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小麦籽粒产量和籽粒蛋白质浓度的基因型×管理互作效应

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国外作物育种 2001年第2期20卷 35-35页

作者：邱敦莲 cooper,m

二氯甲烷对人类健康的影响:主要研究发现和科学问题

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环境与职业医学 2015年第6期32卷 596-596页

作者： Paul m.Schlosser Ambuja S.Bale Catherine F.Gibbons Amina wilkins Glinda S.cooper

[背景]美国EPA的综合风险信息系统(IRIS)在2011年11月完成了对二氯甲烷毒理学综述的更新。[目的]本述评总结了这一综述中的主要结果和关键问题,包括暴露来源、识别潜在的健康影响和更新的基于生理学的药代动力学(PBPK)建模方法。[方法]... 详细信息

[背景]美国EPA的综合风险信息系统(IRIS)在2011年11月完成了对二氯甲烷毒理学综述的更新。[目的]本述评总结了这一综述中的主要结果和关键问题,包括暴露来源、识别潜在的健康影响和更新的基于生理学的药代动力学(PBPK)建模方法。[方法]对基础研究进行全面回顾,并对PBPK模型进行评价。[讨论]在若干经口和吸入暴露的动物研究中发现了肝脏毒性;神经系统的影响也是需要关注的潜在研究领域。二氯甲烷被列为可能对人类具有致癌性,其主要的证据基础是在雄性和雌性B6C3F1小鼠(吸入暴露)的两个部位(肝和肺)和雄性B6C3F1小鼠(饮用水暴露)的一个部位具有致癌作用。最近有关二氯甲烷的流行病学研究(2000年以来发表的7篇造血系统癌症研究)提供了更多的数据,增加了人们对其与非霍奇金淋巴瘤和多发性骨髓瘤之间关联的关注。虽然数据库中仍存在诸多信息缺口,比如二氯甲烷基因毒性(即体内靶组织中的DNA加合物的形成和基因突变),DNA损伤测定的阳性结果与组织和/或物种谷胱甘肽-S-转移酶(GST)代谢活性的获得能力之间的关联,以及二氯甲烷诱发癌症的关键激活途径。IRIS评估中的创新之处在于专门针对推测的敏感基因型(GST-theta-1+/+)估计癌症风险,以及在PBPK建模中考虑生理学分布,该分布基于6个月至80岁所有个体的期望分布。[结论]2011年IRIS的二氯甲烷评估提供了对这一常用溶剂毒性的新认识。

关键词：氯甲烷非霍奇金淋巴瘤激活途径多发性骨髓瘤癌症研究流行病学研究综合风险常用溶剂基因毒性证据基础

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急性下消化道出血部位扫描的有效性

世界核心医学期刊文摘（胃肠病学分册） 2005年第9期1卷 51-52页

作者： Olds G.D. cooper G.S. Chak A. R.C.K. wong 徐瑞 Division of Gastroenterology University Hospitals ofCleveland 11100 Euclid Avenue Cleveland OH 441 06-5066 United States

Goals/Background: Previous studies have demonstrated low yield and conflicting results as to the ability of technetium 99m labeled red blood cell (TRBC) scintigraphy to accurately localize the site of bleeding in acute lower gastrointestinal hemorrhage. Our objective was to evaluate the accuracy of TRBC scintigraphy in clinical day-to-day practice at our institution and to determine predictors of a positive test. methods: A retrospective medical records review of all patients who underwent TRBC scintigraphy over a 5-year period was conducted at a single academic medical center. The site of bleeding found on TRBC scintigraphy was correlated with the endoscopic, angiographic, surgical, and pathologic findings in each patient. Results: A total of 127 scans were performed in 115 patients. Forty-nine scans were positive (39%) and 78 were negative (61%). Forty-two patients had further evaluation after a positive scan, and the bleeding site was confirmed to be accurate in 20 of 42 patients (48%). A contradictory bleeding site was found in 5 of 49 positive scans (10%). Patients transfused greater than 2 units of packed red blood cells within 24 hours preceding the TRBC scan were twice as likely to have a positive scan (64%) than those transfused 2 units or less (32%) (P = 0.002). multivariate analysis demonstrated that the number of units of blood transfused within 24 hours prior to the TRBC scan and the lowest recorded hematocrit were significantly different between patients with positive and negative scans. There was no difference in the rate of endoscopy between patients with a positive or negative scan result. Conclusions: TRBC scintigraphy has a relatively low yield in the evaluation of acute lower gastrointestinal bleeding. Objective selection criteria such as number of units of packed red blood cells transfused prior to obtaining the scan may increase the overall yield.

关键词：下消化道出血闪烁扫描血管造影出血点医学研究中心细胞量血细胞比容客观选择多因素分析

Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver

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world Journal of Gastroenterology 2013年第19期19卷 2883-2893页

作者： Sumaiya Chowdhury Yiqian Chen Tsun-wen Yao Katerina Ajami Xin m wang Yury Popov Detlef Schuppan Patrick Bertolino Geoffrey w mcCaughan Denise mT Yu mark D Gorrell Centenary Institute and Sydney medical School University of SydneySydneyNSW 2006Australia Division of Gastroenterology and Hepatology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02215United States molecular Hepatology Centenary InstituteNewtownSydneyNSW 2042Australia

AIm:To investigate the expression of dipeptidyl peptidase(DPP) 8 and DPP9 in lymphocytes and various models of liver ***:DPP8 and DPP9 expression were measured in mouse splenic CD4 + T-cells,CD8 + T-cells and B-cells(B220 +),human lymphoma cell lines and mouse splenocytes stimulated with pokeweed mitogen(Pwm) or lipopolysaccharide(LPS),and in dithiothreitol(DTT) and mitomycin-C treated Raji ***8 and DPP9 expression were measured in epidermal growth factor(EGF) treated Huh7 hepatoma cells,in fibrotic liver samples from mice treated with carbon tetrachloride(CCl 4) and from multidrug resistance gene 2(mdr2 /Abcb4) gene knockout(gko) mice with biliary fibrosis,and in human end stage primary biliary cirrhosis(PBC).RESULTS:All three lymphocyte subsets expressed DPP8 and DPP9 ***8 and DPP9 expression were upregulated in both Pwm and LPS stimulated mouse splenocytes and in both Jurkat T-and Raji B-cell ***8 and DPP9 were downregulated in DTT treated and upregulated in mitomycin-C treated Raji ***9transfected Raji cells exhibited more annexin V + cells and associated ***8 and DPP9 mRNA were upregulated in CCl 4 induced fibrotic livers but not in the lymphocytes isolated from such livers,while DPP9 was upregulated in EGF stimulated Huh7 *** contrast,intrahepatic DPP8 and DPP9 mRNA expression levels were low in the mdr2 gko mouse and in human PBC compared to non-diseased ***:These expression patterns point to biological roles for DPP8 and DPP9 in lymphocyte activation and apoptosis and in hepatocytes during liver disease pathogenesis.

关键词： Dipeptidyl peptidase CD26 Lymphocytes Liver fibrosis Biliary fibrosis

Human immunodeficiency virus-related primary central nervous system lymphoma: factors influencing survival in 111 patients

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中国神经肿瘤杂志 2004年第2期2卷 91-91页

作者： Newell mE Hoy JF cooper SG DeGraaff B Grulich AE Bryant m millar JL Brew BJ Quinn DI National Centre in HIV Epidemiology and Clinical Research University of New South WalesSydneyAustralia.

BACKGROUND: The current study evaluated factors influencing survival in patients diagnosed with human immunodeficiency virus (HIV)-related primary central nervous system lymphoma (PCNSL), with a focus on the effects of therapeutic radiotherapy (RT) and highly active antiretroviral therapy (HAART). mETHODS: A retrospective chart review of patients with a diagnosis of HIV-related PCNSL at one of five university hospitals between 1987 and 1998 was performed. Clinical details including antiretroviral agent use, brain imaging scan results, RT use, and survival outcomes were recorded. RESULTS: One hundred eleven patients with HIV-related PCNSL were identified. The annual incidence decreased significantly between 1992 and 1995 and between 1996 and 1998 (P=0.04).

关键词：原发性中枢神经系统淋巴瘤生存影响因素人类免疫缺陷病毒

2型糖尿病患者采用血管紧张素转换酶抑制剂治疗后血清肌酐急性升高及其继续治疗对主要临床结局的影响

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中华高血压杂志 2019年第1期27卷 99-99页

作者： Ohkuma T Jun m Rodgers A cooper mE Glasziou P Hamet P Harrap S mancia G marre m Neal B Perkovic V Poulter N williams B Zoungas S Chalmers J woodward m 赵狄练桂丽

血管紧张素转换酶抑制剂开始治疗后血清肌酐急性升高≥30%时推荐停药。但血清肌酐升高后继续服药或停药对主要临床结局的长期影响仍不明确。在ADVANCE(糖尿病与血管疾病行动:培哚普利-吲达帕胺与达美康缓释片对照评估)试验中,11 140例... 详细信息

血管紧张素转换酶抑制剂开始治疗后血清肌酐急性升高≥30%时推荐停药。但血清肌酐升高后继续服药或停药对主要临床结局的长期影响仍不明确。在ADVANCE(糖尿病与血管疾病行动:培哚普利-吲达帕胺与达美康缓释片对照评估)试验中,11 140例糖尿病患者在6周活性导入期后随机采用培哚普利-吲达帕胺或安慰剂治疗。

关键词：血清肌酐血管紧张素转换酶抑制剂临床结局糖尿病患者

Cryo-Em structure of a tetrameric photosystem I from Chroococcidiopsis TS-821, a thermophilic, unicellular, non-heterocyst-forming cyanobacterium

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Plant Communications 2022年第1期3卷 53-70页

作者： Dmitry A.Semchonok Jyotirmoy mondal Connor J.cooper Katrina Schlum meng Li muhamed Amin Carlos O.S.Sorzano Erney Ramirez-Aportela Panagiotis L.Kastritis Egbert J.Boekema Albert Guskov Barry D.Bruce Groningen Biomolecular Sciences&Biotechnology Institute University of GroningenGroningenthe Netherlands Biochemistry&Cellular and molecular Biology Department University of TennesseeKnoxvilleTNUSA Program in Genome Science and Technology University of TennesseeKnoxvilleTNUSA Bredesen Center for Interdisciplinary Research&Education University of TennesseeKnoxvilleTNUSA Department of Sciences University College GroningenGroningenthe Netherlands Biocomputing Unit National Center for Biotechnology(CSIC)Darwin 3Campus Universidad Auto´noma de MadridCantoblanco28049 MadridSpain Universidad CEU San Pablo Campus Urb.Monteprı´ncipeBoadilla del Monte28668 MadridSpain Institute of Biochemistry and Biotechnology Martin Luther University Halle-WittenbergHalle/SaaleGermany microbiology Department University of TennesseeKnoxvilleTNUSA Present address:Institute of Biochemistry and Biotechnology Martin Luther University Halle-WittenbergHalle/SaaleGermany School of Oceanography University of WashingtonSeattleWAUSA

Photosystem I(PSI)is one of two photosystems involved in oxygenic *** of cyanobacteria exists in monomeric,trimeric,and tetrameric forms,in contrast to the strictly monomeric form of PSI in plants and *** tetrameric organization raises questions about its structural,physiological,and evolutionary *** we report the3.72 A˚resolution cryo-electron microscopy structure of tetrameric PSI from the thermophilic,unicellular cyanobacterium Chroococcidiopsis *** structure resolves 44 subunits and 448 cofactor *** conclude that the tetramer is arranged via two different interfaces resulting from a dimer-of-dimers *** localization of chlorophyll molecules permits an excitation energy pathway within and between adjacent *** analysis reveals conserved regions in the PsaL subunit that correlate with the oligomeric *** PSI may function as a key evolutionary step between the trimeric and monomeric forms of PSI organization in photosynthetic organisms.

关键词： cryo-Em photosystem I non-heterocyst-forming cyanobacteria Chroococcidiopsis evolution of chloroplast high light adaptation

Vivid birds do not initiate flight sooner despite their potential conspicuousness

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Current Zoology 2015年第4期61卷 773-780页

作者： Nicholai m. HENSLEY Jonathan P. DRURY Theodore GARLAND, Jr. Daniel T. BLUmSTEIN Department of Ecology Evolution and Marine Biology University of Califomia Santa Barbara CA USA Department of Ecology and Evolutionary Biology University of California Los Angeles CA 90095-1606 USA Institude de Biologie de I'ENS 46 Rue d'Ulm 75005 Paris France Department of Biology University of California Riverside CA 92521 USA

The distance from an approaching threat at which animals initiate flight - flight-initiation distance （FID） -- is a sensitive metric of variation in risk, but the effects on FID associated with the risk of possessing highly detectable external coloration are unknown. we tested whether variation in the degree of plumage vividness in birds explained variation in flight-initiation distance. After controlling for body mass, the distance at which the experimental approach began, and phylogenetic relatedness, plumage vividness was not a predictor of FID. Contrary to the expectation that vividness affects risk, and therefore risk assess- ment, these results suggest that birds do not compensate for greater visual conspicuousness by fleeing sooner from approaching threats [Current Zoology 61 （4）： 773-780, 2015].

关键词： Antipredator behavior Body size Coloration Comparative method Conspicuousness Flight Initiation Distance

New Species of Enantiornithes(Aves:Ornithothoraces) from the Qiaotou Formation in Northern Hebei,China

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Acta Geologica Sinica(English Edition) 2010年第2期84卷 247-256页

作者： wANG Xuri Jingmai K. O＇CONNOR ZHAO Bo Luis m. CHIAPPE GAO Chunling CHENG Xiaodong Dalian Natural History museum Dalian 116023 China Institute of Geology Chinese Academy of Geological Sciences Beijing 100037 China Dinosaur Institute Natural History Museum of Los Angeles Los Angeles CA 90007 USA University of Southern California Los Angeles CA 90089 USA

we report on a new species of enantiornithine bird from the Lower Cretaceous Qiaotou Formation of northern Hebei, China. The new taxon, Shenqiornis mengi gen. et sp. nov., possesses several enantiornithine synapomorphies but is unique from other known species. The specimen has a well-preserved skull that reveals new information about enantiornithine cranial morphology. The new taxon possesses a large postorbital with a long tapering jugal process indicating that some enantiornithines may have had a fully diapsid skull, as in Confuciusornis. The tooth morphology of the specimen is unique and likely represents a previously unknown trophic specialization within Enantiornithes.

关键词： Aves Enantiornithes diapsid teeth Jehol Qiaotou Formation