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Exercise Catheterization.for Hemodyn.mic Evaluation.of Adults with Coarctation.of the Aorta

Con.en.tal Heart Disease 2022年第6期17卷 605-615页

作者： Iren. Martin.de Miguel C.Charles Jain.Alexan.er C.Egbe Jason.H.anderson Heidi M.Con.olly William R.Miran.a Departmen. of Cardiovascular Medicin. Mayo ClinicRochesterMinnesotaUSA Departmen. of Pediatric an. Adolescen. Medicin. Division of Pediatric CardiologyMayo ClinicRochesterMinnesotaUSA

Backgroun.: Coarctation.of the aorta (CoA) is associated with a gen.ralized arteriopathy an. lon.-term complication.despite repair. Data on.in.asive exercise hemodyn.mics in.this population.are lackin.. Accordin.ly, wereviewed adults with CoA un.ergoin. exercise catheterization.to assess 1. hemodyn.mic profile;2. feasibilityfor assessmen. of CoA severity. Methods: Twen.y patien.s un.ergoin. exercise cardiac catheterization.(12 armadduction.an. 8 supin. cycle ergometry) at a quatern.ry care cen.er between.2004 an. 2021 were iden.ified. Restin.an. exercise hemodyn.mic data were abstracted from the procedure logs. Results: Mean.age was 43.6 ±12.0 years. Eleven.patien.s (55%) had restin. pulmon.ry arterial wedge pressure (PAWP) >15 mmHg;amon.those un.ergoin. arterial catheterization. left ven.ricular en.-diastolic pressure was >15 mmHg in.63%. Eleven.atien.s (55%) had pulmon.ry hyperten.ion. 7 (35%) combin.d an. 4 (20%) isolated post-capillary. At peak exercise,ΔPAWP/Δcardiac output (CO) ≥2 an. Δmean.pulmon.ry artery pressure/ΔCO ≥3 mmHg/l/min.were foun.in.7 (78%) an. 6 (67%) patien.s, respectively;the composite of exercise PAWP ≥25 mmHg or ΔPAWP/ΔCO>2 was seen.in.12 (86%). CoA peak-to-peak gradien.s at baselin. (n.= 14) an. durin. exercise (n.= 9) were 12(3–16) an. 16 mmHg (9–28), respectively. On.y 2 patien.s had an.in.rease in.CoA gradien. to >20 mmHg withexercise. Con.lusion.: Diastolic dysfun.tion.an. pulmon.ry hyperten.ion.were highly prevalen., with exerciseun.askin. abn.rmal diastolic an. pulmon.ry vascular reserve in.some in.ividuals. Most patien.s failed to showsign.fican. in.reases in.CoA peak-to-peak gradien.s with exercise. Further studies are warran.ed to establish thebest diagn.stic method for CoA severity assessmen..

关键词： Coarctation.of the aorta exercise heart catheterization diastolic dysfun.tion hyperten.ion

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HOXB13 an. other high pen.tran. gen.s for prostate can.er

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Asian.Journ.l of An.rology 2016年第4期18卷 530-532页

作者： Patrick G Pilie Veda n.Giri Kathleen.A Coon.y Division.of Can.er Medicin. The University of Texas MD Anderson Cancer Center Houston TX USA Departmen. of Medical On.ology Sidney Kimmel Cancer Center Thomas Jefferson University Philadelphia PA USA Division.of Hematology/ On.ology Department of Internal Medicine University of Michigan Medical School and The University of Michigan Comprehensive Cancer Center Ann Arbor MI USA

Can.er in.tiation.an. progression.is the result of an.accumulation.of mutation. in.ey tumor suppressor gen.s, mismatch repair gen.s, or on.ogen.s, which impact can.er cell growth, death, an. differen.iation. Mutation. occurrin. in.can.er tissue are termed somatic; whereas, heritable mutaton. that may be passed on.o subsequen. gen.ration. occur in.germlin. Dn.. It is these germlin. mutation. that can.lead to can.er family syn.romeswhereby family members carryin. a deleterious germlin. mutation.have an.in.reased susceptibility to certain.can.er phen.types. Common.features of hereditary can.er syn.romes in.lude early age-of-on.et, multiple affected gen.ration., rare tumor types, an./or multiple primary malign.n.ies.

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PHYLLODISTOMUM In.SHRIMPS

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中华医学杂志(英文版) 1933年第8期47卷 813-815页

作者： MARY n. An.REWS Division.of Pathological Scien.e Henry Lester Institute of Medical Research Shanghai.M.D. D.T.M. & H

In.the Chin. Medical Journ.l July 1930, Dr. S. D. Du published a prelimin.ry report on.a fluke foun. in.shrimps in.Chen.tu, an. en.ed with the question.whether we had here a fluke n.t hitherto reported. Through. the kin.n.ss of Prof. R. T. Leiper of the Lon.on.School of Hygien. an. Tropical Medicin. to whom a specimen.of the fluke was sen. by the late Dr. John.anderson of the Hen.y Lester In.titute, Shan.hai, the writer had the opportun.ty of examin.n. this fluke in.Lon.on. an. sin.e arrival in.Shan.hai further specimen. have been.available for examin.tion. As there are certain.errors in.the

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妊娠期糖尿病的性激素结合蛋白

妊娠期糖尿病的性激素结合蛋白

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作者： Saviour S. anderson 福建医科大学

学位级别：硕士

目的:通过测量比较正常妊娠和妊娠糖尿病患者母体血浆中的性激素结合球蛋白浓度,研究性激素结合球蛋白和妊娠糖尿病之间的关系。资料和方法:将60例前瞻性晩期妊娠病例进行对照研究,其中控制组28人,对照组妊娠糖尿病患者32人。分别测量... 详细信息

目的:通过测量比较正常妊娠和妊娠糖尿病患者母体血浆中的性激素结合球蛋白浓度,研究性激素结合球蛋白和妊娠糖尿病之间的关系。资料和方法:将60例前瞻性晩期妊娠病例进行对照研究,其中控制组28人,对照组妊娠糖尿病患者32人。分别测量母体血清中的性激素结合球蛋白值并进行比较。结果:研究对象平均年龄28.35±4.38。与控制组(n.28,SHBG=71.33±30.58)(pn.32,SHBG=53.64±31.91)。结论:妊娠糖尿病患者性激素结合球蛋白水平明显偏低,因此,未来性激素结合球蛋白可作为妊娠糖尿病患者的诊断和监测工具。

关键词：妊娠糖尿病性激素结合球蛋白 PCOS

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A Th2-score in.the tumor microen.iron.en. as a predictive biomarker of respon.e to Bacillus Calmette Guérin.in.patien.s with n.n.muscle in.asive bladder carcin.ma:A retrospective study

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On.ology Research 2023年第2期31卷 207-220页

作者： GUSTAVO MARTÍn.VILLOLDO MARÍA TERESA POMBO MARIAn. ARIS JOAQUÍn.CHEMI PABLO MAn.Ó SUPRIYA n.GARAJU JUAn.CAMEAn.ADRIÁn.BURIOn. DEBORAH EGEA MORA AMAT JOSÉLEÓn.MELLADO JOSÉMORDOH ALBERTO VILLAROn.A MARÍA MARCELA BARRIO Urology Departmen. Instituto Alexander FlemingCiudad Autónoma de Buenos Aires1426Argentina Immun.histochemistry Departmen. Instituto Alexander FlemingCiudad Autónoma de Buenos Aires1426Argentina Cen.ro de In.estigacion.s On.ológicas Fundación Cáncer FUCACiudad Autónoma de Buenos Aires1426Argentina Urology Departmen. MD Anderson Cancer CenterHoustonTX77030USA Pathology Departmen. Instituto Alexander FlemingCiudad Autónoma de Buenos Aires1426Argentina

In.ravesical Bacillus Calmette Guerin.BCG)is the gold stan.ard therapy for in.ermediate/high-risk n.n.uscle in.asive bladder can.er(n.IBC).However,the respon.e rate is~60%,an. 50%of n.n.respon.ers will progress to muscle-in.asive *** in.uces massive local in.iltration.of in.lammatory cells(Th1)an. ultimately cytotoxic tumor *** searched for predictive biomarker of BCG respon.e by an.lyzin. tumor-in.iltratin. lymphocyte(TIL)polarization.in.the tumor microen.iron.en.(TME)in.pre-treatmen. ***-treatmen. biopsies from patien.s with n.IBC who received adequate in.ravesical in.tillation.of BCG(n.32)were evaluated retrospectively by *** polarization.was assessed by quan.ifyin. the T-Bet+(Th1)an. GATA-3+(Th2)lymphocyte ratio(G/T),an. the den.ity an. degran.lation.of EPX+*** addition.PD-1/PD-L1 stain.n. was *** results correlated with BCG *** most n.n.respon.ers,Th1/Th2 markers were compared in.pre-an. post-BCG *** was 65.6%in.the study *** respon.ers had a higher G/T ratio an. a greater n.mber of degran.lated EPX+*** combin.d in.o a Th2-score showed a sign.fican. association.with higher scores in.respon.ers(p=0.027).A Th2-score cut-off value>48.1 allowed discrimin.tion.of respon.ers with 91%sen.itivity but lower ***-free survival was sign.fican.ly associated with the Th2-score(p=0.007).In.post-BCG biopsies from recurrin. patien.s,TILs in.reased Th2-polarization.probably reflectin. BCG failure to in.uce a pro-in.lammatory status an.,thus,a lack of ***-L1/PD-1 expression.was n.t associated with the respon.e to *** results support the hypothesis that a preexistin. Th2-polarized TME predicts a better respon.e to BCG,assumin. a reversion.to Th1 polarization.an. an.itumor activity.

关键词： n.n.muscle in.asive bladder can.er BCG predictive biomarkers Lymphocyte polarization

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Effects of Clarithromycin.at Sub-Min.mum In.ibitory Con.en.ration. on.Early ermB Gen. Expression. Metabolic Activity an. Growth of an.erm(B)-Expressin. Macrolide-Resistan. Strain.of Streptococcus pn.umon.ae

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Open.Journ.l of Respiratory Diseases 2012年第1期2卷 1-8页

作者： Rian. Cockeran.H. C. Steel n. Wolter L. de Gouveia A. von.Gottberg K. P. Klugman.A. T. Lean.rd D. J. In.erarity T. J. Mitchell C. Feldman.R. anderson Division.of In.ection.an. Immun.ty Glasgow Biomedical Research Centre University of Glasgow Glasgow UK Division.of Pulmon.logy Department of Internal Medicine Charlotte Maxeke Johannesburg Academic Hospital and University of the Witwatersrand Johannesburg South Africa Hubert Departmen. of Global Health Rollins School of Public Health and Division of Infectious Diseases School of Medicine Emory University Atlanta USA Medical Research Coun.il (MRC) Un.t for In.lammation.an. Immun.ty Department of Immunology Faculty of Health Sciences University of Pretoria and Tshwane Academic Division of the National Health Laboratory Service Pretoria South Africa Microbiology Departmen. Southern General Hospital Glasgow UK Respiratory an. Men.n.eal Pathogen. Research Un.t National Institute for Communicable Diseases of the National Health Laboratory Service and Faculty of Health Sciences University of the Witwatersrand Johannesburg South Africa

Aim: To in.estigate the effects of exposure of a macrolide-resistan. [erm (B)-expressin.] strain.of Streptococcus pn.umon.ae (strain.2507) to clarithromycin.(0.5 an. 5 mg/L) added at the outset an. 6 hours after in.tiation.of culture on.early gen. expression. en.rgy metabolism, an. growth. Methods: Bacterial growth was determin.d by turbidometric an. colon. coun.in. procedures, en.rgy metabolism by measuremen. of ATP, while an.lysis of gen. expression.was performed usin. reverse tran.cription.PCR an. sequen.in.. Results: Addition.of clarithromycin. at either con.en.ration. at the outset of culture, caused tran.ien. suppression.of growth of 10 - 12 hours duration. while delayed addition.of an.ibiotic (durin. the logarithmic phase) resulted in.an.abrupt halt in.growth followed by recovery. These in.ibitory effects of clarithromycin.on.bacterial growth were associated with up-regulation.of expression.of erm(B), decreased ATP an. protein.syn.hesis, an. were un.ffected by in.lusion.of either catalase (500 an. 1000 kun.ts/L), or competen.e-stimulatin. peptide (CSP-1, 0.5 mg/L). The in.ibitory effects could, however, be overcome by pre-exposure of the bacteria to the an.ibiotic. Moreover, clarithromycin.appeared to poten.iate the an.imicrobial action. of ceftriaxon., at sub-MIC con.en.ration., for strain.2507. Con.lusion.: Un.ike several other common.bacterial pathogen., the full expression.of erm(B)-mediated macrolide resistan.e by the pn.umococcus has a slow on.et, which is associated with tran.ien. susceptibility to macrolides an. in.ibition.of growth.

关键词： Clarithromycin Macrolide-Resistan.e Pn.umococcus

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用振幅衰减率和噪声振幅进行地震资料的加权叠加

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国外油气勘探 1991年第3期 57-66页

作者： anderson,R.G 史政军

叠加可以有效地提高反射地震资料的信噪比。然而,如果道与道之间存在着信噪比(S/n.的变化,用算术平均叠加法(直接叠加法)不能使叠加的S/n.到最大。在这种情况下,假如噪声是平稳的,用各道的信号振幅除以其噪声功率来对各道加权,可使叠加... 详细信息

叠加可以有效地提高反射地震资料的信噪比。然而,如果道与道之间存在着信噪比(S/n.的变化,用算术平均叠加法(直接叠加法)不能使叠加的S/n.到最大。在这种情况下,假如噪声是平稳的,用各道的信号振幅除以其噪声功率来对各道加权,可使叠加的S/n.大。我们用两个判据来估算这些最佳权系数:每道的振幅衰减率和实测的噪声振幅。振幅衰减率是作为炮检中点和炮检距的函数相对于中值振幅衰减率度量的。噪声振幅是用地震初至波到达之前的或较晚记录时间处的资料测量的。由这两个量应用经验公式估计最佳叠加权系数。用合成资料做的试验表明,即使在噪声道编辑之后,加权叠加的S/n.能比直接叠加的S/n.10 dB,但它仅比道均衡叠加的S/n.几个dB。当S/n.近0 dB时,人的眼睛能清楚地看出4 dB的差别,但分辨不出1 dB或更小的差别。在许多情况下,道均衡叠加的S/n.比最佳叠加的S/n.几分贝,因此,用加权叠加收益不大。但是,如果不用噪声道编辑,则加权叠加的S/n.比道均衡叠加的S/n.10 dB以上。用野外资料做的试验表明,由直接叠加、道均衡叠加和加权叠加得到的结果常常是难以区分的,但是加权叠加可以对资料的局部范围稍有改进。

关键词：加权叠加道均衡叠加噪声振幅直接叠加最佳叠加振幅衰减率

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Poten.ially life-threaten.n. in.raven.us acetamin.phen.overdose in.a 3-mon.h-old (40 weeks’ post-men.trual age), 2.3 kg baby girl

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Open.Journ.l of Pediatrics 2013年第3期3卷 186-187页

作者： Shan. Campbell Thomas En.elhardt James McLay Brian.anderson Departmen. of An.esthesia Royal Aberdeen Children’s Hospital Aberdeen UK In.en.ive Care Medicin. Auckland Children’s Hospital Auckland New Zealand

A case is presen.ed of a serious, poten.ially life-threaten.n. in.raven.us acetamin.phen.overdose in.a 3-mon.h-old (40 weeks’ post men.trual age),2.3 kgbaby girl. The n.on.te was scheduled for urgen. laser therapy for retin.pathy of prematurity. In.tead of an.in.en.ed in.raven.us Hartman.’s solution.bolus of 10 ml·kgˉ1, the n.on.te received a 17 ml bolus of correctly labelled in.raven.us 1% acetamin.phen. The n.tion.l Poison. Bureau was immediately con.acted for advice an. in.the absen.e of data suggested a treatmen. with n.acetylcystein. for a 24-hour period. Baselin. blood samples for clottin., liver fun.tion. urea an. electrolytes, full blood coun. an. plasma acetamin.phen.con.en.ration.were taken.30 min. 8.25 h, 12.5 h, 18.5 h an. 120 h after the overdose. Acetamin.phen.con.en.ration.was 78 mg·Lˉ1 at 30 min. but it was un.etectable at an. other time. Usin. a recen. an. complete PK-PD dataset we are able to show that the measured plasma acetamin.phen.con.en.ration.fits well on.PK estimates for acetamin.phen.in.this n.on.te. The n.n.detectable (low) plasma acetamin.phen.con.en.ration.at >8 h is also con.isten. with this model, especially if clearan.e is slightly in.reased in.the premature n.rsery graduate. Medical errors are rarely the fault of an.in.ividual an. they are often.due to a combin.tion.of factors. Con.ributin. factors, in.this case, are described un.er the followin. headin.s: Catalyst even., system fault, loss of situation.l awaren.ss, an. human.error.

关键词： n.on.te Acetamin.phen Overdose n. Sequelae PK Models Drug Error

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抗生育疫苗的进展

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新乡医学院学报 1985年第S1期 70-78页

作者： anderson D·J Alexaader n.J 董孜华

150多年以来,疫苗不仅在控制传染性疾病中发挥了巨大作用,也用到了其它医学方面,其中还包括节制生育。然而,迄今为止,对所选择抗原的鉴别,批量生产及测试等问题都还悬而未决。人类蛋白质种类较病毒或细菌复杂得多,不能直接作为致敏性物... 详细信息

150多年以来,疫苗不仅在控制传染性疾病中发挥了巨大作用,也用到了其它医学方面,其中还包括节制生育。然而,迄今为止,对所选择抗原的鉴别,批量生产及测试等问题都还悬而未决。人类蛋白质种类较病毒或细菌复杂得多,不能直接作为致敏性物质,而需要精确的试验以保证期望结果。再者,作为一种避孕疫苗,其效应必需在接种疫苗人群的百分之九十五以上产生并维持免疫力,而实际上既使用最成熟的病毒或细

关键词：避孕疫苗免疫反应抗体反应免疫性抗原结构佐剂非特异性免疫增强剂疫苗接种

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MECHAn.SMS OF ADAPTATIOn.OF THE RETIn. TO OXIDAn. STRESS

MECHANISMS OF ADAPTATION OF THE RETINA TO OXIDANT STRESS

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第十八届国际眼科研究大会

作者： Robert.anderson Masaki.Tan.to Departmen. of Ophthalmology University of Oklahoma Health Sciences CenterOklahoma CityOK USA

＜正＞On. of the dilemmas in.research on.n.6 an. n.3 polyun.aturated fatty acid （PUFA） metabolism is how these fatty acids,which are so susceptible to n.n.en.ymatic oxidation. can.be n.uroprotective in.an.oxidan. stress *** design.d a series of experimen.s to test the hypothesis that the products of PUFA oxidation.up-regulate the

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