检索结果-南通市图书馆

Validation of a surgical model for posthepatectomy liver failure in rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Animal Models and Experimental Medicine 2023年第3期6卷 266-273页

作者： Andrea Lund Michelle Meier Kasper Jarlhelt andersen Marie Ingemann pedersen anders Riegels Knudsen Jakob Kirkegård Frank Viborg Mortensen Aarhus University Hospital Department of Upper Gastrointestinal and Hepato-Pancreato-Biliary SurgeryAarhus NDenmark

Background:The upper limit for liver resections in rats is approximately 90%.In the early postoperative phase,mortality *** aim of the present study was to validate the rat model of 90%partial hepatectomy(PH)as a model of post-hepatectomy liver failure(PHLF).Further,we wanted to test a quantitative scoring system as a detector of lethal outcomes caused by PHLF in ***:Sixty-eight rats were randomized to 90%PH,sham operation,or no ***,block randomization was performed based on time of euthanization:12,24,or 48 h after surgery.A general distress score(GDS)≥10 during the day or≥6 at midnight prompted early euthanization and classification as *** euthanized as planned were classified as *** euthanization,blood and liver tissue were collected,and liver-specific biochemistry was ***:Based on the biochemical results,all animals subjected to 90%PH expe-rienced *** rats were euthanized due to irreversible *** GDS increased for nonsurvivors within 12–18 h after *** mean time for euthaniza-tion was 27 h after ***:Based on the GDS and liver-specific biochemistry,we concluded that the model of 90%PH seems to be a proper model for investigating PHLF in *** a high GDS is associated with increased mortality,the GDS appears to be valuable in detect-ing lethal outcomes caused by PHLF in rats.

关键词： 90%liver resection general distress score liver failure post-hepatectomy liver failure rats

Estimation of Fatigue Life of Laser Welded AISI304 Stainless Steel T-Joint Based on Experiments and Recommendations in Design Codes

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Mechanics 2013年第3期3卷 178-183页

作者： S?ren Heide Lambertsen Lars Damkilde anders Schmidt Kristensen Ronnie Refstrup pedersen Division of Structures and Materials Aalborg University EsbjergEsbjergDenmark

In this paper the fatigue behavior of laser welded T-joints of stainless steel AISI304 is investigated experimentally. In the fatigue experiments 36 specimens with a sheet thickness of 1 mm are exposed to one-dimensional cyclic loading. Three different types of specimens are adopted. Three groups of specimens are used, two of these are non-welded and the third is welded with a transverse welding (T-Joint). The 13 laser welded specimens are cut out with a milling cutter. The non-welded specimens are divided in 13 specimens cut out with a milling cutter and 10 specimens cut out by a plasma cutter. The non-welded specimens are used to study the influence of heat and surface effects on the fatigue life. The fatigue life from the experiments is compared to fatigue life calculated from the guidelines in the standards DNV-RP-C203 and EUROCODE 3 EN-1993-1-9. Insignificant differences in fatigue life of the welded and non-welded specimens are observed in the experiments and the largest difference is found in the High Cycle Fatigue (HCF) area. The specimens show a lower fatigue life compared to DNV-RP-C203 and EUROCODE 3 EN-1993-1-9 when the specimens are exposed to less than 4.0 1E06 cycles. Therefore, we conclude that the fatigue life assessment according to the mentioned standards is not satisfactory and reliable.

关键词： AISI304 Laser Welding Austenite Martensite

Clinical and Immunological Effects in Patients with Advanced Non-Small Cell Lung-Cancer after Vaccination with Dendritic Cells Exposed to an Allogeneic Tumor Cell Lysate

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Vaccines 2013年第2期3卷 68-76页

作者： Lotte Engell-Noerregaard Pia Kvistborg Mai-Britt Zocca Ayako W. pedersen Mogens H. Claesson anders Mellemgaard DanDrit Biotech A/S Copenhagen Denmark Department of International Health Immunology and Microbiology The Panum Institute University of Copenhagen Copenhagen Denmark Department of Oncology Herlev University Hospital Herlev Denmark

Background: We evaluated the clinical and immunological effects of dendritic cell (DC) vaccination of patients with NSCLC. Autologous DCs were pulsed with a MAGE containing allogeneic melanoma cell lysate (MelCancerVac?, Dandrit Biotech,Copenhagen,Denmark). Imiquimod cream, proleukin and celecoxib were used as adjuvants to the vaccines. The objective of the study was to evaluate specific T cell response in vitro by IFNg EliSpot. Secondary objectives were overall survival, response and quality of life (QoL). Results: Twenty-two patients initiated the vaccination program consisting of ten vaccinations. Seven patients remained in stable disease (SD) three months after the first vaccination. After ten vaccinations (six months), four patients still showed SD and continued vaccinations on a monthly basis. These four patients received a total of 12, 16, 26 and 35 vaccinations, respectively. Five patients showed an unexpectedly prolonged survival. The treatment was well tolerated and only minor adverse events were reported. Quality of life did not change during the study period. In four of the seven patients with SD, vaccine-specific T cells were detected by IFNγ EliSpot assays, whereas only one patient with progressive disease (PD) showed vaccine-specific responses. Conclusion: This DC-based vaccine trial has indicated a correlation between vaccine-specific immunity and sustained SD. Furthermore, we observed an unexpectedly prolonged survival in some patients, which may indicate delayed effect of DC vaccination after completion of the treatment. A prospective randomized phase-IIb or -III is needed to further evaluate the use of MelCancerVac? vaccine treatment in patients with progressive NSCLC.

关键词： NSCLC Dendritic Cells Vaccination Tumor Lysate

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

如何更好地管理母猪的妊娠期

国外畜牧学（猪与禽） 2019年第7期39卷 34-37页

作者：黄迪(译) 陈权(校) 马晓迪(制图表) anders Due Haahr pedersen Sigrid Beth Rasmussen Trine Lund pedersen 不详 Danbred Technical Services Team

如何确保种母猪各个生产阶段的生产性能都处于最佳水平上?丹麦育种公司DanBred针对上述问题编写了一本管理手册,手册共分六章,内容涵盖种母猪生产的每一个阶段,并且详细介绍了从检疫到分娩后的各个方面。本文摘选其精华,主要介绍母猪妊... 详细信息

如何确保种母猪各个生产阶段的生产性能都处于最佳水平上?丹麦育种公司DanBred针对上述问题编写了一本管理手册,手册共分六章,内容涵盖种母猪生产的每一个阶段,并且详细介绍了从检疫到分娩后的各个方面。本文摘选其精华,主要介绍母猪妊娠期的管理。

关键词：妊娠母猪免疫接种环境体况

Deployment of Pre-Industrial Autonomous Microbe Sensor in Saudi Arabia’s Injection Seawater System

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Sensor Technology 2018年第1期8卷 1-17页

作者： Mohammed A.Al-Moniee Xiangyang Zhu Rikke Markfoged Aabdullah H.Al-Wadei Poul L.pedersen anders K.Tuxen Fuad I.Al-Nuwaiser Lone Tang Tinna Staghoj Roesen Thomas Lundgaard Saudi Arabian Oil Company(Saudi Aramco) DhahranSaudi Arabia Danish Technological Institute(DTI) AarhusDenmark

Microbial growth in water injection systems can lead to many problems, including biofouling, water quality deterioration, injectivity loss, microbial corrosion, and reservoir formation damage. Monitoring of microbial activities is required in any mitigation strategy, enabling operators to apply and adjust countermeasures properly and in due time. In this study, the pre-industrial autonomous microbe sensor (AMS) was constructed with technical improvements from the prototype for increased sensitivity, durability, robustness, and maintainability. The pre-industrial AMS was lab validated, field proven, and deployed at critical locations of seawater injection network for automated detection of microorganisms under the Saudi Arabia’s harsh environment. An excellent correlation between AMS measurement data (fluorescence count) and actual count of microbial cell number under microscope was established (coefficient of determination, R2 > 0.99) for converting AMS fluorescence count to cell numbers (cell mL-1) in the injection seawater. The pre-industrial AMS only required monthly maintenance with solutions refill, and was able to cope with hot summer months even without protection in an air-conditioned shelter. The study team recommended wider deployment of the online AMS for real-time monitoring of bacteria numbers in the various strategic locations in Saudi Aramco’s complex seawater injection network, as an integral component of pipeline corrosion and leak mitigation program.

关键词： Automated Monitoring Autonomous Microbe Sensor Microbial Sensor DNA Staining Injection Seawater

大剂量阿托伐他汀与常规剂量辛伐他汀在心肌梗死二级预防中的比较——IDEAL研究：随机对照试验

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

美国医学会杂志（中文版） 2006年第1期25卷 3-10页

作者： Terje R．pedersen Ole Faergeman John J. P. Kastelein anders G．Olsson Matti J. Tikkanen Ingar Holme Mogens Lytken Larsen Fridrik S. Bendiksen Christina Lindahl Michael Szarek John Tsai 王淑敏（译）仝其广（译）胡大一（校） Centre for Preventive Medicine Ulleval University Hospital Oslo Norway Department of MedicineCardiology A Arhus University Hospital Arhus Denmark Academic Hospital Amsterdam Amsterdam the Netherlands Department of Internal Medicine University Hospital Linkoping Sweden Department of Medicine Helsinki University Central Hospital Helsinki Finland Pfizer Sweden Taby Sweden Pfizer Inc New York NY Dr Bendiksen is in private practice in Hamar Norway. 不详

背景：证据显示，与临床常规降脂比较，对稳定性冠状动脉疾病患者施行强化降脂降低低密度脂蛋白胆固醇（low—density lipoprotein cholesterol，LDL—C）可进一步获益。目的：比较2种降脂治疗策略对既往有心肌梗死（MyocardialInfarct... 详细信息

背景：证据显示，与临床常规降脂比较，对稳定性冠状动脉疾病患者施行强化降脂降低低密度脂蛋白胆固醇（low—density lipoprotein cholesterol，LDL—C）可进一步获益。目的：比较2种降脂治疗策略对既往有心肌梗死（MyocardialInfarction，MI）病史患者心血管事件危险的影响。设计、地点及研究对象：IDEAL研究是一项前瞻性、随机、开放、盲法终点评价试验。试验于1999年3月至2005年3月在北欧190个心脏病急救单位和专家诊所进行，中位随访时间为4．8年。试验人选8888例有急性MI病史的患者，年龄≤80岁。干预：患者随机分配接受大剂量阿托伐他汀（80mg／d；n=4439）或常规剂量辛伐他汀（20mg／d；n=4449）治疗。主要终点：主要冠脉事件的发生定义为冠脉死亡、证实有非致命性急性MI或心脏骤停复苏。结果：治疗期间，辛伐他汀组平均LDL—C水平为104mg／dL（SE，0．3），阿托伐他汀组为81mg／dL（SE，0．3）。辛伐他汀组有463例（10．4％）患者发生了主要冠脉事件，阿托伐他汀组为411例（9．3％）（风险比[hazardratio，HR]，0．89；95％CI，0．78—1．01；P=0．07）。两组发生非致命性MI者分别为321例（7．2％）和267例（6．0％）（HR，0．83；95％CI，0．71—0．98；P=0．02）。但是另外两个一级终点组分的发生率两组末见显著差异。两组发生主要心血管事件者分别为608例和533例（HR，0．87；95％CI，0．77—0．98；P=0．02）。辛伐他汀组发生任何一种冠脉事件的患者有1059例，阿托伐他汀组898例（HR，0．84；95％CI，0．76—0．91；P〈0．001）。两组发生非心血管死亡者分别为156例（3．5％）和143例（3．2％）（HR，0．92；95％CI，0．73—1．15；P=0．47）。各种原因所致死亡：辛伐他汀组374例（8．4％），阿托伐他汀组366例（8．2％）（HR，0．98；95％CI，0．85—1．13；P=0．81）。阿托伐他汀组患者凶非严重性不良事件而停药的比例较高；因转氨酶升高分别导致43例（1．0％）和5例（0．1％）患者停药（P（0．001）。两组罕见严重肌病及横纹肌溶解。结论：研究表明，在既往有MI的患者，强化降低LDL—C并不能显著降低主要冠脉事件的一级终点，但是能降低其他复合二级终点及非致命性急性MI的危险。心血管死亡率或全因死亡率没有差异。强化降低LDL—C可使MI患者获益，而且不增加非心血管死亡率或其他严重不良反应。

关键词：随机对照试验阿托伐他汀辛伐他汀二级预防心肌梗死常规剂量大剂量低密度脂蛋白胆固醇心血管死亡率心血管事件

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

阿梅格尔巴克/哥本山

城市环境设计 2019年第2期 172-183页

作者： Nanna Gyldholm M?ller Alberto Cumerlato Aleksander Wadas Alexander Codda Alexander Ejsing Alexandra Gustafsson Alina Tamosiunaite Armor Gutierrez anders Hjortn?s Andreas Klok pedersen Annette Jensen Ariel Wallner Ask andersen Balaj IIulian Blake Smith Borko Nikolic Brygida Zawadzka Buster Christensen Chris Falla Chris Zhongtian Yuan Daniel Selensky Dennis Rasmussen Espen Vik Finn N?rkj?r Franck Fdida Gonzalo Castro Gül Ertekin George Abraham Helen Chen Henrick Poulsen Henrik R?mer Kania Horia Spirescu Jakob Ohm Laursen Jelena Vucic Jeppe Ecklon Ji-young Yoon Jing Xu Joanna Jakubowska Johanna Nenander Kamilla Heskje Katarzyna Siedlecka Krzysztof Marciszewski Laura W?tte Liang Wang Lise Jessen Long Zuo Maciej Zawadzki Mads Enggaard Stidsen Marcelina Kolasinska Marcos Bano Maren Allen Mathias Bank Matti N?rgaard Michael andersen Narisara Ladawal Schr?der Niklas A. Rasch Nynne Madsen ?ssur Nols? Pero Vukovic Richard Howis Ryohei Koike Se Hyeon Kim Simon Masson Sunming Lee Toni Mateu Xing Xiong Zoltan David Kalaszi Rasmus Hjortshoj 陈子钰

垃圾焚烧发电厂阿梅格尔巴克/哥本山位于工业区,多年来,该工业区已成为冒险者们的极限运动目的地。原始的工业设施为各种极限运动活动提供了场所,如缆绳滑水、卡丁车和攀岩等。阿梅格尔巴克/哥本山是该地区最重要的地标,其建筑亟须更新... 详细信息

垃圾焚烧发电厂阿梅格尔巴克/哥本山位于工业区,多年来,该工业区已成为冒险者们的极限运动目的地。原始的工业设施为各种极限运动活动提供了场所,如缆绳滑水、卡丁车和攀岩等。阿梅格尔巴克/哥本山是该地区最重要的地标,其建筑亟须更新。我们提出了一种新型的垃圾焚烧发电厂,这种工厂能产生经济、环保和社会效益。我们不将阿梅格尔巴克/哥本山视为一个孤立的对象,而是调动起建筑的

关键词：巴克本山

Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING