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Endoscopic ultrasonography for gastric submucosal lesions

World Journal of Gastrointestinal Endoscopy 2011年第5期3卷 86-94页

作者： Ioannis S Papanikolaou Konstantinos Triantafyllou anastasia kourikou Thomas Rsch Hepatogastroenterology Unit 2nd Department of Internal Medicine-PropaedeuticAttikon University General HospitalMedical SchoolUniversity of Athens Department of Interdisciplinary Endoscopy University Hospital Hamburg-Eppendorf

Gastric submucosal tumors(SMTs) are a rather frequent finding,occurring in about 0.36%of routine upper *** ultrasonography(EUS) has emerged as a reliable investigative procedure for evaluation of these *** EUS has the ability to differentiate intramural tumors from extraluminal compressions and can also show the layer of origin of gastric *** can be further characterized by their layer of origin,echo pattern and ***-risk criteria of their malignant potential are presented,although the emergence of EUS-FNA has opened new indications for transmural tissue diagnosis and expanded the possibilities of EUS in SMTs of the *** diagnosis should address whether the SMT is a Gastrointestinal stromal tumour(GIST) or another tumor type and evaluate the malignant potential of a given ***,there seems to be a lack of data on the optimal strategy in SMTs suspected to be GISTs with a negative EUS-FNA tissue *** current management strategies,as well as open questions regarding their treatment are also presented.

关键词： Endoscopic ultrasound Gastric submucosal tumors EUS-guided fne needle aspiration Gastrointestinal stromal tumours

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Gene polymorphisms associated with functional dyspepsia

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World Journal of Gastroenterology 2015年第25期21卷 7672-7682页

作者： anastasia kourikou George P Karamanolis George D Dimitriadis Konstantinos Triantafyllou Hepatogastroenterology Unit Second Department of Internal Medicine and Research Institute Attikon University General Hospital Medical School Athens University Academic Department of Gastro- enterology Laiko General Hospital

Functional dyspepsia(FD) is a constellation of functional upper abdominal complaints with poorly elucidated pathophysiology. However, there is increasing evidence that susceptibility to FD is influenced by hereditary factors. Genetic association studies in FD have examined genotypes related to gastrointestinal motility or sensation, as well as those related to inflammation or immune response. G-protein b3 subunit gene polymorphisms were first reported as being associated with FD. Thereafter, several gene polymorphisms including serotonin transporter promoter, interlukin-17 F, migration inhibitory factor, cholecystocynine-1 intron 1, cyclooxygenase-1, catechol-o-methyltransferase, transient receptor potential vanilloid 1 receptor, regulated upon activation normal T cell expressed and secreted, p22 PHOX, Toll like receptor 2, SCN10 A, CD14 and adrenoreceptors have been investigated in relation to FD; however, the results are contradictory. Several limitations underscore the value of current studies. Among others, inconsistencies in the definitions of FD and controls, subject composition differences regarding FD subtypes, inadequate samples, geographical and ethnical differences, as well as unadjusted environmental factors. Further well-designed studies are necessary to determine how targeted genes polymorphisms, influence the clinical manifestations and potentially the therapeutic response in FD.

关键词： Functional dyspepsia Gene polymorphism Genetic susceptibility Pathophysiology

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