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Anti-Candida and anti-Cryptococcus evaluation of 15 non-alkaloidal compounds from Pterogyne nitens

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Asian Pacific Journal of Tropical Biomedicine 2016年第10期6卷 841-845页

作者： Caroline Sprengel Lima Carlos Roberto Polaquini Mariana Bastos dos Santos Fernanda Patricia Gullo Fernanda Sangalli Leite Liliane Scorzoni Vanderlan da Silva Bolzani Maria Jose Soares Mendes-Giannini Ana Marisa Fusco-Almeida andréia Alves Rezende luis Octavio Regasini Laboratory of Green and Medicinal Chemistry Department of Chemistry and Environmental Sciences Institute of Biosciences Letters and Exact Sciences Sao Paulo State University (UNESP) Department of Clinical Analysis School of Pharmaceutical Sciences Sao Paulo State University (UNESP) Department of Organic Chemistry Institute of Chemistry Sao Paulo State University (UNESP) Department of Biology and Animal Sciences Faculty of Engineering Sao Paulo State University (UNESP)

Objective: To evaluate anti-Candida and anti-Cryptococcus activities of 15 nonalkaloidal compounds from Pterogyne nitens Tulasne(Leguminosae), a South American medicinal ***: Compounds were submitted to antifungal assays, using microdilution method described by Clinical and Laboratory Standards Institute document, with minor modifications. Five species of Candida and two species of Cryptococcus, including clinical isolates were screened. Antifungal activity was expressed by minimum inhibitory concentration(MIC). Amphotericin B and fluconazole were used as standard antifungal ***: Among tested compounds, six substances presented fungal growth inhibition(MIC < 31.2 mg/m L) [three flavone derivatives(1–3), a glycosylated flavonol derivative(5)and two phenolic acids(10 and 12)]. Sorbifolin(1), exhibited potent antifungal activity,demonstrating MIC value of 3.90 mg/m L against Candida glabrata ATCC 90030, Cryptococcus gattii 118 and fluconazole-resistant clinical isolate of Cryptococcus neoformans var. grubii. Pedalin(2) and nitensoside B(3), two glycosylated flavone derivatives, were active against Cryptococcus neoformans ATCC 90012(MIC = 7.80 mg/m L).Conclusions: Flavone derivatives from Pterogyne nitens can serve as prototypes for the design and development of innovative anti-Candida and anti-Cryptococcus hits.

关键词： Candida Cryptococcus Antifungal Pterogyne nitens Flavonoid Opportunistic fungi

Carbon-13 Solid State NMR Techniques to Evaluate the Morphology of PP/TiO₂ Composites

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Materials Sciences and Applications 2016年第1期7卷 20-25页

作者： Igor Lopes Soares Maria Inês Bruno Tavares andré luis B. B. e Silva Antonio Gabriel Malagueta Feio Instituto de Macromoléculas Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil Instituto Federal do Mato Grosso IFMT Mato Grosso Brazil CENIMAT/I3N Departamento de Ciência dos Materiais Faculdade de Ciências e Tecnologia Universidade Nova de Lisboa Caparica Portugal

Solid state NMR was successfully used to determine the proton spin-lattice relaxation time in the rotating frame (T1ρH) for systems based on polypropylene (PP) and PP with titanium dioxide (TiO2) organically modified or unmodified incorporated, in order to understand the molecular behavior of these systems. These techniques were employed in the samples organically modified and unmodified TiO2 to investigate the effect of organic modification on the dispersion and distribution of the particles in the PP matrix. The results were analyzed in terms of the effect of the particles organic modified or not according to the intermolecular interaction in the composites. According to the T1ρH values, all composites showed at least two domains: the short values were related to the rigid part, which included the crystalline and amorphous phase constricted in it, while the longer times were attributed to the amorphous region, which had higher molecular mobility compared to the rigid region of the materials. The increase in the relaxation time parameter in the composites compared to the pure PP was associated to the strong interaction between titanium dioxide particles and the polymer chains. This effect was more pronounced for the systems containing organically modified TiO2. According to the results, it could be inferred that intermolecular interaction occurred in the CH2 and CH groups, being more intense with CH2 groups. Finally, the solid state NMR techniques were able to evaluate the molecular dynamics of those systems.

关键词： NMR PP TiO2 Composites

Calciphylaxis in Patients with Chronic Kidney Disease Case Presentation and Review

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Open Journal of Nephrology 2021年第3期11卷 335-347页

作者： José Lucas Daza María Camila Correcha Ferro andrés David Cárdenas luis Daza Ivan Ortega Jonathan de Jong John Galindo Gerardo Gutiérrez luis Puello Yaroslad de la Cruz Nephrology Unit Hospital De Clinicas Buenos Aires Argentina Departmentof Medicine Manizales University Manizales Colombia Departmentof Medicine Cooperativa University Ibague Colombia Hematology Unit Fluminense University Rio de Janeiro Brazil Nephrology Unit Fresenius Medical Care Ibague Colombia

Calciphylaxis is a serious disorder that presents itself as ischemia and ne-crosis of the skin which occurs more frequently in patients with an end-stage chronic kidney disease, but not exclusively. The pathogenesis is a result of the reduction of arteriolar blood flow, caused by calcification, fibrosis, and thrombus formation that primarily involve the arterioles of the dermis and hypodermis, with a poor prognosis. Case presentation: A 44-year-old patient with a previous diagnosis of chronic kidney disease receiving hemodialysis secondary to polycystic kidney disease, with a history of parathyroidectomy due to primary hyperparathyroidism in 2011. In 2014 the patient presented skin lesions, for which a diagnostic biopsy of calciphylaxis was performed and began treatment with sodium thiosulfate with a poor progression and evolution. New histology compatible with the diagnosis of pyoderma gangrenosum and findings of calciphylaxis were performed. The patient begins treatment with corticosteroids and cyclosporine, with poor clinical evolution and the patient eventually passes away. The objective of this manuscript is to understand this pathology better, which is infrequent but with a high rate of morbidity and mortality.

关键词： Calciphylaxis Vascular Calcification Syndrome Calcific Uremic Arteriolopathy

Multiple-Organ Extracorporeal Support Therapies in Critically Ill Patients

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Open Journal of Nephrology 2021年第2期11卷 281-293页

作者： José Lucas Daza María C. Correcha Ferro andrés David Cardenas luis Daza Emilio Rey Jonathan de Jong John Galindo Gerardo Gutiérrez luis Puello Yaroslad de la Cruz Nephrology Unit Hospital De Clinicas Buenos Aires Argentina Department of Medicine Manizales University Manizales Colombia Department of Medicine Cooperativa University Ibague Colombia Hematolology Unit Fluminense University Rio de Janeiro Brasil Nephrology Unit Fresenius Medical Care Ibague Colombia

The critically ill patient is capable of presenting a multiple organ dysfunction syndrome (MODS) caused by different diseases, which can be infectious (sepsis, septic shock) as well as non-infectious (pancreatitis, large surgeries, traumatic injuries, burn patients and brain injuries), this syndrome is characterized by global hemodynamic and organ perfusion alterations accompanied by an uncontrolled and marked inflammatory response unresponsive to pharmacological treatment due to which extracorporeal organ support can be a viable option. Acute renal lesion can occur in up to 60% of patients receiving intensive care, and close to 10% - 20% require renal replacement therapy (RRT) globally this can be provided as peritoneal dialysis (PD) or intermittent hemodialysis (IHD), continuous renal replacement therapy (CRRT), hybrid therapies known as sustained slow efficiency dialysis (SLED), which combines the benefits IHD and CRRT, slow continuous ultrafiltration (SCUF). Extracorporeal membrane oxygenation (ECMO) and extracorporeal elimination of CO2, have been used more frequently lately, these are temporal artificial support used for respiratory and/or cardiac insufficiency that is refractory to conventional treatment. Acute liver failure in adults has a mortality rate close to 50% furthermore one-third of patients hospitalized for cirrhosis are likely to progress to acute liver failure which will drastically increase its mortality. Based on concepts of albumin dialysis, one of its most known is the following: Molecular Adsorbent Recirculating System (MARS), Fractionated Plasma Separation and Absorption—FPSA (Prometheus®) and also, hemoperfusion with different cartridges used in different extracorporeal therapies, used in liver failure, rhabdomyolysis, cytokine release syndrome and more in the context of the pandemic covid19. The objective of this review is to know the different extracorporeal therapies and the therapeutic utility in critical patients

关键词： MODS (Multiple Organ Dysfunction Syndrome) RRT (Renal Replacement Therapy CRRT (Continuous Renal Replacement Therapy) SLED (Slow Efficiency Dialysis ECMO (Extracorporeal Membrane Oxygenation) ECCO2 (Extracorporeal Elimination of Carbon Dioxide) ARDS (Acute Respiratory Distress Syndrome) AKI (Acute Kidney Injury)

Height-to-diameter ratios with temporal and dendro/morphometric variables for Brazilian pine in south Brazil

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Journal of Forestry Research 2021年第1期32卷 191-202页

作者： andre Felipe Hess Myrcia Minatti Emanuel Arnoni Costa luis Paulo Baldissera Schorr Gabriel Teixeira da Rosa Isadora de Arruda Souza Geedre Adriano Borsoi Veraldo Liesenberg Thiago Floriani Stepka Roberta Abatti Department of Forest Engineering Santa Catarina State University2090 Luiz de Camoes AvenueLagesSanta Catarina State 88520-000Brazil Department of Forest Engineering Federal University of Parana(UFPR)Pref.Lothario Meissner Ave.900CuritibaParana 80060-000Brazil

Height-to-diameter ratios(HD)are an important measure of the stability,density and competition of forest *** refl ects the vertical growth of the trees,the vulnerability of the forest canopy structure and infl uences volumetric *** ratios vary according to tree size,availability of resources for growth,stand density and species *** were taken from 210 trees and a regression technique of generalized linear models for the HD ratio applicable for forest structure conservation was *** objective of this study was to model the HD ratios of dominant and co-dominant trees of Araucaria angustifolia according to morphometric,dendrometric,annual diameter increment,stand density,and age variables in three sites in southern *** results show that the HD ratio decreases with increasing age,crown area and basal area,and increases with stand density and annual diameter *** of the developed equations was demonstrated by the values of deviation,Bayesian and Akaike *** results are of interest to forest managers since they make decisions about silvicultural *** continuity and forest production indicate that any intervention should be directed at younger trees of smaller sizes,and that one of the main management factors for stand stability and growth is the formation of the stand and its capture of light.

关键词： Forest management Mixed forests Conservation Araucaria angustifolia

Neural Network Approach to Modelling the Behaviour of Ionic Polymer-Metal Composites in Dry Environments

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Journal of Signal and Information Processing 2012年第2期3卷 137-145页

作者： andrés Díaz Lantada Pilar Lafont Morgado José luis Munoz Sanz Juan Manuel Munoz Guijosa Javier Echávarri Otero Mechanical Engineering Department—E.T.S.I.I.Industriales Universidad Politécnica de MadridMadridSpain

Ionic polymer-metal composites (IPMCs) are especially interesting electroactive polymers because they show large a deformation in the presence of a very low driving voltage (around 1 - 2 V) and several applications have recently been proposed. Normally a humid environment is required for the best operation, although some IPMCs can operate in a dry environment, after proper encapsulation or if a solid electrolyte is used in the manufacturing process. However, such solutions usually lead to increasing mechanical stiffness and to a reduction of actuation capabilities. In this study we focus on the behaviour of non-encapsulated IPMCs as actuators in dry environments, in order to obtain relevant information for design tasks linked to the development of active devices based on this kind of smart material. The non-linear response obtained in the characterisation tests is especially well-suited to modelling these actuators with the help of artificial neural networks (ANNs). Once trained with the help of characterisation data, such neural networks prove to be a precise simulation tool for describing IPMC response in dry environments.

关键词： Ionic Polymer-Metal Composites (IPMCs) Artificial Neural Networks (ANNs) Smart Materials Modelling and Simulation

Management of bone metastases in renal cell carcinoma: bone-targeted treatments, systemic therapies, and radiotherapy

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 628-639页

作者： andréMansinho Priscila Nejo Tito Leitão Sandra Casimiro Luís Costa Serviço de Oncologia Médica Centro Hospitalar Universitário Lisboa NorteHospital de Santa MariaLisboa 1649-035Portugal luis Costa Laboratory Instituto de Medicina MolecularFaculdade de Medicina da Universidade de LisboaLisboa 1649-035Portugal Instituto Português de Oncologia Lisboa Francisco Gentil Lisboa 1649-035Portugal Urology Department Centro Hospitalar Universitário Lisboa NorteHospital de Santa MariaLisboa 1649-035Portugal

Metastatic renal cell carcinoma(mRCC)presents with bone metastases in around 20%-30%of patients enrolled in the most recent first-line clinical *** of several new agents in first line,in both monotherapy and combination,has significantly improved patient ***,the activity of such agents on bone metastases is unclear and management of these patients is complex,due to potential complications that can significantly impair quality of *** review addresses mRCC diagnosis and monitoring and summarizes the current evidence on systemic therapy,ablative therapies such as stereotactic ablative radiotherapy and surgery,and supportive therapy with bone-targeting agents for these patients,with the goal of improving their outcomes.

关键词： Bone metastases renal cell carcinoma bone targeted treatments radiotherapy systemic therapy

Hemodialysis in Pregnant with Systemic Lupus Erythematosus: Case Report and Review

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Open Journal of Nephrology 2022年第1期12卷 48-59页

作者： José Lucas Daza Yaroslad de la Cruz John Fredy Galindo luis Puello Gerardo Gutiérrez María Camila Correcha Carlos Alban Daniel Soto andrés Cárdenas luis José Daza Néstor Guarnizo Abel Caraballo Internist-Nephrologist Ibague Colombia Internist-Nephrologist Cali Colombia General Physician Ibague Colombia Internist-Nephrologist Cartagena Colombia Internist-Nephrologist Villavicencio Colombia Medical Student Santa Marta Colombia Internist-Hematologist Cartagena Colombia General Physician University of Tolima Ibague Intensivist Phsysician Barranquilla Colombia

Systemic lupus erythematosus is an autoimmune disease with an etiopathogenesis that is still unclear. With a higher incidence in women of childbearing age. Pregnancy in patients suffering from this pathology is a constant challenge for multidisciplinary teams. The changes of pregnancy, especially to the immune system and the kidney, have repercussions on the renal compromise secondary to lupus. Lupus nephropathy is more active during pregnancy and leads to adverse outcomes for the mother-fetus binomial. The early identification of pregnant women with a higher risk of complications, access to health resources and the participation of a multidisciplinary team is the strategy that increases maternal-fetal survival. A report case of a 25-year-old black female with SLE and a 10-week pregnancy who was admitted to the emergency department with criteria for dialysis. The literature focused on lupus nephritis and dialysis in pregnancy was reviewed. Articles were reviewed in databases such as PubMed, Cochrane, among others, focused on the topic of pregnancy with SLE and pregnancy with dialysis. A total of 15 review articles, 2 meta-analyses, 3 observational studies and 6 cohort studies (3 prospective and 3 retrospective) were filtered.

关键词： Dialysis Lupus Nephritis Pregnancy Renal Disease and Systemic Lupus Erythematous

Primary Effusion Lymphoma in a HIV-1/2-Infected Patient

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World Journal of AIDS 2023年第3期13卷 116-124页

作者： Maria Caixas Lima Pedro Vasques andreia Paulos andré Valente Joana Santos Carla Antunes Matilde Gonçalves Maria Isabel Casella Nuno luis José Poças Department of Infectious Diseases Hospital de S&#227o Bernardo Centro Hospitalar de Setúbal Setúbal Portugal Department of General Surgery Hospital de S&#227o Bernardo Centro Hospitalar de Setúbal Setúbal Portugal Department of Hematology Hospital de Santo António dos Capuchos Centro Hospitalar Lisboa Central Lisboa Portugal Department of Anatomical Pathology Hospital de S&#227o Bernardo Centro Hospitalar de Setúbal Setúbal Portugal

Background: Primary effusion lymphoma (PEL) is a lymphoid proliferation related to Kaposi sarcoma herpesvirus 8/human herpesvirus 8 (KSHV/HHV8) that affects mainly human immunodeficiency virus (HIV) infected individuals but can also occur in other immunodeficiency settings. It is characterized by lymphomatous effusions in different serous body cavities without the presence of a detectable tumor mass. The diagnosis is challenging and the clinical outcomes are poor. Aim: The aim of this paper is to report a rare case of PEL in a man who have sex with women (MSW) with HIV-1/2 infection, history of visceral Kaposi sarcoma (KS) and the development of a seronegative arthritis previous to the lymphoproliferative disease diagnosis. PEL presented with ascites, was treated with high-dose chemotherapy and autologous stem cell transplantation, with a good clinical outcome. Case Presentation: We describe a case of a 48-year-old HIV-1/2-infected patient from a high HHV8 seroprevalent country, hospitalized following a three-month history of increased abdominal volume and general constitutional symptoms. Laboratory data revealed normocytic normochromic anemia and a high level of lactate dehydrogenase. A diagnostic paracentesis was performed with cytology compatible with high-grade B-cell lymphoma. Peritoneal fluid cytology showed large lymphoid cells expressing leucocyte-common antigen CD45 without expression of the CD20 antigen (B-lymphocytes) and positivity for HHV8 by immunocytochemical staining, compatible with the diagnosis of PEL.

关键词： Primary Effusion Lymphoma Acquired Immunodeficiency Syndrome HIV-1 HIV-2 Kaposi Sarcoma Herpesvirus 8/Human Herpesvirus 8 People Living with HIV