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科学通报 2009年第7期54卷 533-534页

作者： andré berger Institut d'Astronomie et de Géophysique G Lemaǐtre Université Catholique de Louvain Chemin du Cyclotron 2 1348 Louvain-la-Neuve Belgium

人类有气象仪器记录的历史太短,不足以捕捉气候系统全部的变率,更难以用来预测未来数十年到数百年的气候变化.重建过去气候变化的历史、理解其机制和过程可以在很大程度上弥补上述不足.在气候系统中,由于季风的演化与变率对人类经济、... 详细信息

人类有气象仪器记录的历史太短,不足以捕捉气候系统全部的变率,更难以用来预测未来数十年到数百年的气候变化.重建过去气候变化的历史、理解其机制和过程可以在很大程度上弥补上述不足.在气候系统中,由于季风的演化与变率对人类经济、文化和生活节奏的许多方面均有重要影响,其研究工作对社会的重要性也日益增加．亚洲季风受欧亚大陆和印度洋．太平洋之间海陆热力差异及青藏高原的强烈影响，是气候系统非常重要的一个组成部分．

关键词：亚洲季风环流系统大气气候系统海陆热力差异气候变化气象仪器生活节奏

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古气候对于二氧化碳和太阳辐射的敏感性

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人类环境杂志 1997年第1期26卷 32-37页

作者： andré berger Marie-France Loutre 王普才章文星陈洪滨 Louvain天主教大学 G.Lemaitre天文和地球物理g/cm~2研究所

最近的第四纪大冰期的特点是全球气候经历了冰期和间冰期的多次相互转换。Louvain-La-Neuve的二维(高度-纬度)气候模型(LLN二维模型)已经被应用于模拟北半球气候的长期变化。这个模型每天和每个纬度都受到二氧化碳和太阳辐射强迫。这里... 详细信息

最近的第四纪大冰期的特点是全球气候经历了冰期和间冰期的多次相互转换。Louvain-La-Neuve的二维(高度-纬度)气候模型(LLN二维模型)已经被应用于模拟北半球气候的长期变化。这个模型每天和每个纬度都受到二氧化碳和太阳辐射强迫。这里分析的时期是从距今20万年以前到今后20万年。这个模型给出了整个大陆的冰含量,与SPECMAP 氧同位素记录比较吻合,各个北半球大冰原的大小和范围与它们的地质重构相当一致。已经做了7个模拟实验来量化太阳辐射和CO_2强迫以及反照率和水汽温度反馈对于末次盛冰期(LGM)时变冷的贡献。这个4.5℃的末次盛冰期降温20.8%是由于CO_2的影响,太阳辐射和反照率温度反馈的影响占40%,水汽的反馈占38.6%。如果我们将低CO_2浓度作为唯一的强迫,但让水汽变化,那么可以解释降温的33%。

关键词：古气候二氧化碳太阳辐射气候冰期敏感性

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Silver-integrated EDM processing of TiAl6V4 implant material has antibacterial capacity while optimizing osseointegration

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Bioactive Materials 2024年第1期31卷 497-508页

作者： Hilmar Büssemaker Ann-Kathrin Meinshausen Viet Duc Bui Joachim Döring Vadym Voropai Adrian Buchholz andreas J.Mueller Karsten Harnisch andré Martin Thomas berger andreas Schubert Jessica Bertrand Department of Orthopaedic Surgery Otto-von-Guericke University MagdeburgGermany Professorship Micromanufacturing Technology Chemnitz University of TechnologyChemnitzGermany Institute of Molecular and Clinical Immunology Otto-von-Guericke University MagdeburgGermany Health Campus Immunology Infectiology and InflammationOtto-von-Guericke University MagdeburgMagdeburgGermany Institute of Materials and Joining Technology Otto-von-Guericke UniversityMagdeburgGermany Fraunhofer Institute for Machine Tools and Forming Technology ChemnitzGermany

Periprosthetic joint infections(PJI)are a common reason for orthopedic revision *** has been shown that the silver surface modification of a titanium alloy(Ti-6Al-4V)by PMEDM(powder mixed electrical discharge machining)exhibits an antibacterial effect on Staphylococcus *** the thickness of the silver-modified surface influences the adhesion and proliferation of bacteria as well as the ossification processes and in-vivo antibacterial capacity has not been investigated ***,the aim of this work is to investigate the antibacterial effect as well as the in vitro ossification process depending on the thickness of PMEDM silver modified *** attachment of *** on the PMEDM modified surfaces was significantly lower than on comparative control samples,independently of the tested surface *** proliferation,however,was not affected by the silver content in the surface *** observed a long-term effect of antibacterial capacity in vitro,as well as in *** induction of ROS,as indicator for oxidative stress,was observed in the bacteria,but not in osteoblast-like *** influence on the in vitro osteoblast function was observed,whereas osteoclast formation was drastically reduced on the silver *** changes in cell death,the metabolic activity and oxidative stress was measured in *** show that already small amounts of silver exhibit a significant antibacterial capacity while not influencing the osteoblast ***,PMEDM using silver nano-powder admixed to the dielectric represents a promising technology to shape and concurrently modify implant surfaces to reduce infections while at the same time optimizing bone ingrowth of endoprosthesis.

关键词： alloy silver powder

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Targeting galectin-3 to counteract spike-phase uncoupling of fast-spiking interneurons to gamma oscillations in Alzheimer’s disease

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Translational Neurodegeneration 2023年第1期12卷 801-823页

作者： Luis Enrique Arroyo-García Sara Bachiller Rocío Ruiz Antonio Boza-Serrano Antonio Rodríguez-Moreno Tomas Deierborg Yuniesky andrade-Talavera andréFisahn Neuronal Oscillations Laboratory Division of NeurogeriatricsCenter for Alzheimer ResearchDepartment of NeurobiologyCare Sciences and SocietyKarolinska Institutet17164 SolnaSweden Experimental Neuroinflammation Laboratory Department of Experimental Medical ScienceLund UniversityBMC B1122184 LundSweden Clinical Unit of Infectious Diseases Microbiology and ParasitologyInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of Biochemistry and Molecular Biology University of SevilleCalle Profesor García González Nº241012 SevilleSpain Laboratory of Cellular Neuroscience and Plasticity Department of PhysiologyAnatomy and Cellular BiologyUniversidad Pablo de OlavideCarretera de Utrera Km-141013 SevilleSpain Department of Biosciences and Nutrition NeoKarolinska Institutet14183 HuddingeSweden

Background Alzheimer’s disease(AD)is a progressive multifaceted neurodegenerative disorder for which no disease-modifying treatment *** is central to the pathology progression,with evidence suggesting that microglia-released galectin-3(gal3)plays a pivotal role by amplifying neuroinflammation in ***,the possible involvement of gal3 in the disruption of neuronal network oscillations typical of AD remains *** Here,we investigated the functional implications of gal3 signaling on experimentally induced gamma oscillations ex vivo(20-80 Hz)by performing electrophysiological recordings in the hippocampal CA3 area of wild-type(WT)mice and of the 5×FAD mouse model of *** addition,the recorded slices from WT mice under acute gal3 application were analyzed with RT-qPCR to detect expression of some neuroinflammation-related genes,and amyloid-β(Aβ)plaque load was quantified by immunostaining in the CA3 area of 6-month-old 5×FAD mice with or without Gal3 knockout(KO).Results Gal3 application decreased gamma oscillation power and rhythmicity in an activity-dependent manner,which was accompanied by impairment of cellular dynamics in fast-spiking interneurons(FSNs)and pyramidal *** found that the gal3-induced disruption was mediated by the gal3 carbohydrate-recognition domain and prevented by the gal3 inhibitor TD139,which also prevented Aβ42-induced degradation of gamma ***-more,the 5×FAD mice lacking gal3(5×FAD-Gal3KO)exhibited WT-like gamma network dynamics and decreased Aβplaque *** We report for the first time that gal3 impairs neuronal network dynamics by spike-phase uncoupling of FSNs,inducing a network performance ***,our findings suggest gal3 inhibition as a potential therapeutic strategy to counteract the neuronal network instability typical of AD and other neurological disorders encompassing neuroinflammation and cognitive decline.

关键词： Galectin-3 Gamma oscillations Neuronal network dynamics Fast-spiking interneurons Alzheimer’s disease models Neuroinflammation TD139 Hippocampus

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Comparative Study of Linear and Non-Linear Controls of Three-Phase Shunt Active Filters for Improving the Quality of Electrical Energy

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Energy and Power Engineering 2019年第3期11卷 149-166页

作者： Mamane Adamou Nabil Alkassoum andré Foulani Amadou Seidou Maiga Department of Physics (FAST) Abdou MOUMOUNI University Niamey Niger Departments of Applied Physics Gaston Berger University Saint-Louis Senegal

The aim of this work is to comparatively study two types of control of a three-phase shunt active filter (TSAF) in order to realize a system of depollution of electrical networks so as to improve the quality of electrical energy. We used two TSA control models which differ in the method of disturbed currents detection, one linear and the other non-linear. The results show that the non-linear control method, although with high calculation blocks, gives more promising results than the linear control method. When connecting a non-linear load (televisions, lamps, variable speed drives, etc.) directly to the public distribution network, the non-linear nature of the load causes the source current to be deformed due to the presence of harmonic currents and voltages. These harmonics thus generate a high reactive power, and therefore considerable electrical losses in the network. One of the solutions to reduce losses on the electricity grid is to incorporate an electronic circuit called a filter into the electricity grid. This work carried out a comparative study of two types of control of a three-phase shunt active filter (TSAF) in order to carry out a system for cleaning up electricity networks in order to improve the quality of electrical energy. We used two TSA control models that differ in the method of detecting disturbed currents, one linear and the other non-linear. The results show that the non-linear control method, although with high calculation blocks, gives better results than the linear control method.

关键词： Power Quality Active Three-Phase Shunt Filter Non-Linear Control Linear Control

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