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Impact of payment source, referral site, and place of residence on outcomes after allogeneic transplantation in Mexico

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World Journal of Transplantation 2024年第2期14卷 76-87页

作者： andrés Gómez-De León Yesica A López-Mora Valeria García-Zárate Ana Varela-Constantino Sergio U Villegas-De Leon Xitlaly J González-Leal Raúl del Toro-Mijares Anna C Rodríguez-Zúñiga Juan F Barrios-Ruiz Victor Mingura-Ledezma Perla R Colunga-Pedraza Olga G Cantú-Rodríguez César H Gutiérrez-Aguirre Luz Tarín-Arzaga Elías E González-López David Gómez-Almaguer Hematology Service Universidad Autónoma de Nuevo LeónFacultad de Medicina y Hospital Universitario Dr.JoséEleuterio GonzálezMonterrey 64460Nuevo LeónMexico Hemato-logy Service Clínica Gómez AlmaguerMonterrey 64710Nuevo LeónMexico Hematology Service Instituto Tecnológico de Estudios Superiores de MonterreyTec SaludEscuela de Medicina Ignacio SantosMonterrey 64710Nuevo LeónMexico

BACKGROUND The impact of social determinants of health in allogeneic transplant recipients in low-and middle-income countries is poorly *** observational study analyzes the impact of place of residence,referring institution,and transplant cost coverage(out-of-pocket vs government-funded vs private insurance)on outcomes after allogeneic hematopoietic stem cell transplantation(alloHSCT)in two of Mexico's largest public and private *** To evaluate the impact of social determinants of health and their relationship with outcomes among allogeneic transplant recipients in *** In this retrospective cohort study,we included adolescents and adults≥16 years who received a matched sibling or haploidentical transplant from *** were selected without regard to their diagnosis and were sourced from both a private clinic and a public University Hospital in *** payment groups were compared:Out-of-pocket(OOP),private insurance,and a federal Universal healthcare program“Seguro Popular”.Outcomes were compared between referred and institution-diagnosed patients,and between residents of Nuevo Leon and *** outcomes included overall survival(OS),categorized by residence,referral,and payment *** outcomes encompassed early mortality,event-free-survival,graft-versus-host-relapse-free survival,and non-relapse-mortality(NRM).Statistical analyses employed appropriate tests,Kaplan-Meier method,and Cox proportional hazard regression *** software included SPSS and R with tidycmprsk *** Our primary outcome was overall *** included 287 patients,n=164 who lived out of state(57.1%),and n=129 referred from another institution(44.9%).The most frequent payment source was OOP(n=139,48.4%),followed by private insurance(n=75,26.1%)and universal coverage(n=73,25.4%).No differences in OS,event-free-survival,NRM,or graft-versus-host-relapse-free survival were observed for patients dia

关键词： Hematopoietic cell transplant Social determinants of health Geography Haploidentical Out-of-pocket Financial toxicity Survival Health services and outcomes Hematopoietic malignancy Aplastic anemia

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Premature losses of leaf area in response to drought and insect herbivory through a leaf lifespan gradient

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Journal of Forestry Research 2022年第1期33卷 39-50页

作者： Sonia Mediavilla Montserrat Martínez-Ortega Santiago andrés Javier Bobo Alfonso Escudero Departamento de Ecología Facultad de BiologíaUniversidad de Salamanca37071 SalamancaSpain Departamento de Botánica y Fisiología Vegetal Facultad de BiologíaUniversidad de Salamanca37071 SalamancaSpain

Implications of the differences in leaf life span are still subject to debate in the field of *** leaf traits associated with these differences may be decisive for determining the distribution of tree species,this topic is particularly relevant in the context of climate *** study analyzes the effects of the differences in leaf life span on premature losses of leaf area owing to insect herbivory and to abiotic *** of leaf area may be an important determinant of total leaf carbon *** Mediterranean tree species,distributed on four sites with different climates were *** species exhibited strong differences in leaf life span and in leaf traits,especially leaf mass per unit *** leaf area losses were estimated in response to insect herbivory and summer drought over two *** results revealed that,despite having older leaf cohorts with more damage,species with longer leaf duration had lower area lost to herbivores and less damage due to accelerated senescence during the summer *** respect to the predicted increase in water stress,deciduous species are at a disadvantage due to their high premature loss of leaf area and thus loss of photosynthetic capacity.

关键词： Accelerated senescence Insect herbivory Leaf life span Leaf structural reinforcement Summer drought

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Sailboat navigation control system based on spiking neural networks

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Control Theory and Technology 2023年第4期21卷 489-504页

作者： Nelson Santiago Giraldo Sebastián Isaza Ricardo andrés Velásquez Department of Electronics and Telecommunications Engineering University of Antioquia67 stMedellin050010AntioquiaColombia

In this paper,we presented the development of a navigation control system for a sailboat based on spiking neural networks(SNN).Our inspiration for this choice of network lies in their potential to achieve fast and low-energy computing on specialized *** train our system,we use the modulated spike time-dependent plasticity reinforcement learning rule and a simulation environment based on the BindsNET library and USVSim *** objective was to develop a spiking neural network-based control systems that can learn policies allowing sailboats to navigate between two points by following a straight line or performing tacking and gybing strategies,depending on the sailing scenario *** presented the mathematical definition of the problem,the operation scheme of the simulation environment,the spiking neural network controllers,and the control strategy *** a result,we obtained 425 SNN-based controllers that completed the proposed navigation task,indicating that the simulation environment and the implemented control strategy work ***,we compare the behavior of our best controller with other algorithms and present some possible strategies to improve its performance.

关键词： Sailboat Control Spiking neuron Reinforcement learning BindsNet USVSim

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Mitochondrial transport of catalytic RNAs and targeting of the organellar transcriptome in human cells

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Journal of Molecular Cell Biology 2023年第8期15卷 40-53页

作者： PawełGłodowicz Konrad Kuczynski Romain Val andréDietrich Katarzyna Rolle Department of Molecular Neurooncology Institute of Bioorganic ChemistryPolish Academy of Sciencesul.Z.Noskowskiego 12/1461-704 PoznanPoland Institute of Plant Molecular Biology French National Center for Scientific Research(CNRS)and University of Strasbourg12 rue du Général Zimmer67084 StrasbourgFrance

Mutations in the small genome present in mitochondria often result in severe *** genetic strategies have been explored,aiming to rescue such mutations.A number of these strategies were based on the capacity of human mitochondria to import RNAs from the cytosol and designed to repress the replication of the mutated genomes or to provide the organelles with wild-type versions of mutant ***,the mutant RNAs present in mitochondria turned out to be an obstacle to therapy and little attention has been devoted so far to their ***,we present the development of a strategy to knockdown mitochondrial RNAs in human cells using the transfer RNA-like structure of Brome mosaic virus or Tobacco mosaic virus as a shuttle to drive trans-cleaving ribozymes into the organelles in human cell *** obtained a specific knockdown of the targeted mitochondrial ATP6 mRNA,followed by a deep drop in ATP6 protein and a functional impairment of the oxidative phosphorylation *** strategy provides a powerful approach to eliminate mutant organellar transcripts and to analyse the control and communication of the human organellar genetic system.

关键词： human cells mitochondria ribozyme RNA trafficking transcriptome manipulation tRNA-like structure

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Management options for the unfavorable nutrient balance of recreational fishing in Lake Balaton(Hungary)

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Ecosystem Health and Sustainability 2022年第1期8卷 436-450页

作者： Gergely Boros Attila Mozsár andrás Specziár Balaton Limnological Research Institute–ELKH TihanyHungary Research Centre for Aquaculture and Fisheries Institute of Aquaculture and Environmental SafetyHungarian University of Agriculture and Life ScienceSzarvasHungary

Various types of ground baits are loaded to lakes by anglers,but the ecological role of these materials is often ***,the aims of this study were to conduct a quantitative and qualitative assessment of the baits used by anglers in the largest lake of Central-Europe(Lake Balaton,Hungary),estimate the annual nutrient balance of recreational fishing,and relate the nutrient loading from this source to the total external *** study demonstrated that popular angler baits varied substantially in their nutrient contents and in their molar nitrogen to phosphorus(N:P)*** net nutrient balance of recreational fishing was+19.3 t total N year^(-1)and+5.2 t total P year^(-1),equivalent to 0.7%and 3.2%of the estimated total annual N and P loads,*** rate of nutrient loading may be doubled if the present trends continue:anglers will use 20%more bait with an even higher nutrient content and will also show higher propensity to release the fish after *** turn,sustainable nutrient balance of fisheries management could be achieved by limiting the anglers’bait use to 1.5 kg day^(-1)and restricting baits to those which have relatively low P(<0.3%)and N(<1.5%)contents.

关键词： Anthropogenic eutrophication boilie catchand-release fishing fish meal sustainable fisheries management

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The panopticon prison as a “social condenser”:The study of the project for De Koepel prison by Rem Koolhaas/OMA (1979e1988)

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Frontiers of Architectural Research 2022年第1期11卷 31-52页

作者： Elena Martinez-Millana andrés Cánovas Alcaraz Departamento de Proyectos Arquitectónicos Escuela Técnica Superior de ArquitecturaUniversidad Politécnica de Madrid28040MadridSpain Department of Architecture Faculty of Architecture and the Built EnvironmentDelft University of Technology2628 BLDelftthe Netherlands

Rem Koolhaas/OMA carried out the study for De Koepel prison throughout a decade(1979-1988).However,only its initial stages(1979-1980)were disclosed and have been *** hypothesis presented in this article suggests that Koolhaas implemented his dthend recent thesis present in Delirious New York(1978)on“life in the metropolis”and the“Culture of Congestion”in the conception and design of this ***,this article has the aim of examining dby means of the documents compelling the entire period of the studyd how the project suggested transforming the domesticity of De Koepel prison into a“social condenser”of the contemporary *** doing so,it makes it possible to consider the role of this project within the first decade of Koolhaas’career as an architect(1978-1989),and to establish that Delirious New York is,in fact,the theory on which it was based on when first *** project anticipated the strategy and the methodology he implemented,at a later time,in other projects,offering a different *** this occasion,this diagrammatic investigation took place in Bentham’s Panopticon;reason why,he was then able to develop the reflections on heterotopias and prisons carried out by Foucault.

关键词： Domesticity Collective housing Panopticon prison Social condenser

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Noninvasive diagnosis of periportal fibrosis in schistosomiasis mansoni:A comprehensive review

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World Journal of Hepatology 2022年第4期14卷 696-707页

作者： Joelma Carvalho Santos Caroline Louise Diniz Pereira Ana Lúcia Coutinho Domingues Edmundo pessoa Lopes Postgraduate Program in Tropical Medicine Center of Health SciencesUniversidade Federal de PernambucoRecife 50670-901PernambucoBrazil Gastroenterology Division Department of Internal Medicine of Center of Health SciencesHospital das Clínicas-Universidade Federal de PernambucoRecife 50670-901PernambucoBrazil

Schistosomiasis mansoni is a neglected disease and key public health problem,mainly due to its high prevalence,the scarcity of public policies,and the severity of some clinical *** fibrosis(PPF)is the commonest complication of chronic schistosomiasis mansoni and its diagnosis requires different *** though wedge biopsy of the liver is considered the gold standard,it is not justified in non-surgical patients,and percutaneous liver biopsy may be informative but does not have sufficient *** PPF tests mostly include biological(serum biomarkers or combined scores)or physical assessments(imaging assessment of fibrosis pattern or tissue stiffness).Moreover,imaging techniques,such as ultrasound,computed tomography,magnetic resonance imaging,and elastography are applied not only to support the diagnosis of schistosomiasis,but also to assess and detect signs of portal hypertension and organ damage due to chronic schistosomiasis.A combination between a comprehensive history and physical examination with biomarkers for liver fibrosis and imaging methods seems to offer the best approach for evaluating these *** addition,understanding their strengths and limitations will allow a more accurate interpretation in the clinical context and can lead to greater accuracy in estimating the degree of fibrosis in patients with Schistosomiasis mansoni(***)*** review will discuss the different noninvasive methods that are currently available for the evaluation of PPF in *** infection,and their application,advantages,and limitations in clinical practice.

关键词： Schistosoma mansoni Parasitic liver diseases Liver fibrosis Biomarkers Elasticity imaging techniques Ultrasonography

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Vertical power flow forecast with LSTMs using regular training updatestrategies

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能源与人工智能(英文) 2022年第2期8卷 92-99页

作者： Katharina Brauns Christoph Scholz Alexander Schultz andréBaier Dominik Jost Fraunhofer IEE Königstor 5934119 KasselGermany

The strong growth of renewable energy sources as well as the increasing amount of volatile energy consumptionis leading to major challenges in the electrical grid. In order to ensure safety and reliability in the electricitygrid, a high quality of power flow forecasts for the next few hours are needed. In this paper we investigateforecasts of the vertical power flow at transformer between the medium and high voltage grid. Forecastingthe vertical power flow is challenging due to constantly changing characteristics of the power flow at thetransformer. We present a novel approach to deal with these challenges. For the multi step time series forecastsa Long-Short Term Memory (LSTM) is used. In our presented approach an update process where the model isretrained regularly is investigated and compared to baseline models. The model is retrained as soon as asufficient amount of new measurements are available. We show that this retraining mostly captures changesin the characteristic of the transformer that the model has not yet seen in the past and therefore cannot bepredicted by the model without an update process. To give more weight to recent data, we examined differentstrategies in terms of the number of epochs and the learning rate. We show that our new approach significantlyoutperforms the investigated baseline models. On average, we achieved an improvement of about 8% with theregular update process compared to the approach without update process.

关键词： Vertical power flow Forecasting LSTM

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INF-γ and IL-2 Profile as Therapeutic Markers in Tuberculosis Patients at the Jamot Hospital of Yaounde-Cameroon

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Journal of Tuberculosis Research 2024年第2期12卷 119-128页

作者： Alexandra Emmanuelle Membangbi Jacky Njiki-Bikoï Esther Del-Florence Moni Ndedi Donatien Serge Mbaga Elsa Nguiffo Makue andré Chris Mikangue Mbongue Koko-Ta Ladiff Sharonne Martha Mesembe Justin Olivier Essindi Aïcha Ngoutane Arnaud Franck Elang Sabine Aimée Touangnou-Chamda George Ikomey Mondinde Eric Walter Perfura-Yone Marie Joseph Nkodo Mindimi Sara Honorine Riwom Essama Department of Microbiology The University of Yaound 1 Yaound Cameroon Center for the Study and Control of Communicable Diseases (CSCCD) Yaound Cameroon The Institute for Medical Research and Medicinal Plants Studies Yaound Cameroon Faculty of Medicine and Biomedical Sciences The University of Yaound I Yaound Cameroon The Pneumology Department Jamot Hospital of Yaound Yaound Cameroon

Background: Tuberculosis (TB) is one of the top lethal infectious diseases worldwide. In recent years, interferon-γ (INF-γ) release assays (IGRAs) have been established as routine tests for diagnosing TB infection. However, produced INF-γ assessment cannot permit to distinguish active ATB from latent TB infection (LTBI), especially in TB epidemic areas. In addition to IFN-γ, interleukin-2 (IL-2), secreted by activated T cells, is involved in immune response against Mycobacterium tuberculosis. This could be involved in the follow up of treatment response. The aim of our study was to determine IFN-γ and IL2 cytokines profiles of patients under antituberculosis treatment. Materials and Methods: A six months’ cross-sectional study was conducted at the Jamot Hospital of Yaoundé, from May to August 2021. Sociodemographic and clinical data as well as 5 mL of blood were collected from each participant. INF-γ and IL-2 were determined using indirect Enzyme linked Immuno-Sorbent Assay (ELISA) according to the manufacturer’s recommendations and spectrum exam in combination with radiography and GeneXpert were used as standard. P-values Results: The results showed that men were more infected 14/61 (31.8%) with a high presence in active and resistant TB groups. The mean age was 41.3 ± 13.1 years with a 95% CI = [38.2 - 44.7], the age group with the highest infection rate was ranged between 31 and 40 years. The IL-2 and INF-γ means were respectively 327.6 ± 160.6 pg/mL and 26.6 ± 13.0 pg/mL in ATB patients, 251.1 ± 30.9 pg/mL and 21.4 ± 9.2 pg/mL in patients with resistant tuberculosis, while it was 149.3 ± 93.3 pg/mL and 17.9 ± 9.4 pg/mL in cured patients, 15.1 ± 8.4 pg/mL and 5.3 ± 2.6 pg/mL in participants presumed healthy (p γ and IL-2rates were observed between the different groups. Conclusion: Monitoring the serum levels of INF-γ and IL-2 would be useful for the follow-up of anti-tuberculosis patients, particularly in the both cytokines association case.

关键词： Tuberculosis Antituberculosis Treatment INF-γ IL-2 ELISA

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The immune hunger games:the effects of fasting on monocytes

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Cellular & Molecular Immunology 2023年第10期20卷 1098-1100页

作者： Jorge Domínguez-andrés Holger Reinecke Yahya Sohrabi Department of Internal Medicine and Radboud Center for Infectious Diseases Radboud University Nijmegen Medical Centre6500HBNijmegenthe Netherlands Department of Cardiology I-Coronary and Peripheral Vascular Disease Heart FailureUniversity Hospital MünsterWestfälische Wilhelms-UniversitätMünsterGermany Institutes of Molecular Genetics of the Czech Academy of Sciences PragueCzech Republic Department of Medical Genetics Third Faculty of MedicineCharles UniversityPragueCzech Republic

Currently,different types of fasting are becoming increasingly popular for their potential health benefits,particularly in improving cardiometabolic ***,how these practices affect immune function is not well *** a recent study published in Immunity,Janssen et *** into the complex relationship among fasting,refeeding,and the immune *** fasting caused monocyte homing in bone marrow(BM),refeeding escalated monocyte counts in the circulation but altered immune responses to bacterial infection[1].

关键词： becoming fasting she

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