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Hereditary gastric cancer:Three rules to reduce missed diagnoses

World Journal of Gastroenterology 2020年第13期26卷 1382-1393页

作者： Paula Assumpcao Taíssa Araújo andré khayat Geraldo Ishak Sidney Santos Williams Barra Joao Felipe Acioli Benedito Rossi Paulo Assumpcao Programa de Pós-Graduacao em Genética e Biologia Molecular Universidade Federal do ParáBelém 66075-110Brazil Núcleo de Pesquisas em Oncologia Universidade Federal do ParáBelém 66073-000Brazil Hospital Universitário Joao de Barros Barreto Universidade Federal do ParáBelém 66073-000Brazil Centro de Oncologia e Aconselhamento Genético Hospital Sírio LibanêsSao Paulo 01308-050Brazil

Gastric cancer remains one of the most lethal cancers.The incidence and mortality rates are quite similar.The main reason for the high mortality is diagnosis at advanced stages of disease,when treatment options are poor.One of the supposed strategies to overcome late-stage diagnosis is identifying people at high risk with the aim of establishing rigorous clinical control,including routine endoscopy and biopsies.Hereditary gastric cancer(HGC)syndromes,though representing a sizeable group to monitor for prevention or,at least,for early diagnosis,are apparently extremely rare.The low rate of HGC diagnosis might be related to the low rates of suspicion,insufficient familiarity about clinical diagnosis criteria,and the supposed conditional necessity of a molecular diagnosis.In this review,we will discuss simple measures to increase HGC diagnosis by applying three rules that might provide an opportunity for precision care to benefit the families affected by this disease.

关键词： Hereditary gastric cancer Rules Diagnosis

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Insights into gastric neuroendocrine tumors burden

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Chinese Journal of Cancer Research 2017年第2期29卷 137-143页

作者： Taíssa Maíra Thomaz Araújo Williams Fernandes Barra andré Salim khayat Paulo Pimentel de Assumpcao Oncology Research Center Federal University of paráPara 66073-005Brazil

Type 1 gastric neuroendocrine tumors （gNETs） are usually small lesions, restricted to mucosal and sub-mucosal layers of corpus and fundus, with low aggressive behavior, for the majority of cases. Nevertheless, some cases present aggressive behavior. The increasing incidence of gNETs brings together a new relevant problem： how to identify potentially aggressive type I gNETs. The challenging problem seems to be finding out signs or features able to predict potentially aggressive cases, allowing a tailored approach, since the involved societies dedicated to provide guidelines for management of these neoplasms apparently failed in producing staging systems able to accurately predict prognosis of these tumors. Additionally, it is also important to try to find out explanations for increasing incidence, as well as to identify potential targets aiming to reach better control of this neoplasia. Here, we discuss potential pathways implicated in aggressive behavior, as well as new strategies to improve clinical management of these tumors.

关键词： gNETs gastrin receptor epidemiology

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Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer

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World Journal of Gastroenterology 2016年第35期22卷 7951-7962页

作者： Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior andré Salim khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno Núcleo de Pesquisas em Oncologia Universidade Federal do Pará Hospital Universitário Joao de Barros Barreto Disciplina de Genética Departamento de Morfologia e Genética Universidade Federal de Sao Paulo Laboratório de Citogenética Humana Instituto de Ciências Biológicas Universidade Federal do Pará

Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity.

关键词： Gastric cancer Epigenetic Diagnostic biomarkers miRNAs Prognostic biomarkers

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