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Fetal lung growth predicts the risk for early-life respiratory infections and childhood asthma

World Journal of Pediatrics 2024年第5期20卷 481-495页

作者： Dimitra E.Zazara Olympia Giannou Steven Schepanski Mirja Pagenkemper anastasios D.Giannou Maike Pincus Ioannis Belios Stefan Bonn Ania C.Muntau Kurt Hecher Anke Diemert Petra Clara Arck Division for Experimental Feto-Maternal Medicine Department of Obstetrics and Fetal MedicineUniversity Medical Center Hamburg-Eppendorf(UKE)Martinistraße 5220251HamburgGermany University Children’s Hospital UKEHamburgGermany Computer Engineering and Informatics Department Polytechnic SchoolUniversity of PatrasPatrasGreece Institute of Developmental Neurophysiology Center for Molecular Neurobiology Hamburg(ZMNH)UKEHamburgGermany Department of Obstetrics and Fetal Medicine UKEHamburgGermany Department of General Visceral and Thoracic SurgeryUKEHamburgGermany Section of Molecular Immunology and Gastroenterology Ⅰ.Department of MedicineUKEHamburgGermany Pediatrics and Pediatric Pneumology Practice BerlinGermany Institute of Medical Systems Biology ZMNHUKEHamburgGermany Hamburg Center for Translational Immunology UKEHamburgGermany

Background Early-life respiratory infections and asthma are major health burdens during *** predicting an increased risk for early-life respiratory diseases are ***,we identified the predictive value of ultrasound-monitored fetal lung growth for the risk of early-life respiratory infections and *** Fetal lung size was serially assessed at standardized time points by transabdominal ultrasound in pregnant women participating in a pregnancy *** between fetal lung growth and respiratory infections in infancy or early-onset asthma at five years were ***-learning models relying on extreme gradient boosting regressor or classifier algorithms were developed to predict respiratory infection or asthma risk based on fetal lung *** model development and validation,study participants were randomly divided into a training and a testing group,respectively,by the employed *** Enhanced fetal lung growth throughout pregnancy predicted a lower early-life respiratory infection *** sex was associated with a higher risk for respiratory infections in *** lung growth could also predict the risk of asthma at five years of *** designed three machine-learning models to predict the risk and number of infections in infancy as well as the risk of early-onset *** models’R2 values were 0.92,0.90 and 0.93,respectively,underscoring a high accuracy and agreement between the actual and predicted *** variables included known risk factors and novel predictors,such as ultrasound-monitored fetal lung *** Sonographic monitoring of fetal lung growth allows to predict the risk for early-life respiratory infections and asthma.

关键词： Asthma Child risk Early-life respiratory infections Prenatal lung development Sexual dimorphism

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Laparoscopic splenectomy:Current concepts

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World Journal of Gastrointestinal Endoscopy 2017年第9期9卷 428-437页

作者： Evangelos P Misiakos George Bagias Theodore Liakakos anastasios Machairas 3rd Department of Surgery Attikon University HospitalUniversity of Athens School of Medicine Clinic for General Visceral and Transplant SurgeryHannover Medical School 1st Department of Surgery National and Kapodistrian University of AthensMedical SchoolLaikon General Hospital

Since early 1990's,when it was inaugurally introduced,laparoscopic splenectomy has been performed with excellent results in terms of intraoperative and postoperative *** laparoscopic splenectomy is the approach of choice for both benign and malignant diseases of the *** some contraindications still *** evolution of the technology has allowed though,cases which were considered to be absolute contraindications for performing a minimal invasive procedure to be treated with modified laparoscopic ***,the introduction of advanced laparoscopic tools for ligation resulted in less intraoperative ***,laparoscopic splenectomy is considered safe,with better outcomes in comparison to open splenectomy,and the increased experience of surgeons allows operative times comparable to those of an open *** this review we discuss the indications and the contraindications of laparoscopic *** we analyze the standard and modified surgical approaches,and we evaluate the short-term and long-term outcomes.

关键词： Laparoscopy Splenectomy Splenomegaly Hand-assisted-laparoscopic-splenectomy Lymphoma

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Occlusive Spasm of the Left Anterior Descending Artery and First Diagonal Branch After Implantation of Everolimus Eluting Stents Without Re-stenosis in a Female Patient with Resting Angina

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Cardiovascular Innovations and Applications 2017年第B5期2卷 395-397页

作者： Giancarlo Pirozzolo anastasios Athanasiadis Udo Sechtem Peter Ong Robert-Bosch-Krankenhaus Department of CardiologyStuttgartGermany

Introduction Myocardial ischemia and angina pectoris can be caused by various mechanisms such as coronary atherosclerosis,vasospasm or coronary microvascular dysfunction[1].We here report a case of a56-year-old female patient with a history of previous percutaneous coronary interventions(PCI)who reported repetitive attacks of resting *** risk factors included hypertension,hypercholesterolemia(LDL=97 mg/dL on atorvastatin),ex-smoker(ceased 2013),and a positive family history(fatal myocardial infarction in father aged52years and brother 59 years).

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Takotsubo cardiomyopathy complicating transcatheter mitral valve-in-valve replacement

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Journal of Geriatric Cardiology 2022年第7期19卷 559-561页

作者： Maria Drakopoulou George Oikonomou George Latsios Andreas Synetos George Benetos Chrysavgi Simopoulou anastasios Apostolos Stergios Soulaidopoulos Konstantina Aggeli Vasilios Lozos Dimitrios Lymperiadis Costas Tsioufis Konstantinos Toutouzas First Department of Cardiology Medical SchoolNational and Kapodistrian University of AthensHippokration General Hospital of AthensAthensGreece Department of Cardiac Surgery Hippokration General Hospital of AthensAthensGreece

A 73-year-old female presented with symp-tomatic heart failure(NYHA class Ⅲ)due to a failed 29-mm Sorin(*** Medical,***,MN)bioprosthetic heart valve surgically implanted 10-year before for severe primary mitral valve regurgitation(flail of the anterior mitral leaf-let at A2 scallop).Preprocedural echocardiography showed preserved left ventricular function with severe bioprosthetic valve stenosis and concomit-ant moderate regurgitation(Video 1 in Supplement).Because of prohibitive surgical risk,a transeptal mitral valve-in-valve(ViV)replacement was planned.

关键词： valve mitral replacement

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Nicotine-induced adrenal beta-arrestin1 upregulation mediates tobacco-related hyperaldosteronism leading to cardiac dysfunction

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World Journal of Cardiology 2020年第5期12卷 192-202页

作者： Natalie Cora Jennifer Ghandour Celina Marie Pollard Victoria Lynn Desimine Krysten Elaine Ferraino Janelle Marie Pereyra Rachel Valiente anastasios Lymperopoulos Laboratory for the Study of Neurohormonal Control of the Circulation Department of Pharmaceutical Sciences(Pharmacology)College of PharmacyNova Southeastern UniversityFort LauderdaleFL 33328-2018United States

BACKGROUND Tobacco-related products,containing the highly addictive nicotine together with numerous other harmful toxicants and carcinogens,have been clearly associated with coronary artery disease,heart failure,stroke,and other heart *** the mechanisms by which nicotine contributes to heart disease is elevation of the renin-angiotensin-aldosterone system(RAAS)***,and its major metabolite in humans cotinine,have been reported to induce RAAS activation,resulting in aldosterone elevation in *** has various direct and indirect adverse cardiac *** is produced by the adrenal cortex in response to angiotensin II(AngII)activating AngII type 1 *** activity increases in chronic smokers,causing raised aldosterone levels(nicotine exposure causes the same in rats).AngII receptors exert their cellular effects via either G proteins or the twoβarrestins(βarrestin1 and-2).AIM Since adrenal?arrestin1 is essential for adrenal aldosterone production and nicotine/cotinine elevate circulating aldosterone levels in humans,we hypothesized that nicotine activates adrenal?arrestin1,which contributes to RAAS activation and heart disease *** We studied human adrenocortical zona glomerulosa H295R cells and found that nicotine and cotinine upregulateβarrestin1 mRNA and protein levels,thereby enhancing AngII-dependent aldosterone synthesis and *** In contrast,siRNA-mediatedβarrestin1 knockdown reversed the effects of nicotine on AngII-induced aldosterone production in H295 R ***,nicotine promotes hyperaldosteronism via adrenalβarrestin1,thereby precipitating cardiac dysfunction,also in vivo,since nicotine-exposed experimental rats with adrenal-specificβarrestin1 knockdown display lower circulating aldosterone levels and better cardiac function than nicotine-exposed control animals with normal adrenalβarrestin1 *** Adrenalβarrestin1 upregulation is one of the mechanisms by whic

关键词： Adrenocortical zona glomerulosa cell Aldosterone βarrestin Nicotine Signal transduction Tobacco-related heart disease

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<i>In Vitro</i>Evaluation of the Staining Effects of Two Intracanal Medicaments over a 3-Month Period

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Open Journal of Stomatology 2014年第8期4卷 381-388页

作者： Taxiarchis G. Kontogiannis anastasios Koursoumis Nikolaos P. Kerezoudis Department of Endodontics Athens Dental School University of Athens Athens Greece

Aim: The aim of this study was to evaluate in vitro the tooth color alterations associated with two intracanal medicaments, calcium hydroxide and calcium hydroxide combined with aquatic solution of chlorexidine, for up to three months post-treatment. Materials & Methods: Thirty-one intact human anterior mature teeth were used. Black adhesive tape with a 4-mm diameter window was used to standardize the enamel surface intended for color analysis. After access cavity preparation, cleaning and shaping were completed with rotary nickel-titanium files. The teeth were randomly divided into two groups (n = 15), each according to the intracanal medicament used: (A) calcium hydroxide paste (UltraCalTM XSTM Ultradent Products, Inc., USA);(B) 2% chlorhexidine aquatic solution combined with pure calcium hydroxide powder. In one tooth, no medicament was placed (pilot). The enamel surfaces were colormetrically evaluated at the following time intervals: before placing the medicaments, immediately after placement, after 1 week as well as after 1, 2 and 3 months post-treatment. The CIE color parameters (L*, a*, b*) were recorded for each material and the corresponding color differences (ΔΕ) were calculated and statistically analyzed. Results: The most significant factor in tooth discoloration was the time intervals. The most important changes of the ΔΕ values were recorded after the 1st week and after the 3rd month. L* presented an overall increase in both groups, resulting in a higher lightness of the crown color. Only L* did show significant alterations during specific time intervals. Conclusions: There is no statistically significant relationship between the type of intracanal medicament and tooth color alteration. Time is statistically the most important factor affecting the discoloration ability of Ca(OH)2, either combined with chlorexidine or not. Consequently, the clinician should always take this into account before using such medicaments for a long-term treatment.

关键词： Calcium Hydroxide Chlorexidine Intracanal Medicaments Discoloration

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Tuberculosis Infection in a Patient with Lung Cancer under PD-L1 Inhibition: A Case Report

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Journal of Tuberculosis Research 2020年第3期8卷 158-164页

作者： Eleni Papadaki Manika Katerina Boutis anastasios Kioumis Ioannis Kontakiotis Theodoros Respiratory Medicine Medical School Aristotle University of Thessaloniki Pulmonary Department “G. Papanikolaou” Hospital Thessaloniki Greece Oncology 1st Department of Medical Oncology Theagenio Cancer Hospital Thessaloniki Greece Respiratory Medicine and Infectious Diseases Medical School Aristotle University of Thessaloniki Respiratory Failure Department “G. Papanikolaou” Hospital Thessaloniki Greece

Background: Immune checkpoint inhibitors have made a great novelty in the treatment of various cancer types, showing favourable outcomes and good tolerance by cancer patients. Immune checkpoint inhibitors enhance and promote anti-tumor immunity, which can result in a wide range of adverse events, termed as immune-related adverse events, which are characterized by excessive immunity response. Although immune related adverse events are not considered to be originated from infectious causes, cases of cancer patients developing active tuberculosis during treatment with immune checkpoint inhibitors have been reported. Aim: The aim of the current case report is to highlight the importance of including opportunistic infections, such as tuberculosis, in the differential diagnosis of complications in the treatment of cancer patients receiving immunotherapy. Case presentation: This case report describes a 62-year-old Caucasian male patient who developed active pulmonary tuberculosis after treatment with Durvalumab, an anti-programmed death cell ligand-1 antibody, administered as therapy for non small cell lung cancer. The diagnosis was challenging because of the fact that the clinical presentation and the radiographic imaging were compatible with disease progression. Conclusion: Screening for active or latent tuberculosis should be part of everyday practice before the initial administration of immunotherapy in oncologic patients.

关键词： Tuberculosis Immune Checkpoint Inhibitors Durvalumab Immunotherapy PD-L1

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Stability of Soil and Biosolid Nanocolloid and Macrocolloid Particles in the Absence and Presence of Arsenic, Selenium, Copper and Lead

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Open Journal of Soil Science 2014年第7期4卷 246-258页

作者： Jessique Ghezzi anastasios Karathanasis Chris Matocha Jason Unrine Yvonne Thompson Department of Plant and Soil Sciences University of Kentucky Lexington KY USA

Due to their enhanced stability and contaminant transport potential, environmental nanoparticles derived from soil and biosolid materials may pose a considerable risk to groundwater quality. Very little information exists on the stability and transportability of environmental or natural nanocolloids in the presence of As, Se, Pb and Cu contaminants, all of which are considered to represent substantial threats to human and animal populations through groundwater contamination. This study involved stability settling experiments of nanocolloids (NCs) ( mixed > kaolinitic > biosolid. Among the nano-fractions, the smectitic and kaolinitic colloids demonstrated lower stability than the MCs, but higher than those of the mixed and biosolid fractions. Physicochemical characterizations indicated that extensive organic carbon surface coatings and higher Al/Fe:Si ratios may have induced higher stability in the NC fractions, but their overall stability may also have been hindered in some cases by nano-aggregation phenomena.

关键词： Nanocolloids Macrocolloids Colloid Stability Contaminant Transport Nanoparticles

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Competitive Sorption Behavior of Arsenic, Selenium, Copper and Lead by Soil and Biosolid Nano- and Macro-Colloid Particles

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Open Journal of Soil Science 2014年第9期4卷 293-304页

作者： Jessique Ghezzi anastasios Karathanasis Chris Matocha Jason Unrine Yvonne Thompson Department of Plant and Soil Sciences University of Kentucky Lexington KY USA

Limited information exists on natural nanocolloid sorption behavior of As, Se, Cu and Pb in the environment. They are expected to have variable competitive sorption characteristics depending on size and composition and may transport elevated contaminant loads into surface and ground waters. A comprehensive characterization of their interactions with contaminants could provide a better understanding of the risks they pose to the environment. This study evaluated the sorption behavior of soil and biosolid nano- and macro-colloids with different mineralogical compositions for As, Se, Cu, and Pb contaminants. Single- and multi-contaminant Freundlich isotherms were us- ed to evaluate sorption affinity for the contaminants among the different colloid sizes and compositions. Sorption trends based on size indicated greater affinity for As and Cu by the smectitic and kaolinitic nanocolloids, greater affinity for Pb by the kaolinitic nanocolloids, and greater affinity for As, Se and Pb by bio-nanocolloids over corresponding macrocolloid fractions. Both, single- and multi-contaminant isotherms indicated sorption preferences for cation over anion contaminants, but with somewhat contrasting sequences depending on size and composition. Multi-contaminant isotherms generally predicted greater sorption affinities likely due to bridging effects, particularly for anionic contaminants. Surface properties such as zeta potentials, cation exchange capacity (CEC), surface area (SA), organic carbon (OC), and OC:SA significantly but variably affected sorption characteristics among the differing colloid sizes and compositions. Colloid zeta potential and pH shifts in the presence of different contaminant loads suggested prevalence of inner sphere bonding mechanisms for sorption of cation contaminants by mineral colloids and outer sphere sorption for cation and anion contaminants by bio-colloids.

关键词： Sorption Affinity Single-Contaminant Isotherms Multi-Contaminant Isotherms Size Effects Composition Effects

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Fragipan Horizon Changes Using Annual Ryegrass and Other Admendments

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Open Journal of Soil Science 2024年第6期14卷 388-397页

作者： Lloyd Murdock anastasios Karathanasis Dottie Call Dana L. Dinnes Amitava Chatterjee Department of Plant & Soil Science University of Kentucky Lexington KY USA USDA-ARS National Laboratory for Agriculture and the Environment University Bldg Ames IA USA

A greenhouse experiment was conducted involving intact fragipan soil cores of 50 cm thickness after removing the topsoil horizons. The cores were maintained in moist condition throughout the experiment and received several treatments with various amendments for different periods ranging from 9 to 17 months. The amendments included annual ryegrass or Festulolium residues, powder limestone and various humate compounds alone or in combination with the grass residues. The results suggested a significant effect of ryegrass and Festulolium in reducing penetration resistance into the top 10 cm of the fragipan within 9 - 17 months, particularly when used in combination with certain humate materials such as Leonardite. Apparently, this is the result of the release of certain soluble organic compounds from the plant residues or the humate amendments that increase the solubility of Si and Al associated with the fragipan brittleness, thus decreasing the density of the compacted fragipan material.

关键词： Fragipan Fragipan Horizon Fragipan Soils Changing the Fragipan Annual Ryegrass Changes Fragipan Festulolium Changes Fragipan Amendments That Change the Fragipan

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