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Steroids reduce local inflammatory mediator secretion and mucosal permeability in collagenous colitis patients

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World Journal of Gastroenterology 2006年第43期12卷 7012-7018页

作者： Yesuf Taha Yngve Raab Marie Carlson anders larsson Mikael Lrdal Lars Lf Magnus Thrn Departments of Medical Sciences University Hospital Uppsala Sweden Department of Medicine KarolinskaInstitutet Karolinska University Hospital Huddinge Sweden Departments of Medical Sciences University Hospital Uppsala Sweden Departments of Clinical Chemistry University Hospital Uppsala Sweden Department of Medicine KarolinskaInstitutet Karolinska University Hospital Huddinge Sweden Center for Clinical Research Central Hospital Vsters Sweden Department of Surgery Karolinska Institutet South Stockholm General Hospital Stockholm Sweden

AIM：. To study the effect of oral steroids upon clinical response and rectal mucosa secretion of eosinophil cationic protein （ECP）, myeloperoxidase （NPO）, basic fibroblast growth factor （bFGF）, vascular endothelial growth factor （VEGF） and albumin in patients with collagenous colitis （CC）. METHODS： A segmental perfusion technique was used to collect perfusates from rectum of CC patients once before and twice （one and four weeks） after the start of steroid treatment. Clinical data was monitored and ECP, MPO, bFGF, VEGF and albumin concentrations were analyzed by immunochemical methods in perfusates and in serum. RESULTS： Steroids reduced the number of bowel movements by more than five times within one week and all patients reported improved subjective wellbeing at wk 1 and 4. At the same time, the median concentrations of ECP, bFGF, VEGF and albumin in rectal perfusates decreased significantly. MPO values were above the detection limit in only 3 patients before treatment and in none during treatment. VEGF, bFGF, ECP and albumin concentrations correlated with each other with the exception of ECP and albumin. A decrease of serum ECP and VEGF concentrations was also seen even if the overtime reduction was not significant.CONCLUSION： Oral steroid treatment in CC patients induced a simultaneous reduction of bowel movements and rectal release of ECP, bFGF, VEGF and albumin, suggesting that these polypeptides and increased mucosal permeability are important components of the pathophysiology in collagenous colitis.

关键词： Collagenous colitis Inflammatory mediator Steroid treatment Eosinophil cationic protein Basicfibroblast growth factor Vascular endothelial growthfactor

Comparison of four non-alcoholic fatty liver disease detection scores in a Caucasian population

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World Journal of Hepatology 2020年第4期12卷 149-159页

作者： Lars Lind Lars Johansson Hakan Ahlstrom Jan W Eriksson anders larsson Ulf Risérus Joel Kullberg Jan Oscarsson Department of Medical Sciences UppsalaUniversityUppsala 75185Sweden Antaros Medical AB BioVenture HubMolndal 43153Sweden Department of Surgical Sciences Uppsala UniversityUppsala 75185Sweden Department of Public Health and Caring Sciences Clinical Nutrition and Metabolism Uppsala UniversityUppsala 75122Sweden Global Medicines Development AstraZenecaMoIndal 43150Sweden

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is a common disorder,with an estimated prevalence ranging from 20%to 35%in the general *** scores based on easily measurable biochemical and clinical parameters,including the fatty liver index(FLI),hepatic steatosis index(HSI),lipid accumulation product(LAP),and NAFLD liver fat score(LFS),have been developed for the detection of ***,comparative information regarding the efficacy of these scores for predicting NAFLD in population-based samples comprising normal and high-risk individuals is *** To evaluate four NAFLD detection scores in two samples with different NAFLD *** NAFLD screening was performed in a population-based sample of 50-year-old individuals in Uppsala,Sweden[n=310;Prospective investigation of obesity,energy and metabolism(POEM)study]and a high-risk population comprising patients with a body mass index>25 kg/m2 and either high plasma triglycerides(≥1.7 mmol/L)or type 2 diabetes(n=310;EFFECT studies).NAFLD was defined as liver fat>5.5%using magnetic resonance imaging-proton density fat ***,HSI,LAP,and NAFLD LFS were assessed.A logistic regression model was used to evaluate the effectiveness of the different *** The prevalence of NAFLD was 23%in *** showed the highest receiver operating characteristic area under the curve(ROC AUC;0.82)and was significantly better than the LAP score(P=0.005 vs LAP,P=0.08 vs LFS,P=0.12 vs HSI)for detection of *** other three indices performed equally in POEM(0.77-0.78).The prevalence of NAFLD was 74%in EFFECT;LFS performed best(ROC AUC 0.80)in this *** ROC AUC for LFS(0.80)was significantly higher than that for FLI(P=0.0019)and LAP(P=0.0022),but not HSI(P=0.11).We performed a sensitivity analysis with stratification for the two high-risk subgroups(patients with diabetes or hypertriglyceridemia)from the EFFECT *** performed best in patients with *** major differences

关键词： Comparison EFFECT studies Fatty liver Non-alcoholic fatty liver disease Non-invasive indices Screening

Evaluation of a Plasma hCG Method for Point of Care Testing with the Aim of Shortening Test-Turnaround-Times

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Open Journal of Obstetrics and Gynecology 2015年第6期5卷 341-343页

作者： Anna-Karin Wikstrom Magnus Hagmar Goran Ronquist anders larsson Department of Women’s and Children’s Health Uppsala UniversityUppsalaSweden Department of Medical Sciences Section of Clinical ChemistryUppsala UniversityUppsalaSweden

Objective: To examine the correlation between plasma hCG results obtained with the new i-STAT® hCG point of care test with those concomitantly obtained from the central hospital laboratory utilizing the same patient samples. Methods: Prospective cross-sectional laboratory test evaluation. We compared plasma hCG results obtained with the i-STAT® hCG test (Abbott Point of Care, Princeton, NJ, USA) with Architect Ci8200 (Abbott Laboratories, Abbott Park, IL, USA). We also calculated the total coefficient of variation (CV) for the i-STAT® method. Results: The two methods showed a good linear correlation (R2 = 0.994;slope 1.03) and CV for the i-STAT® method was 2.1% - 5.2%. Conclusion: We suggest that the i-STAT® hCG blood assay could be used as a complement to urine hCG assays in clinical situations when rapid test results are needed and urine is not available.

关键词： Human Chorionic Gonadotropin Pregnancy Method Evaluation Point of Care Test

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微量抗原脾内免疫

国外医学（免疫学分册） 1990年第2期13卷 94-96页

作者： B.Ove Nilsson anders larsson 鲁刚

Nilsson等介绍了脾内免疫的方法。对此法灵敏度的估计表明当抗原固定于活化琼脂糖小珠时,总量约80毫微克的牛血清白蛋白(BSA)分散注于4点后能诱导产生血清抗体。微量抗原脾内免疫明显比腹腔内和静脉途径更易产生抗体。Spitz 等人报道... 详细信息

Nilsson等介绍了脾内免疫的方法。对此法灵敏度的估计表明当抗原固定于活化琼脂糖小珠时,总量约80毫微克的牛血清白蛋白(BSA)分散注于4点后能诱导产生血清抗体。微量抗原脾内免疫明显比腹腔内和静脉途径更易产生抗体。Spitz 等人报道了脾内一次注射20微克可溶性抗原或2.5×10~5个同种异体细胞均可产生抗体,此后又有所发展。

关键词：抗原脾免疫

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微量免疫原脾内免疫

单克隆抗体通讯 1991年第4期7卷 80-82页

作者： B.Ove Nilsson anders larsson 孙瑛勋

使用微量免疫原获得抗体有两条途径,即体外免疫法和本文论述的脾内免疫法。后者不需大量的实验室工作并可减少杂交培养中常见的污染问题。

关键词：微量免疫原脾内免疫抗原

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巅峰对话涨潮期的抉择

今日工程机械 2018年第6期 20-24页

作者：罗东祁俊 anders P.larsson 陆川周驰军姚广山华北利星行机械(北京)有限公司中国工程机械工业协会沃尔沃建筑设备投资(中国)有限公司徐工集团工程机械股份有限公司合肥湘元工程机械有限公司赛克思液压科技股份有限公司

2018年是一个关键的历史节点,工程机械行业历经数年大幅调整之后蓄力上行、持续发展。2018年,也是工程机械代理制造协会落地中国并茁壮成长的15周年,2018年也是习近平主席倡导的进口博览会举行的年份。在新一轮的大潮中,面对挑战,制造... 详细信息

2018年是一个关键的历史节点,工程机械行业历经数年大幅调整之后蓄力上行、持续发展。2018年,也是工程机械代理制造协会落地中国并茁壮成长的15周年,2018年也是习近平主席倡导的进口博览会举行的年份。在新一轮的大潮中,面对挑战,制造商、代理商、技术服务商如何把握行业上下游价值链的发

关键词：挖掘机市场制造商主机厂工程机械市场代理商

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瑞典多功能绿道的实际建设挑战与机遇

风景园林 2010年第6期17卷 30-33页

作者： [瑞典]克里斯汀·哈兰德安德斯·拉森安娜·彼得森玛茨·圭琳郭湧(翻译) 田甜(翻译) 瑞典农业科学大学景观管理设计及建造系瑞典农业科学大学风景园林系瑞典农业科学大学/工作学商业经济和环境心理系清华大学建筑学院景观学系 "风景园林新青年"网站北京林业大学园林学院意大利博洛尼亚大学建筑系

探讨了瑞典南部的斯堪尼亚在建设多功能绿道时,在改善高强度管理农业区域可达性、休闲活动可能性和生物多样性等方面所面临的挑战和机遇。通过网络检索、与政府部门进行联系,与相关人员进行讨论及召开研讨会,并对绿道的生物多样性进行... 详细信息

探讨了瑞典南部的斯堪尼亚在建设多功能绿道时,在改善高强度管理农业区域可达性、休闲活动可能性和生物多样性等方面所面临的挑战和机遇。通过网络检索、与政府部门进行联系,与相关人员进行讨论及召开研讨会,并对绿道的生物多样性进行实地调查,指出了瑞典绿道的实际问题与改善的可能性。

关键词：瑞典多功能绿道建设生物多样性区域可达性政府部门休闲活动网络检索实际问题实地调查度管理讨论农业南部联系机遇高强

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Patient Safety Culture Change over Time-Health Care Staffs’Perceptions

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Open Journal of Nursing 2020年第3期10卷 320-339页

作者： Anna Nordin Gun Nordstrom Bodil Wilde-larsson anders Hallberg Kersti Theander Faculty of Health Science and TechnologyDepartment of Health ScienceKarlstad UniversityKarlstadSweden Faculty of Social and Health Sciences Department of Health and Nursing SciencesInland Norway University of Applied SciencesElverumNorway Department of Endocrinology and Diabetes County Council of VarmlandKarlstadSweden Head of Centre for Clinical Research County Council of VarmlandKarlstadSweden

Rationale and Aim: Patient safety is of great interest in health care organisations, worldwide. In Sweden, a national patient safety initiative was launched in 2011. The aim of this study was to examine and compare patient safety culture change over time from health care staffs’ perspective. A further aim was to examine factors that have had an effect on patient safety culture. Methods: Patient safety culture was assessed in 2009, 2011 and 2013 using the Swedish version of the Hospital Survey of Patient Safety Culture. Respondents in this study were registered nurses (n = 2149), enrolled nurses (n = 959), physicians (n = 355) and managers (n = 159) working in three health care divisions in a Swedish county council. Results: Patient safety culture decreased significantly over time for all but two dimensions. The dimension “Information to Patients/Relatives” was the only dimension to increase significantly over time. Health care staffs’ profession and health care division belonging had significant main effects on 14 and 8 dimensions, respectively. Managers and enrolled nurses scored patient safety culture significantly higher than registered nurses and physicians. Health care staff working in a mixed medical-surgical health care division scored significantly higher than those working in medical or surgical divisions did. Conclusions: Despite efforts for patient safety work in the county council, health care staffs’ perceptions of patient safety culture decreased over time. To improve hospital patient safety culture, managers and staff groups must meet and communicate with each other in order to create a common view of patient safety.

关键词： Patient Safety Culture Hospital Three-Time Cross-Sectional Healthcare Organisations

Application of Thermodynamic and Kinetic Modeling to Diffusion Simulations in Nickel-Base Superalloy Systems

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Application of Thermodynamic and Kinetic Modeling to Diffusi...