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Effect of clopidogrel in bone healing-experimental study in rabbits

World Journal of Orthopedics 2019年第12期10卷 434-445页

作者： Theodoros Lillis Alexander Veis Nikolaos Sakellaridis anastasios tsirlis Zoe Dailiana Department of Orthopaedic Surgery Faculty of MedicineUniversity of ThessalyBiopolisLarissa 41500Greece Department of Dentoalveolar Surgery Implantology and Oral RadiologyFaculty of DentistryAristotle University of ThessalonikiPanepistimioupoliThessaloniki 54124Greece Department of Clinical Pharmacology Faculty of MedicineUniversity of ThessalyBiopolisLarissa 41500Greece

BACKGROUND Clopidogrel is a widely prescribed drug for prevention of myocardial infarction and stroke in patients at *** inhibits thrombus formation via inhibition of the P2Y12 purinergic receptor on platelets,which is important in their activation by ***,the P2Y12 receptor has also been found to be expressed in both osteoblasts and *** evidence suggests that purinergic receptors regulate important functions of bone *** studies on the effect of clopidogrel on bone metabolism indicated potential harmful effects,but their results remain ***,clopidogrel treatment may affect bone healing,but it has not yet been *** To evaluate if continuous perioperative clopidogrel treatment has any negative effect on bone healing in the rabbit calvarial defect *** Sixteen male white New Zealand rabbits were randomly assigned in two groups:One group received daily 3 mg/kg of clopidogrel per os and the other group received the vehicle alone for a week prior to the surgical procedures;the treatments were continued for another 6 wk *** surgical procedures included generation of two circular calvarial defects 11 mm in diameter in every *** the 6-wk period of healing,postmortem radiographic and histomorphometric evaluation of the defects was *** Both the surgical procedures and the postoperative period were uneventful and well tolerated by all the animals,without any surgical wound dehiscence,signs of infection or other *** bone was formed either inwards from the defect margins or in the central portion of the defect as separated bony *** defect healing was still incomplete in both groups,the clopidogrel group had significantly improved radiographic healing ***,the histomorphometric analysis showed that bone regeneration(%)was 28.07±7.7 for the clopidogrel group and 19.47±4.9 for the control group,showing a statistically significant difference

关键词： Clopidogrel Bone healing Purinergic signaling Calvarial defect Rabbit

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