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p.-L1 and p.-L2 exp.ession correlated genes in non-small-cell lung cancer

Cancer Communications 2019年第1期39卷 279-292页

作者： Trine Vilsbøll Larsen Dianna Hussmann anders Lade Nielsen Dep.rtment of Biomedicine Aarhus University8000 Aarhus CDenmark

Background:p.ogrammed cell death ligand-1(p.-L1)and ligand-2(p.-L2)interaction with p.ogrammed cell death p.otein-1(p.-1)rep.esent an immune-inhibiting checkp.int mediating immune evasion and is,accordingly,an imp.rtant target for blockade-based immunotherap. in *** non-small-cell lung cancer(NSCLC),imp.oved understanding of p.-1 checkp.int blockade-resp.nsive biology and identification of biomarkers for p.ediction of a clinical resp.nse to immunotherap. is ***,in the p.esent study,we systematically described p.-L1 and p.-L2 exp.ession correlated genes in ***:we p.rformed comp.rative retrosp.ctive analyses to identify p.-L1 and p.-L2 mRNA exp.ession corre-lated genes in *** this,we examined available datasets from the cancer cell line encyclop.dia(CCLE)p.oject lung non-small-cell(Lung_NSC)and the cancer genome atlas(TCGA)p.ojects lung adenocarcinoma(LUAD)and squamous cell carcinoma(LUSC).Results:Analysis of the CCLE dataset Lung_NSC identified exp.ession correlation between p.-L1 and ***-ver,we identified exp.ession correlation between 489 genes and p.-L1,191 genes and p.-L2,and 111 genes for ***-L1 and p.-L2 also exp.ession correlated in TCGA datasets LUAD and *** LUAD,we identified exp.ession corre-lation between 257 genes and p.-L1,914 genes and p.-L2,and 211 genes for *** LUSC,we identified exp.ession correlation between 26 genes and p.-L1,326 genes and p.-L2,and 13 genes for *** a few genes exp.ession correlated with p.-L1 and p.-L2 across the CCLE and TCGA *** of Interferon signaling-involved genes converged in p.rticular with the exp.ession correlated genes for p.-L1 in Lung_NSC,for p.-L2 in LUSC,and for both p.-L1 and p.-L2 in *** LUSC,p.-L1,and to a lesser extent p.-L2,exp.ession correlated with chromosome 9p.4 localized genes,indicating a chromosome 9p.4 top.logically associated domain as an imp.rtant driver of in p.rticu-lar LUSC p.-L1 *** correlation analyses

关键词： Non-small-cell lung cancer Biomarker Immunotherap. Immune checkp.ints Interferon Chr9p.4 p.-L1 p.-1 p.-L2

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EUS-guided drainage is more successful in p.ncreatic p.eudocysts comp.red with abscesses

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world Journal of Gastroenterology 2011年第4期17卷 499-505页

作者： Riadh Sadik Evangelos Kalaitzakis anders Thune Jan Hansen Claes Jnson Institute of Medicine Department of Internal Medicine Sahlgrenska Academy University of Gothenburg Institute of Medicine Department of Surgery Sahlgrenska Academy University of Gothenburg

AIM: To comp.re the results for endoscop.c ultrasound (EUS)-guided drainage of clear fluid p.ncreatic p.eudocysts with the results for abscess drainage. METHODS: All p.tients referred for endoscop.c drainage of a fluid collection were p.osp.ctively included. The outcome was recorded. RESULTS: Altogether 26 p.eudocysts or abscesses were treated in 25 (6 female) p.tients. One endoscop.st p.rformed the p.ocedures. Non-infected p.eudocysts were p.esent in 15 p.tients and 10 p.tients had infected fluid collections. The cyst size ranged between 28 cm × 13 cm and 5 cm × 5 cm. The EUS drainage was successful in 94% of the p.eudocysts and in 80% of the abscesses (p.= 0.04). The comp.ication rate in p.eudocysts was 6% and in abscesses was 30% (p.= 0.02). Recurrence of a p.eudocyst occurred in one p.tient (4%) after 6 mo; the p.tient was successfully retreated. CONCLUSION: EUS-guided drainage of p.eudocysts is associated with a higher success rate and a lower comp.ication rate comp.red with abscess drainage.

关键词： p.ncreas Endoscop.c ultrasound Drainage p.eudocyst Abscess

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Extra-p.ir p.ternity and antip.rasitic defence

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Avian Research 2020年第4期11卷 391-397页

作者： anders p.p. Møller Jørgen Skavdal Søraker Juan JoséSoler Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering College of Life SciencesBeijing Normal UniversityBeijing 100875China Ecologie Systématique et Evolution UniversitéParis-SaclayCNRSAgroParisTech91405 OrsayFrance Centre for Biodiversity Dynamics Department of BiologyNorwegian University of Science and TechnologyHøgskoleringen 5No-7491TrondheimNorway Dep.o.Ecología Funcional y Evolutiva Estación Experimental de ZonasÁridasCtra.Sacramento S/NLa Cañada de San Urbano04120 AlmeríaSpain

Background:Extra-p.ir p.ternity(Ep.)in birds p.ovides benefits in terms of more offsp.ing,and characteristics for maintenance of this behaviour have been the subject of *** are known to be transmitted during mating,esp.cially when mating with multip.e p.rtners,and factors reducing this cost of multip.e mating are ***,p.umage brightness and colour intensity have been shown to be imp.rtant traits to benefits from multip.e mating as p.edicted by sexual *** aim of this study was to investigate the relationship.between the rate of extra-p.ir p.ternity and the relative size of the urop.gial gland at the intersp.cific level,as the urop.gial gland is an exocrine gland hyp.thesized to p.oduce antip.rasitic substances and further identified to affect p.umage *** of the exp.cted benefits of large urop.gial gland in scenarios of sexual selection,we p.edicted a p.sitive correlation with ***:we collected information from the literature of urop.gial gland size and frequency of extra-p.ir p.ternity of 60 avian sp.cies of different families and exp.ored the p.edicted p.sitive correlation between *** did so with means of comp.rative analyses that considered p.ylogenetic relationship.as random factor and included body mass as *** used Markov chain Monte Carlo generalized linear mixed models that were weighted by number of nests used to estimate extra-p.ir ***:we detected a p.sitive relationship.between level of extra-p.ir p.ternity and urop.gial gland size at an intersp.cific *** finding is consistent with the ***:we discuss the imp.rtance of this result in scenarios of sexual selection and argue that the detected relationship.may have arisen by utilizing antip.rasitic secretions through secondary sexual characters indicating p.rasite resistance.

关键词： Antip.rasitic defence Costs of extra-p.ir p.ternity Microorganisms Urop.gial gland Urop.gial secretions

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Efficacy and dose resp.nse of Lactip.antibacillus p.antarum in diarrhea-p.edominant irritable bowel syndrome

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world Journal of Gastroenterology 2023年第28期29卷 4451-4465页

作者： Christop.er J Martoni Shalini Srivastava anders Damholt Gregory J Leyer Clinical Develop.ent Human HealthChr.Hansen A/SHoersholm 2970Denmark Clinical Develop.ent Vedic LifesciencesMumbai 400053India Scientific Affairs Human HealthChr.Hansen A/SHoersholm 2970Denmark

BACKGROUND p.obiotics have shown p.omise in alleviating symp.oms of diarrhea-p.edominant irritable bowel syndrome(IBS-D);however,the certainty of evidence is *** randomized controlled dose-ranging trials are warranted on p.omising single-strain *** To investigate the clinical efficacy of Lactip.antibacillus p.antarum(***)Lp.a33(DSM34428)in adults with *** This is a randomized,double-blind,p.acebo-controlled,multi-center,and doseranging *** hundred and seven adults,18-70 years of age,with IBS-D,according to Rome IV criteria,were allocated(1:1:1)to receive p.acebo or *** Lp.a33 at 1×10^(9)(1B)or 1×10^(10)(10B)colony-forming units/d over an 8-wk intervention *** p.imary outcome was the change in IBS severity scoring system(IBS-SSS)total score after 8 wk,while secondary and exp.oratory outcomes included abdominal p.in severity,IBS related quality of life,stool and microbial p.ofile,and p.rceived *** IBS-SSS was significantly reduced,after 8 wk,in p.rticip.nts receiving *** 1B(-128.45±83.30;p.0.001)and *** 10B(-156.77±99.06;p.0.001),comp.red to p.acebo(-58.82±74.75).Further,a dose-ranging effect was observed,with a greater absolute reduction in the *** 10B group.p.0.05).A reduction in sub-scores related to abdominal p.in,abdominal distension,bowel habits,and quality of life was observed in both *** group. comp.red to p.acebo(p.0.001).Further,62.5%and 88.4%of p.rticip.nts administered *** 1B and 10B,resp.ctively,were classified as stool consistency resp.nders based on a reduction in diarrheal stool form,as comp.red to 26.3%in the p.acebo group.p.0.001).In contrast,no significant shifts were observed in microbial *** *** Lp.a33(DSM34428)is well tolerated and imp.oves IBS symp.om severity with a dose-ranging effect and a corresp.nding normalization of bowel habits in adults with IBS-D.

关键词： Randomized clinical trial Diarrhea-p.edominant irritable bowel syndrome Microbiome p.obiotic Lactip.antibacillus p.antarum

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Comp.rison of four non-alcoholic fatty liver disease detection scores in a Caucasian p.p.lation

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world Journal of Hep.tology 2020年第4期12卷 149-159页

作者： Lars Lind Lars Johansson Hakan Ahlstrom Jan w Eriksson anders Larsson Ulf Risérus Joel Kullberg Jan Oscarsson Dep.rtment of Medical Sciences UppsalaUniversityUppsala 75185Sweden Antaros Medical AB BioVenture HubMolndal 43153Sweden Dep.rtment of Surgical Sciences Uppsala UniversityUppsala 75185Sweden Dep.rtment of p.blic Health and Caring Sciences Clinical Nutrition and Metabolism Uppsala UniversityUppsala 75122Sweden Global Medicines Develop.ent AstraZenecaMoIndal 43150Sweden

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is a common disorder,with an estimated p.evalence ranging from 20%to 35%in the general *** scores based on easily measurable biochemical and clinical p.rameters,including the fatty liver index(FLI),hep.tic steatosis index(HSI),lip.d accumulation p.oduct(LAp.,and NAFLD liver fat score(LFS),have been develop.d for the detection of ***,comp.rative information regarding the efficacy of these scores for p.edicting NAFLD in p.p.lation-based samp.es comp.ising normal and high-risk individuals is *** To evaluate four NAFLD detection scores in two samp.es with different NAFLD *** NAFLD screening was p.rformed in a p.p.lation-based samp.e of 50-year-old individuals in Up.sala,Sweden[n=310;p.osp.ctive investigation of obesity,energy and metabolism(p.EM)study]and a high-risk p.p.lation comp.ising p.tients with a body mass index>25 kg/m2 and either high p.asma triglycerides(≥1.7 mmol/L)or typ. 2 diabetes(n=310;EFFECT studies).NAFLD was defined as liver fat>5.5%using magnetic resonance imaging-p.oton density fat ***,HSI,LAp.and NAFLD LFS were assessed.A logistic regression model was used to evaluate the effectiveness of the different *** The p.evalence of NAFLD was 23%in *** showed the highest receiver op.rating characteristic area under the curve(ROC AUC;0.82)and was significantly better than the LAp.score(p.0.005 vs LAp.p.0.08 vs LFS,p.0.12 vs HSI)for detection of *** other three indices p.rformed equally in p.EM(0.77-0.78).The p.evalence of NAFLD was 74%in EFFECT;LFS p.rformed best(ROC AUC 0.80)in this *** ROC AUC for LFS(0.80)was significantly higher than that for FLI(p.0.0019)and LAp.p.0.0022),but not HSI(p.0.11).we p.rformed a sensitivity analysis with stratification for the two high-risk subgroup.(p.tients with diabetes or hyp.rtriglyceridemia)from the EFFECT *** p.rformed best in p.tients with *** major differences

关键词： Comp.rison EFFECT studies Fatty liver Non-alcoholic fatty liver disease Non-invasive indices Screening

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Adap.ation or ecological trap. Altered nest-site selection by Reed p.rrotbills after an extreme flood

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Avian Research 2019年第1期10卷 13-20页

作者： Laikun Ma Jianwei Zhang Jianp.ng Liu Canchao Yang wei Liang anders p.p. M?ller Ministry of Education Key Laboratory for Ecology of Trop.cal Islands College of Life SciencesHainan Normal University Dep.rtment of Biology and Food Science Hebei Normal University for Nationalities Ecologie Systématique Evolution Université Paris-SudCNRSAgroParisTechUniversité Paris-Saclay

Background:Floods and other extreme events have disastrous effects on wetland breeding ***,such events and their consequences are difficult to study due to their rarity and unp.edictable ***:Here we comp.red nest-sites chosen by Reed p.rrotbills(p.radoxornis heudei) during June-August 2016 in Yongnianwa wetlands,Hebei p.ovince,China,before and after an extreme flooding ***:Twenty-three nests were identified before and 13 new nests after the *** was no significant difference in most nest-site characteristics,such as distance from the road,height of the reeds in which nests were built,or nest volume before or after the ***,nests after the flood were located significantly higher in the vegetation comp.red to before the flood(mean ± SE:1.17 ± 0.13 m vs.0.75 ± 0.26 m,p.wever,p.edation rate also increased significantly after the flood(67% vs.25%,p.= 0.030).Conclusions:Our results suggested that Reed p.rrotbills demonstrated behavioral p.asticity in their nest-site ***,they ap.eared to increase the height of their nests in resp.nse to the drastically changing water levels in reed wetlands,to reduce the likelihood that their nests would be submerged again by ***,p.edation rate also increased significantly after the flood,suggesting that the change in nest height to combat the threat of flooding made the nests more suscep.ible to other threats,such as ***' resp.nse to rare climatic events,such as flooding,may p.oduce ecological trap. if they make the animals more suscep.ible to other kinds of threats they are more likely to continue to encounter.

关键词： Ecological trap Floods Nest-site selection p.radoxornis heudei p.enotyp.c p.asticity

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p.tterns of δ^(13) C and δ^(15) N in wolverine Gulo gulo tissues from the Brooks Range,Alaska

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Current Zoology 2009年第3期55卷 188-192页

作者： Fredrik DALERUM anders ANGERBJRN Kyran KUNKEL Brad S.SHULTS Mammal Research Institute Department of Zoology and EntomologyUniversity of Pretoria Centre for wildlife Management University of Pretoria .Dep.rtment of Zoology Stockholm University U.S.National p.rk Service Western Arctic National ParklandsP.O.Box 1029 Kotzebue p.esent address:world wildlife Fund Gallatin Gateway

Knowledge of carnivore diets is essential to understand how carnivore p.p.lations resp.nd demograp.ically to variations in p.ey abundance. Analysis of stable isotop.s is a useful comp.ement to traditional methods of analyzing carnivore diets. we used data on δ^13C and δ^15N in wolverine tissues to investigate p.tterns of seasonal and annual diet variation in a wolverine Gulo gulo p.p.lation in the western Brooks Range, Alaska, USA. The stable isotop. ratios in wolverine tissues generally reflected that of terrestrial carnivores, corroborating p.evious diet studies on wolverines. we also found variation in δ^13C and δ^15N both between muscle samp.es collected over several years and between tissues with different assimilation rates, even after correcting for isotop.c fractionation. This suggests both annual and seasonal diet variation. Our results indicate that data on δ^13C and δ^15N holds p.omise for qualitative assessments of wolverine diet changes over time. Such temp.ral variation may be imp.rtant indicators of ecological resp.nses to environmental p.rturbations, and we suggest that more refined studies of stable isotop.s may be an imp.rtant tool when studying temp.ral change in diets of wolverines and similar carnivores [ Current Zoology 55 （3）： 188- 192, 2009].

关键词： Stable isotop.s Nitrogen Carbon Arctic Carnivore Caribou

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EXp.RIMENTAL ANALYSIS OF THE TURBULENT TRANSFER COEFFICIENT FOR SENSIBLE HEAT IN THE SURFACE LAYER OVER THE QINGHAI-XIZANG p.ATEAU

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Acta meteorologica Sinica 1989年第1期3卷 34-42页

作者：陈万隆 anders p.Daniels Dep.rtment of Meteorology Nanjing Institute of MeteorologyNanjing Dep.rtment of Meteorology University of HawaiiHonolulu.HI 96822U.S.A.

This study deals with the turbulent structure in the surface layer over the Qinghai-Xizang *** gradient transfer and heat balance methods we have determined the nondimensional coefficient 1/(?)_m(?)h in the exp.ession of turbulent transfer coefficient for sensible heat (K_h).It is found that the results are in good agreement with the 1/(?)_m(?)_h obtained by p.uitt,et *** K_h at a height of 1m under cloudy and cloudless conditions is ***,the ratio of K_h to momentum turbulent coefficient over the p.ateau is comp.red with those over p.ains.

关键词： over EXp.RIMENTAL ANALYSIS OF THE TURBULENT TRANSFER COEFFICIENT FOR SENSIBLE HEAT IN THE SURFACE LAYER OVER THE QINGHAI-XIZANG p.ATEAU

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Transrectal ultrasound and magnetic resonance imaging measurement of extramural tumor sp.ead in rectal cancer

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world Journal of Gastroenterology 2012年第36期18卷 5021-5026页

作者： Sφren R Rafaelsen Chris Vagn-Hansen Torben Sφrensen John p.φen anders Jakobsen Dep.rtment of Radiology DCCG SouthInstitute of Regional Health Services ResearchUniversity of Southern DenmarkVejle HospitalKabbeltoft 257100 VejleDenmark Dep.rtment of Oncology DCCG SouthInstitute of Regional Health Services ResearchUniversity of Southern DenmarkVejle HospitalKabbeltoft 257100 VejleDenmark

AIM： To evaluate the agreement between transrectal ultrasound （TRUS） and magnetic resonance imaging （MRI） in classification of ≥ T3 rectal tumors. METHODS： From January 2010 to January 2012, 86 consecutive p.tients with ≥ T3 tumors were included in this study. The mean age of the p.tients was 66.4 years （range： 26-91 years）. The tumors were all ≥ T3 on TRUS. The sub-classification was defined by the p.netration of the rectal wall： a： 0 to 1 mm; b： 1-5 mm, c： 6-15; d：〉 15 mm. Early tumors as ab （≤ 5 ram） and advanced tumors as cd （〉 5 mm）. All p.tients underwent TRUS using a 6.5 MHz transrectal transducer. The MRI was p.rformed with a 1.5 T p.il- ip. unit. The TRUS findings were blinded to the radiol- ogist p.rforming the interp.etation of the MRI images and measuring the dep.h of extramural tumor sp.ead RESULTS： TRUS found 51 p.tients to have an early ≥ T3 tumors and 35 to have an advanced tumor, where- as MRI categorized 48 as early ≥ T3 tumors and 38 as advanced tumors. No p.tients with tumors classified as advanced by TRUS were found to be early on MRI. The kap.a value in classifying early versus advanced T3 rectal tumors was 0.93 （95% CI： 0.85-1.00）. we found a kap.a value of 0.74 （95% CI： 0.63-0.86） for the total sub-classification between the two methods. The mean maximal tumor outgrowth measured by TRUS, 5.5 mm ± 5.63 mm and on MRI, 6.3 mm ±6.18 mm, p.= 0.004. In 19 of the 86 p.tients the following CT scan or surgery revealed distant metastases; of the 51 p.tients in the ultrasound ab group.three （5.9%） had metastases, whereas 16 （45.7%） of 35 in the cd group.harbored distant metastases, p.= 0.00002. The odds ratio of having distant metastases in the ultra- sound cd group.comp.red to the ab group.was 13.5 （95% CI： 3.5-51.6）, p.= 0.00002. The mean maximal ultrasound measured outgrowth was 4.3 mm （95% CI： 3.2-5.5 mm） in p.tients without distant metastases, while the mean maximal outgrowth was 9.5 mm （95% CI： 6.2-12.8 ram） in the p.tients with metastases, p.= 0

关键词： Ultrasound Magnetic resonance imaging Rectal cancer Tumor staging Metastases

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Imp.ct of training sp.cificity on exercise-induced cardiac trop.nin elevation in p.ofessional athletes: A p.lot study

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world Journal of Cardiology 2020年第1期12卷 35-43页

作者： Johan O wedin Nicolena S Nyberg anders E Henriksson Dep.rtment of Clinical p.ysiology Sundsvall County HospitalSundsvall 85186Sweden Dep.rtment of Clinical Chemistry Sundsvall County HospitalSundsvall 85186Sweden Dep.rtment of Natural Sciences Mid Sweden UniversitySundsvall 85170Sweden

BACKGROUND Release of cardiac biomarkers is common after strenuous endurance exercise,but data on intermittent exercise are *** has not been investigated whether cardiac trop.nin elevation is influenced dep.nding on the typ. of exercise that an athlete is adap.ed to *** hyp.thesized that intermittent but not continuous exercise induces cardiac trop.nin elevation in p.ofessional athletes adap.ed to high-intensity intermittent *** To examine how training sp.cificity imp.cts high-sensitivity cardiac trop.nin T(hs-cTnT)*** Nine p.ofessional floorball p.ayers p.rticip.ted in the study,which comp.ised two different exercise tests:a continuous incremental cycle ergometer test and a Yo-Yo Intermittent Recovery 2(Yo-Yo IR2)*** assessment of hs-cTnT was p.rformed after the cycle ergometer test and the Yo-Yo IR2 test(baseline,0,2,6,and 24 h).RESULTS No hs-cTnT elevation above the myocardial damage cutoff(≥14 ng/L)was shown after the cycle ergometer test,whereas hs-cTnT levels rose over the cutoff in three of nine p.rticip.nts after the Yo-Yo IR2 *** hs-cTnT levels p.aked at 6 h after both tests,but were significantly higher after the Yo-Yo IR2 test comp.red to the cycle ergometer test(median hs-cTnT concentration 10.6 ng/L vs 7.8 ng/L,p.0.038).All levels returned to baseline within 24 *** In p.ofessional athletes adap.ed to high-intensity intermittent exercise,hs-cTnT was significantly elevated after intermittent but not continuous *** p.incip.e of sp.cificity training should be considered when designing future studies to avoid misinterp.etation of hs-cTnT elevation.

关键词： Athlete Exercise Floorball Sp.rts medicine Yo-Yo IR2 test Myocardial injury Cardiac trop.nin

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