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Mechanistic research:Selenium regulates virulence factors,reducing adhesion ability and inflammatory damage of Helicobacter pylori

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World Journal of Gastroenterology 2024年第1期30卷 91-107页

作者： chun Qin Gan-Rong huang Ai-Xing Guan Wen-Ting Zhou Hao chen Pei-Pei Luo Xian-Ke Luo Yan-Qiang huang Zan-Song huang Guangxi Technology Innovation cooperation Base of Prevention and control Pathogenic Microbes with Drug Resistance Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Digestive Diseases Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Key Laboratory of the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Pathology Wannan Medical CollegeWuhu 241002Anhui ProvinceChina Department of Gastroenterology Wujin People’s Hospital affiliated to Jiangsu UniversityChangzhou 213004Jiangsu ProvinceChina Department of Gastroenterology Guangzhou Liwan District People's HospitalGuangzhou 510370Guangdong ProvinceChina

BAcKGROUND The pathogenicity of Helicobacter pylori is dependent on factors including the environment and the *** selenium is closely related to pathogenicity as an environmental factor,the specific correlation between them remains *** To investigate how selenium acts on virulence factors and reduces their *** *** strains were induced by sodium *** expression of cytotoxin-associated protein A(cagA)and vacuolating cytotoxin gene A(VacA)was determined by quantitative PcR and Western *** was used to analyze cagA,cagM,cagE,cag1,cag3,and cagT.c57BL/6A mice were infected with the attenuated strains subjected to sodium selenite induction,and *** colonization,inflammatory reactions,and the cell adhesion ability of *** were *** cagA and VacA expression was upregulated at first and then downregulated in the *** strains after sodium selenite *** expression was significantly and steadily downregulated after the 5th cycle(10 d).Transcriptome analysis revealed that sodium selenite altered the levels affect *** virulence factors such as cagA,cagM,cagE,cag1,cag3,and *** these factors,cagM and cagE expression was continuously downregulated and further downregulated after 2 h of induction with sodium ***,cagT expression was upregulated before the 3rd cycle(6 d)and significantly downregulated after the 5th ***1 and cag3 expression was upregulated and downregulated,respectively,but no significant change was observed by the 5th cycle.c57BL/6A mice were infected with the attenuated strains subjected to sodium selenite *** extent of *** colonization in the stomach increased;however,sodium selenite also induced a mild inflammatory reaction in the gastric mucosa of ***-infected mice,and the cell adhesion ability of *** was significantly *** These results demonstrate that *** displayed virulence attenuation after

关键词： Helicobacter pylori Sodium selenite Virulence factors Adherence Inflammation

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Plasma metabolites and risk of myocardial infarction:a bidirectional Mendelian randomization study

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Journal of Geriatric cardiology 2024年第2期21卷 219-231页

作者： Dong-Hua LI Qiang WU Jing-Sheng LAN Shuo cHEN You-Yi huang Lan-Jin WU Zhi-Qing QIN Ying huang Wan-Zhong huang Ting ZENG Xin HAO Hua-Bin SU Qiang SU Department of cardiovascular Medicine Minzu Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Senior Department of cardiology the Sixth Medical CenterChinese PLA General HospitalBeijingChina Library of Graduate School Chinese PLA General HospitalBeijingChina Department of cardiology Jiangbin Hospital of Guangxi Zhuang Autonomous RegionGuangxiChina Health Management Institute the Second Medical CenterChinese PLA General HospitalBeijingChina

BAcKGROUND Myocardial infarction(MI)is a critical cardiovascular event with multifaceted etiology,involving several genetic and environmental *** is essential to understand the function of plasma metabolites in the development of MI and unravel its complex *** This study employed a bidirectional Mendelian randomization(MR)approach to investigate the causal relationships between plasma metabolites and MI *** used genetic instruments as proxies for plasma metabolites and MI and conducted MR analyses in both directions to assess the impact of metabolites on MI risk and vice *** addition,the large-scale genome-wide association studies datasets was used to identify genetic variants associated with plasma metabolite(1400 metabolites)and MI(20,917 individuals with MI and 440,906 individuals without MI)*** variance weighted was the primary method for estimating causal *** estimates are expressed as beta coefficients or odds ratio(OR)with 95%*** We identified 14 plasma metabolites associated with the occurrence of MI(Pch 8 plasma metabolites[propionylglycine levels(OR=0.922,95%cI:0.881–0.965,Pcine levels(OR=0.903,95%cI:0.861–0.948,Pcanedioate(c16-Dc)levels(OR=0.941,95%cI:0.911–0.973,Pcid levels(OR=0.923,95%cI:0.877–0.972,P=0.002),X-24546 levels(OR=0.936,95%cI:0.902–0.971,Pcine levels(OR=0.936,95%cI:0.909–0.964,Pcine to serine ratio(OR=0.930,95%cI:0.888–0.974,P=0.002),and mannose to trans-4-hydroxyproline ratio(OR=0.912,95%cI:0.869–0.958,Pcorrelated with a decreased risk of MI,whereas the remaining 6 plasma metabolites[1-palmitoyl-2-arachidonoyl-GPE(16:0/20:4)levels(OR=1.051,95%cI:1.018–1.084,P=0.002),behenoyl dihydrosphingomyelin(d18:0/22:0)levels(OR=1.076,95%cI:1.027–1.128,P=0.002),1-stearoyl-2-docosahexaenoyl-GPE(18:0/22:6)levels(OR=1.067,95%cI:1.027–1.109,P=0.001),alpha-ketobutyrate levels(OR=1.108,95%

关键词： infarction alterations diagnosis

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Indium-based electrocatalysts for cO_(2) reduction to c1 products

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chinese chemical Letters 2024年第6期35卷 134-145页

作者： Qin cheng Ming huang Qingqing Ye Bangwei Deng Fan Dong Research center for carbon-Neutral Environmental&Energy Technology Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengdu 611731China Yangtze Delta Region Institute(Huzhou)&Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaHuzhou 313000China Suzhou Industrial Technology Research Institute of Zhejiang University Suzhou 215163China

Electrocatalytic cO_(2) reduction at mild conditions is a promising strategy to transform greenhouse gases into fuels or value-added chemicals to solve the increasingly serious environmental and energy *** most crucial factor in determining the cO_(2) reduction performance is to develop efficient electrocatalysts with high selectivity and *** the various electrocatalysts,indium-based catalysts have attracted extensive attention due to their non-toxicity,low cost,and high formic acid/formate *** this work,we comprehensively review the recent development and research progress of indium-based electrocatalysts for cO_(2)*** reaction mechanism,reaction pathways,structure-activity relationship,and strategies to enhance the activity of cO_(2)RR on indium-based catalysts have also been briefly presented and ***,the existing challenges and future developments for indium-based highperformance catalysts for cO_(2)RR are proposed.

关键词： Electrocatalytic cO_(2) reduction In-based catalysts Formate Reaction mechanism Structure-activity relationship

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The early life immune dynamics and cellular drivers at single-cell resolution in lamb forestomachs and abomasum

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Journal of Animal Science and Biotechnology 2024年第1期15卷 218-235页

作者： Kailang huang Bin Yang Zebang Xu Hongwei chen Jiakun Wang Institute of Dairy Science College of Animal SciencesZhejiang UniversityHangzhou 310058China Key Laboratory of Molecular Animal Nutrition Ministry of EducationZhejiang UniversityHangzhou 310058China

Background Four-chambered stomach including the forestomachs(rumen,reticulum,and omasum)and abomasum allows ruminants convert plant fiber into high-quality animal *** early development of this four-chambered stomach is crucial for the health and well-being of young ruminants,especially the immune ***,the dynamics of immune development are poorly *** We investigated the early gene expression patterns across the four-chambered stomach in Hu sheep,at 5,10,15,and 25 days of *** found that forestomachs share similar gene expression patterns,all four stomachs underwent widespread activation of both innate and adaptive immune responses from d 5 to 25,whereas the metabolic function were significantly downregulated with *** constructed a cell landscape of the four-chambered stomach using single-cell *** transcriptomic and single-cell transcriptomic analyses revealed that the immune-associated module hub genes were highly expressed in T cells,monocytes and macrophages,as well as the defense-associated module hub genes were highly expressed in endothelial cells in the four-stomach ***,the non-immune cells such as epithelial cells play key roles in immune *** communication analysis predicted that in addition to immune cells,non-immune cells recruit immune cells through macrophage migration inhibitory factor signaling in the *** Our results demonstrate that the immune and defense responses of four stomachs are quickly developing with age in lamb's early *** also identified the gene expression patterns and functional cells associated with immune ***,we identified some key receptors and signaling involved in immune *** results help to understand the early life immune development at single-cell resolution,which has implications to develop nutritional manipulation and health management strategies based on specific targets including key

关键词： Early life Forestomachs Four-chambered stomach Immune cells Immune system maturation MIF signaling Rumen Ruminant development Single-cell transcriptomic sequencing

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Precise regulation of the phase transformation for pyrolusite during the reduction roasting process

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International Journal of Minerals,Metallurgy and Materials 2024年第1期31卷 81-90页

作者： Ruofeng Wang Peng Gao Shuai Yuan Yanjun Li Yingzhi Liu cheng huang School of Resources and civil Engineering Northeastern UniversityShenyang 110819China National-Local Joint Engineering Research center of High-efficient Exploitation Technology for Refractory Iron Ore Resources Shenyang 110819China

The mechanism involved in the phase transformation process of pyrolusite (MnO_(2)) during roasting in a reducing atmosphere was systematically elucidated in this study,with the aim of effectively using low-grade complex manganese ore *** to single-factor experiment results,the roasted product with a divalent manganese (Mn^(2+)) distribution rate of 95.30% was obtained at a roasting time of 25 min,a roasting temperature of 700℃,a cO concentration of 20at%,and a total gas volume of 500 mL·min^(-1),in which the manganese was mainly in the form of manganosite (MnO).Scanning electron microscopy and Brunauer–Emmett–Teller theory demonstrated the microstructural evolution of the roasted product and the gradual reduction in the pyrolusite ore from the surface to the core Thermodynamic calculations,X-ray photoelectron spectroscopy,and X-ray diffractometry analyses determined that the phase transformation of pyrolusite followed the order of MnO_(2)→Mn_(2)O_(3)→Mn_(3)O_(4)→MnO phase by phase,and the reduction of manganese oxides in each valence state proceeded simultaneously.

关键词： pyrolusite phase transformation reduction roasting microstructural evolution reaction mechanism

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Microstructures and micromechanical behaviors of high -entropy alloys investigated by synchrotron X-ray and neutron diffraction techniques: A review

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1333-1349页

作者： Yubo huang Ning Xu Huaile Lu Yang Ren Shilei Li Yandong Wang Beijing Advanced Innovation center of Materials Genome Engineering State Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology BeijingBeijing 100083China AnSteel Beijing Research Institute co.Ltd. Beijing 102200China Spallation Neutron Source Science center Dongguan 523803China Department of Physics City University of Hong KongHong Kong 999077China Institute for Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China

High-entropy alloys(HEAs)possess outstanding features such as corrosion resistance,irradiation resistance,and good mechan-ical properties.A few HEAs have found applications in the fields of aerospace and *** studies on the deformation mech-anisms of HEAs can guide microstructure control and toughness design,which is vital for understanding and studying state-of-the-art structural *** X-ray and neutron diffraction are necessary techniques for materials science research,especially for in situ coupling of physical/chemical fields and for resolving macro/microcrystallographic information on ***,several re-searchers have applied synchrotron X-ray and neutron diffraction methods to study the deformation mechanisms,phase transformations,stress behaviors,and in situ processes of HEAs,such as variable-temperature,high-pressure,and hydrogenation *** this review,the principles and development of synchrotron X-ray and neutron diffraction are presented,and their applications in the deformation mechanisms of HEAs are *** factors that influence the deformation mechanisms of HEAs are also *** review fo-cuses on the microstructures and micromechanical behaviors during tension/compression or creep/fatigue deformation and the application of synchrotron X-ray and neutron diffraction methods to the characterization of dislocations,stacking faults,twins,phases,and intergrain/interphase stress *** on future developments of synchrotron X-ray and neutron diffraction and on research directions on the deformation mechanisms of novel metals are discussed.

关键词： high-entropy alloys microstructures micromechanical behaviors synchrotron X-ray diffraction neutron diffraction

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Track-Pattern-Based characteristics of Extratropical Transitioning Tropical cyclones in the Western North Pacific

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Advances in Atmospheric Sciences 2024年第6期41卷 1251-1263页

作者： Hong huang Dan WU Yuan WANG Zhen WANG Yu LIU college of Meteorology and Oceanography National University of Defense TechnologyChangsha 410000China No.31631 Army of PLA Huizhou 516000China School of Atmospheric Sciences and Key Laboratory of Mesoscale Severe Weather/Ministry of Education Nanjing 210023China No.93721 Army of PLA Shuozhou 038300China

Based on the Regional Specialized Meteorological center(RSMc)Tokyo-Typhoon center best-track data and the NcEP-NcAR reanalysis dataset,extratropical transitioning(ET)tropical cyclones(ETcs)over the western North Pacific(WNP)during 1951–2021 are classified into six clusters using the fuzzy c-means clustering method(FcM)according to their track *** characteristics of the six hard-clustered ETcs with the highest membership coefficient are *** tropical cyclones(Tcs)that were assigned to clusters c2,c5,and c6 made landfall over eastern Asian countries,which severely threatened these *** landfalling Tcs,93.2%completed their ET after landfall,whereas 39.8%of ETcs completed their transition within one *** frequency of ETcs over the WNP has decreased in the past four decades,wherein cluster c5 demonstrated a significant decrease on both interannual and interdecadal timescales with the expansion and intensification of the western Pacific subtropical high(WPSH).This large-scale circulation pattern is favorable for c2 and causes it to become the dominant track pattern,owning to it containing the largest number of intensifying ETcs among the six clusters,a number that has increased insignificantly over the past four *** surface roughness variation and three-dimensional background circulation led to c5 containing the maximum number of landfalling Tcs and a minimum number of intensifying *** results will facilitate a better understanding of the spatiotemporal distributions of ET events and associated environment background fields,which will benefit the effective monitoring of these events over the WNP.

关键词： Western North Pacific tropical cyclone extratropical transition fuzzy c-means clustering method

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MIL-100(V) derived porous vanadium oxide/carbon microspheres with oxygen defects and intercalated water molecules as high-performance cathode for aqueous zinc ion battery

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Journal of Energy chemistry 2024年第3期90卷 578-589,I0013页

作者： Yuexin Liu Jian huang Xiaoyu Li Jiajia Li Jinhu Yang Kefeng cai Shanghai Key Laboratory of Development and Application for Metal-Functional Materials Key Laboratory of Advanced Civil Engineering MaterialsMinistry of EducationSchool of Materials Science&EngineeringTongji UniversityShanghai 201804China State Key Laboratory of High Performance ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 201800China Research center for Translational Medicine East HospitalTongji University School of MedicineShanghai 200092China

The development of aqueous zinc ion battery cathode materials with high capacity and high magnification is still a ***,porous vanadium oxide/carbon(p-VO_(x)@c,mainly VO_(2) with a small amount of V_(2)O_(3)) core/shell microspheres with oxygen vacancies are facilely fabricated by using a vanadium-based metal-organic framework(MIL-100(V)) as a sacrificial *** unique structure can improve the conductivity of the VO_(x),accelerate electrolyte diffusion,and suppress structural collapse during ***,H_(2)O molecules are introduced into the interlayer of VO_(x) through a highly efficient in-situ electrochemical activation process,facilitating the intercalation and diffusion of zinc *** the activation,an optimal sample exhibits a high specific capacity of 464.3 mA h g^(-1) at0.2 A g^(-1) and 395.2 mA h g^(-1) at 10 A g^(-1),indicating excellent rate ***,the optimal sample maintains a capacity retention of about 89.3% after 2500 cycles at 10 A g^(-1).Density functional theory calculation demonstrates that the presence of oxygen vacancies and intercalated water molecules can significantly reduce the diffusion barrier for zinc *** addition,it is proved that the storage of zinc ions in the cathode is achieved by reversible intercalation/extraction during the charge and discharge process through various ex-situ analysis *** work demonstrates that the p-VO_(x)@c has great potential for applications in aqueous ZIBs after electrochemical activation.

关键词： Metal-organic frameworks Vanadium oxide carbon Zn-ion batteries Electrochemical activation

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Progressive fragmentation of granular assemblies within rockslides: Insights from discrete-continuous numerical modeling

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Journal of Mountain Science 2024年第4期21卷 1174-1189页

作者： JIANG Hui ZHOU Yuande WANG Jinting DU Xiuli huang Hailong Key Laboratory of Urban Security and Disaster Engineering of Ministry of Education Beijing University of TechnologyBeijing 100124China. Key Laboratory of the Hydrosphere Sciences of the Ministry of Water Resources Tsinghua UniversityBeijing 100084China china Three Gorges construction Management co. Ltd.Chengdu 610000China

Rock fragmentation plays a critical role in rock avalanches,yet conventional approaches such as classical granular flow models or the bonded particle model have limitations in accurately characterizing the progressive disintegration and kinematics of multi-deformable rock blocks during *** present study proposes a discrete-continuous numerical model,based on a cohesive zone model,to explicitly incorporate the progressive fragmentation and intricate interparticle interactions inherent in *** rock granular assemblies are released along an inclined plane and flow onto a horizontal *** numerical scenarios are established to incorporate variations in slope angle,initial height,friction coefficient,and particle *** evolutions of fragmentation,kinematic,runout and depositional characteristics are quantitatively analyzed and compared with experimental and field data.A positive linear relationship between the equivalent friction coefficient and the apparent friction coefficient is *** general,the granular mass predominantly exhibits characteristics of a dense granular flow,with the Savage number exhibiting a decreasing trend as the volume of mass *** process of particle breakage gradually occurs in a bottom-up manner,leading to a significant increase in the angular velocities of the rock blocks with increasing *** simulation results reproduce the field observations of inverse grading and source stratigraphy preservation in the *** propose a disintegration index that incorporates factors such as drop height,rock mass volume,and rock *** findings demonstrate a consistent linear relationship between this index and the fragmentation degree in all tested scenarios.

关键词： Rock fragmentation Rockslide Numerical modelling Discrete-continuous modelling Runout cohesive zone model

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High-performance formaldehyde prediction for indoor air quality assessment using time series deep learning

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Building Simulation 2024年第3期17卷 415-429页

作者： Liu Lu Xinyu huang Xiaojun Zhou Junfei Guo Xiaohu Yang Jinyue Yan School of Human Settlements and civil Engineering Xi’an Jiaotong UniversityXi’anChina Department of Building Environment and Energy Engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina Future Energy Profile School of BusinessSocietyand EngineeringMälardalen UniversityVästeråsSweden

Indoor air pollution resulting from volatile organic compounds(VOcs),especially formaldehyde,is a significant health concern needed to predict indoor formaldehyde concentration(cf)in green intelligent building *** study develops a thermal and wet coupling calculation model of porous fabric to account for the migration of formaldehyde molecules in indoor air and cotton,silk,and polyester fabric with heat flux in Harbin,Beijing,Xi’an,Shanghai,Guangzhou,and Kunming,*** time-by-time indoor dry-bulb temperature(T),relative humidity(RH),and cf,obtained from verified simulations,were collated and used as input data for the long short-term memory(LSTM)of the deep learning model that predicts indoor multivariate time series cf from the secondary source effects of indoor fabrics(adsorption and release of formaldehyde).The trained LSTM model can be used to predict multivariate time series cf at other emission times and *** LSTM-based model also predicted cf with mean absolute percentage error(MAPE),symmetric mean absolute percentage error(SMAPE),mean absolute error(MAE),mean square error(MSE),and root mean square error(RMSE)that fell within 10%,10%,0.5,0.5,and 0.8,*** addition,the characteristics of the input dataset,model parameters,the prediction accuracy of different indoor fabrics,and the uncertainty of the data set are *** results show that the prediction accuracy of single data set input is higher than that of temperature and humidity input,and the prediction accuracy of LSTM is better than recurrent neural network(RNN).The method’s feasibility was established,and the study provides theoretical support for guiding indoor air pollution control measures and ensuring human health and safety.

关键词： multivariate time series formaldehyde concentration deep learning heat-humidity coupling mass transfer secondary source effect

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