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The potential of gene therapies for spinal cord injury repair:a systematic review and meta-analysis of pre-clinical studies

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Neural Regeneration Research 2023年第2期18卷 299-305页

作者： Catriona J.Cunningham Mindaugas Viskontas Krzysztof Janowicz Yasmin Sani Malin EHåkansson anastasia heidari Wenlong Huang Xuenong Bo Institute of Medical Sciences School of MedicineMedical Sciences&NutritionUniversity of AberdeenAberdeenUK Centre for Neuroscience Surgery and TraumaBlizard InstituteBarts and the London School of Medicine and DentistryQueen Mary University of LondonLondonUK

Currently,there is no cure for traumatic spinal co rd injury but one therapeutic approach showing promise is gene *** this systematic review and meta-analysis,we aim to assess the efficacy of gene therapies in pre-clinical models of spinal cord injury and the risk of *** this metaanalysis,registe red at PROSPERO(Registration ID:CRD42020185008),we identified relevant controlled in vivo studies published in English by searching the PubMed,Web of Science,and Embase *** restrictions of the year of publication were applied and the last literature search was conducted on August 3,*** then conducted a random-effects meta-analysis using the restricted maximum likelihood estimator.A total of 71 studies met our inclusion crite ria and were included in the systematic *** results showed that overall,gene therapies were associated with improvements in locomotor score(standardized mean difference[SMD]:2.07,95%confidence interval[CI]:1.68-2.47,Tau^(2)=2.13,I^(2)=83.6%)and axonal regrowth(SMD:2.78,95%CI:1.92-3.65,Tau^(2)=4.13,I^(2)=85.5%).There was significant asymmetry in the funnel plots of both outcome measures indicating the presence of publication *** used a modified CAMARADES(Collaborative Approach to M eta-Analysis and Review of Animal Data in Experimental Studies)checklist to assess the risk of bias,finding that the median score was 4(IQR:3-5).In particula r,reports of allocation concealment and sample size calculations were *** conclusion,gene therapies are showing promise as therapies for spinal co rd injury repair,but there is no consensus on which gene or genes should be targeted.

关键词： animal models gene delivery meta-analysis regenerative medicine spinal cord injury systematic review viral vectors

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CFD simulation of impeller shape effect on quality of mixing in two-phase gas–liquid agitated vessel

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Chinese Journal of Chemical Engineering 2020年第11期28卷 2733-2745页

作者： Amir heidari Process Simulation and Modeling Laboratory(PSMlab) Faculty of ChemicalPetroleum and Gas EngineeringSemnan UniversitySemnan ***Iran

Mixing efficiency in two-phase gas–liquid agitated vessel is one of the important challenges in the industrial *** fluid dynamics technique(CFD)was used to investigate the effect of four different pitched blade impellers,including 15°,30°,45°and 60°,on the mixing quality of gas–liquid agitated *** multiphase flow behavior was modeled by Eulerian–Eulerian multiphase approach,and RNG k-εwas used to model the *** CFD results showed that a strong global vortex plays the main role on the mixing quality of the gas phase in the *** on the standard deviation criterion,it was observed that the axial distribution of the gas phase in the 30°impeller is about 55%better than the *** addition,the results showed that the 30°impeller has a uniform radial distribution over the other impellers and the maximum gas phase holdup in the *** of the power consumption of the impellers showed that the 30°impeller has the highest power consumption among the other pitched blade ***,examine the effect of same power condition for pitched blade impellers showed that the 30°impeller has the best mixing quality in this condition.

关键词： Pitched blade impeller Mixing CFD Multiphase flow RNG k-εmodel

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Earthquake acceleration analysis using wavelet method

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Earthquake Engineering and Engineering Vibration 2021年第1期20卷 113-126页

作者： Ali heidari Noorollah Majidi Department of Civil Engineering University of ShahrekordShahrekordIran

There are several methods for analyzing the acceleration of an *** this research,a discrete wavelet theory based on the Mallat method was employed to analyze the acceleration of earthquake *** this purpose,first,the acceleration of the main earthquake was determined using the method of banding,filtering and correction of a filtered ***,the acceleration of the earthquake up to five stages was decomposed using discrete wavelet *** this method,in which the Down-Sampling rule is utilized in each step,the number of earthquake record points is half *** of the waveforms was based on the acceleration of the maximum original earthquake,and the maximum acceleration in all the waves was *** each of the five waves obtained from wavelet decomposition,the velocity curve and ground acceleration are obtained and compared with each ***,a structure was analyzed using the main wave of the earthquake and each of the waveforms was analyzed in five stages and their dynamic response curves were *** results showed that until the third stage of the wavelet decomposition,the error was insignificant and the dynamic response to the magnitude of the earthquake was *** analysis time is about 10% of the analysis time with the main wave,and the error is less than 6%.

关键词： accelerated earthquake mapping discrete wavelet dynamic analysis dynamic response

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Nucleic Acid Metabolism, Proline Concentration and Antioxidants Enzyme Activity in Canola (Brassica nupus L.) Under Salinity Stress

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Agricultural Sciences in China 2010年第4期9卷 504-511页

作者： Mostafa heidari Department of Agronomy and Plant Breeding University of ZabolZabol P.O. Box 98615-538 Iran

Seedling of five canola genotypes, Hyola 308, Hyola 401, Hyola 60, Option 50 and RGS003, were grown in Hoagland nutrient solution containing S1 = 0, S2 = 100, S3 = 200 and S4 = 300 mmol L-1 NaCl in controlled environment. Proline, antioxidant activities like catalase （CAT）, ascobrate peroxidase （APX） and guaiacol peroxidase （GPX） and some enzyme activities of nucleic acid metabolism were determined in shoot and root 20 days after induction of salinity stress. Results showed application of stress significantly affected plant growth components such as fresh （FW） and dry weight （DW） of canola genotypes. Among the genotypes, RGS003 had the highest reduction of FW and DW in S3 treatment. By increasing NaCl levels from 0 to 300 mmol L-1, the activity of two antioxidant enzymes （APX and CAT） in shoot and root increased but GPX in all of genotypes decreased. The increase in salinity stress, increased proline concentration in both root and shoot tissues of canola genotypes. Hyola 401 genotype had the maximum concentration of proline in root and shoot in S3 treatment. Along with increased salinity stress in all of the studied plants, salinity significantly increased the level of the total nucleic acid and the activity of DNase I in all of salinity treatments and at the S3 level, RGS003 had the maximum concentration of nucleolytic enzyme.

关键词： antioxidant activity proline salinity nucleolytic enzyme canola

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A new approach for free vibration analysis of a system of elastically interconnected similar rectangular plates

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Earthquake Engineering and Engineering Vibration 2022年第4期21卷 947-967页

作者： E.heidari A.Ariaei Department of Mechanical Engineering Faculty of EngineeringUniversity of IsfahanIsfahan ***Iran

A new procedure is proposed to ease the analyses of the free vibration of an elastically connected identical plates system with respect to Kirchhoff plate theory.A structure of n parallel,elastically connected rectangular plates is of concern,whereby the motion is explained by a set of n coupled partial differential *** method involves a new change in variables to uncouple equations and form an equal system of n decoupled plates,while each is assumed to be elastically connected to the *** differential quadrature method is adopted to solve the decoupled *** unravel the original system,the inverse transform is *** the equations enables one to solve them based on the solution methods available for a single plate *** also diminishes the computational costs of such *** considering different boundary conditions,a case study is run to present the method and to validate the results with its counterparts,for which excellent agreement is *** the influence of dimensionless thickness,aspect ratio,and stiffness coefficients on the frequencies reveals the different effects of them at the low order of dimensionless natural frequencies in comparison with high orders and for different boundary conditions.

关键词： multiple-plate system elastic connections free vibration Kirchhoff plate theory differential quadrature method

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Optimum Design of Structures for Earthquake Induced Loading by Genetic Algorithm Using Wavelet Transform

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Advances in Applied Mathematics and Mechanics 2010年第1期2卷 107-117页

作者： Ali heidari Department of Civil Engineering University of ShahrekordShahrekordIran

Optimum design of structures is achieved by genetic *** evolutionary algorithm is employed to design *** method improves the computing efficiency of the large-scale optimization problems and enhances the global convergence of the design *** loads are considered as earthquake loads.A time history analysis is carried out for the dynamic *** decrease the computational work,a wavelet transform is used by which the number of points in the earthquake record is reduced.A reverse wavelet transform is also employed to reconstruct the functions under consideration in the time domain.A number of space structures are designed for minimum weight and the results are compared with exact dynamic analysis.

关键词： Genetic algorithm discrete wavelet transform reverse wavelet transform dynamic analysis

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Geochemical indices of soil development on basalt rocks in arid to sub-humid climosequence of Central Iran

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Journal of Mountain Science 2020年第7期17卷 1652-1669页

作者： Ahmad heidari Alireza RAHEB Soil Science Department College of Agriculture and Natural ResourcesUniversity of TehranKarajP.O.Box 4111Iran

Quantitative weathering indices are efficient tools in determining the soil development from the underlying *** order to evaluate the effects of climate on the soils developed under an arid to sub-humid climosequence in central Iran,twenty soil-development indices were *** samples from six pedons were analyzed for routine physico-chemical and geochemical analyses using X-ray fluorescence(XRF).The lowest and highest calculated soil development indices were observed in the arid and sub-humid regions *** the studied indices,fifteen indices showed similar trends concerning the intensity of *** consistency of such trends reveals the feasibility of using these indices to evaluate basalt weathering rate and soil development in arid,semi-arid and sub-humid *** study demonstrated that,among the evaluated weathering indices,the Weathering Index of Parker(WIP)and mass transfer coefficient(τ)were the most proper indices for predicting basalt weathering *** is due to the fact that these indices use the highly mobile earth elements which are the most sensitive elements in basalt chemical *** calculated indices were subdivided into three subgroups including the ratios of mobile/immobile,mobile/mobile and immobile/mobile elements based on the elements used in their *** state of soil evolution was more accurately predicted compared to the other subgroups using the mobile/immobile subgroup of ***,the weathering indices calculated using the mobile elements are better indicators of weathering intensity,soil formation and the exogenous processes across the arid to sub-humid climosequence.

关键词： Basalt Climosequence Geochemical properties Aridisols Mollisols Inceptisols

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Effects of Salinity and Potassium Application on Antioxidant Enzyme Activities and Physiological Parameters in Pearl Millet

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Agricultural Sciences in China 2011年第2期10卷 228-237页

作者： Mostafa heidari Parisa Jamshidi Faculty of Agronomy and Plant Breeding Department University of Zabol Department of Agronomy University of Zabol

A plot culture experiment was conducted in a greenhouse at University of Zabol,Iran,to study the effects of different salinity levels and potassium supply on pearl *** experiment was laid out in a completely randomized factorial design with three *** sulfate was used as the potassium *** rates of potassium treatments were 0,100,and 200 kg *** millet was subjected to different salinity levels（0,4,8,and 12 ds m-1） through addition of NaCl to irrigation *** showed that the increase in the salt concentration from control to 12 ds m-1 decreased grain yield（38.7%） of millet *** this study,we found a negative relationship between potassium and proline accumulation at vegetative（r2=-0.75＊＊） and reproductive stage（r2=-0.66＊＊） in millet *** stress remarkably elevated the activities of CAT and GPX antioxidant enzymes at vegetative and reproductive ***,potassium application had significant effect on grain yield and increased it about 10.6% at the highest salinity treatment（12 ds m-1）.Though,potassium treatment increased antioxidant activity in millet plants,it had no significant effect on proline content in *** treatment decreased potassium uptake but application potassium increased potassium content in leaves at two stages.

关键词： antioxidants enzymes ion content pearl millet potassium proline salinity

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Influence of B source materials on the synthesis of TiB_2-Al_2O_3 nanocomposite powders by mechanical alloying

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International Journal of Minerals,Metallurgy and Materials 2013年第12期20卷 1214-1220页

作者： Majid Abdellahi Javad heidari Rahman Sabouhi Materials Engineering Department Islamic Azad University

An Al2O3-TiB2 nanocomposite was successfully synthesized by ball milling of Al, TiO2 and two B source materials of B2O3 （system （1）） and H3BO3 （system （2））. Phase identification of the milled samples was examined by Xray diffraction. The morphology and microstructure of the milled powders were monitored by scanning electron microscopy and transmission electron microscopy. It was found that the formation of this composite was completed after 15 and 30 h of milling time in systems （1） and （2）, respectively. More milling energy was required for the formation of this composite in system （2） due to the lubricant properties of HaBO3 and also its decomposition to HBO2 and B2O3 during milling. On the basis of X-ray diffraction patterns and thermodynamic calculations, this composite was formed by highly exothermic mechanically induced self-sustaining reactions （MSR） in both systems. The MSR mode took place around 9 h and 25 h of milling in systems （1） and （2）, respectively. At the end of milling （15 h for system （1） and 30 h for system （2）） the grain size of about 35-50 nm was obtained in both systems.

关键词： nanocomposites powders alumina titanium diboride mechanical alloying

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Interaction of benzene-1,3-disulfonylamid-kriptofix[22] with iodine in chloroform and dichloromethane solutions

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Chinese Chemical Letters 2014年第10期25卷 1375-1378页

作者： Tayyebeh Madrakian Sara heidari Faculty of Chemistry Bu-Ali Sina University

The interaction of iodine as an cr-acceptor with a synthetic ligand,benzene-1,3-disulfonylamid-kriptofix[22]（BDSAK） as a π-donor has been investigated spectrophotometrically in chloroform（CHCl3） and dichloromethane（DCM） *** results of mole ratio plots and Job＇s method show the stoichiometry of complexation I2/BDSAK is 1：*** constants have been calculated in various temperatures and thermodynamic parameters have also been determined from the temperatures dependence of the stability constants by using van＇t Hoff *** results indicate the iodine complex with BDSAK is enthalpy stabilized but entropy destabilized.

关键词： Charge transfer complex Iodine Spectrophotometry Solvent effect

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