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Friction 2024年第5期12卷 1042-1056页

作者： anastasiya a.yakovenko Irina G.GORYACHEVA Ishlinsky Institute for Problems in Mechanics RAS Moscow119526Russia

The contact of a rigid body with nominally flat rough surface and an elastic half-space is *** solve the contact problem,the Greenwood-Williamson statistical model and the localization principle are *** developed contact model allows us to investigate the surface approach and the real contact area with taking into account the asperities *** is shown that the mutual influence of asperities changes not only contact characteristics at the macroscale,but also the contact pressure distribution at the *** follows from the results,the inclusion in the contact model of the effect of the mutual influence of asperities is especially significant for studying the real contact area,as well as the contact characteristics at high applied *** results calculated according to the proposed approach are in a good agreement with the experimentally observed effects,i.e.,the real contact area saturation and the additional compliance exhaustion.

关键词： surface roughness elasticity Greenwood-Williamson model localization principle asperity interaction

Molecular therapeutic strategies targeting pancreatic cancer induced cachexia

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World Journal of Gastrointestinal Surgery 2018年第9期10卷 95-106页

作者： Anastasiya.yakovenko Miles Cameron Jose Gilberto Trevino University of Florida College of Medicine GainesvilleFlorida 32610United States Department of Surgery University of Florida Health Sciences CenterGainesvilleFlorida 32610United States

Pancreatic cancer(PC) induced cachexia is a complex metabolic syndrome associated with significantly increased morbidity and mortality and reduced quality of life. The pathophysiology of cachexia is complex and poorly understood. Many molecular signaling pathways are involved in PC and cachexia. Though our understanding of cancer cachexia is growing, therapeutic options remain limited. Thus, further discovery and investigation of the molecular signaling pathways involved in the pathophysiology of cachexia can be applied to development of targeted therapies. This review focuses on three main pathophysiologic processes implicated in the development and progression of cachexia in PC, as well as their utility in the discovery of novel targeted therapies. Skeletal muscle wasting is the most prominent pathophysiologic anomaly in cachectic patients and driven by multiple regulatory pathways. Several known molecular pathways that mediate muscle wasting and cachexia include transforming growth factor-beta(TGF-β), myostatin and activin, IGF-1/PI3 K/AKT, and JAK-STAT signaling. TGF-β antagonism in cachectic mice reduces skeletal muscle catabolism and weight loss, while improving overall survival. Myostatin/activin inhibition has a great therapeutic potential since it plays an essential role in skeletal muscle regulation. Overexpression of insulin-like growth factor binding protein-3(IGFBP-3) leads to increased ubiquitination associated proteolysis, inhibition of myogenesis, and decreased muscle mass in PC induced cachexia. IGFBP-3 antagonism alleviates muscle cell *** component of cachexia is profound systemic inflammation driven by pro-cachectic cytokines such as interleukin-6(IL-6), tumor necrosis factoralpha(TNF-α), and interferon gamma(INF-γ). IL-6 antagonism has been shown to reduce inflammation, reduce skeletal muscle loss, and ameliorate cachexia. While TNF-α inhibitors are clinically available, blocking TNF-α signaling is not effective in the treatment of c

关键词： Cachexia Muscle wasting Pancreatic cancer Cachexia therapies Molecular signaling

Melt Pockets in Garnet Megacrysts from Cenozoic Alkali Basalts of the Shavaryn Tsaram Vicinity,Mongolia

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Acta Geologica Sinica(English Edition) 2022年第1期96卷 111-122页

作者： Anna ASEEVA Oleg AVCHENKO Alexander KARABTSOV Alexander CHASHCHIN Sergey VYSOTSKIY Victoria.yakovenko Natalia ZARUBINA Natalia KHARITONOVA Far East Geological Institute Russian Academy of SciencesVladivostok 690022Russia Far Eastern Federal University Natural Science SchoolVladivostok 690022Russia Lomonosov Moscow State University Geological DepartmentMoscow 119991Russia

Garnet megacryst with a multiphase inclusion from intraplate alkali basalts of the Shavaryn Tsaram(Tariat,Mongolia)was the object of the *** unusual aggregate consists of porous glass,Ti-rich biotite,orthopyroxene,spinel,clinopyroxene,olivine,and *** TWQ 2.32 thermodynamic simulation of this system revealed a few intervals of *** and temperature adjustment reflected in the paragenetic minerals of the melt *** capture of already crystallised garnet megacryst was at P=0.8-1 GPa and T=1120-1160℃.Mineral crystallisation inside the melt pocket,accompanied by external inputs,occurred at P=0.75-0.95 GPa;T=790-1120℃.Symplectite assemblage formed in the garnet megacryst due to decomposition at(P=0.55-0.7 GPa;T=850-930℃).The study of the oxygen isotope content in primary garnet and biotite of the melt pocket showed that the δ^(18)O_(VSMOW) values are the same and correspond to that of typical mantle ***,the chemical and microcomponent composition of the melt pocket minerals reveals a material that differs from basalts and ***,it has been revealed that the multiphase inclusion in the garnet megacryst formed not only on account of the garnet’s substance,but also due to the entrapped material of the Earth’s interior.

关键词： megacrysts garnet alkali basalts WinTWQ 2.32

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Jacques Derrida's Origin of Literature,with Impossible Filiations

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比较文学与世界文学

比较文学与世界文学 2014年第1期 28-36页

作者： Sergiy yakovenko 加拿大阿尔伯塔大学

In his"Resistance to Theory,"Paul de Man suggests that literary theory"should address such questions as the definition of literature(what is literature?)and discuss the distinction between literary and non-literary uses of language,as well as between literary and non-verbal forms of art."(4)Although the questions that de Man poses in his famous essay are of a structuralist and dialectical nature(to mention at

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Modernism after the Postmodern:Other Modernisms

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比较文学与世界文学

比较文学与世界文学 2014年第1期 2-13页

作者： Tamara Hundorova Sergiy yakovenko 乌克兰科学院文学理论部

Aesthetic modernism is a cult phenomenon in twentieth century literature and *** crystallized due to the intellectual efforts of many artists and critics of the first half of the twentieth century,who craved to keep t...

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Azithromycin in a triple therapy for *** eradication in active duodenal ulcer

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World Journal of Gastroenterology 2002年第5期8卷 879-882页

作者： Vladimir T.Ivashkin Tatiana L.Lapina Oksana Yu.Bondarenko Olga A. Sklanskaya Petr Va.Grigoriev Yuri V.Vasiliev Emilia P.yakovenko Pavel V.Gulyaev Valeri I.Fedchenko V.Vasilenko Clinic of internal diseases gastroenterology and hepatology of the Moscow Sechenov Medical Academy119881 Pogodinskaya 5MoscowRussia Pathology Department of the Moscow Sechenov Medical Academy 119881Trubetskaya 8MoscowRussia Gastroenterological Center of the Health Ministry of Russia 105203N.Pervomayskaya ul.70MoscowRussia Central Institution of Gastroenterology 111123Sh.Entusiastov 86MoscowRussia

AIM:To assess and compare the efficacy and safety of two triple regimes:A)metronidazole,amoxicillin and omeprazole, which is still widely used in Russia,and B)azithromycin, amoxicillin and omeprazole in healing active duodenal ulcer and *** eradication. METHODS:100 patients with active duodenal ulcer were included in the open,multicentre,randomized study with comparative *** were randomly assigned to one of the following one-week triple regimes:A) metronidazole 500 mg bid,amoxicillin I g bid and omeprazole 20 mg bid(OAM,n=50)and B)azithromycin 1 god for the first 3 days(total dose 3 g),amoxicillin 1 g bid and omeprazole 20 mg bid(OAA,n=50).Omeprazole 20 mg od was given after the eradication course as a monotherapy for three *** control endoscopy was performed 8 weeks after the *** was determined in the entry of the study and four weeks after the cessation of treatment by means of histology and CLO-test. RESULTS:97 patients completed the study according to the protocol(1 patient of the OAM group did not come to the control endoscopy,2 patients of the OAA group stopped the treatment because of mild allergic urticaria).Duodenal ulcers were healed in 48 patients of the OAM group(96 %, C190.5-100 %)and in 46 patients of the OAA group(92 %, CI 89.5-94.5 %)(p=ns).*** was eradicated in 15 out of 50 patients with OAM(30 %,CI 17-43 %)and in 36 out of 50 patients treated with OAA(72 %;CI 59-85 %) (P<0.001)-ITT ***: The triple therapy with omeprazole, amoxicillin and metronidazole failed to eradicate ***'vc\ the majority of patients, which is an essential argument to withdraw this regimen out of the national recommendations. Macrolide with amoxicillin are preferable to achieve higher eradication rates. Azithromycin (1 g od for the first 3 days) can be considered as a successful component of the triple PPI-based regimen.

关键词： Helicobacter pylori Adolescent Adult Aged Amoxicillin dosage Anti-Bacterial Agents Anti-Ulcer Agents Azithromycin Comparative Study Drug Therapy, Combination Duodenal Ulcer Female Helicobacter Infections Humans Male Metronidazole Middle Aged Omeprazole Penicillins Research Support, Non-U.S. Gov't Treatment Outcome

Impact of In^(3+) cations on structure and electromagnetic state of M-type hexaferrites

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Journal of Energy Chemistry 2022年第6期31卷 667-676,I0018页

作者： Vitalii Alexandrovich Turchenko Sergei Valentnovich Trukhanov Vladmir Grigor'evich Kostishin Francua Damay Florance Porcher Denis Sergeevich Klygach Maxim Grigor'evich Vakhitov Lyudmila Yur'evna Matzui Olena Sergeevna.yakovenko Bernat Bozzo Ignasi Fina Munirah Abdullah Almessiere Yassine Slimani Abdulhadi Baykal Di Zhou Alex Valentinovich Trukhanov Joint Institute for Nuclear Research 6 Joliot-Curie Str.Dubna 141980Russia South Ural State University 76Lenin Av.Chelyabinsk 454080Russia Donetsk Institute of Physics and Technology named after O.O.Galkin of the NASU 46 Nauki Av.Kiev 03680Ukraine SSPA“Scientific and Practical Materials Research Centre of NAS of Belarus” 19 P.Brovki str.Minsk 220072Belarus National University of Science and Technology“MISiS” Leninsky av.4Moscow 119049Russia Laboratoire Leon Brillouin UMR12 CEA-CNRSB̂at.563 CEA SaclayGif sur YvetteCedex 91191France Ural Federal University named after the First President of Russia B.N.Yeltsin Yekaterinburg 620002Russia Taras Shevchenko National University of Kyiv Volodymyrs’ka str.64/13Kyiv 01601Ukraine Institut de Ciencia de Materials de Barcelona-CSIC Campus de la UABBellaterraBarcelona 08193Spain Department of Biophysics Institute for Research and Medical Consultations(IRMC)Imam Abdulrahman Bin Faisal UniversityP.O.Box 1982Dammam 31441Saudi Arabia Department of Nanomedicine Institute for Research and Medical Consultations(IRMC)Imam Abdulrahman Bin Faisal UniversityP.O.Box 1982Dammam 31441Saudi Arabia Electronic Materials Research Laboratory Key Laboratory of the Ministry of Education&International Center for Dielectric ResearchSchool of Electronic Science and EngineeringXi’an Jiaotong UniversityXi'an 710049ShannxiChina Department of Physics College of ScienceImam Abdulrahman Bin Faisal UniversityP.O.Box 1982Dammam 31441Saudi Arabia

The solid solutions of In^(3+) doped M-type strontium hexaferrites were produced using a conventional solid-state reaction method,and Rietveld analysis of the neutron diffraction patterns was ***^(3+) cations occupy octahedral (4f_(Ⅵ)and 12 k) and tetrahedral (4f_(Ⅳ)) positions (SG=P6_(3)/mmc(No.194)).The average particle size is 837–650 *** tempearature (T_(C)) of the compounds monotonically decreased down to~520 K with increasing x.A frustrated magnetic state was detected from ZFC and FC *** magnetization (M_(s)) and effective magnetocrystalline anisotropy coefficient (k_(eff)) were determined using the law of approach to saturation.A real permittivity (ε″) maximum of~3.3 at~45.5 GHz and an imaginary permittivity (ε′) of~1.6 at~42.3 GHz were observed for x=0.1.A real permeability (μ′) maximum of~1.5 at~36.2 GHz was observed for x=0.Aμ″imaginary permeability maximum of~0.8 at~38.3 GHz was observed for x=*** interpretation of the results is based on the type of dielectric polarization and the natural ferromagnetic resonance features.

关键词： Doped strontium hexaferrites Neutron powder diffraction Magnetic properties Permittivity Permeability

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Modeling sustainability:population,inequality,consumption,and bidirectional coupling of the Earth and Human Systems

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National Science Review 2016年第4期3卷 470-494页

作者： Safa Motesharrei Jorge Rivas Eugenia Kalnay Ghassem R.Asrar Antonio J.Busalacchi Robert F.Cahalan Mark A.Cane Rita R.Colwell Kuishuang Feng Rachel S.Franklin Klaus Hubacek Fernando Miralles-Wilhelm Takemasa Miyoshi Matthias Ruth Roald Sagdeev Adel Shirmohammadi Jagadish Shukla Jelena Srebric Victor M.yakovenko Ning Zeng University of Maryland College Park Institute for Global Environment and Society 3. Joint Global Change Research Institute College Park 4. University Corporation for Atmospheric Research 5. Johns Hopkins University Applied Physics Laboratory NASA Goddard Space Flight Center Lamont–Doherty Earth Observatory of Columbia University 8. Spatial Structures in the Social Sciences/Population Studies and Training Center Brown University RIKEN Advanced Institute for Computational Science School of Public Policy and Urban Affairs and Department of Civil and Environmental EngineeringNortheastern University 11. Department of AtmosphericOceanicand Earth SciencesGeorge Mason University

Over the last two centuries,the impact of the Human System has grown dramatically,becoming strongly dominant within the Earth System in many diferent ***,inequality,and population have increased extremely fast,especially since about 1950,threatening to overwhelm the many critical functions and ecosystems of the Earth *** in the Earth System,in turn,have important feedback efects on the Human System,with costly and potentially serious ***,current models do not incorporate these critical *** argue that in order to understand the dynamics of either system,Earth System Models must be coupled with Human System Models through bidirectional couplings representing the positive,negative,and delayed feedbacks that exist in the real *** particular,key Human System variables,such as demographics,inequality,economic growth,and migration,are not coupled with the Earth System but are instead driven by exogenous estimates,such as United Nations population *** makes current models likely to miss important feedbacks in the real Earth–Human system,especially those that may result in unexpected or counterintuitive outcomes,and thus requiring diferent policy interventions from current *** importance and imminence of sustainability challenges,the dominant role of the Human System in the Earth System,and the essential roles the Earth System plays for the Human System,all call for collaboration of natural scientists,social scientists,and engineers in multidisciplinary research and modeling to develop coupled Earth–Human system models for devising efective science-based policies and measures to beneit current and future generations.

关键词： Earth and Human System Models population migration inequality data assimilation bidirectional couplings and feedbacks sustainability

On Near-Wall Limiting Behaviors of Low-Reynolds-Number Reynolds-Stress Models

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On Near-Wall Limiting Behaviors of Low-Reynolds-Number Reyno...

第四届海峡两岸计算流体力学学术研讨会

作者： Sergey N. yakovenko and Keh-Chin CHANG Department of Aeronautics and Astronautics, National Cheng Kung University, Tainan, Taiwan

＜正＞ A new approach is proposed to resolve the unbalance contradiction found during checking near-wall behavior of modeled second-moment equations. In addition to presentation of sought functions as the expansions in terms of y but excluding the condition stemmed from the continuity equation for fluctuation velocity, it solves directly the approximate equations at small y values. The present analysis shows that orders of the major terms of expansions for vertical normal and shear stresses found in the grid-independent LRN RSM models are smaller than those of the conventional expansions.

关键词： Reynolds-stress model Channel flow Asymptotic analysis.

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卷帘式彩色LCoS显示器的对比度改善

现代显示 2004年第4期 17-21页

作者： J.A.Shimizu P.Janssen S.yakovenko D.Anderson 柳玉华徐康兴 Philips Research USA Philips LCoS Microdisplay Systems USA 北京牡丹电子集团公司

卷帘式彩色LCoS(硅上液晶)显示必须展现其快速和高对比度两项特性。这些要求推动了成像核心的液晶和光学系统的设计选择。我们发现,输入方向必须沿着入射偏振方向,且须选择一种补偿性的45TN0效应。高对比度需要对界面反射提出严格的要... 详细信息

卷帘式彩色LCoS(硅上液晶)显示必须展现其快速和高对比度两项特性。这些要求推动了成像核心的液晶和光学系统的设计选择。我们发现,输入方向必须沿着入射偏振方向,且须选择一种补偿性的45TN0效应。高对比度需要对界面反射提出严格的要求。线栅PBS能实现高的对比度且能简化系统结构。在关注上述问题的同时,我们曾报告过,在视屏上的时序对比度为8001。采用90TN0效应,其对比度可以更高,但会有一些光效损失。采用这种效应所测时序对比度为20001。

关键词：硅上液晶对比度投影

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