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核废料埋藏点候选场所生物圈描述的策略:生态系统和景观模型的结合

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AMBIO－人类环境杂志 2006年第8期35卷 410-415页

作者： Tobias lindborg Regina lindborg anders lfgren Bjrn Sderbck Clare Bradshaw Ulrik Kautsky 梁虹瑞典核燃料及核废料管理公司瑞典斯德哥尔摩大学瑞典乌普萨拉大学

为给核废料深埋藏点的许可申请提供必要数据,瑞典核燃料及核废料管理公司已在瑞典境内的两个地点进行了现场调查。本文提出将位点特异性生态系统数据与安全评估研究和环境影响评价所必需的空间模型相结合的策略。对生态系统位点特异性... 详细信息

为给核废料深埋藏点的许可申请提供必要数据,瑞典核燃料及核废料管理公司已在瑞典境内的两个地点进行了现场调查。本文提出将位点特异性生态系统数据与安全评估研究和环境影响评价所必需的空间模型相结合的策略。对生态系统位点特异性的描述是通过从原始数据建立学科特异性模型,识别位点功能单位间的相互作用、物质积累和流动来实现的。概念模型对系统过程量化特征的确定是一个有用的初始工具,可能揭示新的学科界面,提供促进对生态系统特征和景观功能特性之间关系了解的各种新机会。这种生态系统与景观特性整合模型在深埋藏点安全评估中具有重要作用。

关键词：生态系统景观模型核废料埋藏生物圈位点特异性场所环境影响评价

北方景观有机物质库和通量:关于核废料埋藏点安全评估的一些提示

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AMBIO－人类环境杂志 2006年第8期35卷 488-496页

作者： linda Kumblad Bjrn Sderbck anders lfgren Tobias lindborg Erik Wijnbladh Ulrik Kautsky 马爱进瑞典斯德哥尔摩大学瑞典核燃料及核废料管理公司

为了对一处核废料深地质埋藏点的许可申请提供必要的信息,瑞典核燃料及核废料管理公司正在进行选址调查,包括瑞典两处位点地表生态系统不同部分的广泛研究。这里我们利用陆地、湖泊、海洋生态系统中碳动态的详细模拟结果,描述和比较瑞... 详细信息

为了对一处核废料深地质埋藏点的许可申请提供必要的信息,瑞典核燃料及核废料管理公司正在进行选址调查,包括瑞典两处位点地表生态系统不同部分的广泛研究。这里我们利用陆地、湖泊、海洋生态系统中碳动态的详细模拟结果,描述和比较瑞典东南沿海Simpevarp地区有机物质库和通量。本研究以有机碳表示与有机物质结合的放射性核素。结果显示碳与活组织的最大量结合发生于陆地集水区。碳在所有生态系统的土壤或沉积物中均有累积,但碳库在近岸的浅海盆地达到最高值。海洋盆地,特别是外海盆地,多被输送碳及相关污染物进入波罗的海的巨大水平流所控制。结果显示,近岸浅海盆地接收了陆地集水区释放的相对大量的碳,沉积物的碎屑含量和净初级生产量都很高,使其必然成为Simpevarp地区放射性核素主要的累积点。由于冰后期的陆地抬升,先前放射性核素累积的底层可能用于农业目的,从而成为人类未来一个潜在的威胁。

关键词：有机物质核废料安全评估埋藏通量海洋生态系统放射性核素景观

Neurological consequences of human calmodulin mutations

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Neural Regeneration Research 2024年第5期19卷 943-944页

作者： Helene H.Jensen anders Olsen Medical Biotechnology Department of Chemistry and BiosciencesAalborg UniversityAalborgDenmark

When calcium ions enter the cytosol,it is a stimulatory signal for cellular *** calcium sensor calmodulin picks up the change in calcium concentration and relays this information to its more than 300 downstream interaction *** this way,calmodulin affects cellular processes such as fertilization,muscle contraction,neuronal firing,and *** is,calmodulin is involved in(nearly)everything!The significance of calmodulin is emphasized by the fact that we all carry three different genes(CAlM1,2,3)on different chromosomes that encode the exact same calmodulin protein,and these are all expressed in all cell ***,throughout vertebrate evolution,the protein sequence has remained completely unchanged.

关键词： consequences unchanged calmodulin

Emerging potential of progranulin-dependent SorCS2 signaling in healthy and diseased nervous systems

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Neural Regeneration Research 2025年第9期20卷 2591-2593页

作者： Alena Salasova anders Nykjær Danish Research Institute of Translational Neuroscience DANDRITE-Nordic EMBl Partnership for Molecular Medicine and Centre of Excellence PROMEMODepartment of BiomedicineAarhus UniversityAarhusDenmark

The formation of the mammalian nervous system and its maturation into sensory,motor,cognitive,and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young *** neurodevelopm... 详细信息

关键词： progr jointly CS2

Oral fluoroquinolones and the risk of Achilles tendon rupture

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Journal of Sport and Health Science 2024年第6期13卷 749-750页

作者： Peter Vibe Rasmussen Jarl Emanuel Strange anders Holt Department of Cardiology Herlev-Gentofte University HospitalCopenhagen 2730Denmark Department of Cardiology Bispebjerg-Frederiksberg University HospitalCopenhagen 2400Denmark Department of Cardiology Rigshospitalet University HospitalCopenhagen 2100Denmark

Dear editor,Fluoroquinolones(FQs)are a class of antibiotics used to treat bacterial infections,such as lower respiratory,gastrointestinal,and urinary tract *** to its broad-spectrum action and wide availability,it is ... 详细信息

关键词： prescribed spectrum action

Metabolic collaboration between cells in the tumor microenvironment has a negligible effect on tumor growth

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The Innovation 2024年第2期5卷 107-114页

作者： Johan Gustafsson Fariba Roshanzamir anders Hagnestål Sagar M.Patel Oseeyi I.Daudu Donald F.Becker Jonathan l.Robinson Jens Nielsen Department of life Sciences Chalmers University of TechnologySE-41296 GothenburgSweden Hagnesia AB SE-43854 HindåsSweden Department of Biochemistry and Redox Biology Center University of Nebraska-LincolnLincolnNE 68588USA BioInnovation Institute DK2200 CopenhagenDenmark

The tumor microenvironment is composed of a complex mixture of different cell types interacting under conditions of nutrient deprivation,but the metabolism therein is not fully understood due to difficulties in measuring metabolic fluxes and exchange of metabolites between different cell types in ***-scale metabolic modeling enables estimation of such exchange fluxes as well as an opportunity to gain insight into the metabolic behavior of individual cell ***,we estimated the availability of nutrients and oxygen within the tumor microenvironment using concentration measurements from blood together with a metabolite diffusion *** addition,we developed an approach to efficiently apply enzyme usage constraints in a comprehensive metabolic model of human *** combined modeling reproduced severe hypoxic conditions and the Warburg effect,and we found that limitations in enzymatic capacity contribute to cancer cells’preferential use of glutamine as a substrate to the citric acid ***,we investigated the common hypothesis that some stromal cells are exploited by cancer cells to produce metabolites useful for the cancer *** identified over 200 potential metabolites that could support collaboration between cancer cells and cancer-associated fibroblasts,but when limiting to metabolites previously identified to participate in such collaboration,no growth advantage was *** work highlights the importance of enzymatic capacity limitations for cell behaviors and exemplifies the utility of enzyme-constrained models for accurate prediction of metabolism in cells and tumor microenvironments.

关键词： metabolism effect limitations

Highly efficient vanadium redox flow batteries enabled by a trilayer polybenzimidazole membrane assembly

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Carbon Energy 2024年第7期6卷 191-204页

作者： Trung Tuyen Bui Mingyu Shin Mohammad Rahimi anders Bentien Yongchai Kwon Dirk Henkensmeier Hydrogen·Fuel Cell Research Center Korea Institute of Science and Technology(KIST)SeoulRepublic of Korea Department of Chemical and Biomolecular Engineering Seoul National University of Science and TechnologySeoulRepublic of Korea Department of Biological and Chemical Engineering Aarhus UniversityAarhusDenmark KIST School Division of Energy and Environment TechnologyUniversity of Science and TechnologySeoulRepublic of Korea Graduate School of Energy and Environment Korea UniversitySeoulRepublic of Korea

A novel polybenzimidazole(PBI)-based trilayer membrane assembly is developed for application in vanadium redox flow battery(VRFB).The membrane comprises a 1μm thin cross-linked poly[2,2′-(p-oxydiphenylene)−5,5′-bibenzimidazole](OPBI)sandwiched between two 20μm thick porous OPBI membranes(p-OPBI)without further lamination *** trilayer membrane demonstrates exceptional properties,such as high conductivity and low area-specific resistance(ASR)of 51 mS cm−1 and 81mΩcm^(2),*** with vanadium electrolyte increases the ASR of trilayer membrane only to 158mΩcm^(2),while that of Nafion is 193mΩcm^(2).VO^(2+)permeability is 2.73×10^(-9) cm^(2) min^(−1),about 150 times lower than that of Nafion *** addition,the membrane has high mechanical strength and high chemical stability against VO^(2+).In VRFB,the combination of low resistance and low vanadium permeability results in excellent performance,revealing high Coulombic efficiency(>99%),high energy efficiency(EE;90.8%at current density of 80mA cm^(−2)),and long-term *** EE is one of the best reported to date.

关键词： polybenzimidazole porous membrane proton conductivity trilayer VRFBs

Eco-evolutionary evidence for the global diversity pattern of Cycas(Cycadaceae)

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Journal of Integrative Plant Biology 2024年第6期66卷 1170-1191页

作者： Jian liu anders Jlindstrom Yiqing Gong Shanshan Dong Yusheng(Chris)liu Shouzhou Zhang Xun Gong CAS Key laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Department of Economic Plants and Biotechnology Yunnan Key Laboratory for Wild Plant ResourcesKunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China Global Biodiversity Conservancy 144/124 Moo3Soi Bua ThongBangsalaeSattahipChonburi 20250Thailand Key laboratory of Southern Subtropical Plant Diversity Fairy Lake Botanical GardenShenzhen&Chinese Academy of SciencesShenzhen 518004China Department of Earth and Environmental Sciences Indiana University-IndianapolisIndianapolisIN 46202USA

The evolution of the latitudinal diversity gradient(lDG),characterized by a peak in diversity toward the tropics,has captured significant attention in evolutionary biology and ***,the inverse lDG(i-lDG)mechanism,wherein species richness increases toward the poles,remains inadequately *** are among one of the oldest lineages of extant seed plants and have undergone extensive diversification in the ***,the extant cycad abundance exhibits an i-lDG pattern,and the underlying causes for this phenomenon remain largely ***,using 1,843 nuclear genes from a nearly complete sampling,we conducted comprehensive phylogenomic analyses to establish a robust species-level phylogeny for Cycas,the largest genus within *** then reconstructed the spatial-temporal dynamics and integrated global environmental data to evaluate the roles of species ages,diversification rates,contemporary environment,and conservatism to ancestral niches in shaping the i-lDG *** found Cycas experienced decreased diversification rates,coupled with the cooling temperature since its origin in the Eocene from continental *** regions have distinctively contributed to the formation of i-lDG for Cycas,with the northern hemisphere acting as evolutionary museums and the southern hemisphere serving as ***,water-related climate variables,specifically precipitation seasonality and potential evapotranspiration,were identified as paramount factors constraining Cycas species richness in the rainforest biome near the ***,the adherence to ancestral monsoonal climates emerges as a critical factor in sustaining the diversity *** study underscores the imperative of integrating both evolutionary and ecological approaches to comprehensively unravel the mechanisms underpinning global biodiversity patterns.

关键词： cycads latitudinal diversity gradient niche conservatism spatiotemporal diversification species richness

Influence of railway wheel tread damage on wheel-rail impact loads and the durability of wheelsets

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Railway Engineering Science 2024年第1期32卷 20-35页

作者： Michele Maglio Tore Vernersson Jens C.O.Nielsen anders Ekberg Elena Kabo CHARMEC Department of Mechanical and Maritime SciencesChalmers University of TechnologySE‑41296 GothenburgSweden

Dynamic wheel-rail contact forces induced by a severe form of wheel tread damage have been measured by a wheel impact load detector during full-scale field tests at different vehicle *** on laser scanning,the measured three-dimensional damage geometry is employed in simulations of dynamic vehicle-track interaction to calibrate and verify a simulation *** relation between the magnitude of the impact load and various operational parameters,such as vehicle speed,lateral position of wheel-rail contact,track stiffness and position of impact within a sleeper bay,is *** calibrated model is later employed in simulations featuring other forms of tread damage;their effects on impact load and subsequent fatigue impact on bearings,wheel webs and subsurface initiated rolling contact fatigue of the wheel tread are *** results quantify the effects of wheel tread defects and are valuable in a shift towards condition-based maintenance of running gear,and for general assessment of the severity of different types of railway wheel tread damage.

关键词： Wheel tread damage Rolling contact fatigue cluster Field measurements Dynamic vehicle-track interaction Wheel-rail impact load Wheelset durability