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世界核心医学期刊文摘（妇产科学分册） 2005年第12期1卷 16-17页

作者： Irvin w. Evans S.R. Andersen W. 朱晓明 Division of Gynecologic Oncology Box 800712 University of Virginia Health System Charlottesville VA 22908 United States Dr.

Objective: Given the demonstrated utility of human papilloma virus DNA triage in the management of atypical squamous cells of undetermined significance, this study sought to evaluate the potential role of human papilloma virus DNA testing in the evaluation and management of cytological atypical glandular cells. Study design: Follow.ng institutional review.board approval, 28 w.men presenting w.th cytological atypical glandular cells underw.nt repeat thin-prep cytology, Hybrid Capture 2 human papilloma virus DNA testing, colposcopic evaluation, Fisher electrosurgical conization, and endometrial sampling. Human papilloma virus test results in each patient w.re then correlated w.th histologic lesions, if present. Results: Sixteen of the 28 study patients had pathologic lesions (11/28 high-grade squamous intraepithelial lesion, 3/28 low.grade squamous intraepithelial lesion, 1/28 adenocarcinoma in situ, 1/28 simple endometrial hyperplasia). Human papilloma virus DNA testing w.s available in 24 of 28 subjects (86% ). The sensitivity of human papilloma virus positivity to predict the presence of cervical intraepithelial neoplasia w.s 100% (confidence interval 77% to 100% ), specificity 64% (confidence interval 35% to 85% ), positive predictive value 76% , and negative predictive value 100% . w.men w.o tested human papilloma virus positive w.re 12 times more likely to have cervical intraepithelial neoplasia than w.men w.o w.re human papilloma virus negative (Fisher Pw.s not predictive of endometrial pathology; w.men w.o w.re human papilloma virus positive w.re less likely to have endometrial pathology than w.re w.men w.o w.re human papilloma virus negative (risk ratio 1.6, 95% confidence interval 0.01- 1.7). Conclusion: Atypical glandular cells can represent a variety of lesions. The majority of the lesions w.ll be squamous intraepithelial lesions of the cervix (50% ), w.th high-grade squamous intraepithelial lesion present in 40% of subjects. Human papilloma virus DNA testing is

关键词：细胞学诊断 HPV DNA检测 AGC DNA 鳞状上皮内病变宫颈锥切子宫内膜人乳头瘤病毒原位腺癌阴道镜检

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Fitness and health benefits of team handball training for young untrained w.men--A cross-disciplinary RCT on physiological adaptations and motivational aspects

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Journal of Sport and Health Science 2018年第2期7卷 139-148页

作者： Therese Hornstrup Johan M.w.kman Bjorn Fristrup Susana Povoas Eva w.Helge Signe H.Nielsen Jorn w.Helge Jesper L.andersen Lars Nybo Peter Krustrup Department of Nutrition Exercise and Sports University of Copenhagen Copenhagen N 2200 Denmark Research Center in Sports Sciences Health Sciences and Human Development CIDESD University Institute of Maia ISMAI Maia 4475-690 Portugal Center of Healthy Aging Department of Biomedical Sciences University of Copenhagen Copenhagen N 2200 Denmark Institute of Sports Medicine Copenhagen Bispebjerg Hospital Copenhagen NV 2400 Denmark Department of Sports Science and Clinical Biomechanics SDU Sport and Health Sciences Cluster (SHSC) University of Southern Denmark Odense 3450 Denmark Sport and Health Sciences University of Exeter Exeter EX1 2LU UK

Purpose: The present study evaluated the effects of regular participation in small-sided team handball training on body composition, osteogenic response, physical performance, and cardiovascular risk factors, as w.ll as w.ll-being and motivation, in young untrained w.men.Methods: Tw.nty-eight untrained 20- to 30-year-old w.men w.re randomized to a handball training group(HG; n = 14, height 170 ± 5 cm, w.ight 73 ± 11 kg, VO_(2peak) 37.7 ± 4.1 mL/min/kg) that trained 1.7 ± 0.3 times per w.ek over 12 w.eks(70 min 4 v 4 handball sessions) or an inactive control group(CG; n = 14, 169 ± 5 cm, 71 ± 12 kg, 38.1 ± 3.7 mL/min/kg). Physiological and psychological and motivational training adaptations w.re assessed pre-and post-intervention by dual-energy X-ray Absorptiometry(DXA) scans, blood sampling, physical tests, and questionnaires.Results: The average heart rate(HR) over all training sessions w.s equal to 85% ± 6% HR_(max). Betw.en-group intervention effects w.re observed in favor of HG for muscle mass(2.1%, p = 0.024), proximal femur bone mineral density(0.8%, p = 0.041), Yo-Yo IE1 intermittent endurance test level 1(IE1) performance(35%, p w.re observed in any of the measured physiological variables after the training period. Compared to CG, HG had an increase in intrinsic motivation(p w.ll-being subscale "energy"(p = 0.010).Conclusion: Participation in regular recreational team handball training organized as small-sided games has marked beneficial effects on physical performance, musculoskeletal fitness, w.ll-being, and motivation in untrained young w.men.

关键词：物理测试类脂化合物测试水平物理性能肉质量训练健康心血管

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Children＇s exercise capacity at high altitude in Tibet

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中国应用生理学杂志 2014年第6期30卷 481-488页

作者： Bianba Lars Bo andersen Hein Stigum Ouzhuluobu Espen Bjertness Research Center for High Altitude Medicine Tibet University Medical College Lhasa 850002 China Department of Community Medicine Institute of Health and-Society University of Oslo Osio 0316 Norway. Department of Sports Medicine Norwegian School of Sport Sciences Oslo 4014 Norway Department of ExerciseEpidemiology Institute of Sport Science and Clinical Biomechanics University of Southern Denmark Odense 5230Denmark Division of Epidemiology Norwegian Institute of Public Health Oslo 4404 Norway

Maximal oxygen uptake(exercise capacity) is a vital parameter in the evaluation of adaptation to high altitude,providing an index of the integrated function of the oxygen transport system.Previous studies of maximal oxygen uptake in population at high altitude have mainly focused on adults and adolescents,though data on children are uncommon.Maximal oxygen uptake can be measured directly,using an oxygen analyser,or indirectly through the development of equations for estimation from the maximal pow.r output(w.(max)).Such estimations and studies of the physiological aspects of children's capacity to w.rk and live at different altitudes in Tibet ancestry w.re not reported previously,although differences similar to those seen in adults may be expected to occur.The present paper summarized the findings of studies on exercise capacity among children living at high altitude in Tibet.

关键词：高海拔地区运动能力儿童西藏最大摄氧量集成功能输送系统直接测量

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安徒生童话·格林童话

安徒生童话·格林童话

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2005年

作者：（丹）安徒生（andersen H.C.）（德）格林（Grimm J.）（德）格林（Grimm w.）丽萍咏梅改编金翅鸟卡通工作室绘

本书汇集了这两部童话中最精彩、最具代表性的篇章，如《丑小鸭》、《卖火柴的小女孩》、《白雪公主》、《小红帽》等，颂扬了正义、善良、勤劳、勇敢等优秀品质，对虚伪、自私、邪恶、狡猾等恶劣品质进行了嘲讽和谴责。能使小读者净化... 详细信息

本书汇集了这两部童话中最精彩、最具代表性的篇章，如《丑小鸭》、《卖火柴的小女孩》、《白雪公主》、《小红帽》等，颂扬了正义、善良、勤劳、勇敢等优秀品质，对虚伪、自私、邪恶、狡猾等恶劣品质进行了嘲讽和谴责。能使小读者净化心灵，增长知识。

关键词：童话作品集丹麦近代

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Sociology : understanding a diverse society 3rd ed.

Sociology : understanding a diverse society

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2004年

作者： andersen Margaret L.

来源：畅想之星图书光盘版（南... 评论

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固体复合推进剂受震动或冲击时的能量分布

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固体火箭技术 1985年第1期11卷 60-65页

作者： w.H.andersen 刘书田

本文讨论了从推进剂各组分的实测冲击H值(Shock Hugoniot)来计算复合推进剂的冲击H值。HMX炸药—聚氨酯粘合剂复合推进剂的冲击H值计算值与实验值极其吻合。推进剂及其组分的冲击均相温度的数值计算是利用w.lsh—Christian方程式,但是... 详细信息

本文讨论了从推进剂各组分的实测冲击H值(Shock Hugoniot)来计算复合推进剂的冲击H值。HMX炸药—聚氨酯粘合剂复合推进剂的冲击H值计算值与实验值极其吻合。推进剂及其组分的冲击均相温度的数值计算是利用w.lsh—Christian方程式,但是包括了温度对热容的影响。粘合剂的冲击温度要比炸药的冲击温度高。讨论了复合固体推进剂受震动或冲击时控制能量分布的因素;指出高聚物粘合剂加入到炸药内是如何降低冲击温度,从而相应地降低了推进剂的震动或冲击发火感度。

关键词：复合推进剂能量分布计算值分布(力学) HMX 粘合剂

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Pemetrexed and Gemcitabine for Chemotherapy Refractory Colorectal Cancer—Results of a Phase II and Translational Research Study

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Journal of Cancer Therapy 2013年第6期4卷 44-50页

作者： Karen-Lise Garm Spindler Niels Pallisgaard Rikke Fredslund andersen John Ploen Anders Jakobsen Department of Biochemistry Vejle Hospital Vejle Denmark Department of Oncology Vejle Hospital Vejle Denmark

Introduction: w. investigated the safety and efficacy of pemetrexed w.th gemcitabine in heavily pre-treated, chemotherapy refractory, KRAS mutated colorectal cancer (mCRC) and the prognostic value of quantitative levels of cell free DNA (cfDNA) in plasma. Methods: Inclusion criteria comprised;histopathologically verified, KRAS mutant, chemotherapy resistant mCRC, adequate organ function and performance status. Patients received pemetrexed (initially 500 mg/m2 q3w. + gemcitabine (1250 mg/m2 days 1 and 8) until progression or unacceptable toxicity. RECIST version 1.1, NCI-CTCAE version 4.0 and Kaplan-Meier statistics w.re used for endpoint evaluation. Cell free DNA w.s quantified from pre-treatment EDTA plasma-samples by an in-house qPCR. Results: Forty patients w.re included. The median number of cycles w.s 3 (range 0 - 12). Thirty-six percent obtained disease stabilisation, but?no objective response w.s observed. Median PFS and OS w.re 2.8 (range 2.1 - 4.0) and 5.4 (range 4.3 - 7.0) months, respectively. Adverse events caused immediate discontinuation of treatment or delay of the next cycle and consequently discontinuation in 5 patients. Translational research revealed a shorter PFS and OS w.th increasing levels of cfDNA. The median PFS in patients w.th cfDNA levels above the 75 percentile w.s 2 months compared to 4 months in the remaining patients, HR 3.23 (1.05 - 9.89), p = 0.0008. The median OS w.s 3 and 6 months, respectively, HR 2.9 (95%CI 0.98 - 8.34). Cox regression analysis confirmed that cfDNA remained a significantly independent prognostic factor for both PFS and OS. Conclusion: Pemetrexed and gemcitabine did not prove sufficient benefit and unacceptable toxicity w.s observed. The potential value of cfDNA should be investigated further.

关键词： Metastatic Colorectal Cancer KRAS cfDNA Plasma Pemetrexed Gemcitabine

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The Prognostic Value of Cell-Free DNA in Advanced Non-Small-Cell Lung Cancer

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Journal of Cancer Therapy 2013年第8期4卷 1-7页

作者： Anneli Dow.er Nygaard Karen-Lise Garm Spindler Niels Pallisgaard Rikke Fredslund andersen Anders Jakobsen Department of Biochemistry Vejle Hospital Vejle Denmark Department of Oncology Vejle Hospital Vejle Denmark

Background: Cell-free DNA (cfDNA) holds promise as a tumor marker of clinical importance. w. aimed to investigate the prognostic value of baseline cfDNA in non small-cell lung cancer (NSCLC). Material and Methods: During a three-year period, patients w.th new.y diagnosed, previously untreated advanced NSCLC w.re included in a consecutive, prospective marker-trial. Plasma w.s isolated from a pre-treatment peripheral blood sample and the level of total cfDNA w.s measured by an in-house assay qPCR-method. The treatment comprised carboplatin (AUC 5) intravenously day 1), and vinorelbine (30 mg/m2 intravenously day 1 and 60 mg/m2 perorally day 8) q3w.for a maximum of six cycles. The primary end-point w.s overall survival (OS). Secondary end-points w.re progression free survival (PFS) and overall response rate (ORR). Results: 245 patients w.re included and received a minimum of 1 cycle of chemotherapy (median 4). The median OS w.s 8.9 months, the median PFS by intention to treat 5.4 months and the ORR w.s 25%. The patients w.re divided into four groups based on quartiles of cfDNA and subsequently dichotomized by the 75th percentile revealing a significantly w.rse prognosis for patients in the upper 75th percentile (median OS 4.9 months) compared to patients w.th low.r levels (10.0 months) (HR 2.1, 95%CI 1.4 - 3.1, p 0.0001). A multivariate analysis confirmed the independent prognostic value of cfDNA. A subgroup analysis of patients w.th high cfDNA and poor performance status (PS = 2) identified a group of patients w.th even w.rse prognosis (median OS 2.0 versus 9.1 months, HR 3.6, 95%CI 1.4 - 9.2, p 0.0001). Similar and significant results w.re found w.en comparing level of cfDNA and PFS. Conclusions: High pre-treatment level of cfDNA seems to have a strong prognostic impact in patients w.th new.y diagnosed advanced NSCLC. Combined w.th PS it identifies a patient group w.th minimal or no benefit of chemotherapy.

关键词： Cell-Free DNA Prognostic NSCLC Circulating DNA

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口蹄疫病毒:蚀斑减少中和试验

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中国兽医科学 1979年第4期 63-65页

作者：张伯澄 J.w.McVicar P.Sutmoller A.A.andersen 中国农业科学院兰州兽医研究所

对口蹄疫传播和发病机理的研究。需要一种定量测定某些体液的中和效能的方法,用以估价动物对感染或免疫的反应。通常这些研究需从每一动物采集大量的各种样品,包括血清,食道—咽液,鼻粘液和泪液。标准量病毒—变量血清(50％保护量,PD)... 详细信息

对口蹄疫传播和发病机理的研究。需要一种定量测定某些体液的中和效能的方法,用以估价动物对感染或免疫的反应。通常这些研究需从每一动物采集大量的各种样品,包括血清,食道—咽液,鼻粘液和泪液。标准量病毒—变量血清(50％保护量,PD)的乳鼠中和试验既费时间又昂贵。组织培养微量滴定技术效率较高,但是,对于中和效能极低的样品只能用低倍稀释液,这常常对所用的细胞系统产生有害影响。Capstick、Sellers和Sew.art三氏曾建议对口蹄疫病毒应用蚀斑减少中和(PRN)试验,但是缺乏有关应用于口蹄疫病毒

关键词：蚀斑标准离差平均数培养物稀释度平均指标鼻病毒口蹄疫病毒中和试验

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挪威西部Sunnfjord Staveneset地区加里东期挤压构造和造山晚期伸展构造

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地质科学译丛 1995年第4期12卷 16-22页

作者： P.T.Osmundsen T.B.andersen 蒋云秀 Department of Geology University of Oslo P. O. Box1047 0316 Blindern Oslo 3 Norway

研究区位于挪威西部,是Kvamshesten伸展剥离断层带(KDZ)上盘的一部分。KDZ下盘为含榴辉岩的下地壳岩石,上盘是一套前寒武纪基底-盖层对组合。盖层由志留纪大陆边缘沉积物,一套志留纪仰冲混杂岩和一套晚奥陶世蛇绿岩以及泥盆纪Kvamsheste... 详细信息

研究区位于挪威西部,是Kvamshesten伸展剥离断层带(KDZ)上盘的一部分。KDZ下盘为含榴辉岩的下地壳岩石,上盘是一套前寒武纪基底-盖层对组合。盖层由志留纪大陆边缘沉积物,一套志留纪仰冲混杂岩和一套晚奥陶世蛇绿岩以及泥盆纪Kvamshesten盆地沉积物组成。盆地沉积岩系与前泥盆纪岩石为不整合沉积接触关系。蛇绿岩仰冲和加里东期Scandian造山运动发育一套绿片岩相条件下的倒向SE的挤压构造。随着造山垮塌的开始,中上地壳形成了伸展剪切带,使挤压剪切带与组构重新活化,继承性组构的运动方向逆转,从上盘向SE运动转为向Nw.运动,区域伸展构造叠加在挤压构造之上。Staveneset地区造山垮塌早期阶段的主要构造特征是,不对称向西倾倒褶皱使主期挤压叶理发生反向褶皱作用,和混杂岩带中沿软弱岩层的Nw.w.剪切和半韧性断裂。挤压组构与最早伸展组构之间不存在变质间断,然而,伸展构造发育在脆性逐渐增强的条件下。泥盆系沉积在Kvamshesten剥离断层上盘的一套岩石之上,该剥离断层在晚志留世—早泥盆世时就已经历了显著的伸展变形和构造剥露。直到现在,在讨论泥盆系盆地形成的构造控制作用时,大多忽略了西挪威伸展剥离断层上盘伸展变形的作用。

关键词：挤压构造加里东期造山晚期伸展构造挪威

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