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Spectrum of Hypertriglyceridemia at the Onset of Type 2 Diabetes in Ouagadougou

Open Journal of Internal Medicine 2020年第1期10卷 83-89页

作者： Oumar Guira Réné Bognounou Lassané Zoungrana Aline Tonde andré nagalo Réné Traore Joseph Youssouf Drabo Unité de Formation et de Recherche en Sciences de la Santé Université Joseph Ki Zerbo Ouagadougou Burkina Faso Service de Médecine Interne Centre Hospitalier Universitaire Yalgado Ouédraogo Ouagadougou Burkina Faso Laboratoire de Biochimie Centre Hospitalier Universitaire Yalgado Ouédraogo Ouagadougou Burkina Faso

Introduction: Hypertriglyceridemia is a frequent dyslipidemia in type 2 diabetes. We aimed to determine its prevalence, its typology, and its associated factors in newly type 2 diabetes patients in Ouagadougou. Material and Method: This cross-sectional, descriptive and analytic study has been performed from May 2015 to June 2016 in the Internal medicine department in Yalgado Ouédraogo teaching hospital, Ouagadougou. An accidental sample of newly type 2 diabetes outpatients, na?ve of antidiabetics therapy was studied. A 12-hour fasting triglyceridemia was performed;hypertriglyceridemia was defined for triglyceridemia > 1.5 g/L (1.7 mmol/L). Data were analyzed with Epi info 7.***.5.0. Proportions and means were compared respectively with Khi2 or Fisher’s test and Student’s test with a significance of p Results: One hundred and three patients, i.e. 35 (34%) men and 68 (66%) women were included. The sex ratio was 0.51 and the mean age 49.3 ± 10.1 years [limits: 24 and 70]. The mean value of triglyceridemia was 1.8 ± 1.7 mmol/L [limits: 0.5 and 14.9]. Hypertriglyceridemia was reported in 32 patients (31.1%): minor (11.30 mmol/L) in one (3.1%) patients. Hypertriglyceridemia’s phenotype was commonly integrated into a mixed dyslipidemia;it was often combined with a total cholesterolemia increase and a HDL cholesterolemia decrease. In bivariate analysis, hyperglycemia was associated with severe hyperglycemia (p = 0.006) and renal failure (p = 0.03). Conclusion: Hypertriglyceridemia in type 2 diabetes is frequent and often combined with other lipids disorders. It may need an optimal care.

关键词： Hypertriglyceridemia Type 2 Diabetes Burkina Faso

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Can the Urine Dipstick Test Be an Alternative in the Screening of Urinary Tract Infections for Inpatients in the Context of a Low-Income Country?

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Advances in Infectious Diseases 2023年第4期13卷 627-640页

作者： andré nagalo Odilon D. Kaboré Senkaye-Lagom Aimée Kissou Hervé Kafando Boukary Kabré Emmanuel Zongo Cheick Ahmed Ouattara Yacouba Sawadogo Aoua Semdé Jacques Zoungrana Armel Poda Sylvain Godreuil Abdoul-Salam Ouédraogo Bacteriology-Virology Laboratory Sour&#244 Sanou University Hospital Bobo-Dioulasso Burkina Faso Biomedical Analysis Laboratory Regional University Hospital of Ouahigouya Ouahigouya Burkina Faso Department of Medical Pediatrics Sour&#244 Sanou University Hospital Bobo-Dioulasso Burkina Faso Bacteriology-Virology Laboratory Yalgado Ouedraogo University Hospital Ouagadougou Burkina Faso Department of Urology-andrology Regional Hospital of Tenkodogo Tenkodogo Burkina Faso Information Epidemiology Research and Planning Department Sour&#244 Sanou University Hospital Bobo-Dioulasso Burkina Faso Department of Nephrology-Hemodialysis Sour&#244 Sanou University Hospital Bobo-Dioulasso Burkina Faso Department of Infectious Diseases Sour&#244 Sanou University Hospital Bobo-Dioulasso Burkina Faso Laboratory of Bacteriology of the Arnaud de Villeneuve University Hospital Montpellier France

Background: Urinary Tract Infection (UTI), a prevalent bacterial infection in adults, heavily relies on cytobacteriological examination of urine (CBEU) for diagnosis. However, in resource-limited countries, accessibility to CBEU remains hindered by cost and availability. This study aims to assess the utility of the Urinary Dipstick Test (UDT) in diagnosing UTIs among hospitalized patients in the context of limited resources. Methods: A cross-sectional study was conducted from February to May 2019, encompassing hospitalized patients who underwent CBEU at the bacteriology unit of Sour? Sanou University Hospital. UDT and CBEU were concurrently performed, and UDT’s analytical and diagnostic performance was evaluated against CBEU, considered the gold standard. Results: A total of 274 CBEU requests were registered, involving 274 patients (159 males) with a mean age of 45.8 ± 21.3 years (ranging from 1 to 90 years). UTI was confirmed in 90 patients, yielding a frequency of 32.85%. The UTI bacteriological profile was dominated by Enterobacteriaceae (75.23%), primarily Escherichia coli (60.55%). Nitrite and Leukocytes were positive in 54 (19.8%) and 157 (53.6%) of the samples tested. Among patients with confirmed UTI, Nitrite, and Leukocytes were positive in 30 (33%) and 71 (79%) patients respectively. UDT demonstrated variable performance based on nitrite and leukocyte combination: Sensitivity (57%-82%), Specificity (7%-98%), Positive Predictive Value (PPV) (43%-57%), Negative Predictive Value (NPV) (43%-67%). UDT performed slightly better in women (NPV = 88%) and inpatients without urinary catheters (NPV = 75% and PPV = 80%). Conclusion: This study underscores UDT’s potential utility in excluding UTIs among women, younger patients, and inpatients without urinary catheters, albeit with limited confidence. The UDT emerges as a complementary tool for UTI screening, particularly in resource-limited settings.

关键词： Urine Dipstick Test Urinary Tract Infection LMICs Burkina Faso

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