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The influence of the crystalline nature of nano-metal oxides on their antibacterial and toxicity properties

Nano Research 2015年第2期8卷 695-707页

作者： liana Perelshtein anat lipovsky Nina Perkas Aharon Gedanken Elisa Moschini Paride Mantecca Department of Chemistry and Kanbar Laboratory for Nanomaterials Bar-Ilan University Center for Advanced Materials and Nanotechnology Ramat-Gan 52900 Israel Department of Earth and Environmental Sciences Particulate Matter an Health Risk (POLARIS) Research Centre University of Milano Bicocca Milano 20126 Italy

The antibacterial properties of nano-metal oxides （ZnO, CuO） are based on the formation of reactive oxygen species （ROS）. This work reveals that the antibacterial properties of these nano-metal oxides are strongly dependent on their crystalline structure. The antibacterial activity of the nanooxides was tested against four types of bacteria that commonly cause nosocomial infections. The sonochemical method was applied not only for synthesis of nanooxides but also to their coating on textiles. The antibacterial properties of textiles coated with commercial and sonochemically prepared nano-metal oxides were evaluated and compared. The toxicity was evaluated on human lung cells and amphibian embryos, as representative models for inhalation and aquatic toxicology. The sonochemically prepared metal nanooxides are better antimicrobials than commercially available metal oxides with the same particle size range. It was found that the crystallites which have more defects and less organized structure are more toxic. The formation of ROS was studied by electron spin resonance （ESR） measurements for both the sonochemically prepared and commercial samples of ZnO/CuO nanoparticles. A significant increase in the production of radical species was found in the more defective, sonochemically prepared samples, as compared to the commercial ones. Since modulation of the nanoparticle defects influenced their toxicity, the possibility of engineering safer nano-antibacterials is indicated.

关键词： CuO ZnO nanoparticles antibacterial activity reactive oxygen species(ROS) cytotoxicity lung cells

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Immediate and Long Term Clinical Benefits of a Novel Topical Micronized Collagen Face Cream

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Journal of Cosmetics, Dermatological Sciences and Applications 2022年第4期12卷 153-163页

作者： Rachel Lubart anat lipovsky Chemistry Department Bar Ilan University Ramat Gan Israel Physics Department Bar Ilan University Ramat Gan Israel Hava Zingboim Ltd. Ramat Gan Israel

Collagen has been a component of skin care formulations for many years, and over this time, there have been numerous claims of its efficiency. Collagen protein is responsible for firm strong skin, but since collagen fibers are too large to penetrate the stratum corneum (SC), topical creams containing collagen fibers remain on the skin surface without affecting skin quality. To overcome the poor penetration of collagen fibers, we prepared in the past micronized collagen fibers that were proven to reach the epidermis layer while inserted in a cream. In the present paper, we have performed a clinical study that analyzes the effect of the micronized fibrillar collagen containing cream on skin. Fifty five healthy female volunteers were enrolled and completed the study. The anti-ageing, firming, elasticity and moisturization efficacy of the cream were measured using Profilometer, Cutometer and Corneometer respectively. The results showed a significant improvement in skin hydration firmness and elasticity, a significant reduction in fine lines and wrinkles was also observed.

关键词： Micronized Collagen Face Cream Clinical Studies Skin Parameters Penetration

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A Novel Facial Cream Based on Skin Penetrable Hemp Oil Microparticles

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Journal of Cosmetics, Dermatological Sciences and Applications 2023年第3期13卷 165-178页

作者： Rachel Lubart Inbar Yariv Dror Fixler Ayelet Rothstein Arie Gruzman anat lipovsky Department of Chemistry Bar Ilan University Ramat-Gan Israel Physics Department of Faculty of Exact Sciences Bar Ilan University Ramat-Gan Israel Faculty of Engineering Bar Ilan University Ramat-Gan Israel Institute of Nanotechnology and Advanced Materials Bar-Ilan University Ramat-Gan Israel Hava Zingboim Ltd. Ramat-Gan Israel

Objective: Hemp seed oil is perfect for most skin types;it moisturizes skin and protects it from inflammation, oxidation, and other causes of aging. The problem is that the Hemp oil-based products do not penetrate the skin;they remain on the skin’s surface. Recently researchers have been trying to prepare nano emulsions of hemp oil to facilitate its permeation to deep skin layers. In all techniques used today, surfactants are added to the emulsification process. These surfactants may cause unwanted skin side effects. In the present study, we prepare micronized Hemp (m-Hemp) without using any surfactants in the micronization process, thus avoiding the side effects associated with surfactant addition. Methods & Results: Particles size of m-Hemp was evaluated using electron microscopy. Various sizes of m-Hemp were found, the smallest being 100 nm in diameter. The antioxidation properties of m-Hemp were measured using the Electron Spin Resonance (ESR) technique and were found to be enhanced. Skin topography and morphology following a cream containing m-Hemp treatment were visualized by Optical Profilometry and ESEM respectively. The results show a marked improvement in skin topography in all measured parameters. In addition, human keratinocytes (HaCaT) were exposed to inflammatory conditions and were then treated using Hemp. As a result, one of the key inflammatory factors (IL-2) was significantly reduced after treatment with m-Hemp (p ≤ 0.0001). The skin penetration of the cream containing m-Hemp was tested on human skin using the IMOPE (Iterative Multi-plane Optical Property Extraction) system. The results indicate that m-Hemp penetrates both the stratum corneum and the deep epidermal layers towards the dermis. Conclusion: The new cream prepared with micronized Hemp shows significant anti-inflammatory and antioxidative effects and demonstrates the entrance of m-Hemp to the skin epidermal layer.

关键词： Hemp Microparticles Anti-Inflammatory Antioxidant Skin Penetration

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