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Future clinical prospects of C-peptide testing in the early diagnosis of gestational diabetes

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World Journal of Experimental Medicine 2024年第1期14卷 13-21页

作者： Charalampos Milionis Ioannis Ilias anastasia Lekkou Evangelia Venaki Eftychia Koukkou Department of Endocrinology Diabetesand Metabolism‘Elena Venizelou’General HospitalAthens 11521Greece

Gestational diabetes is typically diagnosed in the late second or third trimester of *** is one of the most common metabolic disorders among expectant mothers,with potential serious short-and long-term complications for both maternal and offspring health.C-peptide is secreted from pancreatic beta-cells into circulation in equimolar amounts with *** is a useful biomarker to estimate the beta-cell function because it undergoes negligible hepatic clearance and consequently it has a longer half-life compared to *** induces increased insulin resistance due to physiological changes in hormonal and metabolic *** compensation by islet beta-cells results in *** standard oral glucose tolerance test at 24-28 wk of gestation sets the *** evidence from prospective studies indicates a link between early pregnancy C-peptide levels and the risk of subsequent gestational *** C-peptide levels and surrogate glycemic indices at the beginning of pregnancy could prompt appropriate strategies for secondary prevention.

关键词： C-peptide Gestational diabetes Secondary prevention Pregnancy Clinical laboratory techniques

Is there a correlation between the changes in airway inflammation and the changes in respiratory mechanics after vaping in patients with asthma?

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World Journal of Methodology 2024年第2期14卷 127-133页

作者： Serafeim-Chrysovalantis Kotoulas Kalliopi Domvri Alexandros Tsantos Ioanna Papagiouvanni anastasia Michailidou Dionisios G Spyratos Konstantinos Porpodis Ioanna Grigoriou Despina Papakosta Athanasia Pataka Intensive Care Unit Hippokration General HospitalThessaloniki 54642Greece Pulmonary Department-Oncology Unit Aristotle University of ThessalonikiThessaloniki 57010Greece 2nd Department of Internal Medicine General Hospital of Thessaloniki‘’Ippokration’’Thessaloniki 54642Greece Fourth Department of Internal Medicine Aristotle University of ThessalonikiThessaloniki 54642ThessalonikiGreece 2nd Propaedeutic Department of Internal Medicine General Hospital of Thessaloniki“Ippokration”Thessaloniki 54642Greece Department of Pulmonary Aristotle University of ThessalonikiThessaloniki 57001Greece Respiratory Failure Clinic Papanikolaou General HospitalThessloniki 57001Greece Department of Respiratory Medicine Aristotle Univ ThessalonikiSch MedG Papanikolaou HospResp Failure UnitAristotle University of ThessalonikiThessaloniki 57001Greece

BACKGROUND Electronic cigarettes(ECs)have been promoted as alternatives to traditional *** investigate ECs’effects on respiratory system,especially in patients with respiratory *** We randomly selected 25 smokers with stable moderate asthma and matched them with 25 healthy *** were subjucted to pulmonary function tests(PFTs),impulse oscillometry(IOS),fraction exhaled Nitric Oxide(FeNO),exhaled breathe condensate(EBC)and biomarker measurements before and after vaping one nicotinecontaining *** The increase in FeNO 30 minutes after EC,reflecting airway inflammation,significantly correlated with increase of residual volume(RV),total lung capacity,respiratory impedance at 5 Hz(Z5Hz)and respiratory resistance at 5 and 20 Hz(R5Hz and R20Hz).No significant correlations were found between EBC biomarkers'changes and respiratory *** This is the first study demonstrating that the changes in airway inflammation caused by EC have direct effects in respiratory mechanics of asthmatic patients.

关键词： Asthma Electronic cigarette Airway inflammation Lung function Impulse oscillometry FeNO

A review on ductile mode cutting of brittle materials

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Frontiers of Mechanical Engineering 2018年第2期13卷 251-263页

作者： Elijah Kwabena antwi Kui LIU Hao WANG Department of Mechanical Engineering National University of Singapore Singapore Singapore Institute of Manufacturing Technology Singapore

Brittle materials have been widely employed for industrial applications due to their excellent mechanical, optical, physical and chemical properties. But obtaining smooth and damage-free surface on brittle materials by traditional machining methods like grinding, lapping and polishing is very costly and extremely time consuming. Ductile mode cutting is a very promising way to achieve high quality and crack-free surfaces of brittle materials. Thus the study of ductile mode cutting of brittle materials has been attracting more and more efforts. This paper provides an overview of ductile mode cutting of brittle materials including ductile nature and plasticity of brittle materials, cutting mechanism, cutting characteris- tics, molecular dynamic simulation, critical undeformed chip thickness, brittle-ductile transition, subsurface damage, as well as a detailed discussion of ductile mode cutting enhancement. It is believed that ductile mode cutting of brittle materials could be achieved when both crack-free and no subsurface damage are obtained simultaneously.

关键词： ductile mode cutting brittle materials critical undeformed chip thickness brittle-ductile transition subsurface damage molecular dynamic simulation

Mechanical properties of coppiced and non-coppiced Pterocarpus erinaceus boles and their industrial application

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Journal of Forestry Research 2019年第5期30卷 1973-1980页

作者： Charles antwi-Boasiako Frederick Amin Anthonio Kwasi Frimpong-Mensah Kwame Nkrumah University of Science and Technology

Rosewood(Pterocarpus erinaceus Poir.)is valued for flooring,ornaments,musical instruments and furniture-making due to its durability,strength,beauty and acoustic *** coppices easily which could boost its continual *** parallel to grain,Modulus of Elasticity(MOE)and Modulus of Rupture(MOR)within coppiced and non-coppiced boles were *** properties decreased along both types of *** values for the heartwood were also greater than those for the sapwood of each type of ***,MOR and compression for non-coppiced stems were greater than those from the coppiced *** differences were significant(p<0.05).Mechanical properties from the coppiced and non-coppiced boles are *** have strength properties comparable with those of species widely used for railway sleepers,structural supports,flooring,veneer,furniture,cabinetry,truss and mine ***,coppiced wood could supplement non-coppiced wood for industrial applications which require strength.

关键词： Coppicing Wood density Mechanical property Rosewood Structural application

lncreasing mortality of intrahepatic cholangiocarcinoma in the US:are gender-specific risk factors important?

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Hepatobiliary Surgery and Nutrition 2019年第6期8卷 635-636页

作者： Samuel O.antwi Tushar Patel Department of Health Sciences Research Mayo ClinicJacksonvilleFLUSA Department of Transplantation Mayo ClinicJacksonvilleFLUSA

Intrahepatic cholangiocarcinoma(iCCA)is an often-fatal malignancy,with an annual incidence rate that closely approximates the mortality rate(1,2).The poor prognosis of these cancers is due in part to their nonspecific clinical presentation and the often-late stage at diagnosis—which is not amenable to curative *** understanding the underlying biology of iCCA is important for early detection and therapy development,there is also a need to ascertain the temporal trends of the disease incidence and mortality.A thorough appraisal of trends in iCCA incidence and mortality would inform strategies for the prevention and identification of high-risk populations for screening and *** studies have shown that the incidence and mortality rates of iCCA have increased in the US over the last few decades(1-6),but while some of these studies suggest that the increase in iCCA incidence appears to have plateaued(2,5),others show continuous rise of both the incidence and mortality of iCCA in the US(3,4,6).

关键词： mortality prevention diagnosis

Estimation of environmental effects of photovoltaic generation in North-west China

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Frontiers in Energy 2013年第4期7卷 535-543页

作者： Mengjia REN anastasia SHCHERBAKOVA Energy and Mineral Engineering Department Pennsylvania State University University Park PA 16802 USA

In estimating emissions reductions brought about by renewables in China, much of existing research assumes that renewables displace coal power. In this paper, this assumption is challenged and the potential environmental effects of photovoltaic （PV） power in North-west China are reevaluated when the marginal generator actually being displaced is taken into account. The annual PV power generation in the North-west Grid is estimated, in this paper, to be as high as 17900GW.h in 2015, roughly equaling to the output of 1.5 nuclear power plants in the US today. The total associated emission reduction in 2015 will at most be 0.36 percent of SO2 and 0.25 percent of NOx emissions from their 2010 levels in China. Further, PV power may render no emissions reduction at all if it displaces hydropower, which is often used to meet peak demand in the North-west Grid in China. These results imply that a more cost-effective area of focus in the short- term may be on desulfurization and denitrification technologies for coal plants.

关键词： photovoltaic (PV) emission reduction North- west China marginal generator

Interaction of water droplets with pyrolyzing coal particles and tablets

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Defence Technology（防务技术） 2023年第12期30卷 1-12页

作者： anastasia Islamova Pavel Tkachenko Pavel Strizhak National Research Tomsk Polytechnic University Heat and Mass Transfer Laboratory30 Lenin AvenueTomsk634050Russia

The paper presents the experimental research findings for the patterns of collisions of water droplets with pressed tableted samples used as substrates and with small particles of a pyrolyzing solid *** coal samples were ***-substrate interactions were studied when varying the droplet diameter in the range from 1 to 4 mm and velocity from 0.5 to 4 m/*** corresponded to the Weber number range of *** coal tablet surface temperature was varied from 20 to 700℃.In the interactions of water droplets(0.7-1.5 mm in diameter,pre-collision velocity from 1 to 3 m/s)with coal particles(with a size of 0.2-1 mm,pre-collision velocity 0.7-2 m/s),the temperature of the latter was varied in the range of 330-480℃.The following regimes of the interaction of droplets with solid particles during chemical reactions and phase transformations were distinguished:spreading/agglomeration and break-up/*** in the characteristics of the interaction of water droplets with coal particles at varying temperatures were ***-particle interaction regime maps for B(We),We(Oh)and We(Ca)were *** collision regime boundaries were described using fitted curves that can be utilized to develop the existing mathematical models of droplet-particle collisions in *** was established that the gaseous volatile production in coal pyrolysis has a modest effect on the regimes and characteristics of the droplet destruction in the temperature range under consideration(20-700℃).

关键词： Droplet Particle Solid substrate Collision Agglomeration Separation

The RhoA nuclear localization changes in replicative senescence:New evidence from in vitro human mesenchymal stem cells studies

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BIOCELL 2022年第9期46卷 2053-2058页

作者： DANILA BOBKOV anastasia POLYANSKAYA anastasia MUSORINA GALINA POLJANSKAYA Collection of Vertebrate Cell Cultures Institute of CytologyRussian Academy of SciencesSt.Petersburg194064Russia Laboratory of Intracellular Signaling and Transport Smorodintsev Research Institute of InfluenzaSt.Petersburg197376Russia Research Laboratory of Translational Oncology Almazov National Research CentreSt.Petersburg197341Russia

All non-immortalized mesenchymal stem cells have a limited proliferative potential,that is,replicative senescence(RS)is an integral characteristic of the life of all mesenchymal stem cells(MSCs).It is known that one of the important signs of RS is a decrease of cell motility,and that violations of migration processes contribute to the deterioration of tissue ***,the characterization of the properties of the cell line associated with RS is a prerequisite for the effective use of MSCs in restorative *** of the key proteins regulating cell motility is the small GTPase *** main purpose of this work was to study the nuclear-cytoplasmic redistribution of the RhoA protein during RS in MSC lines recently obtained and characterized in our *** study found that a comparative analysis of the intracellular localization of RhoA in three cell lines(MSCWJ-1,FetMSC,DF2)showed a decrease in the nuclear localization of RhoA during RS.

关键词： Mesenchymal stem cells RhoA Actin cytoskeleton Replicative senescence

The emergence of the United Arab Emirates as a global soft power: Current strategies and future challenges

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Economic and Political Studies 2022年第2期10卷 208-227页

作者： Osman antwi-Boateng Amira Ali Alhashmi Department of Government and Society College of Humanities and Social SciencesUnited Arab Emirates UniversityAl AinUnited Arab Emirates

Using the Soft Power 30 Index,this research focusses on assessing the soft power status of the United Arab Emirates(UAE)by exam-ining the elements of its soft power and potential challenges it may face in the *** study conducts in-depth interviews with foreign diplomats and academics based in the UAE and Emirati diplomats and *** data are supplemented with primary and secondary data from governmental and inter-national agencies as well as media *** UAE’s case dem-onstrates that soft power can be consciously developed by any country regardless of its regime type,size,location,and religious or racial background by getting its domestic affairs in order.A country’s domestic success in governance,enterprise,culture,education and digital infrastructure leads to global attraction,which ultimately enhances the image of a country such as the *** eventually creates opportunities for more global partner-ships and engagements in the areas of multilateralism,philan-thropy,peacebuilding,conflict resolution and event ***,these efforts face the following challenges:the threat of widely diffused actions among public and private actors,the financial cost of soft power engagement and projections,the UAE’s lack of a global media platform for shaping global agendas and its increasing use of hard power in response to geopolitical threats which can negatively affect its image.

关键词： United Arab Emirates soft power nation branding public diplomacy Abraham Accords