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Role of exercise in preventing and restoring gut dysbiosis in patients with inflammatory bowel diseases:A review

World Journal of Gastroenterology 2021年第30期27卷 5037-5046页

作者： Tilemachos Koutouratsas anastassios philippou George Kolios Michael Koutsilieris Maria Gazouli Department of Basic Medical Sciences Laboratory of BiologyMedical SchoolNational and Kapodistrian University of AthensAthens 11527Greece Department of Basic Medical Sciences Laboratory of PhysiologySchool of MedicineNational and Kapodistrian University of AthensAthens 11527Greece Department of Medicine Laboratory of PharmacologyDemocritus University of ThraceAlexandroupolis 68100Greece

Inflammatory bowel diseases(IBD)include a spectrum of chronic inflammatory disorders of the gastrointestinal tract whose pathogenesis is yet to be *** intestinal microbiome has been studied as a causal component,with certain microbiotic alterations having been observed in subtypes of *** exercise is a modulator of the intestinal microbiome,causing shifts in its composition that are partially corrective of those observed in IBD;furthermore,physical exercise may be beneficial in patients with certain IBD *** review studies the effects of physical exercise on the human gut microbiome while investigating pathophysiologic mechanisms that could explain physical activity’s clinical effects on patients with IBD.

关键词： Inflammatory bowel disease Ulcerative colitis Crohn’s disease Pouchitis Microbiome Exercise

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Effectiveness of high intensity interval training on cardiorespiratory fitness and endothelial function in type 2 diabetes:A systematic review

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World Journal of Cardiology 2023年第4期15卷 184-199页

作者： Christos Kourek Eleftherios Karatzanos Vasiliki Raidou Ourania Papazachou anastassios philippou Serafim Nanas Stavros Dimopoulos Clinical Ergospirometry Exercise and Rehabilitation Laboratory1st Critical Care Medicine DepartmentEvangelismos HospitalAthens 10676Greece Department of Cardiology 417 Army Share Fund Hospital of AthensAthens 11521Greece Clinical Ergospirometry Exercise and Rehabilitation LaboratoryNational and Kapodistrian University of AthensAthens 10676Greece Department of Cardiology "Helena Venizelou"HospitalAthens 10676Greece Department of Physiology School of MedicineNational and Kapodistrian University of AthensAthens 11527Greece Cardiac Surgery Intensive Care Unit Onassis Cardiac Surgery CenterAthens 17674Greece

BACKGROUND Type 2 diabetes mellitus(T2DM)is a chronic metabolic syndrome characterized by insulin resistance and hyperglycemia that may lead to endothelial dysfunction,reduced functional capacity and exercise *** aerobic exercise has been promoted as the most beneficial non-pharmacological treatment of cardiovascular *** intensity interval training(HIIT)seems to be superior than moderate-intensity continuous training(MICT)in cardiovascular diseases by improving brachial artery flow-mediated dilation(FMD)and cardiorespiratory fitness to a greater ***,the beneficial effects of HIIT in patients with T2DM still remain under investigation and number of studies is *** To evaluate the effectiveness of high intensity interval training on cardiorespiratory fitness and endothelial function in patients with *** We performed a search on PubMed,PEDro and CINAHL databases,selecting papers published between December 2012 and December 2022 and identified published randomized controlled trials(RCTs)in the English language that included community or outpatient exercise training programs in patients with *** were assessed for methodological rigor and risk of bias via the Physiotherapy Evidence Database(PEDro).The primary outcome was peak VO_(2 ) and the secondary outcome was endothelial function assessed either by FMD or other indices of *** Twelve studies were included in our systematic *** 12 RCTs resulted in 661 participants in *** was performed in 310 patients(46.8%),MICT to 271 and the rest 80 belonged to the control *** VO_(2 ) increased in 10 out of 12 studies after *** studies compared HIIT with other exercise regimens(MICT or strength endurance)and 4 of them demonstrated additional beneficial effects of HIIT over MICT or other exercise ***,4 studies explored the effects of HIIT on endothelial function and FMD in T2DM *** 2 of them,HIIT further impro

关键词： Type 2 diabetes mellitus Exercise High intensity interval training Cardiorespiratory fitness Peak VO_(2) Endothelial function

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