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Exercise benefits meet the esophagus

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Journal of Sport and.Health Science 2024年第5期13卷 685-686页

作者： Alejand.o santos-lozano Pedro l.Valenzuela Carmen Fiuza-luces Alejand.o lucia i+HeAlTH European University Miguel de CervantesValladolid 47012Spain Research Institute of the Hospital 12 de Octubre(“imas12”) Madrid 28041Spain Department of Systems Biology University of AlcalaAlcala de Heranes 28801Spain Faculty of Sport Sciences Universidad Europea de MadridVillaviciosa de Odon(Madrid)28670Spain

Gastroesophageal reflux disease(GERD)is defined by recurrent and.troublesome heartburn and.effortless regurgitation or by the specific complications of this condition—that is,esophagitis,esophageal peptic strictures,and.Barrett esophagus.1Although GERD is caused by gastric contents'reaching the esophagus,gastric juices can also reach other anatomical locations(pharynx,mouth,larynx,and.airways),leading to(or worsening)extra-esophageal conditions(notably asthma)or symptoms(e.g.,wheezing,cough).1 Together with obesity,GERD is the main risk factor for gastroesophageal malignancies.

关键词： esophagus esophageal Barrett

A Theoretically Grounded Question Answering Data Set for Evaluating Machine Common Sense

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Data Intelligence 2024年第1期6卷 1-28页

作者： Henrique santos Ke Shen Alice M.Mulvehill Mayank Kejriwal Deborah l.McGuinness Rensselaer Polytechnic Institute Troy NY Information Sciences Institute Marina del Rey CA

Achieving machine common sense has been a longstand.ng problem within Artificial *** far,benchmark data sets that are grounded in a theory of common sense and.can be used to conduct rigorous,semantic evaluations of common sense reasoning(CSR)systems have been *** expectation of the AI community is that neuro-symbolic reasoners can help bridge this gap towards more dependable systems with common *** propose a novel benchmark,called Theoretically Grounded common sense Reasoning(TG-CSR),modeled as a set of question answering instances,with each instance grounded in a semantic category of common sense,such as space,time,and.*** benchmark is few-shot i.e.,only a few training and.validation examples are provided in the public release to avoid the possibility of *** from recent evaluations suggest that TG-CSR is challenging even for state-of-the-art statistical *** to its semantic rigor,this benchmark can be used to evaluate the common sense reasoning capabilities of neuro-symbolic systems.

关键词： reasoning Intelligence instance

An oxygenating colloidal bioink for the engineering of biomimetic tissue constructs

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Bio-Design and.Manufacturing 2024年第3期7卷 240-261页

作者： Seol-Ha Jeong Jarno Hiemstra Patrick V.Blokzijl Rebeca Damian-Ferrara Danilo Martins dos santos Jéssica H.l.da Fonseca Min-Ho Kang Jihyun Kim Dilara Yilmaz-Aykut Mei l.l.Cham-Pérez Jeroen leijten Su Ryon Shin Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02139USA leijten lab Department of Developmental BioEngineeringFaculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteDrienerlolaan 57522 NB EnschedeThe Netherlands Nanotechnology National laboratory for Agriculture(lNNA) Embrapa InstrumentaçãoSao CarlosSao Paulo 13560-970Brazil Department of Biomedical-Chemical Engineering The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea Department of Biotechnology The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea

Ensuring a sufficient oxygen supply is pivotal for the success of bioprinting applications since it fosters tissue integration and.natural *** in oxygen concentration among diverse tissues necessitates the precise recreation of tissue-specific oxygen levels in imprinted constructs to support the survival of targeted *** oxygen-releasing biomaterials,such as oxygen-generating microparticles(OMPs),have shown promise for enhancing the oxygen supply of microenvironments in injured tissues,whether this approach is scalable for large tissues and.whether tissue-specific bioinks with varying OMP concentrations remain printable remain *** study addresses this critical gap by introducing an innovative class of engineered oxygenated bioinks that combine colloidal-based microgels with *** report that incorporating nanosized calcium peroxide(nCaO_(2))and.manganese oxide nanosheets(nMnO_(2))into hydrophobic polymeric microparticles enables precise modulation of oxygen release while controlling hydrogen peroxide ***,the fabrication of oxygenating and.cytocompatible colloidal gels is achieved using an aqueous two-phase *** study thoroughly evaluates the fundamental characteristics of the resulting bioink,including its rheological behaviors,printability,shape fidelity,mechanical properties,and.oxygen release ***,this study demonstrates the macroscopic scalability and.cytocompatibility of printed constructs produced via cell-laden oxygenating colloidal *** showcasing the effectiveness of extrusion-based bioprinting,this study underscores how it can be used to fabricate biomimetic tissues,indicating its potential for new *** findings presented here advance the bioprinting field by achieving scalability with both high cell viability and.the possibility of mimicking specifically oxygenated *** work thereby offers a promising avenue for the development of functional tissues with e

关键词： 3D bioprinting Bioink Colloidal gels Extrusion printing Oxygen-generating microparticle

A facile strategy for tuning the density of surface-grafted biomolecules for melt extrusion-based additive manufacturing applications

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Bio-Design and.Manufacturing 2024年第3期7卷 277-291页

作者： I.A.O.Beeren G.Dos santos P.J.Dijkstra C.Mota J.Bauer H.Ferreira Rui l.Reis N.Neves S.Camarero-Espinosa M.B.Baker l.Moroni Department of Complex Tissue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-PT Government Associate laboratory 4806-909 Braga/GuimarãesPortugal POlYMAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKERBASQUE Basque Foundation for Science48009 BilbaoSpain

Melt extrusion-based additive manufacturing(ME-AM)is a promising technique to fabricate porous scaffolds for tissue engi-neering ***,most synthetic semicrystalline polymers do not possess the intrinsic biological activity required to control cell *** of biomolecules on polymeric surfaces of AM scaffolds enhances the bioactivity of a construct;however,there are limited strategies available to control the surface ***,we report a strategy to tune the surface density of bioactive groups by blending a low molecular weight poly(ε-caprolactone)5k(PCl5k)containing orthogonally reactive azide groups with an unfunctionalized high molecular weight PCl75k at different *** porous three-dimensional(3D)scaf-folds were then fabricated using a high weight percentage(75 wt.%)of the low molecular weight PCl *** a proof-of-concept test,we prepared films of three different mass ratios of low and.high molecular weight polymers with a thermopress and.reacted with an alkynated fluorescent model compound on the surface,yielding a density of 201-561 pmol/cm^(2).Subsequently,a bone morphogenetic protein 2(BMP-2)-derived peptide was grafted onto the films comprising different blend compositions,and.the effect of peptide surface density on the osteogenic differentiation of human mesenchymal stromal cells(hMSCs)was *** two weeks of culturing in a basic medium,cells expressed higher levels of BMP receptor II(BMPRII)on films with the conjugated *** addition,we found that alkaline phosphatase activity was only significantly enhanced on films contain-ing the highest peptide density(i.e.,561 pmol/cm^(2)),indicating the importance of the surface *** together,these results emphasize that the density of surface peptides on cell differentiation must be considered at the cell-material ***,we have presented a viable strategy for ME-AM community that desires to tune the bulk and.surface functionality via blending of(m

关键词： Additive manufacturing Blending Surface functionalization Surface density Click chemistry Human

Modelling dynamic pantograph loads with combined numerical analysis

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Railway Engineering Science 2024年第1期32卷 81-94页

作者： F.F.Jackson R.Mishra J.M.Rebelo J.santos P.Antunes J.Pombo H.Magalhaes l.Wills M.Askill School of Computing and.Engineering University of HuddersfieldHuddersfieldUK School of Computing and.Engineering Institute of Railway ResearchUniversity of HuddersfieldHuddersfieldUK IDMEC Instituto Superior TecnicoUniversidade de LisboaLisbonPortugal ISEl Instituto Politecnico de LisboaLisbonPortugal Hitachi Rail Newton AycliffeUK Wabtec/Brecknell Willis ChardUK

Appropriate interaction between pantograph and.catenary is imperative for smooth operation of electric *** heights of overhead lines to accommodate level crossings,overbridges,and.tunnels pose significant challenges in maintaining consistent current collection performance as the pantograph aerodynamic profile,and.thus aerodynamic load changes significantly with operational *** research aims to analyse the global flow characteristics and.aerodynamic forces acting on individual components of an HSX pantograph operating in different configurations and.orientations,such that the results can be combined with multibody simulations to obtain accurate dynamic insight into contact ***,computational fluid dynamics simulations are used to investigate the pantograph component loads in a representative setting,such as that of the recessed cavity on a Class 800 *** an aerodynamic perspective,this study indicates that the total drag force acting on non-fixed components of the pantograph is larger for the knuckle-leading orientation rather than the knuckle-trailing,although the difference between the two is found to reduce with increasing pantograph *** the aerodynamic loads acting on individual components with multibody tools allows for realistic dynamic insight into the pantograph *** results obtained show how considering aerodynamic forces enhance the realism of the models,leading to behaviour of the pantograph-catenary contact forces closely matching that seen in experimental tests.

关键词： Pantograph-catenary interaction Pantograph aerodynamics Computational fluid dynamics Pantograph loads Current collection performance

Olympic Games and.24-hour movement behaviors:A match worth making

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Journal of Sport and.Health Science 2024年第6期13卷 728-731页

作者： Mark S.Tremblay Nicholas Kuzik Markus J.Duncan Diego Augusto santos Silva CHEO Research Institute OttawaON K1H 8L1Canada Department of Pediatrics University of OttawaOttawaON K1H 8L1Canada Federal University of Santa Catarina FlorianopolisSanta Catarina 88040-900Brazil

*** The Olympic motto,"Faster,Higher,Stronger-Together",represents the pursuit of athletic excellence,united as a global community."Excellence,respect and.friendship"are the Olympic *** the motto and.values are multifaceted and.holistic in nature,and.all-encompassing in their reach while recognizing no single entity rises above the ***,these foundational statements anchor the Olympic movement in its quest to build a better world through sport.

关键词： movement Together pursuit

Towards precision 24-hour movement behavior recommendations—The next new paradigm?

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Journal of Sport and.Health Science 2024年第6期13卷 743-748页

作者： Mark S.Tremblay Markus J.Duncan Nicholas Kuzik Diego Augusto santos Silva Valerie Carson CHEO Research Institute OttawaON K1H 8L1Canada Department of Pediatrics University of OttawaOttawaON K1H 8L1Canada Federal University of Santa Catarina Santa Catarina 88040900Brazil Faculty of Kinesiology Sportand RecreationUniversity of AlbertaEdmontonAB T6G 2H9Canada

*** The importance of physical activity(PA)for health is unequivocal.^(1)Accordingly,population-based recommendations for exercise,and.more recently public health guidelines for PA,have been developed and.released by authoritative groups for many decades.^(2)Such guidelines emerged with leadership from the exercise physiology discipline and.were rooted in,and.loyal to,the importance of moderate-to-vigorous intensity PA(MVPA)or exercise.

关键词： movement behavior exercise

liquid crystal immunosensors for the selective detection of Escherichia coli with a fast analysis tool

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Photonics Research 2024年第7期12卷 1564-1573页

作者： Sand.O C.OlIVEIRA MARIA S.SOARES BÁRBARA V.GONÇAlVES and.EIA C.M.RODRIGUES AMADEU M.V.M.SOARES RITA G.SOBRAl NUNO F.santos JAN NEDOMA PEDRO l.AlMEIDA CARlOS MARQUES CICECO-Aveiro Institute of Materials Physics DepartmentUniversity of Aveiro3810-193 AveiroPortugal i3N Physics DepartmentUniversity of Aveiro3810-193 AveiroPortugal Associate laboratory i4HB-Institute for Health and.Bioeconomy School of Sciences and TechnologyNOVA University of Lisbon1099-085 LisbonPortugal CESAM-Centre for Environmental and.Marine Studies and.Department of Biology University of Aveiro3810-193 AveiroPortugal Department of Telecommunications VSB-Technical University of OstravaOstrava 70800Czech Republic i3N-CENIMAT School of Sciences and TechnologyNOVA University of Lisbon1099-085 LisbonPortugal UnIRE ISELPolytechnic Institute of Lisbon1549-020 LisbonPortugal Department of Physics VSB-Technical University of OstravaOstrava 70800Czech Republic

The consumption of contaminated food may cause serious illnesses,and.traditional methods to detect Escherichia coli are still associated with long waiting times and.high costs given the necessity to transport samples to specialized *** is a need to develop new technologies that allow cheap,fast,and.direct monitoring at the site of ***,in this work,we developed optical immunosensors for the selective detection of ***,based on liquid crystal technology,whose molecules can align in different manners depending on the boundary conditions (such as substrates) as well as the environment that they *** glass substrate was functionalized with *** antibody using cysteamine as an intermediate,and.a vertical alignment was imposed on the liquid crystal molecules by using DMOAP during *** presence of bacteria disrupts the alignment of the liquid crystal molecules,changing the intensity of light emerging between cross polarizers,measured using a polarized optical microscope and.a *** was possible to detect *** in suspensions in the concentration range from 2.8 cells/ml to 2.8×10^(9) cells∕*** was also evaluated,and.the sensors were used to analyze contaminated water samples.A prototype was developed to allow faster,in-situ,and.easier analysis avoiding bulky instruments.

关键词： crystal alignment analysis

light demand.characteristics,production performance,and.changes in the feeding patterns of broilers

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International Journal of Agricultural and.Biological Engineering 2024年第2期17卷 68-73页

作者： Shouyi Wang Guoping Jiang Chenghao Pan Thebano santos Yasser Elhadidi Ahmed Jado Shufang Jin Jinming Pan College of Biosystems Engineering and.Food Science Zhejiang UniversityHangzhou 310058China Infinova(Hangzhou)Information System Technology Co. Ltd.Hangzhou 310012China Center of Information Technology"Renato Archer"(CIT) Ministry of ScienceTechnologyInnovation and CommunicationCEP:13069-901 Campinas(SP)Brazil Department of Agricultural Engineering Mansoura UniversityMansoura 35516Egypt

Poultry is a light-sensitive animal and.the light environment has an important influence on the growth and.development of these *** studies have mainly focused on the effects of the light environment on various physiological indicators of poultry but seldom explored the light demand.characteristics of broilers under free *** experiment mainly studied the light demand.characteristics of broilers under a yellow lED light environment and.the influence of different breeding densities[low-density(2.5 broilers/m^(2)),high-density(7.5 broilers/m^(2))]on the production performance and.diet characteristics of *** showed that the production performance indexes of low-density groups are higher than those of high-density *** feed and.water consumption in the light area of the two experimental groups were significantly higher than those in the dark area,which means that the broilers showed a great preference for the light ***,as the age of the broilers increased,the food and.water consumption of the broilers decreased,indicating that broilers had a lower preference for light in the middle and.late stages of *** statistical results for the residence frequency distribution characteristics showed that broiler chickens had different light requirements at different growth stages under the condition of active selection:1)low-density breeding environment:23.8l(light):0.2D(dark)for chicks and.22.3l:1.7D for adult broilers;2)high-density breeding environment:22.6l:1.4D for chicks and.15.0l:9.0D for adult *** study will provide a reference for the optimization and.control of light environment in broiler breeding.

关键词： broiler light-demand.characteristics production performance feeding pattern