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Helicobacter pylori infection and endocrine disorders:Is there a link?

World Journal of Gastroenterology 2009年第22期15卷 2701-2707页

作者： Konstantinos X Papamichael Garyphallia Papaioannou Helen Karga anastasios roussos Gerassimos J Mantzaris First Department of Gastroenterology Evaggelismos Hospital B'Department of Endocrinology Alexandra Hospital

Helicobacter pylori(H pylori) infection is a leading world-wide infectious disease as it affects more than half of the world population and causes chronic gastritis,peptic ulcer disease and gastric *** infection elicits a chronic cellular inflammatory response in the gastric ***,the effects of this local inflammation may not be confi ned solely to the digestive tract but may spread to involve extraintestinal tissues and/or ***,H pylori infection has been epidemiologically linked to extra-digestive conditions and *** this context,it has been speculated that H pylori infection may be responsible for various endocrine disorders,such as autoimmune thyroid diseases,diabetes mellitus,dyslipidemia,obesity,osteoporosis and primary *** is a review of the relationship between H pylori infection and these endocrine disorders.

关键词： Helicobacter pylori Hormones Thyroid Osteoporosis Diabetes Dyslipidemia

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Helicobacter pylori infection and respiratory diseases:a review

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World Journal of Gastroenterology 2003年第1期9卷 5-8页

作者： anastasios roussos Nikiforos Philippou Konstantinos I Gourgoulianis 9th Department of Pulmonary Medicine "SOTIRIA"Chest Diseases HospitalAthensGreece Pulmonary Department Medical University of ThesallyLarisaGreece

In the past few years,a variety of extradigestive disorders, including cardiovascular,skin,rheumatic and liver diseases, have been associated with Helicobacter pylori(***) *** activation of inflammatory mediators by *** seems to be the pathogenetic mechanism underlying the observed *** present review summarizes the current literature,including our own studies,concerning the association between *** and respiratory diseases. A small number of epidemiological and serologic,case- control studies suggest that *** infection may be associated with the development of chronic bronchitis.A frequent coexistence of pulmonary tuberculosis and *** infection has also been ***,recent studies have shown an increased *** in patients with bronchiectasis and in those with lung *** the other hand,bronchial asthma seems not to be related with *** infection. All associations between *** infection and respiratory diseases are primarily based on case-control studies, concerning relatively small numbers of ***, there is a lack of studies focused on the pathogenetic link between respiratory diseases and *** infection. Therefore,we believe that larger studies should be undertaken to confirm the observed results and to clarify the underlying pathogenetic mechanisms.

关键词： Helicobacter pylori Asthma Bronchiectasis Bronchitis, Chronic Helicobacter Infections Humans Lung Neoplasms Respiratory Tract Diseases Seroepidemiologic Studies Tuberculosis, Pulmonary

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Prevalence of hepatitis B and C markers among refugees in Athens

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World Journal of Gastroenterology 2003年第5期9卷 993-995页

作者： anastasios roussos Constantin Goritsas Thomas Pappas Maria Spanaki Panagiota Papadaki Angeliki Ferti Department of Internal Medicine General Regional Hospital"Sotiria"AthensGreece Blood Bank General Regional Hospital"Sotiria"AthensGreece

AIM: To assess the prevalence of hepatitis B and C serological markers in a population of refugees living in ***: One hundred and thirty refugees (81 males and 49 females, mean age ±SD: 31.7±8 years) were included in the study. The hepatitis B virus surface antigen (HBsAg),the hepatitis B virus core antibody (anti-HBc) and the hepatitis C virus antibody (anti-HCV) were detected using a third-generation ***: Twenty individuals (15.4%) were HBsAg positive and 69 (53.1%) were anti-HBc positive. The prevalence of HBsAg and anti-HBc was higher among refugees from Albania and Asia (statistical significant difference, P＜0.008 and P＜0.001 respectively). The prevalence of these markers was found irrelevant to age or sex. Anti-HCV was detected in the serum of 3 individuals (2.3 %). No differences among age, sex or ethnicity regarding anti-HCV prevalence were ***: It can be concluded that refugees living in Athens are an immigrant population characterized by a high incidence of HBV infection. The prevalence of HBV markers is higher among refugees from Albania and Asia. It is therefore believed that the adherence to general precautions and the initiation of HBV vaccination programs will be necessary in the future, especially in these *** the prevalence of HCV infection seems to be relatively low, extended epidemiological surveys are needed to provide valid results.

关键词： Refugees Adolescent Adult Aged Albania Asia Biological Markers Female Greece Hepatitis B Hepatitis B Antibodies Hepatitis B Surface Antigens Hepatitis C Hepatitis C Antibodies Humans Male Middle Aged Seroepidemiologic Studies

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