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Genome tuning through HLA and KIR gene clusters impact susceptibility to dengue

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Infectious Medicine

Infectious Medicine 2023年第3期2卷 167-177页

作者： Neha Sharma gaurav Sharma Uma Kanga Devinder Toor Department of Biosciences School of Basic and Applied SciencesGalgotias UniversityGreater Noida 203201India Department of Translational and Regenerative Medicine Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Department of Transplant Immunology and Immunogenetics All India Institute of Medical SciencesNew Delhi 110029India Amity University Uttar Pradesh Amity Institute of Virology and ImmunologyAmity UniversityNoida 201301India

Dengue is amongst the most prevalent viral diseases which globally affects millions of individuals annually and renders billions at risk,particularly in tropical and sub-tropical *** estimated 100-400 mil-lion infections each year and reported 4.2 million active cases in 2019 *** infection is caused by arthropod-transmitted dengue virus which is known to have 5 serotypes(DENV1-5).Most of the cases show mild clinical symptoms;though others may develop severe forms viz;dengue hemorrhagic fever and dengue shock *** limited literature suggests the population-specific genetic influence on susceptibility and the clinical course of dengue;the genetic propensity of dengue is largely unknown in most *** this context,the human leukocyte antigen(HLA)system represents the most polymorphic region of the human genome and is crucial for the initiation of an appropriate immune *** most of the genome-wide association studies,the HLA complex is the most significantly linked genetic region with susceptibility or protection towards vari-ous infectious and noninfectious *** immunoglobulin-like receptors represent another highly variable system present on the surface of natural killer(NK)cells which regulate the activity of NK cells through inter-actions with their cognate HLA *** is conceivable that the interaction of HLA-Killer immunoglobulin-like receptors systems influences the host susceptibility towards dengue infection as well the disease *** we attempt to review these parameters in dengue infection and disease *** detailed investigations are warranted towards the identification of novel susceptibility markers and targeted therapeutic interventions.

关键词： DENV Human leukocyte antigen Killer immunoglobulin receptor Pathogenesis and genetic susceptibility

Optimization of process for the production of bio-oil from eucalyptus wood

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燃料化学学报 2010年第2期38卷 162-167页

作者： gaurav KUMAR Achyut K PANDA R K SINGH National Institute of Technology Rourkela Orissa PIN： 769008 India Jagannath Institute for Technology and Management Parlakhemundi Orissa India

The pyrolysis of eucalyptus wood was carried out in a batch reactor to optimize the yield of *** of various parameters like feed(particle) size,temperature,presence of catalyst and heating rate on the yield of bio-oil was *** optimum conditions for high yield of bio-oil are for the particle size 2 mm^5 mm(average l/d=12.84/2.03 mm) at 450 ℃ in high heating *** reaction kinetics and the quality of bio-oil produced are independent of the presence of different catalysts like mordenite,kaoline clay,fly ash and silica *** physical properties like odour,colour,PH,viscosity,heating value were *** FT-IR analysis of bio-oil indicates the presence of different functional groups such as monomeric alcohol,phenol,ketones,aldehydes,carboxylic acid,amines,and nitro *** composition of the bio-oil at different conditions was analyzed using GC-MS and found that the components are temperature dependent but independent of catalysts used.

关键词：热反应晶体结构生物能源

MLA:A New Mutated Leader Algorithm for Solving Optimization Problems

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Computers, Materials & Continua 2022年第3期70卷 5631-5649页

作者： Fatemeh Ahmadi Zeidabadi Sajjad Amiri Doumari Mohammad Dehghani Zeinab Montazeri Pavel Trojovsky gaurav Dhiman Department of Mathematics and Computer Sciences Sirjan University of TechnologySirjanIran Graduate of Department of Electrical and Electronics Engineering Shiraz University of TechnologyShirazIran Department of Electrical and Electronics Engineering Shiraz University of TechnologyShirazIran Department of Mathematics Faculty of ScienceUniversity of Hradec Králové50003Hradec KrálovéCzech Republic Department of Computer Science Government Bikram College of CommercePatialaPunjabIndia

Optimization plays an effective role in various disciplines of science and *** problems should either be optimized using the appropriate method(i.e.,minimization or maximization).Optimization algorithms are one of the efficient and effective methods in providing quasioptimal solutions for these type of *** this study,a new algorithm called the Mutated Leader Algorithm(MLA)is *** main idea in the proposed MLA is to update the members of the algorithm population in the search space based on the guidance of a mutated *** addition to information about the best member of the population,themutated leader also contains information about the worst member of the population,as well as other normal members of the *** proposed MLA is mathematically modeled for implementation on optimization problems.A standard set consisting of twenty-three objective functions of different types of unimodal,fixed-dimensional multimodal,and high-dimensional multimodal is used to evaluate the ability of the proposed algorithm in ***,the results obtained from theMLA are compared with eight well-known *** results of optimization of objective functions show that the proposed MLA has a high ability to solve various optimization ***,the analysis and comparison of the performance of the proposed MLA against the eight compared algorithms indicates the superiority of the proposed algorithm and ability to provide more suitable quasi-optimal solutions.

关键词： Optimization metaheuristics leader benchmark objective function

Neurological manifestations of hepatitis E virus infection:An overview

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World Journal of Gastroenterology 2021年第18期27卷 2090-2104页

作者： Ashish Kumar Jha gaurav Kumar Vishwa Mohan Dayal Abhay Ranjan Arya Suchismita Department of Gastroenterology Indira Gandhi Institute of Medical SciencesPatna 800014India Department of Neurology Indira Gandhi Institute of Medical SciencesPatna 800014India Department of Pediatric Hepatology Institute of Liver and Biliary SciencesBasant Kunj 110070New DelhiIndia

Hepatitis E virus(HEV)is an important cause of repeated waterborne outbreaks of acute ***,several extrahepatic manifestations(EHMs)have been described in patients with HEV *** these,neurological disorders are the most common EHM associated with *** involvement of both the peripheral nervous system and central nervous system can occur together or in *** can present with normal liver function tests,which can often be misleading for *** is a paucity of data on HEV-related neurological manifestations;and these data are mostly described as case reports and case *** this review,we analyzed data of 163 reported cases of HEV-related neurological *** mechanisms of pathogenesis,clinico-demographic profile,and outcomes of the HEV-related neurological disorders are described in this *** root and plexus disorder were found to be the most commonly reported disease,followed by meningoencephalitis.

关键词： Hepatitis E virus Acute hepatitis E Extrahepatic manifestations Neurological manifestations Neuralgic amyotrophy Guillain-Barrésyndrome

AMBO:All Members-Based Optimizer for Solving Optimization Problems

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Computers, Materials & Continua 2022年第2期70卷 2905-2921页

作者： Fatemeh Ahmadi Zeidabadi Sajjad Amiri Doumari Mohammad Dehghani Zeinab Montazeri Pavel Trojovsky gaurav Dhiman Department of Mathematics and Computer Sciences Sirjan University of TechnologySirjanIran Department of Electrical and Electronics Engineering Shiraz University of TechnologyShirazIran Department of Mathematics Faculty of ScienceUniversity of Hradec KrálovéHradec Králové50003Czech Republic Department of Computer Science Government Bikram College of CommercePatialaPunjabIndia

There are many optimization problems in different branches of science that should be solved using an appropriate *** optimization algorithms are one of the most efficient approaches to solve this type of *** this paper,a new optimization algorithm called All Members-Based Optimizer(AMBO)is introduced to solve various optimization *** main idea in designing the proposedAMBOalgorithm is to use more information from the population members of the algorithm instead of just a few specific members(such as best member and worst member)to update the population ***,in AMBO,any member of the population can play a role in updating the population *** theory of AMBO is described and then mathematically modeled for implementation on optimization *** performance of the proposed algorithm is evaluated on a set of twenty-three standard objective functions,which belong to three different categories:unimodal,high-dimensional multimodal,and fixed-dimensional multimodal *** order to analyze and compare the optimization results for the mentioned objective functions obtained by AMBO,eight other well-known algorithms have been also *** optimization results demonstrate the ability of AMBO to solve various optimization ***,comparison and analysis of the results show that AMBO is superior andmore competitive than the other mentioned algorithms in providing suitable solution.

关键词： Algorithm all members optimization optimization algorithm optimization problem population-based algorithm

Isolated intramedullary tuberculoma of the dorsal cord:a rare clinico-radiological entity

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Asian Pacific Journal of Tropical Medicine 2010年第12期3卷 1004-1005页

作者： Sumeet Bhargava Rajul Rastogi gaurav Jindal Amrit Kumar Singh Vaibhav Rastogi Yash Diagnostic Center Yash Hospital and Research CenterCivil LinesKanth RoadMoradabad(UP)-244001India Neuron Advanced Neurosurgery CenterMoradabodUPIndia Yash Diagnostic Center Yash Hospital and Research CenterCivil LinesKanth RoadMoradabad(UP) -244001India

Tuberculous infection manifesting as an isolated intramedullary tuberculoma of the spinal cord is distinctly *** report a case of a 35 year old woman presenting with an insidious onset of myelopathy,where MRI showed c... 详细信息

关键词： Intramedullary tuberculoma MRI Dorsal cord

Diabetic cardiomyopathy: Pathophysiology, theories and evidence to date

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World Journal of Diabetes 2019年第10期10卷 490-510页

作者： Lavanya Athithan gaurav S Gulsin Gerald P McCann Eylem Levelt Department of Cardiovascular Sciences University of Leicester and NIHR Leicester Cardiovascular Biomedical Research CentreGlenfield HospitalLeicester LE3 9QPUnited Kingdom Multidisciplinary Cardiovascular Research Centre and Biomedical Imaging Science Department Leeds Institute of Cardiovascular and Metabolic MedicineUniversity of LeedsLeeds LF9 7TFUnited Kingdom

The prevalence of type 2 diabetes(T2D)has increased worldwide and doubled over the last two *** features among the top 10 causes of mortality and morbidity in the *** disease is the leading cause of complications in diabetes and within this,heart failure has been shown to be the leading cause of emergency admissions in the United *** are many hypotheses and well-evidenced mechanisms by which diabetic cardiomyopathy as an entity *** review aims to give an overview of these mechanisms,with particular emphasis on metabolic inflexibility.T2D is associated with inefficient substrate utilisation,an inability to increase glucose metabolism and dependence on fatty acid oxidation within the diabetic heart resulting in mitochondrial uncoupling,glucotoxicity,lipotoxicity and initially subclinical cardiac dysfunction and finally in overt heart *** review also gives a concise update on developments within clinical imaging,specifically cardiac magnetic resonance studies to characterise and phenotype early cardiac dysfunction in T2D.A better understanding of the pathophysiology involved provides a platform for targeted therapy in diabetes to prevent the development of early heart failure with preserved ejection fraction.

关键词： Diabetic cardiomyopathy Cardiac metabolism Myocardial steatosis Myocardial strain

Comparison of gliclazide vs linagliptin on hypoglycemia and cardiovascular events in type 2 diabetes mellitus: A systematic review

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World Journal of Diabetes 2022年第12期13卷 1168-1183页

作者： Viswanathan Mohan Subhash Wangnoo Sambit Das Rajnish Dhediya Kumar gaurav Department of Diabetes Madras Diabetes Research Foundation&Dr Mohan’s Diabetes Specialties CentreChennai 600086Tamil NaduIndia Department of Diabetes Apollo Hospital Education and Research FoundationNew Delhi 110001India Department of Endocrinology Endeavour ClinicsBhubaneswar 750017India Medical Affairs Dr.Reddy’s Laboratories LtdHyderabad 500016India

BACKGROUND Cardiovascular outcome trials have demonstrated cardiovascular safety of glimepiride(a sulfonylureas) against dipeptidyl peptidase-4 inhibitor ***(another newer sulfonylureas) has shown similar glycemic efficacy and 50% decreased risk of hypoglycemia compared to *** Considering the absence of cardiovascular outcome trials for gliclazide, we decided to conduct a systematic review of the literature to assess the cardiovascular(CV) safety by assessing the risk for major adverse CV events and hypoglycemia risk of gliclazide vs linagliptin in patients with type 2 diabetes(T2D).METHODS This systematic review followed the current Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to analyze all the clinical studies published from 2008 that compared the two drugs in patients with T2D with no risk of CV disease(CVD). We included only evidence designated high quality by the Oxford Center for Evidence-based Medicine-Levels of *** Eight clinical studies were included in the narrative descriptive analysis(gliclazide: 5 and linagliptin: 3). The CV safety of gliclazide in the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation trial and of linagliptin in the Cardiovascular and Renal Microvascular Outcome Study With Linagliptin(CARMELINA) and CARdiovascular Outcome study of LINAgliptin vs glimepiride in patients with T2D(CAROLINA)trials were excluded from the comparative analysis as these trials demonstrated CV and hypoglycemia benefits in patients at high risk of CVD. However, since these are landmark trials,they were discussed in brief to show the CV benefits and low hypoglycemia risk of gliclazide and linagliptin. We did not find any study comparing gliclazide with linagliptin. Hence, direct comparison of their major adverse CV events and hypoglycemia risk could not be carried ***, the literature meeting the inclusion criteria showed that b

关键词： Linagliptin Gliclazide Hypoglycemia Major cardiovascular adverse events Type 2 diabetes

Modelling vehicular interactions for heterogeneous traffic flow using cellular automata with position preference

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Journal of Modern Transportation 2017年第3期25卷 163-177页

作者： gaurav Pandey K.Ramachandra Rao Dinesh Mohan Department of Civil Engineering and Transportation Research and Injury Prevention Programme Indian Institute of Technology Delhi Shiv Nadar University

This paper proposes and validates a modified cellular automata model for determining interaction rate （i.e. number of car-following/overtaking instances） using traffic flow data measured in the field. The proposed model considers lateral position preference by each vehicle type and introduces a position preference parameter fl in the model which facilitates gradual drifting towards preferred position on road, even if the gap in front is sufficient. Additionally, the model also improves upon the conven- tional model by calculating safe front and back gap dynamically based on speed and deceleration properties of leader and follower vehicles. Sensitivity analysis was carried out to determine the effect of β on vehicular interac- tions and the model was calibrated and validated using interaction rates observed in the field. Paired tests were conducted to determine the determining interaction rates validity of the model in Results of the simulations show that there is a parabolic relationship between area occupancy and interaction rate of different vehicle types. The model performed satisfactorily as the simulated interaction rate between different vehicle types were found to be statistically similar to those observed in field. Also, as expected, the interaction rate between light motor vehicles （LMVs） and heavy motor vehicles （HMVs） were found to be higher than that between LMVs and three wheelers because LMVs and HMVs share the same lane. This could not be done using conventional CA models as lateral movement rules were dictated by only speeds and gaps. So, in conventional models, the vehicles would end up in positions which are not realistic. The position preference parameter introduced in this model motivates vehicles to stay in their preferred positions. This study demonstrates the use of interaction rate as a measure to validate micro- scopic traffic flow models.

关键词： Cellular automata Vehicular interaction ratePosition preference Traffic flow modelling Video-graphic survey