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Characterization of cerebral blood flow dynamics with multiscale entropy

Journal of Innovative Optical Health Sciences 2017年第5期10卷 85-93页

作者： Alexey N.Pavlov Arkady S.Abdurashitov Olga N.Pavlova Maria V.Ulanova anastasia a.bodrova Natalia A.Shushunova Alexander P.Khorovodov Oxana V.Semyachkina-Glushkovskaya Yuri Gagarin State Technical University of Saratov 77 Politechnicheskaya Street Saratov 410054Russia Saratov National Research State University 83 Astrakhanskaya Street Saratov 410012Russia

Based on the laser speckle contrast imaging(LSCI)and the multiscale entropy(MSE),we study in this work the blood flow dynamics at the levels of cerebral veins and the surrounding network of microcerebral *** discuss how the phenylephrine-related acute peripheral bypertension is refected in the cerebral circulation and show that the observed changes are scale dependent,and they are signifcantly more pronounced in microcerebral vessels,while the macrocerebral dynamics does not demonstrate authentic inter-group *** also consider the permeability of blood-brain barrier(BBB)and study its opening caused by sound *** show that alterations associated with the BBB opening can be revealed by the analysis of blood flow at the level of macrocerebral vessels.

关键词： Cerebral blood flow laser speckle contrast imaging arterial pressure complexity

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Laser speckle imaging and wavelet analysis of cerebral blood flow associated with the opening of the blood–brain barrier by sound

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Chinese Optics Letters 2017年第9期15卷 2-6页

作者： O.Semyachkina-Glushkovskaya A.Abdurashitov A.Pavlov A.Shirokov N.Navolokin O.Pavlova A.Gekalyuk M.Ulanova N.Shushunova a.bodrova E.Saranceva A.Khorovodov I.Agranovich V.Fedorova M.Sagatova A.E.Shareef C.Zhang D.Zhu V.Tuchin Saratov National Research State University Saratov 410012Russia Yuri Gagarin State Technical University of Saratov Saratov 410054Russia Institute of Biochemistry and Physiology of Plants and Microorganisms Russian Academy of SciencesSaratov 410049Russia Saratov State Medical University Saratov 410012Russia Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics(WNLO)Huazhong University of Science and Technology(HUST)Wuhan 430074China Key Laboratory for Biomedical Photonics HUSTMinistry of EducationWuhan 430074China National Research Tomsk State University Tomsk 634050Russia Institute of Precision Mechanics and Control Russian Academy of SciencesSaratov 410028Russia

The cerebral blood flow（CBF） alterations related to sound-induced opening of the blood–brain barrier（BBB） in adult mice are studied using laser speckle contrast imaging（LSCI） and wavelet analysis of vascular *** results clearly show that the opening of the BBB is accompanied by the changes of venous but not microvessel circulation in the brain. The elevation of the BBB permeability is associated with the decrease of venous CBF and the increase of its complexity. These data suggest that the cerebral veins rather than microvessels are sensitive components of the CBF related to the opening BBB.

关键词： BBB Laser speckle imaging and wavelet analysis of cerebral blood flow associated with the opening of the blood brain barrier by sound

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铜中无骨架填充Cr和W电触头复合材料的智能显微组织

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Transactions of Nonferrous Metals Society of China 2021年第9期31卷 2773-2786页

作者： L.E.bodrova S.Yu.MELCHAKOV A.B.SHUBIN E.Yu.GOYDA Institute of Metallurgy of the Ural Branch of the Russian Academy of Sciences 620016Ekaterinburg101Amundsen StreetRussian Federation

为了研究抗电弧断路器合金显微组织的智能响应机制,制备W_(45)Cu_(55)、Cr_(65)Cu_(35)和Cr_(32)W_(14)Cu_(54)合金。与工业合金不同,这些合金中Cr和W相是无骨架填充到铜基体中。其制备方法是在振动(80 Hz)下,将铜熔体渗透到未压实的Cr... 详细信息

为了研究抗电弧断路器合金显微组织的智能响应机制,制备W_(45)Cu_(55)、Cr_(65)Cu_(35)和Cr_(32)W_(14)Cu_(54)合金。与工业合金不同,这些合金中Cr和W相是无骨架填充到铜基体中。其制备方法是在振动(80 Hz)下,将铜熔体渗透到未压实的Cr和W混合粉末中。结果显示,当W由“骨架”填充变为“无骨架”填充后,触头的抗弧性能有所提高,Cr对抗弧相的自扩散和W、Cu钝化过程起决定性作用。基于所得结果,总结铜中无骨架填充抗电弧相的优点,以及含Cr触头显微组织在含氧和惰性气氛下对功能载荷响应时“智能行为”的原因。

关键词： Cr−W−Cu电触头材料熔渗智能结构自扩散

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PPPM (Predictive, Preventive and Personalized Medicine) as a New Model of the National and International Healthcare Services and Thus a Promising Strategy to Prevent a Disease: From Basics to Practice

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International Journal of Clinical Medicine 2014年第14期5卷 855-870页

作者： I. A. Sadkovsky O. Golubnitschaja M. A. Mandrik M. A. Studneva H. Abe H. Schroeder E. N. Antonova F. Betsou T. A. bodrova K. Payne S. V. Suchkov Department of Medicine Genetics and Comparative Pathology University of Alabama at Birmingham (UAB) Birmingham USA European Association for Predictive Preventive and Personalized Medicine (EPMA) Brussels EU Rheinische Friedrich-Wilhelms-University of Bonn Bonn Germany I.M. Sechenov First Moscow State Medical University Moscow Russia I.M. Sechenov First Moscow State Medical University Moscow Russia A.I. Evdokimov Moscow State Medical & Dental University Moscow Russia United Cultural Convention (UCC) Cambridge UK Institute of Population Health and Health Economics University of Manchester Manchester UK International Society for Personalized Medicine (ISPM) Tokyo Japan National Research University “Higher School of Economics” Moscow Russia Université du Luxembourg and IBBL (Integrated BioBank of Luxembourg) Luxembourg EU

Nowadays the system of public health is constructed in such a manner so that its main objective is the recovery of an already sick person, while prediction and prevention receive little attention. Meanwhile the development of these aspects of medicine can lead to the ability to control morbidity among the population, to identify chronic and genetic diseases in the early stages of development, and thus to prevent their further progression. This will reduce traditionally high costs of sick people treatment and the number of disabled population, and improve the quality and duration of life. The elaboration of new fields of science that are working on the study and interpretation of data obtained during laboratory and clinical research, creation of new methods for diagnosis, prognosis and treatment, provides an opportunity now to implement a new strategy, called PPPM, and gets promising results, which should lead to further development of an existing medicine.

关键词： Predictive Preventive and Personalized Medicine Biomarkers Subclinical Metabolomics Genomics Proteomics Bioinformatics Public Health Predisposition

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