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Molecular mechanisms of aflatoxin neurotoxicity and potential neuroprotective agents

Food Science and Human Wellness 2024年第5期13卷 2445-2455页

作者： Chongshan Dai Erjie Tian Hui Li Subhajit Das gupta Zhihui Hao Zhanhui Wang Tony Velkov Jianzhong Shen National Key Laboratory of Veterinary Public Health and Safety Beijing Key Laboratory of Detection Technology for Animal-Derived Food SafetyCollege of Veterinary MedicineChina Agricultural UniversityBeijing 100193China Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou 510642China College of Animal Science and Technology Henan University of Science and TechnologyLuoyang 471023China Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning Beijing Center for Disease Prevention and ControlBeijing 100013China Department of Internal Medicine University of Texas Southwestern Medical CenterDallas 75230USA Monash Biomedicine Discovery Institute Department of PharmacologyMonash UniversityVictoria 3800Australia

Aflatoxins(AFTs)represent one of the most notorious classes of deadly mycotoxins produced by certain fungi that are found on agricultural *** are highly toxic to mammals and are known to cause a series of detrimental effects,including neuro-,hepato-,nephron-,and *** this original review we summarize the mechanisms of aflatoxin-induced neurotoxicity and the clinical potential of novel neuroprotective *** B1(AFB1)is the most toxic congener among the 21 identified *** studies have shown that food borne exposure to AFB1 and/or its metabolites often leads to fatal neurotoxicity in animals and *** studies indicated that AFB1 exposure could induce abnormal behavioral changes,including anxiety,lethargy disorders,depression-like behavior,cognitive,learning and memory defects,and decreased feeding ***,AFB1 exposure has been associated with lipid peroxidation,ablation of non-enzymatic and enzymatic antioxidant defense systems and decreased neurotransmitter ***1 exposure has also been shown to induce DNA damage,apoptosis,pyroptosis,and mitochondrial dysfunction in the brain *** signaling pathways,including gasdermin D,toll like receptor 2(TLR2),TLR4,Akt,NF-κB,ERK/MAPK,protein kinase C(PKC),and mitochondrial apoptotic pathways have been shown to participate in AFB1-induced neuronal or astrocyte cell *** these pathways by small molecules(e.g.,quercetin,curcumin,and gallic acid,and dimethyl fumarate),Chinese herbal extracts(e.g.,Artichoke leaf extract,Chelidonium majus ethanolic extract,pumpkin extract,and Crocus sativus ***),and probiotic supplements could effectively improve AFB1-induced neurobehavioral abnormalities and *** date,the precise molecular mechanisms of AFB1-induced neurotoxicity and potential neuroprotective agents remain *** the present review,the clinical manifestations,molecular mechanisms,and potential neuroprotective agents of AFB1

关键词： Aflatoxin B1(AFB1) Neurotoxicity Molecular mechanisms Chemical preventions

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Dual ecological and socio-cultural fragmentation induced by hydropower dams: Case studies from the Greater Himalayan region of India

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Zoological Research(Diversity and Conservation) 2024年第2期1卷 117-120页

作者： Garima gupta Rahul Kotiyal Isabel L.Jones Biological and Environmental Sciences University of StirlingScotland FK94LAUK Baramasa.in Narrating Himalaya 248001India

Climate change and biodiversity loss are pressing global challenges(Pörtner et al.,2021).However,as global energy demand continues to increase(IEA,2021),nations face significant challenges to decarbonization and reaching“net zero”due to trade-offs between the often-competing needs of renewable energy generation and biodiversity *** example,hydropower generates renewable energy(Gibson et al.,2017),yet there are well-documented and severe consequences of dam development for biodiversity(e.g.,Zarfl et al.,2019)and people(e.g.,Bisht,2009)due to reservoir creation and disruption of river *** such potentially damaging ecological and social trade-offs,hydropower currently contributes 70%of global renewable energy and there are at least 3700 large dams planned or under construction globally(Zhang&Gu,2023).

关键词： reservoir consequences globally

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User Perspective of Misplaced PPIUCD and Factors Resulting in PPIUCD Removal: Qualitative Pilot Study

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Open Journal of Epidemiology 2024年第3期14卷 517-532页

作者： A. G. Radhika Rashmi gupta Pooja Kashyap Ravleen Bakshi Department of Obstetrics and Gynecology University College of Medical Sciences & Guru Teg Bahadur Hospital Dilshad Garden Delhi India GTB Hospital Delhi India Indian Council of Medical Research Delhi India

Objective: The aim of the current study was to assess the impact of operative interventions for misplaced device among women who opted for PPIIUCD and the evaluation of reasons for PPIUCD removal within the follow up period of two years. Design: A descriptive exploratory study was conducted over three months among fourteen PPIUCD acceptors at a tertiary care health facility in Delhi, India. Face-to-face & telephonic in-depth interviews were conducted with a selected sample of PPIUCD acceptors who had later opted for its removal. Results: Participants (n = 14) aged 24 – 40 exhibited generally positive attitudes towards PPIUCDs indicating an indicate an understanding of the importance of PPIUCD in preventing unintended pregnancies. Menstrual disturbance and misplaced IUCD were major reasons for removal. despite their own experience necessitating the removal of IUCD, positive experience by other family members (mothers in law) in this study helped to keep the confidence on the contraceptive. Themes included (a) general experience of PPIUCD use (b) Health Facility accessed for removal of IUCD (c) Would she recommend it to others? (d) preferred contraceptive after removal of IUCD. Conclusion: Misplaced IUCD, missing thread, menstrual irregularities, and pain are all associated with PPIUCD and are important reasons for dissatisfaction. Appropriate, timely and supportive individualized care that address knowledge gaps, societal perceptions, and healthcare system challenges would certainly help in reducing dissatisfaction due to PPIUCD and thereby the removal rates.

关键词： Postpartum Intrauterine Device PPIUCD LARC Long Acting Reversible Contraception Postpartum Family Planning Contraception

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Reflection of plane waves from a micropolar thermoelastic solid half-space with impedance boundary conditions

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Journal of Ocean Engineering and Science 2019年第2期4卷 122-131页

作者： Baljeet Singh anand Kumar Yadav Deepak gupta Department of Mathematics Post Graduate Government CollegeSector 11ChandigarhIndia Department of Mathematics M.M.University MullanaAmbalaIndia

In this paper,the governing equations of linear,isotropic,homogeneous and generalized micropolar thermoelasticity are specialized in a *** governing equations are solved for plane harmonic wave *** separate velocity equations are obtained which indicate the existence of four plane waves with distinct speeds.A problem on reflection of plane waves from a thermally insulated/isothermal surface is considered with impedance boundary *** potentials for incident and reflected waves are formulated which satisfy the boundary conditions at a plane *** between reflection coefficients as well as the expressions of energy ratios for various reflected waves are *** illustration,the reflection coefficients and energy ratios of reflected waves are computed for relevant material parameters of an aluminium-epoxy *** of impedance parameters on all reflected waves is shown graphically at each angle of incidence.

关键词： Micropolar thermoelasticity Impedance boundary Plane waves Reflection coefficients Energy ratios.

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Investigating computational models for diagnosis and prognosis of sepsis based on clinical parameters: Opportunities, challenges, and future research directions

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Journal of Intensive Medicine 2024年第4期4卷 468-477页

作者： Jyotirmoy gupta Amit Kumar Majumder Diganta Sengupta Mahamuda Sultana Suman Bhattacharya Department of Computer Science and Engineering(IOTCSBT) Future Institute of TechnologyKolkataWest BengalIndia Department of Electronics and Communications Engineering Future Institute of TechnologyKolkataWest BengalIndia Department of Computer Science and Engineering Heritage Institute of TechnologyKolkataWest BengalIndia Department of Computer Science and Engineering Guru Nanak Institute of TechnologyKolkataWest BengalIndia

This study investigates the use of computational frameworks for *** consider two dimensions for investi-gation-early diagnosis of sepsis(EDS)and mortality prediction rate for sepsis patients(MPS).We concentrate on the clinical parameters on which sepsis diagnosis and prognosis are currently done,including customized treatment plans based on historical data of the *** identify the most notable literature that uses com-putational models to address EDS and MPS based on those clinical *** addition to the review of the computational models built upon the clinical parameters,we also provide details regarding the popular publicly available data *** provide brief reviews for each model in terms of prior art and present an analysis of their results,as claimed by the respective *** respect to the use of machine learning models,we have provided avenues for model analysis in terms of model selection,model validation,model interpretation,and model *** further present the challenges and limitations of the use of computational models,providing future research *** study intends to serve as a benchmark for first-hand impressions on the use of computational models for EDS and MPS of sepsis,along with the details regarding which model has been the most promising to *** have provided details regarding all the ML models that have been used to date for EDS and MPS of sepsis.

关键词： Sepsis Computing methodologies Early prediction of sepsis Mortality prediction of sepsis Machine learning Artificial intelligence

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Graphene derivatives as efficient hole transport materials for lead-free double perovskite(CsSnI) solar cells: a numerical study

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Optoelectronics Letters 2024年

作者： SARITA YADAV SARAL K gupta C.M.S.NEGI Department of Physical Science，Banasthali Vidyapith

The double perovskite Cs2SnI6has notable optical and electrical characteristics， rendering it a highly prospective candidate for deployment as the absorber layer in perovskite solar cells (PSCs). We simulated the performance of PSCs using lead-free Cs2SnI6double perovskite absorber layer and graphene derivatives， namely graphene oxide (GO) and reduced graphene oxide (rGO)， as hole transport layers (HTLs). Our findings show that rGO offers an excellent hole extraction property with minimal interfacial recombination compared to GO. PSC utilizing rGO as the HTL material achieved a power conversion efficiency of 19.07%， while those employing GO HTL attained only 16.9%. The superior performance of rGO is attributed to its greater charge carrier mobility of rGO and its favorable energy level alignment with the double perovskite absorber layer. In contrast， the mismatch in the charge transport properties between the absorber layer and the GO HTL resulted in poor performance. Our study showcases the potential of using graphene derivative-based HTLs for realizing lead-free PSCs.

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Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity

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National Science Review 2024年第7期11卷 80-94页

作者： Pan Liu Can Yue Bo Meng Tianhe Xiao Sijie Yang Shuo Liu Fanchong Jian Qianhui Zhu Yuanling Yu Yanyan Ren Peng Wang Yixin Li Jinyue Wang Xin Mao Fei Shao Youchun Wang Ravindra Kumar gupta Yunlong Cao Xiangxi Wang CAS Key Laboratory of Infection and Immunity National Laboratory of MacromoleculesInstitute of BiophysicsChinese Academy of Sciences University of Chinese Academy of Sciences Cambridge Institute of Therapeutic Immunology&Infectious Disease(CITIID) University of Cambridge Biomedical Pioneering Innovation Center(BIOPIC) Peking University Changping Laboratory Joint Graduate Program of Peking-Tsinghua-NIBS Academy for Advanced Interdisciplinary Studies Peking University Peking-Tsinghua Center for Life Sciences Tsinghua University Chinese Academy of Medical Sciences&Peking Union Medical College

Selective pressures have given rise to a number of SARS-CoV-2 variants during the prolonged course of the COVID-19 pandemic. Recently evolved variants differ from ancestors in additional glycosylation within the spike protein receptor-binding domain(RBD). Details of how the acquisition of glycosylation impacts viral fitness and human adaptation are not clearly understood. Here, we dissected the role of N354-linked glycosylation, acquired by BA.2.86 sub-lineages, as a RBD conformational control element in attenuating viral infectivity. The reduced infectivity is recovered in the presence of heparin sulfate, which targets the‘N354 pocket’ to ease restrictions of conformational transition resulting in a ‘RBD-up’ state, thereby conferring an adjustable infectivity. Furthermore, N354 glycosylation improved spike cleavage and cell–cell fusion, and in particular escaped one subset of ADCC antibodies. Together with reduced immunogenicity in hybrid immunity background, these indicate a single spike amino acid glycosylation event provides selective advantage in humans through multiple mechanisms.

关键词： coronavirus glycosylation viral fitness adjustable infectivity co-factor usage viral evolution conformational modulator

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成人注意缺陷多动障碍的创新疗法

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空中英语教室（高级版．彭蒙惠英语） 2024年第5期 28-29,46,47页

作者： Shalene gupta 不详

对于成年注意缺陷多动障碍的患者而言,一家公司的游戏可能作为不必服药的解决方案。七十岁的芭芭拉·瓦格纳不太能适应她的退休生活。她长年从事物业管理,又是一位成功的企业家,在2017年决定退休,但是她似乎无法进入退休的状态。她盖了... 详细信息

对于成年注意缺陷多动障碍的患者而言,一家公司的游戏可能作为不必服药的解决方案。七十岁的芭芭拉·瓦格纳不太能适应她的退休生活。她长年从事物业管理,又是一位成功的企业家,在2017年决定退休,但是她似乎无法进入退休的状态。她盖了一栋房子,接着又盖了另一栋。她搬了家,然后再度搬家。

关键词：退休生活注意缺陷多动障碍物业管理芭芭拉瓦格纳七十岁企业家创新疗法

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Neuroprotective effects of resveratrol on retinal ganglion cells in glaucoma in rodents:A narrative review

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Animal Models and Experimental Medicine 2024年第3期7卷 195-207页

作者： Maryam Golmohammadi Seyed Arash Aghaei Meibodi Sulieman Ibraheem Shelash Al-Hawary Jitendra gupta Ibrohim B.Sapaev Mazin A.A.Najm Marim Alwave Mozhgan Nazifi Mohammadreza Rahmani Mohammad Yasin Zamanian Gervason Moriasi School of Medicine Shahid Beheshti University of Medical SciencesTehranIran Department of Business Administration Business SchoolAl al-Bayt UniversityMafraqJordan Institute of Pharmaceutical Research GLA UniversityMathuraIndia Tashkent Institute of Irrigation and Agricultural Mechanization Engineers TashkentUzbekistan New Uzbekistan University TashkentUzbekistan Pharmaceutical Chemistry Department College of PharmacyAl-Ayen UniversityThi-QarIraq Medical Technical College Al-Farahidi UniversityBaghdadIraq Department of Neurology Hamadan University of Medical SciencesHamadanIran Physiology-Pharmacology Research Center Research Institute of Basic Medical SciencesRafsanjan University of Medical SciencesRafsanjanIran Department of Physiology and Pharmacology School of MedicineRafsanjan University of Medical SciencesRafsanjanIran Neurophysiology Research Center Hamadan University of Medical SciencesHamadanIran Department of Pharmacology and Toxicology School of PharmacyHamadan University of Medical SciencesHamadanIran Department of Medical Biochemistry School of MedicineCollege of Health SciencesMount Kenya UniversityThikaKenya

Glaucoma,an irreversible optic neuropathy,primarily affects retinal ganglion cells(RGC)and causes vision loss and *** damage to RGCs in glaucoma occurs by various mechanisms,including elevated intraocular pressure,oxidative stress,inflammation,and other neurodegenerative *** the disease progresses,the loss of RGCs leads to vision ***,protecting RGCs from damage and promoting their survival are important goals in managing *** this regard,resveratrol(RES),a polyphenolic phytoalexin,exerts antioxidant effects and slows down the evolution and progression of *** present review shows that RES plays a protective role in RGCs in cases of ischemic injury and hypoxia as well as in ErbB2 protein expression in the ***,RES plays protective roles in RGCs by promoting cell growth,reducing apoptosis,and decreasing oxidative stress in H_(2)O_(2)-exposed *** was also found to inhibit oxidative stress damage in RGCs and suppress the activation of mitogen-activated protein kinase signaling *** could alleviate retinal function impairment by suppressing the hypoxia-i nducible factor-1 alpha/vascular endothelial growth factor and p38/p53 axes while stimulating the PI3K/Akt ***,RES might exert potential therapeutic effects for managing glaucoma by protecting RGCs from damage and promoting their survival.

关键词： glaucoma ischemic-reperfusion injury oxidative stress resveratrol retinal ganglion cells

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Deep Learning Based Automated Diagnosis of Skin Diseases Using Dermoscopy

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Computers, Materials & Continua 2022年第5期71卷 3145-3160页

作者： Vatsala anand Sheifali gupta Deepika Koundal Shubham Mahajan Amit Kant Pandit Atef Zaguia Chitkara University Institute of Engineering and Technology Chitkara UniversityPunjabIndia Department of Systemics School of Computer ScienceUniversity of Petroleum&Energy StudiesDehradunUttrakhandIndia School of Electronics&Communication Shri Mata Vaishno Devi UniversityKatra182320India Department of Computer Science College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia

Biomedical image analysis has been exploited considerably by recent technology involvements,carrying about a pattern shift towards‘automation’and‘error free diagnosis’classification methods with markedly improved accurate diagnosis productivity and cost *** paper proposes an automated deep learning model to diagnose skin disease at an early stage by using Dermoscopy *** proposed model has four convolutional layers,two maxpool layers,one fully connected layer and three dense *** the convolutional layers are using the kernel size of 3∗3 whereas the maxpool layer is using the kernel size of 2∗*** dermoscopy images are taken from the HAM10000 *** proposed model is compared with the three different models of ResNet that are ResNet18,ResNet50 and *** models are simulated with 32 batch size and Adadelta *** proposed model has obtained the best accuracy value of 0.96 whereas the ResNet101 model has obtained 0.90,the ResNet50 has obtained 0.89 and the ResNet18 model has obtained value as ***,features obtained from the proposed model are more capable for improving the classification performance of multiple skin disease *** model can be used for early diagnosis of skin disease and can also act as a second opinion tool for dermatologists.

关键词： Dermoscopy images CNN deep learning classification optimizer ResNet diagnosis skin disease

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