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Anti-viral role of toll like receptor 4 in hepatitis B virus infection: An in vitro study

World Journal of Gastroenterology 2016年第47期22卷 10341-10352页

作者： Dipanwita Das Neelakshi Sarkar Isha Sengupta ananya pal Debraj Saha Manikankana Bandopadhyay Chandrima Das Jimmy Narayan Shivram Prasad Singh Runu Chakravarty ICMR Virus Unit Kolkata ID and BG Hospital Campus Biophysics and Structural Genomics Division Saha Institute of Nuclear Physics Department of Gastroenterology SCB Medical College Kalinga Gastroenterology Foundation Beam Diagnostics Premises

AIM Toll like receptors plays a significant anti-viral role in different infections. The aim of this study was to look into the role of toll like receptor 4(TLR4) in hepatitis B virus(HBV) *** Real time PCR was used to analyze the transcription of TLR4 signaling molecules, cell cycle regulators and HBV DNA viral load after triggering the Hep G2.2.15 cells with TLR4 specific ligand. Nuclear factor(NF)-κB translocation on TLR4 activation was analyzed using microscopic techniques. Protein and cell cycle analysis was done using Western Blot and FACS *** The present study shows that TLR4 activation represses HBV infection. As a result of HBV suppression, there are several changes in host factors which include partial release in G1/S cell cycle arrest and changes in host epigenetic marks. Finally, it was observed that anti-viral action of TLR4 takes place through the NF-κB *** The study shows that TLR4 activation in HBV infection brings about changes in hepatocyte microenvironment and can be used for developing a promising therapeutic target in future.

关键词： Hepatitis B virus Toll like receptor 4 Cell cycle Epigenetic marks Innate immune response

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Insights into human immunodeficiency virus-hepatitis B virus co-infection in India

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World Journal of Virology 2015年第3期4卷 255-264页

作者： Runu Chakravarty ananya pal ICMR Virus Unit KolkataID and BG Hospital CampusGB 4

Shared routes of transmission lead to frequent human immunodeficiency virus(HIV)-hepatitis B virus(HBV) coinfection in a host which results in about 10% of HIV positive individuals to have chronic hepatitis B infection worldwide. In post-antiretroviral therapy era, liverdiseases have emerged as the leading cause of morbidity and mortality in HIV-infected individuals and HBV coinfection have become the major health issue among this population particularly from the regions with endemic HBV infection. In setting of HIV-HBV co-infection, HIV significantly impacts the natural history of HBV infection, its disease profile and the treatment outcome in negative manner. Moreover, the epidemiological pattern of HBV infection and the diversity in HBV genome(genotypic and phenotypic) are also varied in HIV co-infected subjects as compared to HBV mono-infected individuals. Several reports on the abovementioned issues are available from developed parts of the world as well as from sub-Saharan African countries. In contrast, most of these research areas remained unexplored in India despite having considerable burden of HIV and HBV infections. This review discusses present knowledge from the studies on HIV-HBV co-infection in India and relevant reports from different parts of the world. Issues needed for the future research relevant to HIV-HBV co-infection in India are also highlighted here, including a call for further investigations on this field of study.

关键词： Human immunodeficiency virus-hepatitis B virus co-infection India Genetic diversity Liver diseases

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ROS-hormone interaction in regulating integrative défense signaling of plant cell

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BIOCELL 2023年第3期47卷 503-521页

作者： DURGA KORA ananya DEY BABITA pal UTHpal KRISHNA ROY NIVEDITA DEY TREESHA BHATACHARJEE SOUMEN BHATTACHARJEE Plant Physiology and Biochemistry Research Laboratory Department of BotanyUniversity of BurdwanBurdwan713104India Department of Botany University of RajsahiRajsahi6205Bangladesh

The elaborate redox network of the cell,comprising of events like turnover of reactive oxygen species(ROS),redox sensing,signaling,expression of redox-sensitive genes,etc.,often orchestrates with other bonafide hormonal signaling pathways through their synergistic or antagonistic action in the plant *** redox cue generated in plant cells under fluctuating environmental conditions can significantly influence other hormonal biosynthetic or signaling mechanisms,thereby modulating physiology towards stress acclimation and *** is also strong evidence of the recruitment of ROS as a‘second messenger’in different hormonal signaling pathways under ***,the retrograde signaling initiated by ROS also found to strongly influence hormonal homeostasis and *** present review,in this aspect,is an effort towards understanding the regulatory roles of ROS in integrating and orchestrating other hormonal signaling pathways or vice versa so as to unfold the relationship between these two signaling episodes of plant cells under environmental *** also accentuate the significance of understanding the utterly complex interactions,which occur both at metabolic and genetic levels between ROS and phytohormones during stress ***,the significant and decisive role of ROS turnover,particularly the contribution of RBOH(respiratory burst oxidase homologs)in the synergism of redox and hormone signaling during systemic acquired acclimation under stress is also discussed.

关键词： ROS-hormone cross-talking Abiotic stress Integrative signaling Redox cue Stress tolerance

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