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MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits

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Neural Regeneration Research 2025年第5期20卷 1431-1444页

作者： Yuehua Cui Xiaokuang Ma Jing Wei Chang Chen Neha Shakir Hitesch Guirram Zhiyu Dai Trent anderson Deveroux Ferguson Shenfeng Qiu Basic Medical Sciences University of Arizona College of Medicine-PhoenixPhoenixAZUSA Department of Medicine University of Arizona College of Medicine-PhoenixPhoenixAZUSA

Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse *** have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine *** investigate whether enhancing MET in adult cortex has synapse regenerating potential,we created a knockin mouse line,in which the human MET gene expression and signaling can be turned on in adult(10–12 months)cortical neurons through doxycycline-containing *** found that similar to the developing brain,turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection *** findings are further corroborated by increased synaptic activity and transient generation of immature silent *** MET signaling resulted in an increasedα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-Daspartate(AMPA/NMDA)receptor current ratio,indicative of enhanced synaptic function and *** data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult *** findings may have implications for regenerative therapy in aging and neurodegeneration conditions.

关键词： aging circuit connectivity cortical circuits molecular mechanisms neural regeneration neurodegeneration synapses

Subsidence over room and pillar retreat mining in a low coal seam

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International Journal of Mining Science and Technology 2019年第1期29卷 51-57页

作者： Andre Zingano anderson Weiss Mining Engineering Department University Federal of Rio Grande do Sul Carb.Do CambuíInc.

The objective of this paper is to study the behavior of a low thick and low depth coal seam and the overburden rock mass. The mining method is room and pillar in retreat and partial pillar recovery. The excavation method is conventional drill and blast because of the small production. The partial pillar recovery is about 30% of the previous pillar size, 7 m × 7 m. The roof displacement was monitored during retreat operation; the surface movement was also monitored. The effect of the blasting vibration on the final pillar strength had been considered. Due to blasting, the pillar reduced about 20%. The consequence is more pillar deformation and roof vertical displacement. The pillar retreat and ground movement were simulated in a three-dimensional numerical model. This model was created to predict the surface subsidence and compare to the subsidence measured. This study showed that the remaining pillar and low seam reduce the subsidence that was predicted with conventional methods.

关键词： Subsidence Room-and-pillar mining Retreat mining Coal

Robust control for electric vehicle powertrains

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Control Theory and Technology 2019年第4期17卷 382-392页

作者： Johannes BUERGER James anderson BMW Group MunichGermany Department of Computing and Mathematical Sciences the California Institute of TechnologyPasadenaU.S.A.

This paper considers the application of robust control methods(μ-and H∞-synthesis)to the speed and acceleration control problem encountered in electric vehicle *** this end,we consider a two degree of freedom control structure with a reference *** underlying powertrain model is derived and combined into the corresponding interconnected system required forμ-and H∞-*** closed-loop performance of the resulting controllers are compared in a detailed simulation analysis that includes nonlinear *** is observed that theμ-controller offers performance advantages in particular for the acceleration control problem,but at the price of a high-order controller.

关键词： Automotive control electric vehicle powertrains robust control

The impact of increased flooding caused by climate change on heritage in England and North Wales, and possible preventative measures: what could/should be done?

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Built Heritage 2023年第1期7卷 44-58页

作者： Kelly anderson Independent Consultant ManchesterEngland

Despite 30 years of discussion,adaptation work is not routinely being carried out at heritage sites to minimise future impacts of climate change,particularly increased flooding *** understand barriers to essential work being carried out,interviews were carried out with six heritage sites that have already experienced river flooding to understand levels of preparation both before and after the flooding *** results prove that despite funding,or lack of,being an important contributor,it is not the sole barrier to *** flooded sites still do not have a flood plan in place,outside agencies are preventing work being carried out,measures which have been put in place through listing status are prohibiting necessary work and delays in decision making about what is acceptable are all delaying adaptation while allowing more damage to be caused from weather *** responsibility for adaptation lies locally this situation will not improve;responsibility needs to lie more *** the principle of replacing like for like is a sound one with the best of intentions behind it,this is also contributing to losses in heritage and must be reconsidered when big decisions are finally made about what will be acceptable if impacts to heritage from future climate change are to be minimised.

关键词： climate change adaptation barriers heritage flooding site interviews

Heat stress management in underground mines

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International Journal of Mining Science and Technology 2017年第4期27卷 651-655页

作者： Ryan anderson Euler De Souza K1 Mine Maintenance Mosaic Potash Esterhazy SOA2AO Canada Department of Mining Engineering Queen's University Kingston KTL3N6 Canada

Heat management must be maintained within the mine working environment to minimize stress on equipment and personnel. The issue is a growing concern as mines continue to expand in size, depth and infrastructure. Heat management is a concern as it relates to both heat sensitive equipment and more importantly the health and safety of the workers found within the mine. Proper application of engineering protocols and work practice controls will have a direct impact on the health and safety of workers and increased productivity. Using continuous monitoring stations placed in strategic locations throughout the mine to capture the environmental conditions, various strategies can be used in the planning and prevention of potential hazard exposure. Economic analysis is used to select the most feasible strategy for heat stress control. This paper presents a step by step methodology that may be considered by ventilation specialists to effectively implement a heat management control system. A case study based on a detailed heat management assessment conducted for a potash mine in Saskatchewan, Canada is presented.

关键词： Heat Management Enthalpy Mine Environment monitoring

Review of Energy Management and Planning of Islanded Microgrids

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CSEE Journal of Power and Energy Systems 2020年第2期6卷 329-343页

作者： Alexander A.anderson Siddharth Suryanarayanan EmpowerPack SPC North BendWA 98045 USA Department of Electrical Engineering Colorado State UniversityFort CollinsCO 80523 USA

This survey paper provides a critical overview of optimization formulations for planning and operation of islanded microgrids,including optimization objectives,constraints,and control *** optimization approaches reviewed address methods both for increasing the resiliency of advanced distribution systems and electrification of remote *** paper examines over 120 individual optimization studies and discovers that all optimizations studies of islanded microgrids are based on formulations selecting a combination of 16 possible objective functions,14 constraints,and 13 control *** of the objectives,constraints,and variables are discussed exhaustively both from the perspective of their importance to islanded microgrids and chronological trends in their popularity.

关键词： Energy system planning islanded microgrids multi-objective optimization power system operation renewables forecasting

ENERGY USE EXCELLENCE AND THE BUILDING ENVELOPE

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Journal of Green Building 2019年第3期14卷 181-204页

作者： Jodi Smits anderson DASNY AlbanyNew York

We have spent the last 40-50 years working for energy efficiency in our buildings, and we have done so by increasing the performance of the heating, cooling, lighting, and ventilation systems we use. Only recently have we realized the importance of the building envelope in this endeavor. The spaces within a building are created to support the purpose and programs of that building, and it is the envelope made up of the walls, windows, doors, roof, skylights, and floor that protect and shelter those programs and purpose. In this article we will explore various components of the building envelope and discuss ways to achieve optimal energy use.

关键词： building envelope air barrier greenhouse gas(GHG) embodied carbon operational carbon zero-net energy R-value U-factor fenestration

Diuretic window hypothesis in cirrhosis: Changing the point of view

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World Journal of Gastroenterology 2019年第26期25卷 3283-3290页

作者： anderson Brito-Azevedo Liver Transplant Unit S?o Lucas Hospital Liver Transplant Unit S?o Francisco na Providência de Deus Hospital Liver Transplant Unit Adventist Silvestre Hospital

Since the 1970s,non-selective beta-blockers(NSBB)have been used to prevent variceal upper bleeding in advanced cirrhotic ***,several recent studies have raised the doubt about the benefit of NSBB in end-stage cirrhotic *** fact,they suggested a detrimental effect in these patients that even reduced *** of these studies have been assembled to compose the“window therapy hypothesis”,in which NSBB would have traditional indication to be initiated to prevent variceal upper bleeding;however,treatment should be stopped(or not be initiated)in patients with end-stage *** would reduce the cardiac reserve of these patients,worsening systemic perfusion and ***,it should be emphasized that these studies present important bias issues,and their results also suggested that diuretic treatment may also be behind the effects *** this opinion review,we changed the point of view from NSBB to diuretic treatment,based on a physiopathogenic approach of circulatory parameters of cirrhotic patients studied,and based on diuretic effect in blood pressure lowering and in other hypervolemic disease,as heart *** suggest a“diuretic window hypothesis”,composed by an open window in hypervolemic phase,an attention window when patient present in a normal plasma volume phase,and a closed window during the plasma hypovolemic phase.

关键词： Cirrhosis Non-selective beta-blockers Diuretic Window hypothesis Baveno Cardiac output

Mathematical Models of Self-Appraisal in Social Networks

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Journal of Systems Science & Complexity 2021年第5期34卷 1604-1633页

作者： anderson Brian D.O. YE Mengbin School of Engineering Australian National UniversityActon 2601A.C.T.Australia.

In social networks where individuals discuss opinions on a sequence of topics,the selfconfidence an individual exercises in relation to one topic,as measured by the weighting given to their own opinion as against the opinion of all others,can vary in the light of the self-appraisal by the individual of their contribution to the previous *** observation gives rise to a type of model termed a De Groot-Friedkin *** paper reviews a number of results concerning this *** include the asymptotic behavior of the self-confidence(as the number of topics goes to infinity),the possible emergence of an autocrat or small cohort of leaders,the effect of changes in the weighting given to opinions of others(in the light for example of their perceived expertise in relation to a particular topic under discussion),and the inclusion in the model of individual behavioral characteristics such as humility,arrogance,*** behavioral characteristics create new opportunities for autocrats to emerge.

关键词： De Groot Degroot-Friedkin opinion dynamics self-appraisal social influence network