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Role of ion channels in gastrointestinal cancer

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World journal of Gastroenterology 2019年第38期25卷 5732-5772页

作者： Kyle j anderson Robert T Cormier Patricia M Scott Department of Biomedical Sciences University of Minnesota Medical School

In their seminal papers Hanahan and Weinberg described oncogenic processes a normal cell undergoes to be transformed into a cancer *** functions of ion channels in the gastrointestinal(GI)tract influence a variety of cellular processes,many of which overlap with these hallmarks of *** this review we focus on the roles of the calcium(Ca^2+),sodium(Na^+),potassium(K^+),chloride(Cl^-)and zinc(Zn^2+)transporters in GI cancer,with a special emphasis on the roles of the KCNQ1 K+channel and CFTR Cl-channel in colorectal cancer(CRC).Ca^2+is a ubiquitous second messenger,serving as a signaling molecule for a variety of cellular processes such as control of the cell cycle,apoptosis,and *** members of the TRP superfamily,including TRPM8,TRPM7,TRPM6 and TRPM2,have been implicated in GI cancers,especially through overexpression in pancreatic adenocarcinomas and down-regulation in colon ***-gated sodium channels(VGSCs)are classically associated with the initiation and conduction of action potentials in electrically excitable cells such as neurons and muscle *** VGSC NaV1.5 is abundantly expressed in human colorectal CRC cell lines as well as being highly expressed in primary CRC *** have demonstrated that conductance through NaV1.5 contributes significantly to CRC cell invasiveness and cancer ***2+transporters of the ZIP/SLC39A and ZnT/SLC30A families are dysregulated in all major GI organ cancers,in particular,ZIP4 up-regulation in pancreatic cancer(PC).More than 70 K+channel genes,clustered in four families,are found expressed in the GI tract,where they regulate a range of cellular processes,including gastrin secretion in the stomach and anion secretion and fluid balance in the intestinal *** distinct types of K+channels are found dysregulated in the GI *** are hERG1 upregulation in PC,gastric cancer(GC)and CRC,leading to enhanced cancer angiogenesis and invasion,and KCNQ1 down-regulation in CR

关键词： Ion channels Gastrointestinal cancer Colorectal cancer Gastric cancer Pancreatic cancer Esophageal cancer Hepatocellular carcinoma Prognostic biomarker Novel therapies Clinical targets

Thermodynamic description of the ternary compounds in the Cu-In-Se system

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Rare Metals 2006年第5期25卷 481-487页

作者： SHEN jianyun W.K. Kim SHANG Shunli CHU Maoyou CAO Song T.j. anderson Department of Chemical Engineering University of Florida Gainesville FL 32611 USA General Research Institute for Non-ferrous Metals of Beijing 100088 Beijing China

A set of thermodynamic descriptions of the temary compounds （mainly α-CulnSe2, δ-CulnSe2, Culn3Se5 and CulnsSe8） in the Cu-In-Se system was established by adopting sub-lattice model. The model parameters are carefully evaluated by integrating the experimental data of thermodynamic properties, phase equilibrium and theoretical calculation of formation energies of different point defects. The evaluated Gibbs energies of the compounds reasonably agree with that estimated from EMF experiment and ab initio calculation. The calculated phase relationships in the Cu-In-Se system are in accord with the experimental phase diagrams. The obtained standard enthalpy of formation of CulnSe2 is close to that reported in the literatures.

关键词： Cu-In-Se system thermodynamics Gibbs energy defect compound

Lactate as a regulator of iron homeostasis

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Life Metabolism 2023年第5期2卷 8-11页

作者： Gregory j.anderson David M.Frazer Iron Metabolism Laboratory QIMR Berghofer Medical Research InstituteBrisbaneQueensland 4006Australia Molecular Nutrition Laboratory QIMR Berghofer Medical Research InstituteBrisbaneQueensland 4006Australia

The key metabolic intermediate lactate can increase expression of the liver-derived peptide hepcidin,the central regulator of body iron homeostasis.A new paper by Liu et *** that lactate achieves this by binding to and activating soluble adenylyl cyclase,thereby increasing cellular cyclic adenosine monophosphate(cAMP)and enhancing signaling through the bone morphogenetic protein(BMP)pathway to modulate hepcidin expression.

关键词： expression thereby homeostasis

A numerical study on the influence of grain boundary oxides on dwell fatigue crack growth of a nickel-based superalloy

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journal of Materials Science & Technology 2022年第9期104卷 224-235页

作者： C.Z.Fang H.C.Basoalto M.j.anderson H.Y.Li S.j.Williams P.Bowen Department of Materials Science and Engineering University of SheffieldMappin StSheffield S13JDUK School of Metallurgy and Materials University of BirminghamEdgbastonBirmingham B152TTUK Institute of Structural Materials Swansea UniversitySwansea SA18ENUK

A theoretical treatment on the oxide-controlled dwell fatigue crack growth of aγ'strengthened nickelbased superalloys is *** particular,this study investigates the influence of an externally applied load and variations in theγ'dispersion on the grain boundary oxide growth kinetics.A dislocation-based viscoplastic constitutive description for high temperature deformation is used to simulate the stress state evolution in the vicinity of a crack at elevated *** viscoplastic model explicitly accounts for multimodalγ'particle size distributions.A multicomponent mass transport formulation is used to simulate the formation/evolution of an oxide wedge ahead of the crack tip,where stress-assisted vacancy diffusion is assumed to *** resulting set of constitutive and mass transport equations have been implemented within a finite element *** of predicted compositional fields across the matrix/oxide interface are compared with experiments and shown to be in good *** indicate that the presence of a fineγ'size distribution has a strong influence on the predicted ow stress of the material and consequently on the relaxation in the vicinity of the crack-tip/oxide *** is shown that a unimodal dispersion leads to reduced oxide growth rates(parabolic behavior)when compared to a bimodal *** conditions for oxide formation are investigated and is associated with the prediction of compressive stresses within the oxide layer just ahead of the crack tip,which become progressively negative as the oxide wedge ***,mechanical equilibrium requirements induce tensile stresses at the tip of the oxide wedge,where failure of the oxide is *** time taken to reach this critical stress for oxide failure has been calculated,from which dwell crack growth rates are computationally *** predicted rates are shown to be in good agreement with available experimental data.

关键词： Nickel based superalloy Dwell crack growth Gamma prime Creep Oxidation Dislocation-based modeling Multicomponent diffusion Finite element method

Assembly and metrology of NIF target subassemblies using robotic systems

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High Power Laser Science and Engineering 2017年第4期5卷 14-19页

作者： K.-j.Boehm N.Alexander j.anderson L.Carlson M.Farrell General Atomics P.O.Box 85608San DiegoCA 92186-5608USA

With European Laser Facilities such as the Extreme Light Infrastructure(ELI) and the Helmholtz International Beamline for Extreme Fields(HIBEF) scheduled to come online within the next couple of years, General Atomics, as a major supplier of targets and target components for the High Energy Density Physics community in the United States, is gearing up to meet their demand for large numbers of low cost targets. Using the production of a subassembly for the National Ignition Facility's fusion targets as an example, we demonstrate that through automation of assembly tasks, the design of targets and their experimental setup can be fairly complex while keeping the assembly time and cost as a minimum.A six-axis Mitsubishi robot is used in combination with vision feedback and a force–torque sensor to assemble target subassemblies of different scales and designs with minimal change of tooling, allowing for design flexibility and short assembly setup times. Implementing automated measurement routines on a Nikon NEXIV microscope further reduces the effort required for target metrology, while electronic data collection and transfer complete a streamlined target production operation that can be adapted to a large variety of target designs.

关键词： assembly automation hohlraum robotics target

Liver-gut axis in the regulation of iron homeostasis

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World journal of Gastroenterology 2007年第35期13卷 4737-4745页

作者： Deepak Darshan Gregory j anderson Iron Metabolism Laboratory The Queensland Institute of Medical ResearchBrisbaneAustralia

The human body requires about 1-2 mg of iron per day for its normal functioning, and dietary iron is the only source for this essential metal. Since humans do not possess a mechanism for the active excretion of iron, the amount of iron in the body is determined by the amount absorbed across the proximal small intestine and, consequently, intestinal iron absorption is a highly regulated process. In recent years, the liver has emerged as a central regulator of both iron absorption and iron release from other tissues. It achieves this by secreting a peptide hormone called hepcidin that acts on the small intestinal epithelium and other cells to limit iron delivery to the plasma. Hepcidin itself is regulated in response to various systemic stimuli including variations in body iron stores, the rate of erythropoiesis, inflammation and hypoxia, the same stimuli that have been known for many years to modulate iron absorption. This review will summarize recent findings on the role played by the liver and hepcidin in the regulation of body iron absorption.

关键词： Iron Homeostasis Intestinal iron absorption Liver Hepcidin

克洛斯湖地区花岗伟晶岩脉中磷灰石的PIXE分析

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原子能科学技术 1993年第3期27卷 248-255页

作者：马鑫培 j.D.MacArthur A.j.anderson 中国原子能科学研究院北京102413 加拿大

应用质子激发X 射线(PIXE)方法分析克洛斯湖地区花岗伟晶岩中的31个磷灰石样品。讨论在伟晶岩系统中稀土元素和其它痕量元素的行为以及磷灰石中元素浓度分布与地理位置的关系。围岩钾长石中钾铷的比值c_k/c_(Rb)一般被认为是“世代”和... 详细信息

应用质子激发X 射线(PIXE)方法分析克洛斯湖地区花岗伟晶岩中的31个磷灰石样品。讨论在伟晶岩系统中稀土元素和其它痕量元素的行为以及磷灰石中元素浓度分布与地理位置的关系。围岩钾长石中钾铷的比值c_k/c_(Rb)一般被认为是“世代”和结晶分异总体水平的指示。因此磷灰石中元素浓度对于钾长石中钾铷比值的相关图可以给出磷灰石中元素在“交代”过程中的“世代”差异。

关键词：花岗伟晶岩脉磷灰石 X射线谱 PIXE

Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

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四川生理科学杂志 2020年第4期42卷 468-468页

作者： Evan j anderson From the Center for Childhood Infections and Vaccines of Children’s Healthcare of Atlanta and the Department of Pediatrics Emory University School of Medicine (E.J.A. V.V.E. K.F. M.S.S. C.A.R.) and Emory Vaccine Center Yerkes National Primate Research Center Emory University (M.S.S.) Atlanta and Hope Clinic Department of Medicine Emory University School of Medicine Decatur (E.J.A. N.G.R. V.K.P.) — both in Georgia the Vaccine Research Center (A.T.W. A.B.M. B.F. B.C.L. N.A.D.-R. S.O. S.D.S. K.S.C. P.A.S. M.P. J.E.L. B.S.G.) and the Division of Microbiology and Infectious Diseases (P.C.R. M. Makhene W.B. C.J.L. J.H.B.) National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda the University of Maryland School of Medicine Baltimore (K.M.N.) and the Emmes Company Rockville (M. Makowski J.A. K.C.) — all in Maryland Kaiser Permanente Washington Health Research Institute Seattle (L.A.J.) the Department of Pediatrics (j.D.C. M.R.D. L.J.S. A.J.P.) the Vanderbilt Institute for Infection Immunology and Inflammation (J.D.C. M.R.D. A.J.P.) and the Departments of Pathology Microbiology and Immunology (M.R.D.) Vanderbilt University Medical Center Nashville Moderna Cambridge MA (H.B. B.L.) and the Departments of Epidemiology and Microbiology and Immunology University of North Carolina at Chapel Hill Chapel Hill (D.R.M. R.B.).

Background:Testing of vaccine candidates to prevent infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in an older population is important,since increased incidences of illness and death from co... 详细信息

关键词： vaccine acute respiratory

Fucoidan and topography modification improved in situ endothelialization on acellular synthetic vascular grafts

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生物活性材料(英文) 2023年第4期22卷 535-550页

作者： Yuan Yao Aung Moe Zaw Deirdre E.j.anderson Yejin jeong joshua Kunihiro Monica T.Hinds Evelyn K.F.Yim Department of Chemical Engineering University of Waterloo200 University Avenue WestWaterlooONN2L 3G1Canada Department of Biomedical Engineering Oregon Health&Science UniversityPortlandOR97239USA Waterloo Institute for Nanotechnology University of Waterloo200 University Avenue WestWaterlooONN2L 3G1Canada Center for Biotechnology and Bioengineering University of Waterloo200 University Avenue WestWaterlooONN2L 3G1Canada

Thrombogenesis remains the primary failure of synthetic vascular *** coverage is crucial to provide an antithrombogenic ***,most synthetic materials do not support cell adhesion,and transanastomotic endothelial migration is ***,a surface modification strategy using fucoidan and topography was developed to enable fast in situ endothelialization of polyvinyl alcohol,which is not endothelial *** three different immobilization approaches compared,conjugation of aminated-fucoidan promoted endothelial monolayer formation while minimizing thrombogenicity in both in vitro platelet rich plasma testing and ex vivo non-human primate shunt *** of six topographical patterns showed that 2μm gratings increased endothelial cell migration without inducing inflammation responses of endothelial *** studies demonstrated that fucoidan could attract fibronectin,enabling integrin binding and focal adhesion formation and activating focal adhesion kinase(FAK)signaling,and 2μm gratings further enhanced FAK-mediated cell *** a clinically relevant rabbit carotid artery end-to-side anastomosis model,60%in situ endothelialization was observed throughout the entire lumen of 1.7 mm inner diameter modified grafts,compared to 0%of unmodified graft,and the four-week graft patency also *** work presents a promising strategy to stimulate in situ endothelialization on synthetic materials for improving long-term performance.

关键词： Blood-contacting devices Small diameter vascular graft Endothelialization Topography Fucoidan