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Oxygen is an essential gasotransmitter directly sensed via protein gasoreceptors

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Animal Models and Experimental Medicine 2024年第2期7卷 189-193页

作者： Savani anbalagan Faculty of Biology Institute of Molecular Biology and BiotechnologyAdam Mickiewicz UniversityPoznańPoland

The current restrictive criteria for gasotransmitters exclude oxygen(O_(2))as a gasotransmitter in *** this manuscript,I propose a revision of gasotransmitter criteria to include O_(2) per se as a signaling molecule and'essential gasotransmitter'for *** revision would enable us to search for protein-based O_(2)-binding sensors(gasoreceptors)in all cells in the brain or other tissues rather than specialized tissues such as the carotid body or *** microorganisms have protein-based O_(2)-binding sensors or gasoreceptors such as DosP or FixL or FNR with diverse signaling domains,then eukaryotic cells must also have O_(2)-binding sensors or *** as there are proteinbased receptor(s)for nitric oxide(GUCY1A,GUCY1B,CLOCK,NR1D2)in cells of diverse tissues,it is reasonable to consider that there are protein-based receptors for O_(2) in cells of diverse tissues as *** mammals,O_(2) must be acting as a gasotransmitter or gaseous signaling molecule via protein-based gasoreceptors such as androglobin that very likely mediate acute sensing of O_(2).Accepting O_(2) as an essential gasotransmitter will enable us to search for gasoreceptors not only for O_(2) but also for other nonessential gasotransmitters such as hydrogen sulfide,ammonia,methane,and *** will also allow us to investigate the role of environment-derived metal ions in acute gas(or solute)sensing within and between ***,accepting O_(2) per se as a signaling molecule acting via gasoreceptors will open up the field of gasocrinology.

关键词： essential gasotransmitter gasocrine gasoreceptor gasocrinology

An Adaptive Scalable Data Pipeline for Multiclass Attack Classification in Large-Scale IoT Networks

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Big Data Mining and Analytics 2024年第2期7卷 500-511页

作者： Selvam saravanan Uma Maheswari Balasubramanian Department of Computer Science and Engineering Amrita School of ComputingAmrita Vishwa VidyapeethamBengaluru 560035India

The current large-scale Internet of Things(IoT)networks typically generate high-velocity network traffic *** use IoT devices to create botnets and launch attacks,such as DDoS,Spamming,Cryptocurrency mining,Phishing,*** service providers of large-scale IoT networks need to set up a data pipeline to collect the vast network traffic data from the IoT devices,store it,analyze it,and report the malicious IoT devices and types of ***,the attacks originating from IoT devices are dynamic,as attackers launch one kind of attack at one time and another kind of attack at another *** number of attacks and benign instances also vary from time to *** phenomenon of change in attack patterns is called concept ***,the attack detection system must learn continuously from the ever-changing real-time attack patterns in large-scale IoT network *** meet this requirement,in this work,we propose a data pipeline with Apache Kafka,Apache Spark structured streaming,and MongoDB that can adapt to the ever-changing attack patterns in real time and classify attacks in large-scale IoT *** concept drift is detected,the proposed system retrains the classifier with the instances that cause the drift and a representative subsample instances from the previous training of the *** proposed approach is evaluated with the latest dataset,IoT23,which consists of benign and several attack instances from various IoT *** classification accuracy is improved from 97.8%to 99.46%by the proposed *** training time of distributed random forest algorithm is also studied by varying the number of cores in Apache Spark environment.

关键词： Internet of Things(IoT) concept drift Apache Spark MongoDB Apache Kafka streaming

Lateral clavicle fracture-plating options and considerations

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World Journal of Clinical Cases 2024年第6期12卷 1039-1044页

作者： Sathish Muthu saravanan Annamalai Velmurugan Kandasamy Department of Orthopaedics Orthopaedic Research GroupCoimbatore 641045Tamil NaduIndia Department of Biotechnology Karpagam Academy of Higher EducationCoimbatore 641021Tamil NaduIndia Department of Orthopaedics Government Karur Medical CollegeKarur 639004Tamil NaduIndia Department of Orthopaedics Government Thiruvallur Medical CollegeThiruvallur 631203Tamil NaduIndia Department of Orthopaedics Government Kilpauk Medical CollegeChennai 600010Tamil NaduIndia

Clavicle fractures are among the most prevalent types of fractures with numerous treatment strategies that have evolved over *** the realm of lateral-third clavicle fracture management,several surgical methods are available,with plate and screw constructs being one of the most frequently employed *** this construct,numerous choices exist for fixing the *** editorial provides an overview of the common plate options utilized in the management of distal third clavicle fractures underscoring the critical considerations and approaches that guide clinicians in selecting the most appropriate fixation techniques,considering the complex landscape of clavicle fractures and their challenging management.

关键词： Clavicle fracture Surgical management Distal clavicle plating Superior plating Anterior plating

Tenosynovitis of hand: Causes and complications

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World Journal of Clinical Cases 2024年第4期12卷 671-676页

作者： Sathish Muthu saravanan Annamalai Velmurugan Kandasamy Department of Orthopaedics Government Medical CollegeKarur 639004Tamil NaduIndia Orthopaedic Research Group Coimbatore 641045Tamil NaduIndia Department of Biotechnology Faculty of EngineeringKarpagam Academy of Higher EducationCoimbatore 641021Tamil NaduIndia Department of Orthopaedics Government Thiruvallur Medical CollegeThiruvallur 631203Tamil NaduIndia Department of Orthopaedics Government Kilpauk Medical CollegeChennai 600010Tamil NaduIndia

Tenosynovitis represents a common clinical condition characterized by inflam-mation of the synovium that encases the tendon *** tenosynovities may be noted in any tendon in the body,extremities such as hand,and foot remain the sites of high predilection to acquire this *** predominant cause of this predilection rests in the intricate tendon arrangements in these extremities that permit fine motor *** editorial explores the common causes and the complications associated with this condition to improve the understanding of the readers of this common condition encountered in our everyday clinical practice.

关键词： Tenosynovitis Gout Hand Complications Infection

Modified Black Widow Optimization-Based Enhanced Threshold Energy Detection Technique for Spectrum Sensing in Cognitive Radio Networks

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2339-2356页

作者： R.saravanan R.Muthaiah A.Rajesh School of Computing SASTRA Deemed UniversityThanjavur613401India School of Electrical&Electronics Engineering SASTRA Deemed UniversityThanjavur613401India

This study develops an Enhanced Threshold Based Energy Detection approach(ETBED)for spectrum sensing in a cognitive radio *** threshold identification method is implemented in the received signal at the secondary user based on the square *** proposed method is implemented with the signal transmission of multiple outputs-orthogonal frequency division ***,the proposed method is considered the dynamic detection threshold adjustments and energy identification spectrum sensing technique in cognitive radio *** the dynamic threshold,the signal ratio-based threshold is *** threshold is computed by considering the Modified Black Widow Optimization Algorithm(MBWO).So,the proposed methodology is a combination of dynamic threshold detection and *** general threshold-based detection technique has different limitations such as the inability optimal signal threshold for determining the presence of the primary user *** limitations undermine the sensing accuracy of the energy identification ***,the ETBED technique is developed to enhance the energy efficiency of cognitive radio *** projected approach is executed and analyzed with performance and comparison *** proposed method is contrasted with the conventional techniques of theWhale Optimization Algorithm(WOA)and GreyWolf Optimization(GWO).It indicated superior results,achieving a high average throughput of 2.2 Mbps and an energy efficiency of 3.8,outperforming conventional techniques.

关键词： Cognitive radio network spectrum sensing noise uncertainty modified black widow optimization algorithm energy detection technique

The circuitry landscape of perovskite solar cells:An in-depth analysis

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Journal of Energy Chemistry 2024年第7期94卷 393-413页

作者： Siddhi Vinayak Pandey Daniel Prochowicz Apurba Mahapatra saravanan Pandiaraj Abdullah N.Alodhayb Seckin Akin Pankaj Yadav Department of Solar Energy School of Energy TechnologyPandit Deendayal Energy UniversityGandhinagar 382007GujaratIndia Department of Physical Chemistry Polish Academy of SciencesKasprzaka 44/5201-224 WarsawPoland Department of Self-Development Skills King Saud UniversityRiyadh 11451Saudi Arabia Department of Physics and Astronomy College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia Department of Metallurgical and Materials Engineering Necmettin Erbakan University42060 KonyaTurkey Department of Physics School of Energy TechnologyPandit Deendayal Energy UniversityGandhinagar 382007GujaratIndia

The extensive research and development in perovskite solar cells (PSCs) have rekindled the hopes of converting solar energy into *** elusive understanding of underlying mechanisms is required for the development of efficient *** the years,Impedance Spectroscopy (IS) characterization,along with complementary techniques,has proven to be an effective way to understand and analyze the charge transport and recombination at interface and bulk of *** IS of PSCs have been analyzed,interpreted,and improvised continuously,revealing intricate details about the ***,there is a lack of centralized source of these details,which make it tougher to account for the generalized approach to understand the device *** present work is focused on compiling the research done on various PSC device architectures via IS to construct a comprehensive foundation of information on impedance plots,equivalent circuits,and associated processes.

关键词： Impedance Spectroscopy Perovskite solar cells Equivalent Circuits

Successful fiberoptic orotracheal intubation by lifting large thyroid mass and tongue protrusion in left lateral position:a case report

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Emergency and Critical Care Medicine 2024年第2期4卷 97-99页

作者： Sarfaraz Ahmad Neeraj Kumar Ajeet Kumar saravanan Palasevam Department of Anaesthesiology All India Institute of Medical Sciences PatnaBiharIndia

Introduction:Awake fiberoptic bronchoscopy has long been considered the criterion standard for the management of difficult airways because of large thyroid *** an unsuccessful attempt to intubate with a fiberoptic bronchoscope in the supine position,the decision to switch to the left lateral position was *** present this case to propose the utilization of the lateral position for awake *** presentation:We report a rare case of a patient with a large papillary carcinoma of the thyroid planned for surgical *** patient presented to our hospital with complaints of difficulty breathing while lying down in the supine position and oozing blood from the necrotic *** breathing difficulties subsided in the lateral ***:We demonstrated how the left lateral position with an adjunct maneuver facilitates intubation in large thyroid malignancies.

关键词： Awake intubation Case report Lateral position Thyroid malignancy

“Blind men and an elephant”:The need for animals in research,drug safety studies,and understanding civilizational diseases

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Animal Models and Experimental Medicine 2023年第6期6卷 627-633页

作者： Savani anbalagan Faculty of Biology Institute of Molecular Biology and BiotechnologyAdam Mickiewicz University in PoznańPoznańPoland

Animal-based research and drug safety studies are essential to understanding the mysteries of nature and the long-term survival of *** to the rapid increase in the global human population,conflict-and economically driven human migration,tourism-related activities,densely populated metropolitan areas,and local policies,humans will be affected by a multitude of novel disease-causing microorganisms and civilizational *** disparities among countries,recent and planned changes in regulations concerning animal research and drug safety studies could have detrimental effects on both the animal research community and nations lacking sufficient social support *** on existing scientific literature,I argue that we need animal research encompassing aspects such as animal development,behavior,drug safety studies,and for the understanding of future civilizational *** on the nature of the research questions and local challenges,a suitable animal model organism should be made mandatory.

关键词： animal model drug safety studies research zebrafish

Synchronization of nonlinear multi-agent systems using a non-fragile sampled data control approach and its application to circuit systems

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Frontiers of Information Technology & Electronic Engineering 2023年第4期24卷 553-566页

作者： Stephen AROCKIA SAMY Raja RAMACHANDRAN Pratap anbalagan Yang CAO Department of Mathematics Alagappa UniversityKaraikudi 630003Tamil NaduIndia Ramanujan Centre for Higher Mathematics Alagappa UniversityKaraikudi 630003Tamil NaduIndia Research Center for Wind Energy Systems Kunsan National UniversityGunsan 573-701Republic of Korea School of Cyber Science and Engineering Southeast UniversityNanjing 210096China

The main aim of this work is to design a non-fragile sampled data control(NFSDC) scheme for the asymptotic synchronization criteria for interconnected coupled circuit systems(multi-agent systems, MASs). NFSDC is used to conduct synchronization analysis of the considered MASs in the presence of time-varying delays. By constructing suitable Lyapunov functions, sufficient conditions are derived in terms of linear matrix inequalities(LMIs) to ensure synchronization between the MAS leader and follower systems. Finally, two numerical examples are given to show the effectiveness of the proposed control scheme and less conservation of the proposed Lyapunov functions.

关键词： Multi-agent systems(MASs) Non-fragile sampled data control(NFSDC) Time-varying delay Linear matrix inequality(LMI) Asymptotic synchronization