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An analysis of underweight status on 30-day outcomes after breast reconstruction

Plastic and Aesthetic Research 2016年第1期3卷 8-14页

作者： anas eid Jon P.Ver Halen Division of Plastic Reconstructiveand Hand SurgeryBaptist Cancer CenterGermantownTN 38139USA Department of Surgery Vanderbilt-Ingram Cancer CenterNashvilleTN 37232USA.

Aim:To examine the impact of underweight body mass index(BMI)values on breast reconstruction ***:The American College of Surgeons National Surgical Quality Improvement Program(ACS-NSQIP)database was retrospectively reviewed for all patients who underwent breast reconstruction between 2006 and *** were first stratified by breast reconstruction modality into prosthetic or autologous cohorts,and second by BMI values into underweight(BMI<18.5),normal to overweight(reference,BMI 18.5-29.99),moderate obesity(BMI 30-34.99),severe obesity(BMI 35-39.99),and morbid obesity *** logistic regression models were used to determine independent predictors of ***:With regard to prosthetic breast reconstruction patients,obese patients demonstrated increased rates of surgical complications,while underweight patients did not have any differences on multivariable *** respect to autologous reconstruction,risk-adjusted multivariate regression models showed a dose dependent response between obesity and risk for surgical complications and reoperation,but not for underweight ***:On multivariable analysis of over 4,600 patients,there were no significant differences in the rates of adverse events between underweight patients(BMI<18.5)and their reference-weight counterparts,in spite of a significant increase in surgical and medical complication rates in underweight patients on univariate analysis.

关键词： Breast reconstruction underweight complications body mass index obesity

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Use of negative pressure wound therapy in pediatric oncology patients:a single-center review of 66 patients

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Plastic and Aesthetic Research 2016年第1期3卷 248-253页

作者： Stacy Wong anas eid Warren Southerland Jon P.Ver Halen Department of Surgery Division of Plastic SurgeryBaylor Scott and White HealthcareTexas A&M School of MedicineTempleTX 76513USA Division of Plastic Reconstructive and Hand SurgeryBaptist Cancer CenterMemphisTN 38120USA University of Tennessee Health Science Center School of MedicineMemphisTN 38163USA

Aim:Negative pressure wound therapy(NPWT)has been studied extensively in adult patients,but less is known about pediatric *** study assesses the efficacy and safety of vacuum-assisted closure®usage in pediatric oncology ***:Retrospective data on all patients treated with NPWT at a single pediatric oncology hospital were collected between April 2005 and September *** on pre-treatment factors,treatment course,and post-treatment events were *** control group was available for ***:Sixty-six patients were identified,with a total of 74 *** age at the time of NPWT application was 13 years(range,10 months-23 years).Median duration of treatment was 21 days(range,3-236 days).NPWT therapy was started with continuous high negative pressures(125 mmHg)in most ***-nine percent of patients had their wounds healed without intervention,and 20%of patients required surgical *** was discontinued temporarily secondary to skin maceration or cellulitis in 12%of *** was used in a number of non-standard clinical situations,including primarily-closed incisional wound NPWT and bridging NPWT through adjuvant ***:In pediatric oncology patients,NPWT is safe,effective,and *** this study is retrospective in nature,and there was no control group for comparison,these data are important for clinicians to guide therapy as device monitoring agencies and payors increasingly require outcomes data for the approval of therapeutic decisions.

关键词： Pediatric oncology negative pressure wound therapy

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Whole Exome Sequencing: Novel Genetic Polymorphisms in Saudi Arabian Attention Deficit Hyperactivity Disorder (ADHD) Children

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Natural Science 2019年第2期11卷 45-60页

作者： Neda Mostafa Bogari Amr Ahmed Amin Ashwag Aljohani Ghida Dairi Mahmoud Zaki El-Readi anas Dannoun Udaya Raja Mohammad Adil Nermeen Qutub Suhair Alhelfawi Amal Alobaidi Derar Alqudah Hussain Banni Safaa Yehia eid Huda Balto Faisal Al-Allaf Mohiuddin Taher Hiba Saed Al-Amoodi Ahmed Fawzy Department of Medical Genetics Faculty of Medicine Umm Al-Qura University Makkah KSA Biochemistry Department Faculty of Medicine Umm Al-Qura University Makkah KSA Faculty of Medicine Ain Shams University Cairo Egypt Umm Al-Qura University Makkah KSA Biochemistry Department Faculty of Pharmacy Al-Azhar University Assuit Egypt Integrated Gulf Biosystems Jeddah KSA Special Needs Department School of Education Umm Al-Qura University Mecca KSA Sinad City for Special Needs Makkah KSA Institute of Education University of Reading Reading UK Faculty of Medicine King Abdulaziz University Jeddah KSA Science and Technology Unit Umm Al-Qura University Makkah KSA Division of Human Genetics & Genome Researches Department of Molecular Genetics and Enzymology National Research Centre Dokki Egypt

Background: Attention-deficit hyperactivity disorder (ADHD) is a widespread and debilitating disorder with relatively high prevalence in Saudi Arabia. Neuropsychological and radiological investigations have revealed that there are some differences in the components of the brain regions in children with and without ADHD. In this study we have performed whole exome sequencing (WES) in four non-familial cases of ADHD from Makkah Region to identify the genetic polymorphisms associated with the disease in our Saudi population. Methods: Exome sequencing was carried out using Ion Proton with AmpliSeq Exome library methods, and the data were analysed by Ion Reporter 5.6 software. Results: A total of 33 variants were identified from 222 genes selected from the GWAS catalogue for ADHD associated genes. However, the SNPs we identified in these genes were not reported to be associated with ADHD in previous studies. We have identified 2 novel missense variants;one in c.3451G > T;p. (Ala1151Ser) in ITGA1 gene and another is c.988G > A;p. (Ala330Thr) in SPATA13 genes. The variants rs928661, rs11150370 and rs386792899 were the only three variants that appeared on all the 4 patients studied. Six missense variants, rs16841277, rs2228209, rs2230283, rs3741883, rs1716 and rs2272606, were found in 3 different patients, respectively. However, the three documented variants are rs13166360 with bipolar disorder, rs920829 with neuropathic pain, and rs6558702 with schizophrenia. Conclusion: We have identified 2 novel variants in ADHD children. SIFT score of all variants indicates that these substitutions have damaging effects on the protein function. Further screening studies are recommended for confirmation.

关键词： Next Generation DNA Sequencing Single Nucleotide Polymorphisms Saudi Children Attention-Deficit Hyperactivity Disorder ADHD

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