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*** binding properties of the C-terminal segment of retinol dehydrogenase 8

Annals of Eye Science 2018年第1期 428-428页

作者： andréhädicke Ana I.A.Coutinho François Otis Mustapha Lhor Line Cantin Manuel Prieto Normand Voyer Christian Salesse PROTEO and CUO-Recherche Centre de recherche du CHU de Québec-UniversitéLavalHôpital St-SacrementQuébecCanada Centro Química-Física Molecular Instituto Superior TécnicoUniversidade de LisboaLisboaPortugal PROTEO and Dépt.Chimie FacultéSciences et génieUniversitéLavalQuébecCanada

Background:Retinol dehydrogenase 8(RDh8)is a 312-amino acid(aa)protein involved in the visual *** to the outer segment disk membranes of photoreceptors,it reduces all-trans-retinal to all-trans-retinol1 as one of the rate-limiting steps of the visual ***8 is a member of the short-chain dehydrogenase/reductase *** C-terminal segment allows its membrane-anchoring through the postulated presence of an amphipathicα-helix and of 1 to 3 acyl groups at positions 299,302 and *** secondary structure and membrane binding characteristics of RDh8 and its C-terminal segment have not yet been ***:To evaluate the membrane binding of RDh8,the full-length protein(aa 1-312),a truncated form(aa 1-296),its C-terminal segment(aa 281-312 and 297-312)as well as different additional variants of this segment were *** truncated protein binds membranes less efficiently than the full-length ***,the C-terminal segment of RDh8 is essential for the binding and has thus been further *** intrinsic fluorescence of tryptophan residues at positions 289 and 310 of the wild-type C-terminal segment of RDh8 and the mutants W289F,W310F and W310R have thus been used to determine their extent of binding to lipid vesicles and to monitor their local *** lipid vesicles composed of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine(POPC)or a mixture of POPC and 1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-L-serine(POPS)were used to mimic the phospholipid content of the outer segment disk membranes of ***:An increase in fluorescence intensity and in fluorescence lifetime is observed upon increasing the concentration of lipid *** data allowed calculating values of partition coefficient of the C-terminal segment of RDh8 varying between Kp=1.1 E6 to 1.7 *** is noteworthy that the observation of a more intense shift to lower wavelengths upon membrane binding of the mutant W310R and W310F indicates a deeper inco

关键词： Peptide-membrane binding electrostatic interactions hydrophobic interactions fluorescence spectroscopy

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Touristic urbanization and greening of coastal dune fields:A long-term assessment of a temperate sandy barrier of Argentina

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Journal of Geographical Sciences 2025年第1期 206-230页

作者： GARZO Pedro andrés DADON José Roberto ISLA Federico Ignacio Instituto de Investigaciones Marinas y Costeras (IIMyC-CONICET/UNMDP) Instituto de Geología de Costas y del Cuaternario Dr.Enrique J.Schnack (IGCC-CIC/UNMDP) Universidad de Buenos Aires Facultad de Arquitectura Dise?o y Urbanismo Centro de Investigaciones Gestión de Espacios Costeros (GEC-FADU/UBA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)

Dune barrier systems represent highly sought-after coastal landscapes for tourism and urban development around the world. however, a century ago, they were considered hazardous environments due to their great dynamic nature. As a result, stabilization practices were considered necessary. The systematic introduction of fast-growing exotic trees helped stabilize the sand, making it easier for tourism urbanization to take place, but also leading to erosion processes. This paper aims to assess long-term changes in vegetation cover over a large temperate barrier in Argentina. This complex region includes urban resorts, afforestation zones, and protected areas. A GIS-based geospatial analysis was conducted using a large satellite database(> 350 images), and the future evolution of the vegetation was modeled. The results revealed two primary spatiotemporal patterns associated with a gradual expansion of vegetation cover, accompanied by a concurrent reduction in sandy areas. In 1986, the dune area comprised 75% more surface than vegetation, whereas in 2021, it represented 60% less than vegetation. Furthermore, the 2050 scenario suggests a potential 40% reduction of dunes in certain areas. It is necessary to enhance management actions aimed at maintaining dune mobility and ensuring local and regional sediment balance. Long-term management strategies must focus on restoring native plant communities and controlling invasive species, and avoiding new dune fixation initiatives based on the introduction of exotic species.

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Evaluation of a cost effective technique for treating aquaculture water discharge using Lolium perenne Lam as a biofilter

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Journal of Environmental Sciences 2007年第9期19卷 1079-1085页

作者： NDUWIMANA andré College of Biosystems Engineering and Food Sciences Zhejiang UniversityHangzhou 310029China.

Wastewater stabilization ponds generate low cost by-products that are useful for agriculture. The utilization of these by-products for soil amendment and as a source of nutrients for plants requires a high level of sanitation and stabilization of the organic matter, to maintain acceptable levels of soil, water and air quality. In this study, two aquaculture wastewater treatment systems; recirculating system and a floating plant bed system were designed to improve the quality of irrigation water in local communities with low income. In both systems the grass species Lolium perenne Lam was used as a plant biofilter while vegetable specie Amaranthus viridis was used to evaluate the performance of the system and the suitability of the phyto-treated water for irrigation. It was found that the harmful material removal rate for recirculating system was 88.9% for TAN （total ammonia nitrogen）, 90% for NO2--N, 64.8% for NO3--N while for floating plant bed system 82.7% for TAN, 82% for NO2--N and 60.5% for NO3--N. Comparative analysis of the efficiency of waste element removal between the two systems revealed that both systems performed well, however, plant growth was not robust for floating plant bed system while recirculating system is energy consuming. Although both systems did not attain sufficient levels of TN （total nitrogen） and TP （total phosphorus） load reduction, the treatment with L. perenne remarkably improved the irrigation water quality. A. viridis plants irrigated with the phyto-treated discharge water had lesser concentrations of heavy metals in their tissues compared to those irrigated with untreated discharge. The control plants irrigated with untreated discharge were also found to be highly lignified with few stems and small leaves.

关键词： recirculating system float system plant filter Lolium perenne Lam Amaranthus viridis Burundi

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Setpoint Feasibility and Stability of Wind Park Control Interactions at Weak Grids

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Journal of Modern Power Systems and Clean Energy 2022年第6期10卷 1790-1796页

作者： Argüello andrés IEEE the School of Electrical Engi‐neering and Computation University of CampinasCampinasBrazil

The controllers of wind parks that are connected to weak grids can induce unstable oscillations near the fundamental *** phenomenon can be studied with equivalent impedances of the wind generators,which depend on their operational setpoints at the fundamental *** feasibility of such setpoint,i.e.,solution to the power flow,does not depend on the control ***,oscillations from unfeasible setpoints and control instabilities both occur at weak grids and near the fundamental *** letter presents an exploratory study to map the conditions where both phenomena occur,using sensitivity studies comprising multiple setpoints and control parameter *** results are visually presented as the regions which inform the configurations leading to unfeasible setpoints,and unstable control interaction *** the results,it can be observed that the trajectory of the eigenvalues in the Nyquist plots towards an unfeasible setpoint approaches a fundamental frequency instability.

关键词： Control interaction impedance power quality resonance stability wind generator

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Litterfall production modeling based on climatic variables and nutrient return from stands of Eucalyptus grandis hill ex Maiden and Pinus taeda L.

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Journal of Forestry Research 2024年第5期35卷 26-36页

作者： andrés Baietto andrés hirigoyen Jorge hernández Amabelia del Pino Forest Department Faculty of AgronomyUniversity of the Republic12900 MontevideoUruguay National Research Program of Forest Production National Agriculture Research InstituteINIA97000 TacuarembóUruguay Soil and Water Department Faculty of AgronomyUniversity of the Republic12900 MontevideoUruguay

Native grasslands in the Pampas of South America are increasingly being replaced by Eucalyptus and Pinus *** short rotation regimes used for the stands require high nutrient levels,with litterfall being a major source of nutrient *** model the litterfall production using climatic variables and assess the nutrient return in 14-year-old Eucalyptus grandis and Pinus taeda stands,we measured litter production over 2 years,using conical litter traps,and monitored climatic *** temperature,accumulated precipitation,and mean maximum vapor pres-sure deficit at the seasonal level influenced litterfall produc-tion by ***;seasonal accumulated precipitation and mean maximum temperature affected litterfall by *** regression tree modeling based on these climatic vari-ables had great accuracy and predictive power for ***(N=33;MAE(mean absolute error)=0.65;RMSE(root mean square error)=0.91;R^(2)=0.71)and ***(N=108;MAE=1.50;RMSE=1.59;R^(2)=0.72).The nutrient return followed a similar pattern to litterfall deposition,as well as the order of importance of macronutrients(***:Ca>N>K>Mg>P;***:N>Ca>K>Mg>P)and micronutrients(*** and ***:Mn>Fe>Zn>Cu)in both *** study constitutes a first approximation of factors that affect litterfall and nutrient return in these systems.

关键词： Afforestation Litterfall Nutrient recycling Climate modeling Myrtaceae Pinaceae

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Surface movement above old coal longwalls after mine closure

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International Journal of Mining Science and Technology 2017年第3期27卷 481-490页

作者： andré Vervoort Pierre-Yves Declercq Department of Civil Engineering KU Leuven Leuven 3001 Belgium Geological Survey of Belgium Royal Belgian Institute of Natural Sciences Brussels 1000 Belgium

Although most subsidence occurs in the months and years after mining by the longwall method, surface movement is still occurring many decades after the mining. The aim of the study is to quantify the long term behavior. Satellite data(radar-interferometry) were analyzed to study an area of about 2 km^2 during the 18 years following the closure of the underground infrastructure and the flooding of the underground workings and rock mass. It was observed that, on average, a residual downward movement took place till 7–12 years after the closure, followed by a clear uplift. however, the first signs of an uplift occurred in certain sub-areas 3–4 years after the closure. Zones within the area studied were identified with either larger or smaller movements. however, the spatial variation of the surface subsidence or uplift could not be directly explained by the characteristics of mining.

关键词： Coal mining Surface movement Subsidence Uplift Radar-interferometry

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Electrocardiographic and echocardiographic dyssynchrony parameters that might better predict the response to cardiac resynchronization therapy than QRS morphology and duration

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Journal of Geriatric Cardiology 2022年第2期19卷 98-100页

作者： andrás Vereckei Department of Medicine and hematology Semmelweis UniversityBudapestHungary

Cardiac resynchronization therapy(CRT)is an evidence-based effective therapy of symptomatic heart failure with reduced ejection fraction refractory to optimal medical ther-apy and associated with intraventricular conduction disturbance,that results in a significant electrical ventricular ***,the non-response rate to CRT is still 20%−40%.[1]The potential underlying causes of CRT nonresponse are:(1)suboptimal localization of the left ventricular(LV)electrode,far away from the latest activated LV region.

关键词： ventricular synchronization echocardiographic

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Upward surface movement above deep coal mines after closure and flooding of underground workings

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International Journal of Mining Science and Technology 2018年第1期28卷 53-59页

作者： andré Vervoort Pierre-Yves Declercq Department of Civil Engineering KU Leuven Geological Survey of Belgium Royal Belgian Institute of Natural Sciences

After the mass closures of entire coal mine districts in Europe at the end of the last century, a new phenomenon of surface movement was observed—an upward *** most surface movement(i.e., subsidence) occurs in the months and years after mining by the longwall method, surface movement still occurs many decades after mining is *** the closure and flooding of underground excavations and surrounding rock, this movement was *** paper focuses on quantifying the upward movement in two neighboring coal mines(Winterslag and Zwartberg, Belgium).The study is based on data from a remote sensing technique: interferometry with synthetic aperture radar(INSAR).The results of the study show that the rate of upward movement in the decade after closure is about 10 mm/year on *** upward movements are not linked directly to the past exploitation directly underneath a *** amounts of subsidence at specific locations are linked mainly to their positions relative to an inverse trough shape situated over the entire mined-out areas and their immediate *** features, such as geological faults, can have a secondary effect on the local variation of the *** processes of subsidence and uplift are based on completely different *** is initiated by a caving process, while the process of uplift is clearly linked to flooding.

关键词： Coal mining Surface movement Subsidence Uplift Radar-interferometry

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Cobalamin deficiency as an extra intestinal manifestation of helicobacter pylori infection

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World Journal of Gastroenterology 2015年第11期21卷 3447-3448页

作者： Emmanuel andrès Department of Internal Medicine University Hospital of Strasbourg

We read with great interest the excellent review by Wong et al on extra intestinal manifestations of helicobacter pylori(***) infection published in the *** is a well-documented and structured ***,I believe that Wong ... 详细信息

关键词： Cobalamin deficiency helicobacter pylori Food-coba

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The exercise-cognition relationship:A virtuous circle

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Journal of Sport and health Science 2019年第4期8卷 339-347页

作者： Michel Audiffren Nathalie andré Research Institute on Cognition and Learning (UMR CNRS 7295) University of PoitiersSport Sciences Faculty

Exercise and health psychology have generated 2 sets of empirical studies guided by separate theory-driven *** first axis focuses on the causal relationship between chronic exercise and cognition and,more particularly,high-level cognitive functions such as executive functions(EFs).The second axis examines factors influencing the adherence process to physical activity(PA).Research conducted during the past decade shows that these 2 topics are closely linked,with EFs and effortful control playing a pivotal role in the bidirectional relationship linking PA and mental/brain *** present article supports the idea that an individual engaged in the regular practice of effortful PA initiates a virtuous circle linking PA and effortful control in a bidirectional *** the one hand,chronic exercise leads to an improvement of EFs and effortful *** the other hand,gains in EFs and effortful control effectiveness lead to a reciprocal facilitation of the maintenance of PA over *** limitations and perspectives to this effort hypothesis are proposed in the last part of the article.

关键词： Adherence Effort Executive functions Physical activity Salience network

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