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Val279Phe variant of Lp-PLA2 is a risk factor for a subpopulation of Indonesia patients with acute myocardial infarction

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Genes & Diseases 2016年第4期3卷 289-293页

作者： Miryanti Cahyaningtias Mohammad Saifur Rohman Widodo andi wahjono adi Rina Yuda Yanna Indrayana Jayarani Fatimah Putri Rusdianto Mifetika Lukitasari Dadang Hendrawan Department of Cardiology and Vascular Medicine Faculty of MedicineBrawijaya UniversityMalangIndonesia Biology Department Faculty of Mathematics and Natural SciencesBrawijaya UniversityMalangIndonesia Pusat Studi Biosystem LPPMBrawijaya UniversityMalangIndonesia Nursing Science Faculty of MedicineBrawijaya UniversityMalangIndonesia Department of Cardiology and Vascular Medicine Brawijaya University HospitalMalangIndonesia

Lipoprotein-associated phospholipase A2(Lp-PLA2),a member of the phospholipase A2 superfamily,is an enzyme that hydrolyses phospholipids,is found in blood circulation as a sign of inflammation,and takes a role in *** is an epidemiologic relation between increased Lp-PLA2 levels and coronary heart ***-PLA2 is an enzyme that is produced by macrophages and takes a role as an independent predictor of a coronary event.A genetic variant of Val279Phe on the Lp-PLA2 gene has been reported with various results in Japan,China,Korea,and Caucasian *** study aims to analyse the influence of the Val279Phe genetic variant on acute myocardial infarction(AMI)at Saiful Anwar Hospital,*** study was conducted on 151 patients(111 AMI patients and 40 non-AMI patients).The genetic variant of Val279Phe was identified through a genotyping *** were no significant differences in age,total cholesterol level,LDL-C(low-density lipoprotein cholesterol)level,and family history data between AMI and non-AMI ***,AMI patients had low HDL-C(high-density lipoprotein cholesterol),triglyceride levels,dyslipidaemia,and hypertension risk factors compared to non-AMI *** frequency of the GG genotype(279Val)was dominant in both AMI and non-AMI *** analysis suggested that the GG genotype has a 2.9 times greater risk of AMI compared to the GT/TT genotype(279Phe).This study concluded that the Val279Phe genetic variant undoubtedly influenced AMI risk,which is a warrant for further development of early detection and improving strategy to prevent AMI in patients.

关键词： Acute myocardial infarction AMI predictor Atherosclerosis Lp-PLA2 Val279Phe

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