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Long term omeprazole therapy for reflux esophagitis:follow-up in serum gastrin levels,EC cell hyperplasia and neoplasia

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World Journal of Gastroenterology 2000年第6期6卷 789-792页

作者： Pankaj Singh anant indaram Ronald Greenberg Vernu Visvalingam Simmy Bank Division of Gastroenterology Albert Einstein Colege of MedicineLong Island Jewish Medical CenterNew Hyde ParkNew York

AIM To evaluate the long-term safety ofomeprazole in patients of gastroesophagealreflux disease resistant to treatment with H2receptor *** We prospectively followed 33patients on omeprazole therapy for severeerosive esophagitis for 5-8 years,with periodicgastrin levels,*** infection,gastricbiopsies for incidence of ECL cell hyperplasia,carcinoids,gastric atrophy and *** 185 patient follow-up years and 137 gastricbiopsies were *** Among the 33 patients,36% reachedtheir peak gastrin levels in an average of 8months to one year,then drifted Down slowlyover 1-2 year period to just above their baselinelevel,24% of the patients had a peak gastrinlevel above 400ng·L^1 and one patient had apeak level above 1000 ng·L^*** patient had amild ECL cell hyperplasia which was self limitingand did not show any dysplastic *** percent of patients were positive *** *** gastric biopsies did notshow gastric atrophy,intestinal metaplasia orneoplastic *** In a series of 33 patients followed for 5 - 8 years on omeprazole therapy for severe reflux esophagitis, we did not observe any evidence of significant ECL cell hyperplasia, gastric atrophy, intestinal metaplasia, dysplasia or neoplastic changes.

关键词： gastroesophageal reflux proton pump inhibitors enterochromaffin cell hypergastrinemia carcinoid tumor biopsy

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Elevated basal intestinal mucosal cytokine levels in asymptomatic first-degree relatives of patients with Crohn's disease

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World Journal of Gastroenterology 2000年第1期6卷 49-52页

作者： indaram AVK Nandi S Weissman S Lam S Bailey B Blumstein M Greenberg R Bank S Division of Gastroenterology Long Island Jewish Medical CenterAlbert Einstein College of MedicineNew YorkUSA

AIM To determine levels of cytokines incolonic mucosa of asymptomatic first degreerelatives of Crohn’s disease *** Cytokines(Interleukin(IL)1-Beta,IL-2,IL-5 and IL-8)were measured using ELISAin biopsy samples of normal looking colonicmucosa of first degree relatives of Crohn’sdisease patients(n = 9)and from normalcontrols(n = 10)with no family history ofCrohn’s *** Asymptomatic first degree relativesof patients with Crohn’s disease had significantlyhigher levels of basal intestinal mucosalcytokines(IL-2,IL-5 and IL-8)than *** these increased cytokinelevels serve as phenotypic markers for a geneticpredisposition to developing Crohns diseaselater on,or whether they indicate early(pre-clinical)damage has yet to be further *** Asymptomatic first degreerelatives of Crohn’s disease patients have higherlevels of cytokines in their normal-lookingintestinal mucosa compared to normal controls,This supports the hypothesis that increasedcytokines may be a cause or an early event inthe inflammatory cascade of Crohns disease andare not merely a result of the inflammatoryprocess.

关键词： Subject headings crohns disease cytokine/analysis intestinal mucosa

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