunice maia de andrade andréa Dardes de Almeida Castanho Lécio Resende Pereira Júnior Helba Araújo de Queiroz Palácio Instituto Nacional de Colonização e Reforma Agrária Fortaleza Brazil Department of Agricultural Engineering Federal University of Ceará Fortaleza Brazil Woods Hole Research Center Falmouth USA Federal Institute of Education Science and Technology Iguatu Brazil

The aim of this study was to quantify the dynamics of herbaceous biomass and fine root productivity, and their relationship to stocks of carbon and nitrogen, in the Vertisols of two adjacent watersheds of a seasonally dry tropical forest (SDTF) under two different types of ground cover. The two watersheds are located in the county of Iguatu in the State of Ceará, Brazil. The control watershed of 2.1 ha, has been under regeneration for 35 years (RC35), while the second watershed (1.1 ha) was subjected to thinning for a period of 5 years (TC5). The sampled variables were herbaceous shoot biomass, fine roots, gravimetric moisture, the isotope δ13C (‰), total soil carbon (TSC) and total nitrogen (TN) in the 0 - 20, 20 - 40 and 40 - 60 cm layers, between April 2013 and March 2014. To quantify herbaceous shoot biomass, samples were taken monthly. For TSC and TN, the campaigns were held every two months. The data underwent analysis of means and were compared by t-test (p < 0.05). Under TC5, there was an increase in the stocks of TSC and TN of 151 and 137% respectively in the 40 - 60 cm layer, in relation to RC35. The implementation of thinning in a SDFT is seen as a management alternative to be considered in sustainability programs in the semi-arid region, contributing to maximising the production of herbaceous forage for feeding large and small ruminants, and for bee pasture, in addition to increasing the stock of carbon in the soil of SDFT and reducing global warming.

关键词： Carbon Sequestration Dry Forests Isotope δ13C Herbaceous Plants